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| 1 | Endoscopic management of postoperative bile leaks显示文摘BACKGROUND: Significant bile leak as an uncommon complication after biliary tract surgery may constitute a serious and difficult management problem. Surgical management of biliary fistulae is associated with high morbidity and mortality. Biliary endoscopic procedures have become the treatment of choice for management of biliary Gstulae. METHODS: Ninety patients presented with bile leaks after cholecystectomy ( open cholecystectomy in 45 patients, cholecystectomy with common bile duct exploration in 20 and laparoscopic cholecystectomy in 25). The presence of bile leaks was confirmed by ERCP and the appearance of bile in percutaneous drainage of abdominal collections. Of the 90 patients with postoperative bile leaks, 18 patients had complete transaction of the common bile duct by ERCP and were subjected to bilioenteric anastomosis. In the remaining patients after cholangiography and localization of the site of bile leaks. therapeutic procedures like sphinctero-tomy, biliary stenting and nasobiliary drainage ( NBD ) were performed. If residual stones were seen in the common bile duct, sphincterotomy was followed by stone extraction using dormia basket. Nasobiliary drain or stents of 7F size were placed according to the standard techniques. The NBD was removed when bile leak stopped and closure of the fistula confirmed cholangiographically. The stents were removed after an interval of 6-8 weeks. RESULTS: Bile leaks in 72 patients occurred in the cystic duct (38 patients), the common bile duct (30 ), and the right hepatic duct (4). Of the 72 patients with post-operative bile leak, 24 had associated retained common bile duct stones and 1 had ascaris in common bile duct. All the 72 patients were subjected to therapeutic procedures including sphincterotomy with stone extraction followed by biliary stenting (24 patients), removal of ascaris and biliary stenting (1), sphincterotomy with biliary stenting (18), sphincterotomy with NBD (12), biliary stenting alone (12), and NBD alone (5). Bile leaks stopped in all patients at a median interval of 3 days (range 3-16 days) after endoscopic in- terventions. No difference was observed in efficacy and in time for the treatment of bile leak by sphincterotomy with endoprosthesis or endoprosthesis alone in patients with bile leak after surgery. CONCLUSIONS: Post-cholecystectomy bile leaks occur most commonly in the cystic duct and associated common bile duct stones are found in one-third of cases. Endoscopic therapy is safe and effective in the management of bile leaks and fistulae after surgery. Sphincterotomy with endoprosthesis or endoprosthesis alone is equally effective in the management of postoperative bile leak. | Naresh Agarwal Barjesh Chander Sharma Sanjay Garg Rakesh Kumar Shiv K Sarin | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，2： | 33 |
| 2 | Perfusion computed tomography in renal cell carcinoma显示文摘Various imaging modalities are available for the diagnosis, staging and response evaluation of patients with renal cell carcinoma(RCC). While contrast enhanced computed tomography(CT) is used as the standard of imaging for size, morphological evaluation and response assessment in RCC, a new functional imaging technique like perfusion CT(p CT), goes down to the molecular level and provides new perspectives in imaging of RCC. p CT depicts regional tumor perfusion and vascular permeability which are indirect parameters of tumor angiogenesis and thereby provides vital information regarding tumor microenvironment. Also response evaluation using p CT may predate the size criteria used in Response Evaluation Criteria in Solid Tumors, as changes in the perfusion occurs earlier following tissue kinase inhibitors before any actual change in size. This may potentially help in predicting prognosis, better selection of therapy and more accurate and better response evaluation in patients with RCC. This article describes the techniques and role of p CT in staging and response assessment in patients with RCCs. | Chandan J Das Usha Thingujam Ananya Panda Sanjay Sharma Arun Kumar Gupta | 2015 | World Journal of Radiology2015，7，7： | 8 |
