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| 1 | Effect of dyspnea and clinical variables on the quality of life and functional capacity in patients with chronic obstructive pulmonary disease and congestive heart failure显示文摘背景:长期的妨碍的肺的疾病(COPD ) 和充血心力衰竭(CHF ) 是否定地影响病人的生命的功能的条件和质量的二慢性病。我们在在 COPD 和 CHF 病人的生命的功能的能力和质量上估计了症状和临床的变量的效果。方法:学习包括了 42 COPD 和 39 个 CHF 病人。在两个耐心的组,呼吸困难用 Borg 规模被估计;由梭散步和心肺的锻练测试和由短 form-36 (SF36 ) 的生命的质量的功能的能力。结果:不,统计上,有效差量关于呼吸困难分数,梭散步测试和 SF36 的亚群分数的多数在两二个疾病组被发现(P >
0.05 ) 。一统计上,有效差量在山峰 VO (2 ) 被观察赞成 COPD 组(P <
0.05 ) 。没有重要关系在呼吸困难 20 之间被建立并且在 CHF 病人在 COPD 病人,和左室的喷射部分(LVEF ) 在一秒(FEV (1 )) 强迫了吐气的体积(P >
0.05 ) 。重要否定关联在在两个疾病组的呼吸困难分数和功能的能力测试之间被观察(P <
0.05 ) 。在另一方面,没有关系在 LVEF 和 FEV 和生命和功能的能力的质量(1 ) 之间被发现(P >
0.05 ) 。结论:然而,症状影响在两个疾病组的生命的功能的能力和质量,这被揭示疾病严厉的客观指示物不显示出一种类似的关系。除了与疾病有关的客观数据,因此,我们建议症状应该也被考虑估计心肺的康复节目并且在后面起来期间。 | Hale Karapolat Sibel Eyigor Alev Atasever Mehdi Zoghi Sanem Nalbantgil Berrin Durmaz | 2008 | Chinese Medical Journal2008，，7： | 4 |
| 2 | Utility Investments in Resiliency: Balancing Benefits with Cost in an Uncertain Environment显示文摘 | William P. Zarakas Sanem Sergici Heidi Bishop Jake Zahniser-Word Peter Fox-Penner | 2014 | The Electricity Journal2014，，： | 1 |
| 3 | Who can get the Next Nobel Prizes in Infectious Diseases?显示文摘 | Onder Ergonul Can Ege Yalcin Mahmut Alp Erkent Mert Demirci Sanem Pinar Uysal Nur Zeynep Ay Asena Omeroglu | 2016 | International Journal of Infectious Diseases2016，，： | 1 |
| 4 | The impact of informational feedback on energy consumption: A survey of the experimental evidence显示文摘 | Ahmad Faruqui Sanem Sergici Ahmed Sharif | 2010 | Energy2010，35，4： | 1 |
| 5 | Ultrasound anatomy of the brachial plexus nerves in the neurovascular bundle at the axilla in patients undergoing upper-extremity block anesthesia显示文摘 | Evren Ustuner Ayse Y?lmaz Enver ?zgencil Feyhan Okten Sanem Cakar Turhan | 2013 | Skeletal Radiology2013，，5： | 1 |
| 6 | Listening to music during arteriovenous fistula surgery alleviates anxiety: A randomized single-blind clinical trial显示文摘BACKGROUND Both end-stage renal disease and being wait-listed for a kidney transplant are anxiety-causing situations.Wait-listed patients usually require arteriovenous fistula surgery for dialysis access.This procedure is performed under local anesthesia.We investigated the effects of music on the anxiety,perceived pain and satisfaction levels of patients who underwent fistula surgery.AIM To investigate the effect of music therapy on anxiety levels and perceived pain of patients undergoing fistula surgery.METHODS Patients who were on a waiting list for kidney transplants and scheduled for fistula surgery were randomized to control and music groups.The music group patients listened to music throughout the fistula surgery.The State-Trait Anxiety Inventory was performed to assess anxiety,additionally visual analog scale was used to evaluate perceived pain,willingness to repeat the procedure and patient satisfaction.Demographic features,comorbidities,surgical history,basic surgical data(location of fistula creation,duration of surgery,incision length)and intraoperative hemodynamic parameters were recorded by an investigator blinded to the study group.An additional trait anxiety assessment was performed following the surgery.RESULTS There was a total of 55 patients included in the study.However,14 patients did not fulfill the criteria due to requirement of sedation during surgery or uncompleted questionnaires.The remaining 41 patients were included in the analysis.There were 26 males and 15 females.The control and music groups consisted of 20 and 21 patients,respectively.With regard to basic surgical and demographic data,there was no difference between the groups.Overall patient satisfaction was significantly higher and intra-operative heart rate and blood pressure were significantly lower in the music group(P<0.05).Postoperative state anxiety levels were significantly lower in the music group.CONCLUSION Music therapy can be a complimentary treatment for patients undergoing fistula surgery.It can reduce anxiety and perceived pain,improve intraoperative hemodynamic parameters and enhance treatment satisfaction,thus may contribute to better compliance of the patients. | Sanem Guler Cimen Ebru Oguz Ayse Gokcen Gundogmus Sertac Cimen Fatih Sandikci Mehmet Deniz Ayli | 2020 | World Journal of Transplantation2020，10，4： | 1 |
