|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serum Bcl-2 concentrations in overweight-obese subjects with nonalcoholic fatty liver disease显示文摘AIM: To shed some light on the relationship between anti-apoptotic serum Bcl-2 concentrations and metabolic status, anthropometric parameters, inflammation indices, and non-alcoholic fatty liver disease severity were investigated in 43 young individuals with fatty liver (FL)and 41 with nonalcoholic steatohepatitis (NASH).METHODS: Circulating levels of Bcl-2 were detected in 84 patients with ultrasono graphic findings of 'bright liver' and/or hyper-transaminasemia of unknown origin and/or increase in γ-glutamyl-transpeptidase (γ-GT)strictly in the absence of other acute or chronic liver disease, whose age was not advanced, who gave consent to liver biopsy and were then divided on the basis of the histological results into two groups (43 with FL and 41 with NASH). Twenty lean subjects, apparently healthy and young, were chosen as controls.RESULTS: Serum Bcl-2 concentrations were significantly higher in the FL group than in the NASH group. Insulin resistance and γ-GT activity were significantly higher in NASH subjects. Apoptotic hepatocytes were significantly more numerous in NASH patients. NASH patients presented with larger spleens and augmented C-reactive protein (CRP) concentrations than healthy subjects. Steatosis grade at histology was similar in both NASH and FL populations. The number of apoptotic cells was significantly related to anti-apoptotic Bcl-2 protein values in FL patients. Bcl-2 serum levels positively correlated to body mass index (BMI) values (P ≤ 0.0001) but not to age of the population. Triglycerides/HDL ratio correlated well to waist circumference in males (P = 0.0008).γ-GT activity was associated with homeostatic metabolic assessment (HOMA) (P = 0.0003) and with serum ferritin (P = 0.02). Bcl-2 concentrations were not related to either spleen size or CRP values. NASH patients presented a weak negative correlation between lobular inflammation and Bcl-2 levels. A prediction by low values of serum Bcl-2 towards a greater presence of metaboli-cally unhealthy overweight/obese patients (MUOs) was evidenced. HOMA, BMI and uric acid, in that sequence,best predicted serum Bcl-2 concentrations.CONCLUSION: MUOs could be detected by Bcl-2 levels.By favoring the life span of hepatocytes, and enhancing triglyceride formation, the anti-apoptotic process inhibits free fatty acids toxicity in FL. | Giovanni Tarantino Francesco Scopacasa Annamaria Colao Domenico Capone Marianna Tarantino Ernesto Grimaldi Silvia Savastano | 2011 | World Journal of Gastroenterology2011，17，48： | 10 |
| 2 | Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats 显示文摘 | Scopacasa BS Teixeira VPA Franchini KG | 2003 | J Appl Physiol2003，94，： | 1 |
| 3 | Relation between calcium absorption and serum calcitriol in normal men:evidence for age-related intestinal resistance to calcitriol显示文摘 | Scopacasa F Wishart JM Horowitz M Morris HA Need AG | 2004 | EurJ Clin Nutr2004，58，2： | 1 |
| 4 | Measurement of soluble adhesion molecules in primary Raynaud's phenomenon and in Raynaud's phenomenon secondary to connective tissue diseases显示文摘 | G Brevetti M De Caterina VD Martone S Corrado A Silvestro G Spadaro and F Scopacasa | 2000 | Int J Clin Lab Res2000，30，2： | 1 |
| 5 | Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats显示文摘 | Scopacasa BS Teixeira VP Franchini KG | 2003 | J Appl Physiol2003，94，4： | 1 |
| 6 | Evaluation of the Abbott CELL-DYN 4000 hematology analyzer显示文摘 | Grimaldi E Scopacasa F | 2000 | Am J Clin Pathol2000，113，4： | 1 |
| 7 | Rela- tion between calcium absorption and serum ealcitriol in normal men: evidence forage-related intestinal resist- ance to calcitriol显示文摘 | Scopacasa F Wishart JM Horowitz M | 2004 | Eur J Clin Nutr2004，58，2： | 1 |
| 8 | Evaluation of the reticulocyte counting by the Mindray BC 6800 auto- mated hematology analyzer:comparison with ABX Pentra 120,Coulter LH 750, and microscopy显示文摘 | Grillone R Grimaldi E Scopacasa F | 2015 | Int J Lab He- matol2015，37，1： | 1 |
| 9 | Relation between calcium absorption and serum calcitriol in normal men: evidence for age-related intestinal resistance to caleitriol显示文摘 | Scopacasa F Wishart JM Horowitz M | 2004 | Eur J Clin Nutr2004，58，： | 1 |
| 10 | Blood pressure and metabolic changes during dietary l -arginine supplementation in humans显示文摘 | Alfonso Siani Ermenegilda Pagano Roberto Iacone Licia Iacoviello Francesco Scopacasa Pasquale Strazzullo | 2000 | American Journal of Hypertension2000，，5： | 1 |
| 11 | Evaluation of the Abbott CELLDYN 4000 hematology analyzer 显示文摘 | GRIMALDI E SCOPACASA F | 2000 | Am J Clin Pathol2000，113，： | 1 |
| 12 | Relation between calcium absorption and serum calcitriol in normal men:evidence for age-related intestinal resistance to calcitriol显示文摘 | Scopacasa F Wishart JM Horowitz M | 2004 | Eur J Clin Nutr2004，58，： | 1 |
| 13 | Evaluation of the Abbott CELLDYN 4000 hematology analyzer显示文摘 | GRIMALDI E SCOPACASA F | 2000 | Mn J Clin Pathol2000，113，4： | 1 |
| 14 | Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats显示文摘 | Teixeira VP Franchini KG | 2003 | J Appl Physiol2003，94，： | 1 |
| 15 | Relation be- tween calcium absorption and serum calcitriol innormal men : evidence for age related intestinal resistance to calcitri- ol显示文摘 | Scopacasa F Wishart JM Horowitz M | 2004 | Eur J Clin Nutr2004，58，2： | 1 |
| 16 | Could inflammatory markers help diagnose nonalcoholic steatohepatitis?显示文摘 | Giovanni Tarantino Paolo Conca Fabrizio Pasanisi Manuela Ariello Maria Mastrolia Adriano Arena Marianna Tarantino Francesco Scopacasa Raffaela Vecchione | 2009 | European Journal of Gastroenterology & Hepatology2009，，5： | 1 |
| 17 | Evaluation of the Beckman-Coulter Gen-S hematology analyzer显示文摘 | Grimaldi E Scopacasa F | 1998 | Laboratory Hematoloty1998，4，： | 1 |
| 18 | In-travenous uterine leiomyomatosis extending into the right heart 显示文摘 | Oehler M K Scopacasa L Brown M Kumar G Edwards J | 2011 | Aust N Z J Obstet Gynaecol2011，51，： | 1 |
| 19 | Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aorticconstricted rats显示文摘 | Scopacasa BS Teixeira VP Franchini KG | 2003 | J Appl Physiol2003，94，4： | 1 |
| 20 | Colchicine attenuates left ventricular hypertrophy but preserves cardiac funcfon of aortic-constricted rats显示文摘 | Scopacasa BS Teixeira VP Franchini KG | 2003 | J Appl Physiol2003，94，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员