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| 1 | COVID-19 and neurologic manifestations:a synthesis from the child neurologist’s corner显示文摘Background Since December 2019,the SARS-CoV-2 virus has been a global health issue.The main clinical presentation of this virus is a flu-like disease;however,patients with diverse neurologic manifestations have also been reported.In this review,we attempt to summarize,discuss and update the knowledge of the neurologic manifestations in the pediatric population affected by SARS-CoV-2 infection and the pandemic’s effects in children with neurologic diseases.Data sources This review analyzes studies found on the PubMed database using the following keywords:Neurologic manifestations COVID-19,Neurological COVID-19,coronavirus,SARS-CoV-2,pediatric COVID-19,COVID-19 in children,MIS-C,Pediatric Inflammatory Multisystem Syndrome,Guillain BarréSyndrome,Stroke,ADEM,and Anti-NMDA encephalitis.All studies cited were published between 2004 and 2022,and represent the most relevant articles in the field.The World Health Organization COVID-19 online dashboard was assessed to obtain updated epidemiological data.Results The most common neurologic symptoms in the pediatric population are headache,seizures,encephalopathy,and muscle weakness.These can be present during COVID-19 or weeks after recovering from it.Children who presented with multi-system inflammatory syndrome had a higher incidence of neurologic manifestations,which conferred a greater risk of morbidity and mortality.Several neuro-pathophysiological mechanisms have been proposed,including direct virus invasion,hyper-inflammatory reactions,multi-systemic failure,prothrombotic states,and immune-mediated processes.On the other hand,the COVID-19 pandemic has affected patients with neurologic diseases,making it challenging to access controls,treatment,and therapies.Conclusions Various neurologic manifestations have been associated with children’s SARS-CoV-2 infection.It is important to identify and give them proper and opportune treatment because they can be potentially grave and life-threatening;some can lead to long-lasting sequelae.Different neuro-pathophysiological mechanisms have been proposed,however,a causal relationship between SARS-CoV-2 infection and neurologic manifestations remains to be proven.Patients with neurologic diseases are especially affected by COVID-19,not only by the disease itself but also by its complications and pandemic management measures. | Carolina Valderas Gastón Méndez Alejandra Echeverría Nelson Suarez Katherin Julio Francisca Sandoval | 2022 | World Journal of Pediatrics2022，18，6： | 2 |
| 2 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 3 | Lisinopril lowers cardiac adrenergic drive and increase beta-receptor density in the failing human heart显示文摘 | GILBERT E M SANDOVAL A LARRABEE P | 1993 | Circulation1993，88，： | 1 |
| 4 | Epidemio!ogy and clinical characteristics of Ulcerative colitis in north - eastern Mexico 显示文摘 | Bosques-Padilla F J Sandoval - Garcia E R Martinez - Vazquez M A | 2011 | Rev Gastroenterol Mex2011，76，1： | 1 |
| 5 | Ultraviolet spectra of QSOs, BL Lacertae objects, and Seyfert galaxies显示文摘 | LANZETTA K M TURNSHEK D A SANDOVAL J | 1993 | ApJS1993，84，2： | 1 |
| 6 | Agave tequilana MADS genes show novel expression patterns in meristems, development bulbils and floral organs 显示文摘 | Sandoval S C D Ju6rez M J A Simpson J | 2012 | Sexual Plant Reproduction2012，25，1： | 1 |
| 7 | Bioplastics from Microorganisms 显示文摘 | LUENGO J M GARCIA B SANDOVAL A | 2003 | Curr Opin Microbiol2003，6，： | 1 |
| 8 | Effects of cornoil on glass transition temperatures of cassava starch显示文摘 | L Madrigal A J Sandoval A J M il ller | 2011 | Carbohydrate Polymer2011，85，4： | 1 |
| 9 | Bioplastics from microorganisms 显示文摘 | Jose' M Luengo Bele' n Garcl'a Angel Sandoval | 2003 | Current Opinion in Microbiology2003，6，： | 1 |
| 10 | Protective effect of quercetin on experimental chronic cadmiumnephrotoxicity in rats is based on its antioxidant properties 显示文摘 | MORALES A I VICENTE-SANCHEZ C SANDOVAL J M etal | 2006 | Foodand Chemical Toxicology2006，44，12： | 1 |
| 11 | Hopfield neural networks for optimization:study of the different dynamics显示文摘 | Joya G Atencia M A Sandoval F | | 0，，1： | 1 |
| 12 | A Unified Nomenclature for Yeast Autophagy-Related Genes显示文摘 | Daniel J Klionsky James M Cregg William A Dunn Scott D Emr Yasuyoshi Sakai Ignacio V Sandoval Andrei Sibirny Suresh Subramani Michael Thumm Marten Veenhuis Yoshinori Ohsumi | 2003 | Developmental Cell2003，，4： | 1 |
| 13 | Bioplastics from microorganisms显示文摘 | Luengo J M Garcia B Sandoval A | 2003 | Current Opin Microbio2003，6，3： | 1 |
| 14 | Mechanical testing of cordierite porous ceramics using high temperature diametral compression 显示文摘 | SANDOVAL M L TALOU M H TOMBA MARTINEZ A G | 2010 | J Eur Ceram Soc2010，45，18： | 1 |
| 15 | Synthesis of hybrid (Ni-Mo) carbides/carbon-coated mesoporous materials and their catalytic properties for hydrocracking of intermediate paraffins (n-C8)显示文摘 | TORREA R D L I DOMINGUEZ J M MELO-BANDA J A RAMOS G C E SANDOVAL G | | 0，，1： | 1 |
| 16 | Europium doped TiO2 hollow nanoshells: two-photon imaging of cell binding显示文摘 | Sandoval S Yang J Alfaro J G Liberman A Makale M Chiang C E Schuller I K Kummel A C Trogler W C | 2012 | Chemistry Materials2012，24，21： | 1 |
| 17 | Comparison of two assay (EIA and EITB) and two samples(saliva and serum) for the diagnosis of neurocysticercosis显示文摘 | Feldman M Plancarte A Sandoval M | 1990 | Trans R soc Trop Med Hyg1990，84，4： | 1 |
| 18 | Comparative study of the microstructural and magnetic properties of spinel ferrites obtained by co-precipitation 显示文摘 | Gonzalez Sandoval M P Beesley A M Miki-Yoshida M | 2004 | J Alloy Compd2004，369，： | 1 |
| 19 | Strong antibody responses induced by protein antigens conjugated onto the surface of lecithin - based nanoparticles 显示文摘 | Sloat B R Sandoval M A Hau A M | 2010 | Journal of Controlled Release2010，141，2： | 1 |
| 20 | Simultaneous design and control of the tennessee eastman process显示文摘 | Sandoval R Budman L A Douglas H M | 2008 | IFAC Proceedings Volumes(IFAC-PapersOnline)2008，27，： | 1 |
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