| 7 | Prosthetic repair of acutely incarcerated groin hernias: a prospective clinical observational cohort study显示文摘 | Koray Atila Sanem Guler Abdullah Inal Selman Sokmen Sedat Karademir Seymen Bora | 2010 | Langenbeck’s Archives of Surgery2010，，5： | 1 |
| 8 | Effect of complexation conditions on xanthan-chitosan polyelectro|yte complex gels 显示文摘 | Sanem A S Kofinas P Lo Y M | 2009 | Food Hydro2009，23，1： | 1 |
| 9 | Apical hypertrophic cardiomyopathy might lead to misdiagnosis of ischaemic heart disease显示文摘 | Hamza Duygu Mehdi Zoghi Sanem Nalbantgil Filiz Ozerkan Azem Akilli Mustafa Akin Remzi Onder Umit Erturk | 2008 | The International Journal of Cardiovascular Imaging2008，，7： | 1 |
| 10 | Vitamin D deficiency may predispose patients to increased risk of kidney transplant rejection显示文摘BACKGROUND Vitamin D deficiency occurs in more than 80%of kidney transplant recipients.Its immunomodulatory effects can predispose transplant recipients to rejection and chronic allograft nephropathy(CAN).This study determined the association between serum 25(OH)vitamin D,biopsy-proven allograft rejection,and CAN rates.AIM To determine the relationship between serum 25(OH)vitamin D level and biopsy-proven allograft rejection and CAN rate in renal transplant recipients.METHODS Adult renal transplant recipients followed at the clinic between January 2013 and 2018 were included.Recipients requiring graft biopsy due to declined function,hematuria,and proteinuria were reviewed.The two groups were compared regarding collected data,including the biopsy results,immunologic parameters,vitamin D,parathyroid hormone(PTH),phosphorus,albumin levels,and graft function tests.RESULTS Fifty-two recipients who underwent graft biopsy met the inclusion criteria.In all,14 recipients had a vitamin D level>15 ng/mL(group 1)vs≤15 ng/mL(group 2)in 38.In total,27 patients had biopsy-proven rejection,and 19 had CAN.There was only 1 recipient with biopsyproven rejection in group 1,whereas there were 24 patients with rejection in group 2.The rejection rate was significantly higher in group 2 than in group 1(P<0.001).Four patients were diagnosed with CAN in group 1 vs fifteen in group 2.There was no significant difference in the CAN rate between the two groups.PTH was higher at the time of graft biopsy(P=0.009,P=0.022)in group 1 with a mean of 268 pg/mL.Donor-specific antibodies were detected in 14(56.0%)of the recipients with rejection.Vitamin D level was 9.7±3.4 ng/mL in the rejection group vs 14.7±7.2 in the non-rejection group;this difference was statistically significant(P=0.003).The albumin levels were significantly lower in patients with rejection than in those without rejection(P=0.001).In univariate regression analysis of risk factors affecting rejection,sex,serum vitamin D,phosphorus and albumin were found to have an impact(P=0.027,P=0.007,P=0.023,P=0.008).In multivariate regression analysis,the same factors did not affect rejection.CONCLUSION The serum 25(OH)vitamin D level in kidney transplant recipients remained low.Although low serum vitamin D level emerged as a risk factor for rejection in univariate analysis,this finding was not confirmed by multivariate analysis.Prospective studies are required to determine the effect of serum vitamin D levels on allograft rejection. | Semih Buyukdemirci Ebru Gok Oguz Sanem Guler Cimen Hatice Sahin Sertac Cimen Mehmet Deniz Ayli | 2022 | World Journal of Transplantation2022，12，9： | 0 |
