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| 1 | Lymphomatoidgastropathy mimicking extranodal NK/T cell lymphoma,nasal type:A case report显示文摘Extranodal natural killer(NK)/T-cell lymphoma,nasal type,exhibits aggressive tumor behavior and carries a poor prognosis.Recently,lymphomatoid gastropathy with NK/T cell infiltration into gastric mucosa has been recognized as a pseudo-malignant disease which regresses without treatment.Because the conventional immunohistochemical criteria of lymphomatoid gastropathy is similar to that of extranodal NK/T-cell lymphoma nasal type,it is difficult to distinguish between the two conditions by histopathological evaluation only.Here,we report a rare case of lymphomatoid gastropathy in a 57-year-old female.Gastroendoscopy on routine check-up revealed elevated reddish lesions < 1 cm in diameter in the gastric fornix and body.Although repeat endoscopies at 1 and 6 mo later revealed no gastric lesions at any locations without any treatments,at 12 mo later gastric lymphomatoid lesions recurred at gastric fornix and body.Histological examination of endoscopic biopsy specimens at 12 mo showed atypical NK cell infiltration with CD3+,CD4-,CD5-,CD7+,CD8-,CD20-,CD30-,CD56+,CD79a-and T-cell-restricted intracellular antigen-1+ into gastric mucosa.After treatment for Helicobacter pylori(H.pylori) eradication,the lesions disappeared in all locations of the gastric fornix and body over the subsequent 12 mo.Here,we report a case of H.pylori-positive lymphomatoid gastropathy with massive NK-cell proliferation,and also review the literature concerning newly identified lymphomatoid gastropathy based on comparison of extra nodal NK/T-cell lymphoma nasal type.In any case,these lesions are evaluated with biopsy specimens,the possibility of this benign entity should be considered,and excessive treatment should be carefully avoided.Close follow-up for this case of lymphomatoid gastropathy is necessary to exclude any underlying malignancy. | Tomohiro Terai Mitsushige Sugimoto Hiroki Uozaki Tetsushi Kitagawa Mana Kinoshita Satoshi Baba Takanori Yamada Satoshi Osawa Ken Sugimoto | 2012 | World Journal of Gastroenterology2012，18，17： | 5 |
| 2 | Acid suppressive therapy improved symptoms due to circumferential cervical inlet patch with proton pumps(H^+/K^+-ATPase)显示文摘Cervical inlet patch(CIP), also referred to as esophageal heterotopic gastric mucosa, is regarded as the residue of columnar epithelium of the embryonic esophagus. Narrow band imaging increases the detection rate of CIP. Herein, we present a 55-year-old man with symptomatic circumferential inlet patch. He exhibited globus and dysphagia, and esophagogastroduodenoscopy found cir-cumferential CIP, where im-munohistochemistry revealed the existence of pro-ton pumps(H^+, K^+ -ATPase). His throat symptoms were relieved by acid suppressive therapy with pump inhibitors. This case indicated that CIP should be considered as a differential diagnosis for the cause of globus symptoms in rare cases. | Takanori Yamada Atsushi Tsuji Shunya Onoue Masanao Kaneko Fumihiko Tanioka Satoshi Osawa Yasuhiko Saida | 2017 | World Journal of Clinical Cases2017，5，11： | 3 |
| 3 | Inverted Meckel's diverticulum preoperatively diagnosed using double-balloon enteroscopy显示文摘An inverted Meckel's diverticulum is a rare gastrointestinal congenital anomaly that is difficult to diagnose prior to surgery and presents with anemia, abdominal pain, or intussusception. Here, we report the case of 57-year-old men with an inverted Meckel's diverticulum, who was preoperatively diagnosed using doubleballoon enteroscopy. He had repeatedly experienced epigastric pain for 2 mo. Ultrasonography and computed tomography showed intestinal wall thickening in the pelvis. Double-balloon enteroscopy via the anal route was performed for further examination, which demonstrated an approximately 8-cm, sausage-shaped, submucosal tumor located approximately 80 cm proximal to the ileocecal valve. A small depressed erosion was observed at the tip of this lesion. Forceps biopsy revealed heterotopic gastric mucosa. Thus, the patient was diagnosed with an inverted Meckel's diverticulum, and single-incision laparoscopic surgery was performed. This case suggests that an inverted Meckel's diverticulum should be considered as a differential diagnosis for a submucosal tumor in the ileum. Balloon-assisted enteroscopy with forceps biopsy facilitate a precise diagnosis of this condition. | Kosuke Takagaki Satoshi Osawa Tatsuhiro Ito Moriya Iwaizumi Yasushi Hamaya Hiroe Tsukui Takahisa Furuta Hidetoshi Wada Satoshi Baba Ken Sugimoto | 2016 | World Journal of Gastroenterology2016，22，17： | 2 |
