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| 1 | 动脉瘤性蛛网膜下腔出血患者的重症监护处理:神经危重症监护学会多学科共识会议的推荐意见显示文摘蛛网膜下腔出血(subarachnoidhemorrhage,SAH)是一种可对中枢神经系统造成毁灭性打击并对其他多个器官产生显著影响的急性脑血管病。SAH患者被常规收入重症监护病房并由多学科团队进行治疗。由于高质量研究证据的缺乏,使得治疗方法各异,可供选择的指导意见不多。现有的指南主要强调危险因素、预防、自然史以及再出血的预防,很少涉及SAH患者的重症监护问题。美国神经危重症监护学会组织了一次国际性多学科共识会议来探讨SAH的重症监护处理。根据发表的文章和研究领域,此次会议召集了来自欧洲和北美地区的神经重症监护科、神经外科、神经内科、介入神经放射科和神经麻醉科方面的专家。根据临床经验和制定实践指南方面的经验,选择4名经验丰富的神经重症监护专家组成评判委员会。应用推荐分级的评估、制定与评价(GradesofRecommendationsAssessment,DevelopmentandEvaluation,GRADE)系统进行文献回顾,结合参会者的经验、评判委员会的审评以及文献讨论产生推荐意见。应用GRADE系统制定推荐意见,其制定原则不仅强调研究资料的质量,而且还重视利弊权衡与实践转化。对SAH患者日常处理过程中面临的所有问题均提供指导和推荐意见,即使缺乏高质量的证据。 | Michael N. Diringer Thomas P. Bleck J. Claude Hemphill David Menon Lori Shutter Paul Vespa Nicolas Bruder E. Sander Connolly Jr Giuseppe Citerio Daryl Gress Daniel Hanggi Brian L. Hoh Giuseppe Lanzino Peter Le Roux Alejandro Rabinstein, Erich Schmut zhard Nino Stocchetti Jose I. Suarez Miriam Tresgiari Ming-Yuan Tseng Mervyn D. I. Vergouwen Stefan Wolf Gregory Zip fel 田飞(译) 宿 英英(译) | 2013 | 国际脑血管病杂志2013，21，5： | 5 |
| 2 | 神经重症监护患者的液体治疗:ESICM专家共识及临床实践推荐显示文摘目的发布欧洲重症医学学会(European Society of Intensive Care Medicine, ESICM)关于神经重症监护患者液体治疗的专家共识和临床实践推荐意见。设计在2016年10月召开的ESICM LIVE 2016会议上召集了一个由22名国际专家组成的共识委员会,随后委员会成员通过电话会议和在线讨论制定本专家共识。方法回顾人群、干预、对比和结局(population, intervention,comparison, and outcomes, PICO)问题,根据需要进行更新并得到证据概要。本共识关注3个主要议题:(1)神经重症监护患者的液体复苏和维持;(2)高渗液体在颅内压控制中的应用;(3)蛛网膜下腔出血后迟发性脑缺血的液体管理。经过广泛的文献检索,应用推荐分级的评估、制订与评价(Gradingof Recommendations Assessment, Development and Evaluation, GRADE)系统原则评估证据质量(从高到极低),制定治疗推荐(强或弱),并在适用时发布最佳实践声明。基于文献和专家意见提供的综合证据,应用改良德尔菲方法(使用序贯方法以避免偏倚和误解)产生最终共识声明。结果最终共识包含总共32条声明,其中13条为强推荐,17条为弱推荐,另外2条声明未提供推荐意见。结论我们发布了一份关于神经重症监护患者液体治疗的共识声明和临床实践推荐。 | Mauro Oddo Daniele Poole Raimund Helbok Geert Meyfroidt Nino Stocchetti Pierre Bouzat Maurizio Cecconi Thomas Geeraerts Ignacio-Martin Loeches Herve Quintard Fabio Silvio Taccone Romergryko G. Geocadin Claude Hemphill Carole Ichai David Menon Jean-Francois Payen Anders Perner Martin Smith Jose Suarez Walter Videtta Elisa R. Zanier Giuseppe Citerio 何毅华(译) 常远(译) 王晓蔷(译) 潘速跃(译) | 2019 | 国际脑血管病杂志2019，27，2： | 4 |
| 3 | IL-25 Induces IL-4, IL-5, and IL-13 and Th2-Associated Pathologies In Vivo显示文摘 | Madeline M. Fort Jeanne Cheung David Yen Joana Li Sandra M. Zurawski Sylvia Lo Satish Menon Teresa Clifford Brisdell Hunte Robin Lesley Tony Muchamuel Stephen D. Hurst Gerard Zurawski Michael W. Leach Daniel M. Gorman Donna M. Rennick | 2001 | Immunity2001，，6： | 2 |
| 4 | Itolizumab-a humanized anti-CD6monoclonal antibody with a better side effects profile for the treatment of psoriasis显示文摘 | Menon R David B G | 2015 | Clin Cosmet Investig Dermatol2015，7，8： | 1 |
| 5 | Serum Albumin Level as a Predictor of Outcome in Traumatic Brain Injury: Potential for Treatment显示文摘 | Francis Bernard Yahia Z. Al-Tamimi Doris Chatfield Andrew G. Lynch Basil F. Matta David K. Menon | 2008 | The Journal of Trauma: Injury, Infection, and Critical Care2008，，4： | 1 |
