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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | The transition from face-to-face to online CME facilitation显示文摘 | Lockyer J Sargeant J Curran V | 2006 | Med Teach2006，28，7： | 1 |
| 3 | Clinicopathological features of prostate cancer in Jamaican men 显示文摘 | Shirley SE Escoffery CT Sargeant LA et aI | 2002 | BJU Int2002，89，4： | 1 |
| 4 | A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis显示文摘 | Arun J. Sanyal Pouneh S. Mofrad Melissa J. Contos Carol Sargeant Velimir A. Luketic Richard K. Sterling R. Todd Stravitz Mitchell L. Shiffman John Clore Alan S. Mills | 2004 | Clinical Gastroenterology and Hepatology2004，，12： | 1 |
| 5 | The conservation of dinucleotide microsatellites among mammalian genomes allows the use of heterologous pcr primer pairs in closely related species显示文摘 | MOORE S S SARGEANT L L KING T J | | 0，，03： | 1 |
| 6 | Transcriptomic analysis reveals calcium regulation of specific promoter motifs in Arabidopsis 显示文摘 | Whalley H J Sargeant A W Steele J F | 2011 | Plant Cell2011，23，11： | 1 |
| 7 | TNF, acting through inducibly expressed TNFR2, drives activation and cell cycle entry of c‐Kit<sup>+</sup> cardiac stem cells in ischemic heart disease显示文摘 | Rafia S. Al‐Lamki Wanhua Lu Jun Wang Jun Yang Timothy J. Sargeant Richard Wells Chenqu Suo Penny Wright Martin Goddard Qunhua Huang Amir H. Lebastchi George Tellides Yingqun Huang Wang Min Jordan S. Pober John R. Bradley | 2013 | Stem Cells2013，，9： | 1 |
| 8 | Household knowledge,attitudes and practices related to pet contact and associated zoonoses in Ontario,Canada显示文摘 | Stull JW Peregrine AS Sargeant JM | 2012 | BMC public health2012，12，1： | 1 |
| 9 | The conservation of dinucleotide microsatellites among mammalian genomes allows the use of heterelogous PCR primer pairs in closely related species显示文摘 | Moore S S Sargeant L L King T J | 1991 | Cenomica1991，10，： | 1 |
| 10 | The conservation of dinucleotide microsatellites among mammalian genomes allows the use of heterologous PCR primer pairs in closely related species显示文摘 | MooreSS Sargeant LL KingTJ etal | 1991 | Genomics1991，10，3： | 1 |
| 11 | Factorsassociated with the presence of Escherichia coli 0157 in feedlot-cattle water and feed in the Midwestern USA显示文摘 | SARGEANT J M SANDERSON M W GRIFFIN D D | 2004 | Preventive VeterinaryMedicine2004，66，： | 1 |
| 12 | Associations between management,climate, and Escherichia coli0157 in the faeces of feedlot cattle in the Midwestern USA显示文摘 | SARGEANT J M SANDERSON M W SMITH R A | 2004 | Preventive Veterinary Medicine2004，66，： | 1 |
| 13 | Ethnicity, trust and cooperation with police: Testing the dominance of the process-based model 显示文摘 | Sargeant E Murphy K Cherney A | 2014 | European Journal of Criminolo- gy2014，11，4： | 1 |
| 14 | Perceptual Determinants of Nonprofit Giving Behavior 显示文摘 | SARGEANT A FORD J B WEST D C | 2006 | Journal of Business Research2006，59，2： | 1 |
| 15 | An investigation of the population impact of variation in HbAlc levels in older people in England and Wales : from a population based multi - centre longi- tudinal study显示文摘 | Gao L Matthews FE Sargeant LA | 2008 | BMC Public Health2008，，8： | 1 |
| 16 | Dietary zinc oxide affects the expression of genes associated with inflammation: Transcriptome analysis in piglets challenged with ETEC K88显示文摘 | Hannah R. Sargeant Kenneth J. McDowall Helen M. Miller Marie-Anne Shaw | 2010 | Veterinary Immunology and Immunopathology2010，，1： | 1 |
| 17 | Mapping quantitative trait loci controlling milk production by exploiting progeny testing显示文摘 | Georges M Nielsen D Mackinnon M Mishra A Okimoto R Pasquino A T Sargeant L S Sorensen A Steele M R and Zhao X | 1995 | Genetics1995，139，： | 1 |
| 18 | Conservation of dinucleotide mircrosatelletes among mammalian genomes allows use of heterologo PCR primer pairs in closely related species显示文摘 | MOORESS SARGEANT L L King T G | 1991 | Genomics1991，10，： | 1 |
| 19 | 显示文摘 | Bansiddhi A Sargeant T D Stupp S I | 2008 | Acta Biomaterialia2008，4，： | 1 |
| 20 | Relationship of bull fertility to sperm nuclear shape 显示文摘 | Ostermeier GC Sargeant GA Yandell BS | 2001 | J Androl2001，22，4： | 1 |
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