| 4 | Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype显示文摘 | Takahiro Uotani Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Shu Sahara Takanori Yamada Satoshi Osawa Ken Sugimoto Tatsuo Tanaka Kazuo Umemura Hiroshi Watanabe Hiroaki Miyajima Takahisa Furuta | 2012 | Clinical Gastroenterology and Hepatology2012，，8： | 2 |
| 5 | Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction:A case report显示文摘BACKGROUND Tuberous sclerosis complex(TSC)is a rare inherited disease with non-cancerous tumor growths in the skin,brain,kidneys,heart,and lungs.The co-occurrence of neuroendocrine neoplasm(NEN)with TSC is even rarer.There have been few reports on the relationship between TSC and neuroendocrine tumors(NETs),and fewer on the relationship between TSC and neuroendocrine carcinoma(NEC),a subtype of NEN.This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC.CASE SUMMARY A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and dizziness.Computed tomography scans revealed thickness of the gastric cardia,multiple metastatic lesions of the liver,and enlarged lymph nodes near the lesser curvature of the stomach.Esophagogastroduodenoscopy revealed a type 3 tumor located from the esophagogastric junction to the fundus,and the pathological diagnosis by biopsy was NEC.The patient was treated with seven courses of cisplatin+irinotecan,followed by eight courses of ramucirumab+nab-paclitaxel,one course of nivolumab,and two courses of S-1+oxaliplatin.Twenty-three months after the first treatment,the patient died because of disease progression and deterioration of the general condition.CONCLUSION This case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs. | Natsuki Ishida Takahiro Miyazu Satoshi Tamura Satoshi Suzuki Shinya Tani Mihoko Yamade Moriya Iwaizumi Satoshi Osawa Yasushi Hamaya Kazuya Shinmura Haruhiko Sugimura Katsutoshi Miura Takahisa Furuta Ken Sugimoto | 2020 | World Journal of Gastroenterology2020，26，45： | 2 |
| 6 | A case of small bowel adenocarcinoma in a patient with Crohn’s disease detected by PET/CT and double-balloon enteroscopy显示文摘Small bowel adenocarcinoma (SBA) in patients with Crohn’s disease (CD) is quite rare, difficult to diagnose without surgery, and has a poor prognosis. Here, we report a 48-year-old man with SBA and a 21-year history of CD who was diagnosed by a combination of positron emission tomography/computed tomography (PET/CT) and double-balloon enteroscopy (DBE). Since the age of 27 years, the patient had been treated for ileal CD and was referred to our hospital with persistent melena. Multiple hepatic tumors were found by CT. PET/CT detected an accumulation spot in the small bowel. DBE revealed an ulcerative tumor in the ileum about 100 cm from the ileocecal valve. An endoscopic forceps biopsy specimen showed poorly differentiated adenocarcinoma. There were some longitudinal ulcer scars near the tumor, and the chronic inflammation inthe small bowel appeared to be associated with the cancer development. Previous reports suggest the risk of SBA in patients with CD is higher than in the overall population. Since early diagnosis is extremely difficult in these cases, novel techniques, such as PET/CT and DBE, may be expected to help in making a preoperative diagnosis of the development of SBA in CD. | Chise Kodaira Satoshi Osawa Chihiro Mochizuki Yoshihiko Sato Masafumi Nishino Takanori Yamada Yasuhiro Takayanagi Kosuke Takagaki Ken Sugimoto Shigeru Kanaoka Takahisa Furuta Mutsuhiro Ikuma | 2009 | World Journal of Gastroenterology2009，15，14： | 2 |
| 7 | Sitafloxacin‐based third‐line rescue regimens for H elicobacter pylori infection in J apan显示文摘 | Takahisa Furuta Mitsushige Sugimoto Chise Kodaira Masafumi Nishino Mihoko Yamade Takahiro Uotani Shu Sahara Hitomi Ichikawa Takanori Yamada Satoshi Osawa Ken Sugimoto Hiroshi Watanabe Kazuo Umemura | 2014 | J Gastroenterol Hepatol2014，，3： | 1 |
| 8 | Effects of functional groups and surface roughness on interracial shear strength in ultrahigh molecular weight polyethylene fiber/polyethylene system 显示文摘 | Toshio ogawa Hiroaki mukai Satoshi osawa | 1999 | J Appl Polym Sci1999，，71： | 1 |
| 9 | Preparation of super-hydrophobic surface on biodegradable polymer by transcribing microscopic pattern of water- repellent leaf显示文摘 | Satoshi Osawa | 2006 | Polymer2006，47，： | 1 |
| 10 | Copyright Man-agement Project regarding the Open Access and Self Archiving :Its Activities and Issues 显示文摘 | Osawa Rurisa Nakayama Satoshi | 2011 | Journal of College and UniversityLibraries2011，，93： | 1 |
| 11 | BACE1 activity is modulated by cell-associated sphingosine-1-phosphate显示文摘 | Taisuke Tomita Nobumasa Takasugi Tomoki Sasaki Satoko Osawa Satoshi Yokoshima Tohru Fukuyama Virginia Lee John Trojanowski Takeshi Iwatsubo | 2011 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2011，，4： | 1 |
| 12 | Enhances recovery from aluminum-caused inhibition of root elongation in wheat显示文摘 | Satoshi Kikui Takayuki Sasaki Hiroki Osawa | 2007 | Plant Soil2007，290，： | 1 |