| 11 | Psychological review of hemodialysis patients and kidney transplant recipients during the COVID-19 pandemic显示文摘BACKGROUND Kidney transplantation(KT)and end-stage renal disease(ESRD)requiring hemodialysis(HD)increase the incidence of morbidity and mortality associated with coronavirus disease 2019(COVID-19)infection.The COVID-19 pandemic has had a negative effect on the psychological well-being of COVID-19 patients,especially those with a high-risk of infectious complications.The prevalence of anxiety and depression is known to be higher in ESRD patients undergoing HD than in the general population.On the other hand,KT recipients have different treatment requirements compared to HD patients,including adherence to complex immunosuppressive regimens and compliance with follow-up appointments.We hypothesized that psychosocial difficulties and stressors would differ between ESRD patients undergoing HD and KT recipients during the COVID-19 pandemic.If so,each group may require different interventions to maintain their psychosocial well-being.AIM To measure and compare the levels of stress,anxiety,depression,concerns related to the pandemic,and coping skills in ESRD patients undergoing HD and KT recipients during the COVID-19 pandemic.METHODS This cross-sectional study was performed at a training and research hospital.The study included ESRD patients undergoing HD(HD group)and KT recipients(with stable graft function for≥6 mo prior to the study)(KT group).Patients completed a demographics form,the impact of events scale,the hospital anxiety and depression scale,and the Connor-Davidson resilience scale.Laboratory findings at the last clinical follow-up were recorded.Theχ^(2)test was used to assess the relationship between the HD and KT groups and the categorical variables.The relationships between the scale scores were analyzed using Pearson’s correlation test,and differences between the groups were analyzed using the independent groups t-test.RESULTS The study included 125 patients,of which 89(71.2%)were in the HD group and 36(28.8%)were in the KT group.The levels of anxiety and depression were higher in the HD group than in the KT group[9.36±4.38 vs 6.89±4.06(P=0.004)and 8.78±4.05 vs 6.42±4.26(P=0.004),respectively],whereas the post-traumatic stress score was higher in the KT group[46.75±13.98 vs 37.66±18.50(P=0.009)].The concern with the highest intensity in the HD group was transmission of COVID-19 to family and friends(93.3%)and in the KT group was loss of caregiver and social support(77.8%).Concerns regarding financial hardship,stigmatization,loneliness,limited access to health care services,failure to find medical supplies,and transmission of COVID-19 to family and friends were more prevalent in the HD group.Connor-Davidson resilience scale tenacity and personal competence,tolerance,and negative affect scores were higher in the KT group than in the HD group[43.47±11.39 vs 33.72±12.58,15.58±4.95 vs 11.45±5.05,and 68.75±17.39 vs 55.39±18.65(P<0.001),respectively].Biochemical parameters,such as creatine,urea,phosphorus,parathyroid hormone,and calcium,were lower,and the albumin and hemoglobin values were higher in the KT group than in the HD group(P<0.001).CONCLUSION Psychosocial difficulties and the level of stress differ in ESRD patients undergoing HD and KT recipients;therefore,psychosocial interventions should be tailored for each patient group. | Ayse Gokcen Gundogmus Ebru Gok Oguz Sanem Guler-Cimen Yasemin Kocyigit Ahmet Emin Dogan Mehmet Deniz Ayli | 2023 | World Journal of Clinical Cases2023，11，16： | 0 |
