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| 1 | Hepatobiliary complications of alveolar echinococcosis: A long-term follow-up study显示文摘AIM:To determine the long-term hepatobiliary complications of alveolar echinococcosis(AE) and treatment options using interventional methods.METHODS:Included in the study were 35 patients with AE enrolled in the Echinococcus Multilocularis Data Bank of the University Hospital of Ulm.Patients underwent endoscopic intervention for treatment of hepatobiliary complications between 1979 and 2012.Patients' epidemiologic data, clinical symptoms, and indications for the intervention, the type of intervention and any additional procedures, hepatic laboratory parameters(pre- and post-intervention), medication and surgical treatment(pre- and post-intervention), as well as complications associated with the intervention and patients‘ subsequent clinical courses were analyzed.In order to compare patients with AE with and without history of intervention, data from an additional 322 patients with AE who had not experienced hepatobiliary complications and had not undergone endoscopic intervention were retrieved and analyzed.RESULTS:Included in the study were 22 male and 13 female patients whose average age at first diagnosis was 48.1 years and 52.7 years at the time of intervention.The average time elapsed between first diagnosis and onset of hepatobiliary complications was 3.7 years.The most common symptoms were jaundice, abdominal pains, and weight loss.Thenumber of interventions per patient ranged from one to ten.Endoscopic retrograde cholangiopancreatography(ERCP)was most frequently performed in combination with stent placement(82.9%),followed by percutaneous transhepatic cholangiodrainage(31.4%)and ERCP without stent placement(22.9%).In 14.3%of cases,magnetic resonance cholangiopancreatography was performed.A total of eight patients received a biliary stent.A comparison of biochemical hepatic function parameters at first diagnosis between patients who had or had not undergone intervention revealed that these were significantly elevated in six patients who had undergone intervention.Complications(cholangitis,pancreatitis)occurred in six patients during and in 12patients following the intervention.The average survival following onset of hepatobiliary complications was 8.8years.CONCLUSION:Hepatobiliary complications occur in about 10%of patients.A significant increase in hepatic transaminase concentrations facilitates the diagnosis.Interventional methods represent viable management options. | Tilmann Graeter Franziska Ehing Suemeyra Oeztuerk Richard Andrew Mason Mark Martin Haenle Wolfgang Kratzer Thomas Seufferlein Beate Gruener | 2015 | World Journal of Gastroenterology2015，21，16： | 6 |
| 2 | S3-Leitlinie ?Exokrines Pankreaskarzinom” 2007显示文摘 | G Adler T Seufferlein S Bischoff H.-J Brambs S Feuerbach G Grabenbauer S Hahn V Heinemann W Hohenberger J Langrehr M Lutz O Micke H Neuhaus P Neuhaus H Oettle P Schlag R Schmid W Schmiegel K Schlottmann J Werner B Wiedenmann I Kopp | 2007 | Z Gastroenterol2007，，06： | 1 |
| 3 | Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells显示文摘 | Martin Steinkamp Irmlind Geerling Thomas Seufferlein Georg von Boyen Bernhard Egger Johannes Grossmann Leopold Ludwig Guido Adler Max Reinshagen | 2003 | Gastroenterology2003，，： | 1 |
| 4 | Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells显示文摘 | Seckl MJ Schwam E | 2002 | Br J Cancer2002，86，7： | 1 |
| 5 | Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells显示文摘 | Withers DJ Coppock HA Seufferlein T | 1996 | FEBS Lett1996，378，： | 1 |
| 6 | Cetuximab with irinotecan, folinic acid and 5-fluorouracil as first-line treatment in advanced gastroesophageal cancer:a prospective multi-center biomarker-oriented phase Ⅱ study显示文摘 | Moehler M Mueller A Trarbach T Lordick F Seufferlein T Kubicka S | 2011 | Ann Oncol2011，22，： | 1 |
| 7 | Glial - derived neurotrophic factor regulates apoptosis in colonic epithelial cells 显示文摘 | Steinkamp M Geerling I Seufferlein T | 2003 | Gastroenterology2003，124，7： | 1 |
| 8 | Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells显示文摘 | Seufferlein T Seckl M J Schwarz E | 2002 | Br J Cancer2002，86，7： | 1 |
| 9 | Adrenomedullin stimulates DNA synthesis and cell proliferasion via elevation of cAMP in Swiss 3T3 cells显示文摘 | Withers DJ Coppock HA Seufferlein T | 1996 | FEBS Lett1996，378，1： | 1 |
| 10 | Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity显示文摘 | Zhou S Bachem MG Seufferlein T | 2008 | Cell Signal2008，20，4： | 1 |
| 11 | Molecular mechanisms of low intensity pulsed ultrasound inhuman skin fibroblasts显示文摘 | Zhou S Schmelz A Seufferlein T | 2004 | Biol Chem2004，279，54： | 1 |
| 12 | Mechanisms of nordihydroguaiaretic acid - induced growth inhibition and apoptosis in human cancer cell显示文摘 | Seckl M J Schwarz E | 2002 | Br J Cancer2002，86，7： | 1 |
| 13 | Regorafenib 显示文摘 | Ettrich TJ Seufferlein T | 2014 | Recent Results CaneerRes2014，2111，： | 1 |
| 14 | Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells显示文摘 | Tobias Busch Milena Armacki Tim Eiseler Golsa Joodi Claudia Temme Julia Jansen G?tz von Wichert M. Bishr Omary Joachim Spatz Thomas Seufferlein | 2012 | Journal of Cell Science2012，，9： | 1 |
| 15 | Adrenomedullin stimulates DNA synthesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells显示文摘 | Withers D J Coppock H A Seufferlein T Smith D M Bloom S R Rozengurt E | 1996 | FEBS Lett1996，378，： | 1 |
| 16 | Mechanisms of nordihydroguaiaretic acid-induced growth inhibition and apoptosis in human cancer cells显示文摘 | SEUFFERLEIN T SECKL MJ SCHWARZ E | 2002 | Br J Cancer2002，86，7： | 1 |
| 17 | Mechanisms of nordihydroguaiaretic acid -induced growth inhibition and apoptosis in human cancer cell显示文摘 | Seufferlein T Seckl MJ Schwarz E | 2002 | Br J Cancer2002，86，7： | 1 |
| 18 | Glial-derived neurotrophic factor regulates apoptosis in colonic epithelial cells 显示文摘 | Steinkamp M Geerling I Seufferlein T | 2003 | Gastroenterology2003，124，7： | 1 |
| 19 | Adrenomedullin stimulates DNA sythesis and cell proliferation via elevation of cAMP in Swiss 3T3 cells显示文摘 | Withers DJ Coppock HA Seufferlein T | 1996 | FEBS Lett1996，378，1： | 1 |
| 20 | Cetuximab with irinotecan/folinic acid/5-FU as first-line treatment in advanced gastric cancer:a nonrandomized multicenter AIO phase Ⅱ study显示文摘 | Kanzler S Trarbach T Seufferlein T | 2009 | J Clin Oncol2009，27，15： | 1 |
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