| 3 | Peripheral primitive neuroectodermal tumor of the kidney presenting with pulmonary tumor embolism: A case report显示文摘Peripheral primitive neuroectodermal tumor(PNET) of the kidney is a rare, aggressive tumor known for its recurrence and metastatic potential. Despite the frequency of venous extension to the renal veins and inferior vena cava, pulmonary tumor embolism at the initial presentation is not common. We report a case of 22-year-old female with PNET of the kidney who presented with tumor embolism in the inferior vena cava(IVC) and bilateral pulmonary artery. The patient underwent surgical resection and histopathological analysis confirmed the presence of tumor within the IVC and pulmonary arteries. The patient received adjuvant chemotherapy and is currently doing well on follow-up. | Sathya Chinnaa Chandan J Das Sanjay Sharma Prabhjot Singh Amlesh Seth Suvendu Purkait Sandeep R Mathur | 2014 | World Journal of Radiology2014，6，10： | 7 |
| 4 | Extraocular retinoblastoma in Indian children:clinical,imaging and histopathological features显示文摘AIM:To study eyes with extraocular dissemination(EORB),with the following aims:first to establish the mean lag period and to understand various reasons for delayed presentation,second to study their imaging profiles and third to analyze histopathological features of eyes enucleated after neoadjuvant chemotherapy.·METHODS:Prospective study of clinical and imaging features of EORBs(stage Ⅲ and Ⅳ International Retinoblastoma Staging System) presenting to a tertiary eye care centre.Histopathological features of eyes enucleated after receiving neoadjuvant chemotherapy were analyzed.A pictorial illustration of the varied imaging profile of EORB was also presented.·RESULTS:Over a period of one year,97 eyes were diagnosed with retinoblastoma;32 children(36 eyes)(37.1%) had EORB.Mean age 3.6±1.9 years,71.9% males,71.9% unilateral,3.1% with positive family history and40.6% with metastasis.On imaging,there was extrascleral involvement in 22.2%,involvement of orbital part of optic nerve in 33.3%,involvement of central nervous system in 27.8% and orbital wall involvement in2.9% eyes.On histopathological analysis of eyesenucleated after neoadjuvant chemotherapy,25.0% had no residual viable tumour tissue and rest all tumours were poorly differentiated.·CONCLUSION:There are very few human malignancies where definitive treatment is started without any confirmed histopathological diagnosis and imaging plays an important role in diagnosis and appropriate staging of the disease.Chemotherapy has a variable effect on EORB,75.0% of eyes with EORB had residual viable tumour tissue when enucleated after receiving neoadjuvant chemotherapy. | Sumita Sethi Neelam Pushker Seema Kashyap Sanjay Sharma Mridula Mehta Sameer Bakhshi Saurbhi Khurana Supriyo Ghose | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 5 |
| 5 | A Wavelet Neural Network Based Non-linear Model Predictive Controller for a Multi-variable Coupled Tank System显示文摘In this paper, a novel real time non-linear model predictive controller(NMPC) for a multi-variable coupled tank system(CTS) is designed. CTSs are highly non-linear and can be found in many industrial process applications. The involvement of multi-input multi-output(MIMO) system makes the design of an effective controller a challenging task. MIMO systems have inherent couplings,interactions in-between the process input-output variables and generally have an complex internal structure. The aim of this paper is to design, simulate, and implement a novel real time constrained NMPC for a multi-variable CTS with the aid of intelligent system techniques. There are two major formidable challenges hindering the success of the implementation of a NMPC strategy in the MIMO case. The first is the difficulty