| 12 | COVID-19 infection in a kidney transplant recipient—special emphasis on pharmacokinetic interactions:A case report显示文摘BACKGROUND Solid organ transplant recipients are considered to be at high-risk of developing coronavirus disease 2019(COVID-19)-related complications.The optimal treatment for this patient group is unknown.Consequently,the treatment of COVID-19 in kidney transplant recipients should be determined individually,considering patient age and comorbidities,as well as graft function,time of transplant,and immunosuppressive treatment.Immunosuppressive treatments may give rise to severe COVID-19.On the contrary,they may also lead to a milder and atypical presentation by diminishing the immune system overdrive.CASE SUMMARY A 50-year old female kidney transplant recipient presented to the transplant clinic with a progressive dry cough and fever that started three days ago.Although the COVID-19 test was found to be negative,chest computed tomography images showed consolidation typical of the disease;thus,following hospital admission,anti-bacterial and COVID-19 treatments were initiated.However,despite clinical improvement of the lung consolidation,her creatinine levels continued to increase.Ultrasound of the graft showed no pathology.The tacrolimus blood level was determined and the elevation in creatinine was found to be related to an interaction between tacrolimus and azithromycin.CONCLUSION During the COVID-19 pandemic,various single or combination drugs have been utilized to find an effective treatment regimen.This has increased the possibility of drug interactions.A limited number of studies published in the literature have highlighted some of these pharmacokinetic interactions.Treatments used for COVID-19 therapy;azithromycin,atazanavir,lopinavir/ritonavir,remdesivir,favipiravir,chloroquine,hydroxychloroquine,nitazoxanide,ribavirin,and tocilizumab,interact with immunosuppressive treatments,most importantly with calcineurin inhibitors.Thus,their levels should be frequently monitored to prevent toxicity. | Ebru Gok Oguz Kadir Gokhan Atilgan Sanem Guler Cimen Hatice Sahin Tamer Selen Fatma AyerdenEbinc Sertac Cimen Mehmet Deniz Ayli | 2020 | World Journal of Transplantation2020，10，11： | 0 |
| 13 | Current practice of live donor nephrectomy in Turkey显示文摘BACKGROUND Over the last few years,the deceased donor organ donation rate was declined or remained stable,whereas the live donor organ donation rate has increased to compensate for the demand.Minimally invasive techniques for live donor nephrectomy(LDN)have also improved the live donor kidney donation rates.This increase has led to an interest in the surgical procedures used for LDN.AIM To evaluate the LDN techniques performed in Turkey,the structure of surgical teams,and the training received.Additionally,the number of kidney transplantations at different centers,the surgeon experience level,differences in surgical approach during donor surgeries,and outcomes were assessed.METHODS A questionnaire was sent to the Turkish Ministry of Health-accredited transplant centers.It inquired of the number of LDN surgeries,surgical techniques,complications,optimization protocols,the experience of surgeons,and the training.Descriptive statistics were outlined as follows:Discrete numeric variables were expressed as medians(minimum-maximum),while categorical variables were shown as numbers and percentages.As a result of the goodness-of-fit tests,if the significance of the differences between the groups in discrete numerical variables for which the parametric test statistical assumptions were not met,data were analyzed with the Mann Whitney U test and theχ^(2)test.RESULTS The questionnaire was sent to 72 transplant centers,all of which replied.Five centers that reported not performing LDN procedures were excluded.Responses from the remaining 67 centers were analyzed.In 2019,the median number of kidney transplants performed was 45,and the median number of kidney transplants from living donors was 28(1-238).Eleven(16.5%)centers performed 5-10,while 34(50.7%)centers performed more than 100 live donor kidney transplants in 2019.While 19(28.4%)centers performed the LDN procedures using the open technique,48(71.6%)centers implemented minimally invasive techniques.Among the centers preferring