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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Experimental Separation of Rashba and Dresselhaus Spin - Splittings in Semiconductor Quantum Wells 显示文摘 | Ganichev S D Bel'kov V V GoRlub L E Ivchenko E L Schneider P Giglberger S Eroms J DeBoeck J Borghs G Wegscheider W Weiss D Prettl W | | cond0，，： | 1 |
| 3 | Related articles, links polymorphisms in MHC - DRA and - DRB alleles of water buf- falo ( Bubalus bubalis) reveal different features from cattle DR alleles 显示文摘 | SENA L SCHNEIDER M P BRENIG B | 2003 | Anim Genet2003，34，1： | 1 |
| 4 | Insitu treatment of radioactive mine water using reactive materials-results of laboratory and field experiments in uranium ore mines in Germany显示文摘 | Schneider P Neitzel P L Osenbruck K | 2001 | Acta Hydrochimica et Hydrobiologica2001，29，23： | 1 |
| 5 | Polo- like kinase 2 regulates selective autophagic alpha-synuclein clearance and suppresses its toxicity in vivo显示文摘 | OUESLATI A SCHNEIDER B L AEBISCHER P A | 2013 | Proceedings of the National Academy of Sciences of the United States of America2013，110，41： | 1 |
| 6 | Grain refinement of aluminium alloys by inoculation 显示文摘 | GREER A L COOPER P S MEREDITH M W SCHNEIDER W SCHUMACHER P SPITTLE J A | 2003 | Advanced Engineering Materials2003，5，： | 1 |
| 7 | The atmospheric input of trace species to the world ocean显示文摘 | Duce R A Liss P S Merrill J T Atlas L L Buat-Menard P Hicks B B Miller J M Prospero J M Arimoto R Church T M Ellis W Galloway F N Hansen L Jickells T D Knap A H Reinhardt K H Schneider B Soudine A Tokos J J Tsunogai S Wollast R Zhou M | 1991 | Global Biogeochemical Cycles1991，5，： | 1 |
| 8 | Phylogeny,classification and floral evolution of water lilies (Nymphaeaceae,Nymphaeales):A synthesis of non-molecular,rbcL,matK,and 18S rDNA data显示文摘 | Les D H Schneider E L Padgett D J Soltis P S Soltis D E Zanis M | 1999 | Systematic Botany1999，24，1： | 1 |
| 9 | Effectiveness of atypical antipsychotic drugs in patients with Alzheimer's disease显示文摘 | SCHNEIDER L S TARIOT P N DAGERMAN K S | 2006 | New Engl J Med2006，355，15： | 1 |
| 10 | Phylogenetic interpretations from selected floral vasculature characters in the Nymphaeaceae sensu lato显示文摘 | Moseley M F Schneider E L Williamson P S | 1993 | Aquatic Botany1993，44，： | 1 |
| 11 | Validity of 10 electronic pedometers for measuring steps, dis tance, and energy cost显示文摘 | CROUTER S E SCHNEIDER P L KARABULUT M | 2003 | Med Sci Sports Exe2003，35，8： | 1 |
| 12 | Investigation of cosolute-pro- tein preferential interaction coefficients: new insight into the mechanism by which arginine inhibits aggregation显示文摘 | SCHNEIDER C P TROUT B L | 2009 | The Jour- nal of Physical Chemistry B2009，113，7： | 1 |
| 13 | Risk of death with atypi- cal antipsychotic drug treatmentfor dementia: meta-analysis of randomized placebo-controlled trials显示文摘 | Schneider L S Dagerman K S Insel P | 2005 | JAMA2005，294，15： | 1 |
| 14 | Structure of an Fab-protease complex reveals a highly specific non-canonical mechanism of inhibition显示文摘 | Farady C J Egea P F Schneider E L | 2008 | J Mol Biol2008，380，2： | 1 |
| 15 | Vertical and horizontal variability of volatile organic compounds in homes in Eastern Germany 显示文摘 | SCHNEIDER P LORINCI G GEBEFUGI I L | 1999 | Journal of Exposure Analysis and Environmental Epidemiology1999，9，4： | 1 |
| 16 | Small-angle X-ray-scattering study of phase separation and crystallizatioin in the bulk amorphous Mg62Cu25Y10Li3 alloy显示文摘 | LIU W Johnson W L Schneider S Geyer U Thiyagarajan P A | 1999 | Phys Rev B1999，59，11： | 1 |
| 17 | TRAIL-receptor1(DR4) and 2(DR5) signal FADD-dependent apoptosis and activate NF-KappaB 显示文摘 | Thome M Bodmer J L | 1997 | Immunity1997，7，6： | 1 |
| 18 | An economic evaluation of phosphorus recovery as struvite from digester supernatant 显示文摘 | SHU L SCHNEIDER P JEGATHEESAN V | 2006 | Bioresource Technology2006，97，17： | 1 |
| 19 | Person organisation fit across cultures: an empirical investigation of individualism and collectivism 显示文摘 | Parkes L P Bochner S Schneider S K | 2001 | Apply Psychology2001，50，： | 1 |
| 20 | Phase II trial of docetaxel in patients with platinum refractory advanced ovarian cancer显示文摘 | Francis P Schneider J Hann L | 1994 | J Clin Oncol1994，12，11： | 1 |
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