| 6 | Standardizing data collection in traumatic brain injury显示文摘 | Andrew I.R.Maas Cynthia L.Harrison-Felix David Menon | | 0，，： | 1 |
| 7 | Cerebrovascular Cytokine Responses During Coronary Artery Bypass Surgery: Specific Production of Interleukin-8 and Its Attenuation by Hypothermic Cardiopulmonary Bypass显示文摘 | Koichiroh Nandate Alain Vuylsteke Alan E. Crosbie Souad Messahel Amo Oduro-Dominah David K. Menon | 1999 | Anesthesia & Analgesia1999，，4： | 1 |
| 8 | Long-term blood pressure control in a cohort of peritoneal dialysis patients and its association with residual renal function.显示文摘 | Murali K Menon David M Naimark Joanne M Bargman | | 0，，： | 1 |
| 9 | Racial differences are seen in blood pressure response to fosinopril in hypertensive children显示文摘 | Sharad Menon Katherine Y. Berezny Rakhi Kilaru Daniel K. Benjamin Joseph D. Kay Lydie Hazan Ronald Portman Ronald Hogg David Deitchman Robert M. Califf Jennifer S. Li | 2006 | American Heart Journal2006，，2： | 1 |
| 10 | Traumatic brain injury显示文摘 | Jane E. Risdall David K. Menon | 2011 | Philosophical Transactions of the Royal Society B2011，，1562： | 1 |
| 11 | Vulnerabilities in mIDH2 AML confer sensitivity to APL-like targeted combination therapy显示文摘Although targeted therapies have proven effective and even curative in human leukaemia, resistance often ensues. IDH enzymes are mutated in ~20% of human AML, with targeted therapies under clinical evaluation. We here characterize leukaemia evolution from mutant IDH2 (mIDH2)-dependence to independence identifying key targetable vulnerabilities of mIDH2 leukaemia that are retained during evolution and progression from early to late stages. Mechanistically, we find that mIDH2 leukaemia are metastable and vulnerable at two distinct levels. On the one hand, they are characterized by oxidative and genotoxic stress, in spite of increased 1-carbon metabolism and glutathione levels. On the other hand, mIDH2 leukaemia display inhibition of LSD1 and a resulting transcriptional signature of all-trans retinoic acid (ATRA) sensitization, in spite of a state of suppressed ATRA signalling due to increased levels of PIN1. We further identify GSH/ROS and PIN1/LSD1 as critical nodes for leukaemia maintenance and the combination of ATRA and arsenic trioxide (ATO) as a key therapeutic modality to target these vulnerabilities. Strikingly, we demonstrate that the combination of ATRA and ATO proves to be a powerfully synergistic and effective therapy in a number of mouse and human mIDH1/2 leukemic models. Thus, our findings pave the way towards the treatment of a sizable fraction of human AMLs through targeted APL-like combinatorial therapies. | Vera Mugoni Riccardo Panella Giulia Cheloni Ming Chen Olga Pozdnyakova Dina Stroopinsky Jlenia Guarnerio Emanuele Monteleone Jonathan David Lee Lourdes Mendez Archita Venugopal Menon Jon Christopher Aster Andrew A. Lane Richard Maury Stone Ilene Galinsky José Cervera Zamora Francesco Lo-Coco Manoj Kumar Bhasin David Avigan Letizia Longo John Gerard Clohessy Pier Paolo Pandolfi | 2019 | Cell Research2019，29，6： | 1 |
