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| 1 | Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures显示文摘 | Bin-Kuan Chou Prashant Mali Xiaosong Huang Zhaohui Ye Sarah N Dowey Linda MS Resar Chunlin Zou Alex Zhang Jay Tong Linzhao Cheng | 2011 | Cell Research2011，21，3： | 38 |
| 2 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 3 | Prevalence of occult hepatitis B virus infection in haemodialysis patients from central Greece显示文摘AIM:To assess the hepatitis B virus(HBV)-DNA and the prevalence of occult HBV infection in end-stage renal failure(ESRF)patients from Central Greece. METHODS:Sera from 366 ESRF patients attending five out of six dialysis units from Central Greece were investigated for HBV-DNA by real-time polymerase chain reaction.Only serum samples with repeatedly detectable HBV-DNA were considered positive.IgG antibodies to hepatitis C virus(anti-HCV)were tested by a third generation enzyme linked immunosorbent assay(ELISA),while IgG antibodies to hepatitis E virus (anti-HEV)were tested by two commercially available ELISAs.RESULTS:HBV-DNA was detected in 15/366 patient (4.1%)and HBsAg in 20/366(5.5%).The prevalenc of occult HBV infection was 0.9%(3/346 HBsAg negative patients).Occult HBV was not associate with a specific marker of HBV infection or anti-HCV o anti-HEV reactivity.There was no significant differenc in HBV-DNA titres,demographic and biochemica features,between patients with occult HBV infectio and those with HBsAg-positive chronic HBV infection. CONCLUSION:In central Greece,4%of ESRF patient had detectable HBV-DNA,though in this setting,th prevalence of occult HBV seems to be very low(0.9%). | Paraskevi Mina Sarah P Georgiadou Christos Rizos George N Dalekos Eirini I Rigopoulou | 2010 | World Journal of Gastroenterology2010，16，2： | 8 |
| 4 | Reversion of severe hepatopulmonary syndrome in a non cirrhotic patient after corticosteroid treatment for granulomatous hepatitis:A case report and review of the literature显示文摘肝肺症候群(HPS ) 包括肺内的脉管的膨胀的肝疾病,反常肺的煤气的交换和证据被定义为一个临床的三个一组。我们报导在最后年与疲劳,长持续的发烧,体重减轻,门静脉高血压的符号,肝脾大,胆汁郁积和进步 dyspnoea 介绍的 61 岁的男性。临床,实验室和组织检查所见证实了肉芽肿肝炎的诊断。由于肝的导致 granuloma 的门静脉高血压的 HPS 被证明是由提高对比的回响心动描记法证实了的病人的严重血氧不足的原因。在皮质甾治疗以后的 HPS 的回复被新提高对比的回响心动描记法与胆汁郁积的酶的正规化和病人的条件的改进一起证实。这是在有肝的肉芽肿的一个非肝脏硬化症的病人的 HPS 的完全的回复的第一个案例,显示在肝疾病的那肺内分流是功能的现象, HPS 能甚至在象在这种情况中的其他的肝参与被开发。 | Nikolaos Tzovaras Aggelos Stefos Sarah P Georgiadou Nikolaos Gatselis Georgia Papadamou Eirini Rigopoulou Maria Ioannou Ioannis Skoularigis Georgios N Dalekos | 2006 | World Journal of Gastroenterology2006，12，2： | 3 |
| 5 | 当在小肠的囊内视镜检查法计算路易斯分数时,蓝模式不在白光上提供任何利益显示文摘 AIM: To check the usefulness of blue mode (BM) review in lewis score (LS) calculation, by comparing it with respective LS results obtained by white light (WL) small-bowel capsule endoscopy (SBCE) review and mucosal inflammation as reflected by faecal calprotectin (FC) levels, considered as ’gold standard’ for this study. METHODS: Computational analysis of our SBCE database to identify patients who underwent SBCE with PillCam? and had FC measured within a 30-day period from their test. Only patients with prior colonoscopy were included, to exclude any colon pathology-associated FC rise. Each small bowel tertile was reviewed (viewing speed 8 fps) with WL and BM, in a back-to-back mode, by a single experienced reviewer. LS were calculated after each WL and BM reviews. Pearson rank correlation (rho, r) statistic was applied.RESULTS: Twenty-seven (n = 27, 20F/7M) patients were included. Thirteen (n = 13) had SBCE with PillCam?SB1, and the remainder (n = 14) with PillCam? SB2. The median level of FC in this cohort was 125 μg/g. LS (calculated in WL SBCE review) correlation with FC levels was r = 0.490 (P = 0.01), while for BM review and LS correlation with FC was r = 0.472 (P = 0.013). | Anastasios Koulaouzidis Sarah Douglas John N Plevris | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，2： | 3 |
