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| 1 | PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15显示文摘Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer patients.Recently,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse models.Herein,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer patients.Single-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)TILs.Furthermore,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)TILs.Transcriptionally and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 expression.Notably,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)TILs.Taken together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies. | Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee Ji Won Han Seong Jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim Jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-Cheol Shin | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 2 | Multi-image matching for a general motion stereo camera model 显示文摘 | Ja Seong Ku Kyoung Mu Lee Sang Uk Lee | 2001 | Pattern Recognition2001，，34： | 1 |
| 3 | Anti-metastatic effect of cantharidin in A549 human lung cancer cells显示文摘 | Young Min Kim Min Jeong Ku Young-Jin Son Jung-Mi Yun Seong Hwan Kim Sang Yeol Lee | 2013 | Archives of Pharmacal Research2013，，4： | 1 |
| 4 | Three-dimensional microfabrication using two-photon absorption by femtosecond laser显示文摘 | Shin Wook YI Seong Ku LEE Hong Jin KONG | 2004 | SPIE2004，5342，： | 1 |
| 5 | Multi--imagematching for a general motion stereo camera model显示文摘 | Ja Seong Ku Kyoung Mu Lee Sang Uk Lee | 2001 | Pattern Recognition2001，，34： | 1 |
| 6 | Multi-millijoule terahertz emission from laser- wakefield-accelerated electrons显示文摘High-power terahertz radiation was observed to be emitted from a gas jet irradiated by 100-terawatt-class laser pulses in the laser-wakefield acceleration of electrons.The emitted terahertz radiation was characterized in terms of its spectrum,polarization,and energy dependence on the accompanying electron bunch energy and charge under various gas target conditions.With a nitrogen target,more than 4 mJ of energy Was produced at<10 THz with a laser-to-terahertz conversion efficiency of~0.15%.Such strong terahertz radiation is hypothesized to be produced from plasma electrons accelerated by the ponderomotive force of the laser and the plasma wakefelds on the time scale of the laser pulse duration and plasma period.This model is examined with analytic calculations and particle-in-cell simulations to better understand the generation mechanism of high-energy terahertz radiation in laser-wakefield acceleration. | Taegyu Pak Mohammad Rezaei-Pandari Sang Beom Kim Geonwoo Lee Dae Hee Wi Calin loan Hojbota Mohammad Mirzaie Hyeongmun Kim Jae Hee Sung Seong Ku Lee Chul Kang Ki-Yong Kim | 2023 | Light(Science & Applications)2023，12，2： | 1 |
| 7 | Spatial and spectral measurement of laser-driven protons through radioactivation显示文摘The simultaneous measurement of the spatial profile and spectrum of laser-accelerated protons is important for further optimization of the beam qualities and applications.We report a detailed study regarding the underlying physics and regular procedure of such a measurement through the radioactivation of a stack composed of aluminum,copper,and CR-39 plates as well as radiochromic films(RCFs).After being radioactivated,the copper plates are placed on imaging plates(IPs)to detect the positrons emitted by the reaction products through contact imaging.The spectrum and energy-dependent spatial profile of the protons are then obtained from the IPs and confirmed by the measured ones from the RCFs and CR-39 plates.We also discuss the detection range,influence of electrons,radiation safety,and spatial resolution of this measurement.Finally,insights regarding the extension of the current method to online measurements and dynamic proton imaging are also provided. | Yin‑Ren Shou Xue‑Zhi Wu Gwang‑Eun Ahn Seung Yeon Kim Seong Hoon Kim Hwang Woon Lee Jin Woo Yoon Jae Hee Sung Seong Ku Lee Xue‑Qing Yan Il Woo Choi Chang Hee Nam | 2023 | Nuclear Science and Techniques2023，34，12： | 0 |
| 8 | Changes of the intestinal endocrine cells in the C57BL/6 mouse after implantation of murine lung carcinoma (3LL): An immunohistochemical quantitative study显示文摘AIM: To study the distributions and frequencies of intestinal endocrine cells in the C57BL/6 mouse with immunohistochemical method using seven types of specific antisera against chromogranin A (CGA), serotonin,somatostatin, glucagons, gastrin, cholecystokinin (CCK)-8 and human pancreatic polypeptide (hPP) after abdominal subcutaneous implantation of murine lung carcinoma (3LL).METHODS: The experimental animals were divided into two groups, one is non-implanted Sham and the other is 3LL-implanted group. Samples were collected from six regions of intestinal tract at 28th d after implantation of 3LL cells (1×105 cell/mouse).RESULTS: In this study, five types of immunoreactive (IR) cells were identified except for gastrin and hPP. The regional distributions of the intestinal endocrine cells in the 3LL-implanted group were similar to those of the non-implanted Sham. However, significant decreases of IR cells were detected in 3LL-implanted group compared to those of non-implanted Sham. CGA- and serotonin-IR cells significantly decreased in 3LL-implanted groups compared to that of non-implanted Sham. Somatostatin-IR cells in the jejunum and ileum and CCK-8-IR cells in the jejunum of 3LL-implanted groups significantly decreased compared to that of non-implanted Sham. In addition,glucagon-IR cells were restricted to the ileum and colon of non-implanted Sham.CONCLUSION: Implantation of tumor cell mass (3LL)induced severe quantifiable changes of intestinal endocrine cell density and the abnormality in density of intestinal endocrine cells may contribute to the development of gastrointestinal symptoms such as anorexia and indigestion, frequently encountered in patients with cancer. | Sae-Kwang Ku Seung-Kyoo Seong Dae-Young Kim Hyeung-Sik Lee Jong-Dae Kim Hae-Yun Choi Bu-Il Seo Jae-Hyun Lee | 2005 | World Journal of Gastroenterology2005，11，35： | 0 |
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