of obtaining a good non-linear model by training a non-convex complex network to avoid being trapped in a local minimum solution. The second is the online real time optimisation(RTO) of the manipulated variable at every sampling time.A novel wavelet neural network(WNN) with high predicting precision and time-frequency localisation characteristic was selected for an MIMO model and a fast stochastic wavelet gradient algorithm was used for initial training of the network. Furthermore, a genetic algorithm was used to obtain the optimised parameters of the WNN as well as the RTO during the NMPC strategy. The proposed strategy performed well in both simulation and real time on an MIMO CTS. The results indicated that WNN provided better trajectory regulation with less mean-squared-error and average control energy compared to an artificial neural network. It is also shown that the WNN is more robust during abnormal operating conditions. | Kayode Owa Sanjay Sharma Robert Sutton | 2015 | International Journal of Automation and computing2015，12，2： | 4 |
| 6 | Genetics on early onset inflammatory bowel disease:An update显示文摘Inflammatory bowel disease(IBD)is more common in adults than in children.Onset of IBD before 17 years of age is referred as pediatric onset IBD and is further categorized as very early onset IBD(VEO-IBD)for children who are diagnosed before 6 years of age,infantile IBD who had the disease before 2 years of age and neonatal onset IBD for children less than 28 days of life.Children presenting with early onset disease may have a monogenic basis.Knowledge and awareness of the clinical manifestations facilitates early evaluation and diagnosis.Next generation sequencing is helpful in making the genetic diagnosis.Treatment of childhood IBD is difficult;targeted therapies and hematopoietic stem cell transplantation form the mainstay.In this review we aim to summarize the genetic defects associated with IBD phenotype.We describe genetic location and functions of various genetic defect associated with VEO-IBD with their key clinical manifestations.We also provide clinical clues to suspect these conditions and approaches to the diagnosis of these disorders and suitable treatment options. | Johnson Nameirakpam Rashmi Rikhi Sanjay Singh Rawat Jyoti Sharma Deepti Suri | 2020 | Genes & Diseases2020，7，1： | 3 |
| 7 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 8 | Epidemiology of patients admitted to a major trauma centre in northern India显示文摘在印度的 ObjectiveTrauma 是一个逐渐地重要的问题,特别地考虑到快速的开发和增加的动力化。社会变化在损伤的传染病学正在导致改变。学习的目的是估计在同意到一个主要损伤中心进入随机的分类选择的 748 个病人的北 India.MethodsAn 观察学习的病人影响损害的原因的各种各样的流行病学的参数在 1 年(到 2009 年 7 月的 2008 年 8 月) 的一个时期上被执行。年龄,性别,损害类型和模式被注意。上面、更低的手足的损害模式也是 noted.ResultsInjuries 在 15-30 年的年龄组主要发生。男性们与男性一起招致了更多的损害到 6:1 的女比率。最脆弱的组是摩托车用户。在之中伤害,农民们是通常包含的大多数。钝损害(94.92%) 比渗透损害是更普通的。在有头损害的病人之中,二 wheelers 联系了事故最普通(40.3%) 。最针的绳索损害从高度(51.09%) 到下降被引起。大多数更低的手足破裂是简单类型。更低的手足的复合破裂比交通规则的上面的手足 fractures.ConclusionStrict 实施更普通,与改进基础结构和行为变化结合了能减少在印度和另外的发展中的国家的道路交通事故的负担。这研究能在作为需要被称为死亡和病态的一个可防止的原因的一个公共健康问题提起道路交通事故的侧面帮助,并且为这主要挑战计划适当干预。预防策略应该根据这些流行病学的趋势被做。 | Devarshi Rastogi Sanjay Meena Vineet Sharma Girish Kumar Singh | 2014 | Chinese Journal of Traumatology2014，17，2： | 2 |
| 9 | Effect of rifaximin, probiotics, and l-ornithine l-aspartate on minimal hepatic encephalopathy: A randomized controlled trial显示文摘 | Kapil Sharma Sanjay Pant Sriprakash Misra Manisha Dwivedi Alok Misra Sushil Narang Reshu Tewari Ajeet Bhadoria | 2014 | Saudi Journal of Gastroenterology2014，，4： | 2 |
| 10 | Traumatic posterior hip dislocation in a 16-month-old child: a case report and review of literature显示文摘创伤的以后的新潮的脱臼是在孩子的不平常的损害,组成不到 5% 儿科学的脱臼。在一个更小的孩子(< 5 年) ,次要的损伤例如一从低高度的 slip 或秋天可以引起新潮的脱臼,而在一个青少年脱臼被象机动车辆事故那样的一处主要损伤通常引起。在这份情况报告我们在场在一个 16-month-old 女孩的创伤的新潮的脱臼的一个稀罕案例。早察觉和关上的减小在我们的情况中保证了好结果。因为在这个时期以后的减小将极大地增加复杂并发症的风险,怀疑的一个高索引是必要的在六小时脱臼以内完成令人满意的减小。 | Sanjay Meena Tanmay Kishanpuria Shreesh Kumar Gangari Pankaj Sharma | 2012 | Chinese Journal of Traumatology2012，15，6： | 2 |