minimally invasive techniques for LDN,eight(16.6%)used more than one surgical technique.The most and the least common surgical techniques were transperitoneal laparoscopic(43 centers,89.6%)and single port laparoscopic LDN(1 center,2.1%)techniques,respectively.A positive association was found between the performance of minimally invasive techniques and the case volume of a transplant center,both in the total number and live donor kidney transplants(15 vs 55,P=0.001 and 9 vs 42,P≤0001 respectively).The most frequently reported complication was postoperative atelectasis(n=33,49.2%).There was no difference between the techniques concerning complications except for the chyle leak.CONCLUSION Turkish transplant centers performed LDN surgeries successfully through various techniques.Centers implementing minimally invasive techniques had a relatively higher number of live donor kidney transplants in 2019. | Bakytbek Mankiev Sanem Guler Cimen Ismail Oskay Kaya Sertac Cimen Asir Eraslan | 2022 | World Journal of Transplantation2022，12，12： | 0 |
| 14 | 腐植酸+黄腐酸缓解Cd对独行菜植株生长、生理和生化特性的不利影响显示文摘镉(Cd)是一种有毒的、流动性很强的重金属,可以被植物大量地吸附和吸收而没有任何明显的迹象。因此,对保护生物多样性和食品安全来说,在植物吸收之前稳定Cd是至关重要的。由于在其结构中含有大量的羧基和酚羟基,腐殖物质与重金属形成强烈的结合,这使它们成为完美的稳定剂。本研究的目的是确定在温室条件下,腐植酸和黄腐酸(HA+FA)的水平(0、3500、5250和7000 mg/L)对减轻独行菜(Lepidium sativum)受Cd(CdSO_(4)•8H_(2)O,0、100和200 Cd mg/kg)污染的Cd毒性的影响。我们的研究结果表明,Cd胁迫对独行菜的生长有负面影响,叶鲜重、叶干重、根鲜重和根干重、叶片相对含水量(LRWC)和除Cd外的矿物质含量均下降,膜渗透性(MP)和酶(CAT、SOD和POD)活性增加。然而,HA+FA的应用减少了Cd污染的不利影响。在200 mg/kg的Cd污染下,HA+FA的应用浓度为7000 mg/L时,与对照组相比,叶鲜重、叶干重、根鲜重、根干重、茎粗、叶面积、叶绿素读取值(CRV)、MP和LRWC值分别增加了262%、137%、550%、133%、92%、104%、34%、537%和32%。尽管在200 mg/L的镉污染下获得了最高的H2O2、丙二醛(MDA)、脯氨酸和蔗糖值,但HA+FA的应用浓度在200 mg/kg的Cd污染水平下,7000 mg/L的HA+FA成功地缓解了Cd胁迫的有害影响,使H2O2、MDA、脯氨酸和蔗糖值分别下降了66%、68%、70%和56%。浓度为7000 mg/L的HA+FA应用成功地缓解了Cd污染的负面影响,使N、P、K、Ca、Mg、Fe、Mn、Cu、Zn和B分别提高75%、23%、84%、87%、40%、85%、143%、1%、65%和115%。此外,HA+FA的应用浓度为7000 mg/L成功地减少了95%的Cd吸收和80%的Cl吸收。考虑到植物生长参数,当HA+FA浓度为7000 mg/L时,确定了最佳结果。我们已经证明,使用高比例的FA的腐殖质是非常关键的,FA的比例为10%,可以达到减轻重金属胁迫对植物生长不利影响的目的。总之,HA+FA的应用可以作为一种有效的解决方案,通过稳定土壤中的Cd,防止Cd从植物的根部转移到其嫩枝和叶片,从而减少植物对Cd的吸收。 | Ertan Yildirim Melek Ekinci Metin Turan Güleray Ağar Atilla Dursun Raziye Kul Zeynep Alim Sanem Argin 牛华琳(译) 庄琪(译) | 2023 | 腐植酸2023，，6： | 0 |
| 15 | Challenges of pancreas transplantation in developing countries,exploring the Turkey example显示文摘Pancreas transplantation significantly improves the quality of life for people with type 1 diabetes,primarily by eliminating the need for insulin and frequent blood glucose measurements.Despite the growing numbers of solid organ transplantations worldwide,number of pancreas transplantations in the developing countries`remain significantly low.This difference of pancreas transplantation practices was striking among the participating countries at the 1st International Transplant Network Meeting which was held in Turkey on 2018.In this meeting more than 40 countries were represented.Most of these counties were developing countries located in Africa,Middle East or Asia.The aim of this article is to identify the challenges and limiting factors for pancreas transplantations in these developing countries,by exploring the Turkish example.The challenges faced by the developing countries are broadly classified in four categories;wait-listing,donor pool,team work and follow up.Under these categorical titles,issues are further discussed in detail,giving examples from Turkish practice of pancreas transplantation.Additionally,several solutions to these challenges have been proposed-some of which have already been undertaken by the Turkish Ministry of Health.With the insight and methods presented in this article,pancreas transplantation should be made possible for the potential recipients in the developing countries. | Sanem Guler Cimen Sertac Cimen Nicos Kessaris Eyup Kahveci Acar Tuzuner | 2019 | World Journal of Transplantation2019，9，8： | 0 |
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