| 6 | Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease显示文摘Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 years.Parkinson’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic neurons.In addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-synuclein.Although it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s disease.In addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative disorders.Among such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s disease.Environmental enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating neurotransmission.In this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic factors.We describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease. | Tamara Andrea Alarcón Sarah Martins Presti-Silva Ana Paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires | 2023 | Neural Regeneration Research2023，18，7： | 2 |
| 7 | Curtis neutralisation of TGF of binding of VLA-4 to fibronectin prevents rat tendon adhesion following transection显示文摘 | Heather G Jorgense N Sarah D | 2005 | Cytokine2005，30，： | 1 |
| 8 | Microbes Central to Human Reproduction显示文摘 | Gregor Reid Patrizia Brigidi Jeremy P. Burton Nikhat Contractor Sylvia Duncan Emilie Fargier Colin Hill Sarah Lebeer Rocio Martín Andrew J. McBain Gil Mor Catherine O’Neill Juan Miguel Rodríguez Jonathan Swann Saskia Hemert Juliett Ansell | 2015 | Am J Reprod Immunol2015，，1： | 1 |
| 9 | Experimental production of clay rims by macrobiotic sediment ingestion and excretion Processes 显示文摘 | Sarah J N Richard H W Duncan M | 2005 | Journal of Sedimentary Research2005，75，： | 1 |
| 10 | Determination of System Losses of Geosmin and MIB inBench-Scale Filtration Apparatus显示文摘 | Elhadi Sarah L N | 2004 | Water Quality Research Journal of Cana-da2004，，3： | 1 |
| 11 | Neuroprotective signaling pathways are modulated by adenosine in the anoxia tolerant turtle显示文摘 | GAURI H N HOWARD M P SARAH L M | 2011 | J Cereb Blood Flow Metab2011，31，2： | 1 |
| 12 | Coping styles as correlates of health in high school students显示文摘 | Hans S Sarah J Erickon N | 2002 | Journal of Adolescent Health2002，30，： | 1 |
| 13 | Gestational trophoblastic neoplasia mangement:an update 显示文摘 | Sarah N Michael J Seckl | 2007 | Curr Opin 0ncol2007，19，： | 1 |
| 14 | Neurobiology of PTSD: A Review of Neuroimaging Findings显示文摘 | Garfinkel Sarah N Liberzon Israel | 2009 | Psychiatric Annals2009，，6： | 1 |
| 15 | Structure of Ca 2+-Bound S100A4and its interaction with peptides derived from non-muscle myosin-IIA显示文摘 | Vladimir N Kristen M Sarah C | 2008 | Biochemistry2008，47，18： | 1 |
| 16 | Localized delivery of paclitaxel in solid rumors from biodegradable chitin microparticle formulations显示文摘 | Sarah N Mansoor A | 2002 | Biomaterials2002，23，： | 1 |
| 17 | Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-κB-mediated IL-8 gene expression显示文摘 | Stavros Sougioultzis Simos Simeonidis K. Ramakrishnan Bhaskar Xinhua Chen Pauline M. Anton Sarah Keates Charalabos Pothoulakis Ciarán P. Kelly | 2006 | Biochemical and Biophysical Research Communications2006，，1： | 1 |
| 18 | Reactive Glass and Vegetation Patterns 显示文摘 | Shnerh N M Sarah P Lavee H | 2003 | Physical Review Letters2003，90，24： | 1 |
| 19 | Simple and efficient traversal methods for quadtrees and octrees 显示文摘 | Sarah F F Ronald N P | 2002 | Journal of Graphics Tools2002，7，3： | 1 |
| 20 | TGF- maintains dormancy of prostatic stem ceils in the proximal region of ducts 显示文摘 | Sarah N Salm Patricia E | 2005 | Cell Biol2005，170，： | 1 |
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