| 11 | Managerial Interpretations and Organizational Context as Predictors of Corporate Choice of Environmental Strategy显示文摘 | Sharma Sanjay | 2000 | Academy of Management Journal2000，43，4： | 1 |
| 12 | Revisiting the Role of Computerized Tomographic Scan and Cystoscopy for Detecting Bladder Invasion in the Revised FIGO Staging System for Carcinoma of the Uterine Cervix显示文摘 | Daya Nand Sharma Sanjay Thulkar Shikha Goyal Nootan Kumar Shukla Sunesh Kumar Goura Kisor Rath Parmod Kumar Julka Gagan Saini Amit Bahl | 2010 | International Journal of Gynecological Cancer2010，，3： | 1 |
| 13 | Studies on the Genotoxicity of Endosulfan in Different Tissues of Fresh Water Fish Mystus vittatus Using the Comet Assay显示文摘 | Shilpi Sharma N. S. Nagpure Ravindra Kumar Sanjay Pandey Satish K. Srivastava Poonam J. Singh P. K. Mathur | 2007 | Archives of Environmental Contamination and Toxicology2007，，4： | 1 |
| 14 | Influence of tool rotation speeds on mechanical and morphological properties of friction stir processed nano hybrid composite of MWCNT-Graphene-AZ31 magnesium显示文摘The ever-increasing demand for light weighted hard materials for transportation industries encouraged researchers to develop composites with excellent mechanical properties which can transform it into more economical and eco-friendly.Reinforcing the metals with carbonaceous nanomaterials are progressively in focus due to their excellent capability to inculcate and tailor the properties of MMCs.In the present research,a hybrid nanocomposite of MWCNT-Graphene-AZ31 Mg alloy has been developed by using variable tool rotation speeds with friction stir processing(FSP).Optimized reinforcement ratio of 1.6%vol.MWCNT and 0.3%vol.of graphene have been used with variable tool rotation speeds,whereas other processing parameters are kept constant.The developed specimens were investigated using standard testing equipment for evaluating and comparing the mechanical properties on the basis of the microstructure of the processing regions and their morphological analysis,according to the ASTM standards.The obtained results revealed an improvement of 19.72%in microhardness and 77.5% of compressive strength in comparison with the base metal AZ 31 Magnesium alloy,with a tool rotational speed of 1400rpm.The values of tensile stress and percentage area reduction were recorded as less than that of the base metal matrix,but an increasing trend has been observed in the values of both with the improvement on rotational speeds of the tool.The effectual strengthening mechanisms are analyzed on the bases of SEM images and observed that discussed and found that grain refinement strengthening is the major contributor to the strength of the nanocomposite. | Sanjay Sharma Amit Handa Sahib Sartaj Singh Deepak Verma | 2019 | Journal of Magnesium and Alloys2019，7，3： | 1 |
| 15 | Instantaneous thermal efficiency of an active solar still显示文摘 | Tiwari G N Kumar Sanjay Sharma P B | 1996 | Applied Thermal Engineering1996，16，2： | 1 |
| 16 | Rate of serious adverse effects in a series of bevacizumab and ranibizumab injections显示文摘 | Sanjay Sharma Davin Johnson Marwan Abouammoh Simon Hollands Ashley Brissette | 2012 | Canadian Journal of Ophthalmology/Journal canadien d’ophtalmologie2012，，3： | 1 |
| 17 | A fresh approach to performance evaluation in a multiltem production seenario显示文摘 | Sanjay Sharma | 2007 | European Journal of Op- erational Research2007，178，： | 1 |
| 18 | Effect of wet milling process on the solid state of indomethacin and simvastatin 显示文摘 | Sharma Puneet Denny William A Garg Sanjay | 2009 | International Journal of Pharmaeeutics2009，380，12： | 1 |
| 19 | Stakeholder influences on sustainability practices in the Canadian forest products industry显示文摘 | Sanjay Sharma Irene Henriques | 2005 | Strategic Management Journal2005，，26： | 1 |
| 20 | Utility values and diabetic retinopathy显示文摘 | Melissa M Brown Gary C Brown Sanjay Sharma Gaurav Shah | 1999 | American Journal of Ophthalmology1999，，3： | 1 |
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