| 13 | Identification of immature podocyte specific antigen using retrovirus-mediated gene transfer and cell sorting显示文摘 | Joichi Usui Mitsujiro Osawa Satoshi Yamazaki Yohei Morita Akio Koyama Hiromitsu Nakauchi | 2005 | Clinical and Experimental Nephrology2005，，4： | 1 |
| 14 | Effect of dosing schemes of amoxicillin on eradication rates of Helicobacter pylori with amoxicillin-based triple therapy显示文摘 | Takahisa Furuta Mitsushige Sugimoto Mihoko Yamade Takahiro Uotani Shu Sahara Hitomi Ichikawa Takanori Yamada Satoshi Osawa Ken Sugimoto Hiroshi Watanabe Kazuo Umemura | 2014 | Journal of Clinical Pharmacology2014，，3： | 1 |
| 15 | Isolation of tannin degrading lactobacilli from humans and fermented foods 显示文摘 | Osawa R Keiko K Satoshi G | 2000 | Appl Environ Microbiol2000，66，： | 1 |
| 16 | Early serum albumin changes in patients with ulcerative colitis treated with tacrolimus will predict clinical outcome显示文摘BACKGROUND Oral tacrolimus is a therapeutic agent for moderate to severe steroid-dependent or resistant ulcerative colitis(UC),but remission induction is difficult,and it is necessary to treat the patient while considering the next treatment.AIM To examine serum albumin(Alb)level as a prognostic factor for the therapeutic effect of tacrolimus in clinical practice.METHODS Forty-seven patients with UC treated with tacrolimus at our institution were divided into remission and failure groups(colectomy or switch to biologics),and the biological data at the start of observation and at weeks 1 and 2 were retrospectively examined.Kaplan-Meier and multivariate analyses were performed using Alb as a prognostic factor in UC treatment.RESULTS During the three months observed,17(36.2%)patients failed treatment with tacrolimus.A comparison between the failure and remission groups showed a significant difference only in Alb in week 2,and in the week 2/week 0 Alb ratio,which showed the rate of change in Alb.The cut-off value of the week 2/week 0 Alb ratio that predicted failure was 1,and its area under the curve was 0.751(95%CI:0.604-0.898).In the Kaplan-Meier analysis,a week 2/week 0 Alb ratio≤1 had a significantly higher failure rate than that of>1;Cox proportional hazard regression analysis also showed that a week 2/week 0 Alb ratio≤1 was an independent prognostic factor for failure within 3 mo after the start of tacrolimus treatment.CONCLUSION A week 2/week 0 Alb ratio≤1 predicts failure within 3 mo of tacrolimus administration for UC.High failure risk exists with week 2 Alb values≤1 on admission. | Natsuki Ishida Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto | 2021 | World Journal of Gastroenterology2021，27，22： | 1 |
| 17 | A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus显示文摘 | Hirohiko Iwasaki Masayoshi Kajimura Satoshi Osawa Shigeru Kanaoka Takahisa Furuta Mutsuhiro Ikuma Akira Hishida | 2006 | Journal of Gastroenterology2006，，11： | 1 |
| 18 | Internal frontier:The pathophysiology of the small intestine显示文摘Even though the small intestine occupies a major portion of the abdominal space and is essential for life,in most pathology textbooks any chapter on small intestinal diseases,especially in human beings,is typically shorter than those for other gastrointestinal organs.Clinical and experimental investigations of the small intestine in various clinical situations,such as nutrition management,obesity interventions,and emergency care,have elucidated several important biological problems associated with the small intestine,the last frontier of gastroenterology.In this issue,a review by Professor Basson and his team at Michigan State University sheds light on the changes in the human small intestine under various conditions based on their clinical and surgical experience.With the advent of recent innovations in enteroscopy,a form of endoscopy used to examine deep within the small intestine,the issue that they highlighted,i.e.,mucosal adaptation and atrophy of the human small intestine,has emerged as a major and manageable challenge for gastroenterologists in general,including the readers of the World Journal of Gastroenterology. | Haruhiko Sugimura Satoshi Osawa | 2013 | World Journal of Gastroenterology2013，19，2： | 1 |
| 19 | Japanese-Specific Filagg-rin Gene Mut-ations in Japanese Patients Suffering from Atopic Eczema and Asthma显示文摘 | Rinko Osawa Satoshi Konno Masashi Akiyama | 2010 | Journal of Investiga tive Dermatology2010，130，： | 1 |
| 20 | Effects of Functional Groups and Surface Roughness on Interfacial Shear Strength in Ultrahigh Molecular Weight Polyethylene Fiber/Polyethylene System显示文摘 | Toshio ogawa Hiroaki mukai Satoshi osawa | 1999 | J ApplPolymSci1999，，71： | 1 |
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