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| 1 | Functional dyspepsia:Are psychosocial factors of relevance?显示文摘机能性消化不良(FD ) 的致病仍然保持不清楚,显得多样并且是不充分地理解的 thus。与另外的功能的胃肠的混乱类似,研究表明了在这普通诊断和精神分析聚会因素和精神病学的病态之间的一个协会。Conceptualising 在 FD 的症候群以内的这些因素的关联要求疾病的 biopsychosocial 模型的申请。用这个范例,在大脑和内脏之间的相互的通讯的 dysregulation 对症状产生,解释和恶化中央。对各种各样的心理状态的 neurobiological 相互关联的欣赏和理解也是相关的。精神分析聚会因素施加的看法他们在 FD 的影响也主要通过寻求的护理的动机坚持。这显得太一个维考虑到可得到的证据的断言支持一个更内在的病因论的连接。病原的机制的演变理解和症候群的异构的性质将便于有效管理。公司疾病的精神病学的病与常规治疗保证处理。在 FD,其度服从于变化,承认精神分析聚会变量的关联为评价和管理有含意。可得到的证据建议心理治疗可以特别地有益于 FD 病人那些与长期的症状。为在 FD 的治疗精神病的药的使用的基本原理是明显的,但是支持抗抑郁剂药物疗法的使用的证据底是标明日期有限的。 | Sandra Barry Timothy G Dinan | 2006 | World Journal of Gastroenterology2006，12，17： | 50 |
| 2 | Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review显示文摘BACKGROUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment strategies.Different signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell mechanisms.BRAF gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its behavior.Targeted therapies have been used as an alternative in the case of resistance or contraindications to conventional treatments.AIM To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these tumors.METHODS An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDLINE,Cochrane,EMBASE,and SpringerLink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO guidelines.Inclusion criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF V600E.Articles were evaluated by two independent reviewers and retrieved for full-text evaluation.The EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible studies.Descriptive statistical analysis was performed.RESULTS Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this study.The analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatomic location,laboratory tests,expression of BRAF mutation,and additional mutations were registered.The BRAF V600E mutation was found in 297 AM(57%),63 UA(77.7%),3 AC(23%),1 MA(50%),and 5 PA(83.3%).Follicular type predominated with a total of 116 cases(40%),followed by plexiform type with 63 cases(22.1%).Furthermore,both types presented additional mutations,in which alterations in JAK3 P132T,SMARCB1,PIK3CA,CTNNB1,SMO,and BRAF G606E genes were found.Four case reports were found with targeted therapy to BRAF V600E.CONCLUSION The identification of BRAF V600E and additional mutations as an aid in targeted therapies has been a breakthrough in alternative treatments of ameloblastomas where surgical treatments are contraindicated. | Rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina | 2020 | World Journal of Clinical Oncology2020，11，1： | 6 |
| 3 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 4 | Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221]显示文摘 | Angela L. McCleary-Wheeler Gwen A. Lomberk Frank U. Weiss Günter Schneider Muller Fabbri Tara L. Poshusta Nelson J. Dusetti Sandra Baumgart Juan L. Iovanna Volker Ellenrieder Raul Urrutia Martin E. Fernandez-Zapico | 2013 | Cancer Letters2013，，1： | 2 |
| 5 | Review of cases reported over the past twenty -five years 显示文摘 | Miguel G madariaga NG Sandra D polymyositis - like syn- drome in hypothyroidism | 2002 | Thyroid2002，12，： | 1 |
| 6 | Changes in portlandite morphology with solvent composition:Atomistic simulations and ex- periment显示文摘 | SANDRA G ANNE A RUFFRAY N | 2011 | Cement and Concrete Research2011，，： | 1 |
| 7 | Incidence and predictors of glaucoma following surgery for congenital cataract in the first year of life in V ictoria, A ustralia显示文摘 | Jonathan B Ruddle Sandra E Staffieri Jonathan G Crowston Justin C Sherwin David A Mackey | 2013 | Clin Experiment Ophthalmol2013，，7： | 1 |
| 8 | Therapeutic effects of organic Germanium显示文摘 | Sandra G | 1988 | J Medical Hypotheses1988，26，3： | 1 |
| 9 | Increasing Circulation? A comparative news-flow study of the Montreal Gazette's hard-copy and on-line editions 显示文摘 | Mike G Sandra G | 2004 | Journalism Studies2004，5，3： | 1 |
| 10 | A review of cost-accounting methods for nursing services显示文摘 | Edwardson S R Sandra R Phyllis B G | 1987 | Nurs Econ1987，5，3： | 1 |
| 11 | Effect of ibuprofen exposure on blood, gill, liver, and brain on common carp ( Cyprinus carpio ) using oxidative stress biomarkers显示文摘 | Hariz Islas-Flores Leobardo Manuel Gómez-Oliván Marcela Galar-Martínez Sandra García-Medina Nadia Neri-Cruz Octavio Dublán-García | 2014 | Environmental Science and Pollution Research2014，，7： | 1 |
| 12 | Ceftiofur Sodium Monoclonal antibody development and cross - reactivity studies with structurally related cephalosporins显示文摘 | Beate G R Sandra A B Carol K H | 1996 | J Agric Food Chem1996，44，： | 1 |
| 13 | An investigation of relationships between communication style and leadermember显示文摘 | Augusta C Y Sandra H William P G | 2002 | Journal of Communication Management2002，6，3： | 1 |
| 14 | Semi-conductor-assisted photodegradation of liglin, dye, and kraft effluent by Ag-doped ZnO 显示文摘 | Carlos A K Goerver F W Sandra G M | 2000 | Chenmosphere2000，40，4： | 1 |
| 15 | The effect of ultra high-pressure homogenization (UHPH) on rennet coagulation properties of unheated and heated fresh skimmed milk显示文摘 | SANDRA S DALGLEISH D G | 2007 | International Dairy Journal2007，17，： | 1 |
| 16 | Effects of ultra-high-pressure homogenization and heating on structural properties of casein micelles in reconstituted skim milk powder显示文摘 | Sandra S Dalgleish D G | 2005 | International Dairy Journal2005，15，11： | 1 |
| 17 | Modeling the evaporation of a hydrocarbon feedstock in the convec- tion section of a steam cracker 显示文摘 | Sandra C K Heynderickx G J Marin G B | 2009 | Computers and Chemical Engineering2009，，33： | 1 |
| 18 | Dispersive Liquid-Liquid Microextraetion Combined with Microvolume Speetrophotometry to Turn Green the 5530 APHA Standard Method for Determining Phenols in Water and Wastewater显示文摘 | Isela L Sandra G Marta C | 2012 | Talanta2012，98，： | 1 |
| 19 | Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma显示文摘 | Asunción Fernández-Barral Jose Luis Orgaz Pablo Baquero Zaheer Ali Alberto Moreno María Tiana Valentí Gómez Erica Riveiro-Falkenbach Carmen Ca?adas Sandra Zazo Corine Bertolotto Irwin Davidson Jose Luis Rodríguez-Peralto Ignacio Palmero Federico Rojo Lass | 2014 | Neoplasia2014，，： | 1 |
| 20 | The rennet coagulation mechanism of skim milk as observed by transmission Diffusing Wave Spectroscopy 显示文摘 | Sandra S Alexander M Dalgleish D G | 2007 | Journal of Colloid and Interface Science2007，308，： | 1 |
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