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| 1 | Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease显示文摘Hepatitis B virus(HBV) infection is a dynamic state ofinteractions among HBV, hepatocytes, and the host immune system. Natural history studies of chronic hepatitis B(CHB) infection have shown an association between active viral replication and adverse clinical outcomes such as cirrhosis and hepatocellular carcinoma. The goal of therapy for CHB is to improve quality of life and survival by preventing progression of the disease to cirrhosis, decompensation, end-stage liver disease, hepatocellular carcinoma(HCC) and death. This goal can be achieved if HBV replication is suppressed in a sustained manner. The accompanying reduction in histological activity of CHB lessens the risk of cirrhosis and of HCC, particularly in non-cirrhotic patients. However, CHB infection cannot be completely eradicated, due to the persistence of covalently closed circular DNA in the nucleus of infected hepatocytes, which may explain HBV reactivation. Moreover, the integration of the HBV genome into the host genome may favour oncogenesis, development of HCC and may also contribute to HBV reactivation. | Francesco Paolo Russo Kryssia Rodríguez-Castro Laura Scribano Giorgia Gottardo Veronica Vanin Fabio Farinati | 2015 | World Journal of Hepatology2015，7，8： | 10 |
| 2 | Use of antibiotics in the treatment of Crohn’s disease显示文摘Many data coming from animal models and clinical observations support an involvement of intestinal microbiota in the pathogenesis of Crohn's disease(CD). It is hypothesized in fact,that the development of chronic intestinal inflammation is caused by an abnormal immune response to normal flora in genetically susceptible hosts.The involvement of bacteria in CD inflammation has provided the rationale for including antibiotics in the therapeutic armamentarium.However, randomized controlled trials have failed to demonstrate an efficacy of these drugs in patients with active uncomplicated CD,even if a subgroup of patients with colonic location seems to get benefit from antibiotics. Nitroimidazole compounds have been shown to be efficacious in decreasing CD recurrence rates in operated patients,and the use of metronidazole and ciprofloxacin is recommended in perianal disease.However,the appearance of systemic side effects limits antibiotic long-term employment necessary for treating a chronic relapsing disease.Rifaximin,characterized by an excellent safety profile,has provided promising results in inducing remission of CD. | Maria Lia Scribano Cosimo Prantera | 2013 | World Journal of Gastroenterology2013，19，5： | 2 |
| 3 | CT and MR imaging findings in athletes with early tibial stress injuries:comparison with bone scintigraphy findings and emphasis on cortical abnormalities显示文摘 | Gaeta M Minutoli F Scribano E | | 0，，02： | 1 |
| 4 | Antibiotics and probiotics in in- flammatory bowel disease :why,when, and how 显示文摘 | Prantera C Scribano ML | 2009 | Curr Opin Gastroenterol2009，，： | 1 |
| 5 | Computed Tomography Halo Sign in Pulmonary Nodules:Frequency and Diagnostic Value显示文摘 | Gaeta M Blandino A Scribano E | 1999 | J Thorac Imaging1999，14，2： | 1 |
| 6 | Nonlinear Cointegration and Nonlinear Error Correction: Record Counting Cointegration Tests显示文摘 | scribano A Sipols A E Aparicio F | 2006 | Communications in Statistics Simulation and Computation2006，35，4： | 1 |
| 7 | Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission显示文摘 | Susan Levenstein Cosimo Prantera Vilma Varvo Maria Lia Scribano Arnaldo Andreoli Carlo Luzi Massimo Arcà Eva Berto Giustina Milite Adriana Marcheggiano | 2000 | The American Journal of Gastroenterology2000，，： | 1 |
| 8 | Muscle fat fraction in neu- ronmscular disorders: dual-echo dual-flip-angle spoiled gradient- recalled MR imaging technique for quantification: a feasibility study显示文摘 | Gaeta M Scribano E Mileto A | 2011 | Radiology2011，259，2： | 1 |
| 9 | CT and MR imaging findings in athletes with early tibial stress injuries:comparison with bone scintigraphy findings and emphasis on cortical abnormalities显示文摘 | Gaeta M Minutoli F Scribano E | 2005 | Radiology2005，235，： | 1 |
| 10 | Antibiotics and inflammatory boweldiseases显示文摘 | Scribano ML Prantera C | 2013 | Dig Dis2013，31，34： | 1 |
| 11 | Us power doppler of hepatic angiomyolipoma with low fat content显示文摘 | G. Ascenti M. Gaeta G. Zimbaro D. Villari A. Blandino E. Scribano | 2000 | European Radiology2000，，6： | 1 |
| 12 | Barriers to successful treatment completion in child sexual abuse survivors显示文摘 | Paul Mc Pherson Philip Scribano Jack Stevens | 2012 | Journal of Interpersonal Violence2012，27，1： | 1 |
| 13 | Vedolizumab for inflammatory bowel disease:from randomized controlled trials to real-life evidence显示文摘The biologic antitumor necrosis factor alpha(anti-TNFα) agents have revolutionised the treatment of inflammatorybowel disease(IBD). However,some patients experience primary nonresponse,loss of response,or intolerance. Therefore,introducing a newer class of therapy with a mechanism of action that acts on different inflammatory pathways involved in IBD pathogenesis is appealing. Vedolizumab is a fully humanised monoclonal antibody that selectively targets α4β7 integrin. Based on the results of the pivotal clinical GEMINI trials,vedolizumab was approved for the treatment of adult patients with moderately to severely active ulcerative colitis(UC) and Crohn's disease(CD) refractory or intolerant to either conventional therapy or TNFα inhibitors. This review describes the efficacy,safety,and tolerability of vedolizumab reported in both randomized,controlled,clinical trials and from real-world experience in patients with UC and CD in order to identify its place in treatment algorithms for IBD. | Maria Lia Scribano | 2018 | World Journal of Gastroenterology2018，24，23： | 1 |
| 14 | Computed tomography halo sign in pulmonary nodules:frequency and diagnostic value显示文摘 | Gaeta M Blandino A Scribano E | 1999 | J Thorac Imaging1999，14，2： | 1 |
| 15 | Computed tomography halo sign in pulmonary nodules:frequency and diagnostic value显示文摘 | Gaeta M Blandino A Scribano E | 1999 | J Thorac Imaging1999，14，2： | 1 |
| 16 | Air-space pattern in lung metastasis from adenocarcinoma of the GI tract显示文摘 | Gaeta M Volta S Scribano E | 1996 | J Comput Assist Tomogr1996，20，2： | 1 |
| 17 | Medical treatment of moderate to severe Crohn's disease显示文摘 | Scribano M Prantera C | | 0，，2： | 1 |
| 18 | Computed tomography halo sign in pulmonary nodules:frequency and diagnostic value显示文摘 | Blandino A Scribano E Minutoli F | 1999 | J Thorac Imaging1999，14，2： | 1 |
| 19 | Probiotics and Crohn's disease显示文摘 | Prantera C Scribano ML | 2002 | Dig Liver Dis2002，34，2： | 1 |
| 20 | Role of Rifaximin in Inflammatory Bowel Disease Treatment显示文摘 | Maria Lia Scribano | 2016 | Mini-Reviews in Medicinal Chemistry2016，，： | 1 |
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