| 12 | Long-Term Trends in Audit Fees显示文摘 | Krishnagopal Menon David D Williams | 2001 | Auditing: A Journal of Practice and Theory2001，，20： | 1 |
| 13 | Specialist neurocritical care and outcome from head injury显示文摘 | Hiren C. Patel David K. Menon Susan Tebbs Rebecca Hawker Peter J. Hutchinson Peter J. Kirkpatrick | 2002 | Intensive Care Medicine2002，，5： | 1 |
| 14 | Monitoring of Cerebral Autoregulation in Head-Injured Patients显示文摘 | Marek Czosnyka Piotr Smielewski Peter FRCS(NS) Kirkpatrick David K. Menon John D. MChir Pickard | 1996 | Stroke A Journal of Cerebral Circulation1996，，： | 1 |
| 15 | Long-term blood pressure control in a cohort of peritoneal dialysis ipatients and its association with residual renal function显示文摘 | Murali K Menon David M | 2001 | Nephrol Dial Transplant2001，12，： | 1 |
| 16 | Jugular venous and arterial concentrations of serum S-100B protein in patients with severe head injury:a pilot study显示文摘 | Andreas Rabbe David K Menon Gupta Marek Czosnka | 1998 | J Neurosurg Psychiatry1998，65，： | 1 |
| 17 | Effect of functional grade and etiology on in vivo hepatic phosphorus-31 magnetic resonance spectroscopy in cirrhosis: Biochemical basis of spectral appearances显示文摘 | David K. Menon Janet Sargentoni Simon D. Taylor-robinson Jimmy D. Bell I.Jane Cox David J. Bryant Glyn A. Coutts Keith Rolles Andrew K. Burroughs Marsha Y. Morgan | 1995 | Hepatology1995，，2： | 1 |
| 18 | Biological factors and brain imaging显示文摘 | Professor David Menon | 2010 | TheMedico-legal Journal2010，78，2： | 1 |
| 19 | Standardized Bleeding Definitions for Cardiovascular Clinical Trials: A Consensus Report From the Bleeding Academic Research Consortium显示文摘 | Roxana Mehran Sunil V. Rao Deepak L. Bhatt C. Michael Gibson Adriano Caixeta John Eikelboom Sanjay Kaul Stephen D. Wiviott Venu Menon Eugenia Nikolsky Victor Serebruany Marco Valgimigli Pascal Vranckx David Taggart Joseph F. Sabik Donald E. Cutlip Mitchel | 2011 | Circulation2011，，23： | 1 |
| 20 | Consensus summary statement of the International Multidisciplinary Consensus Conference on Multimodality Monitoring in Neurocritical Care显示文摘 | Peter Roux David K. Menon Giuseppe Citerio Paul Vespa Mary Kay Bader Gretchen M. Brophy Michael N. Diringer Nino Stocchetti Walter Videtta Rocco Armonda Neeraj Badjatia Julian B?esel Randall Chesnut Sherry Chou Jan Claassen Marek Czosnyka Michael Georgia | 2014 | Intensive Care Medicine2014，，9： | 1 |
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