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| 1 | Brain-derived neurotrophic factor plasma levels and premature cognitive impairment/dementia in type 2 diabetes显示文摘AIM To assess the relationship of brain-derived neurotrophic factor(BDNF) with cognitive impairment in patients with type 2 diabetes. METHODS The study included 40 patients with diabetes mellitus type 2(DM2), 37 patients with chronic kidney disease in hem dialysis hemodialysis therapy(HD) and 40 healthy subjects. BDNF in serum was quantified by ELISA. The Folstein Mini-Mental State Examination was used to evaluate cognitive impairment.RESULTS The patients with DM2 and the patients in HD were categorized into two groups, with cognitive impairment and without cognitive impairment. The levels of BDNF showed significant differences between patients with DM2(43.78 ± 9.05 vs 31.55 ± 10.24, P = 0.005). There were no differences between patients in HD(11.39 ± 8.87 vs 11.11 ± 10.64 P = 0.77); interestingly, ferritin levels were higher in patients with cognitive impairment(1564 ± 1335 vs 664 ± 484 P = 0.001). The comparison of BDNF values, using a Kruskal Wallis test, between patients with DM2, in HD and healthy controls showed statistical differences(P < 0.001).CONCLUSION Low levels of BDNF are associated with cognitive impairment in patients with DM2. The decrease of BDNF occurs early and progressively in patients in HD. | Blanca Murillo Ortíz Joel Ramírez Emiliano Edna Ramos-Rodríguez Sandra Martínez-Garza Hilda Macías-Cervantes Sergio Solorio-Meza Texar Alfonso Pereyra-Nobara | 2016 | World Journal of Diabetes2016，7，20： | 7 |
| 2 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 3 | Method development for the simultaneous determination of methylmercury and inorganic mercury in seafood显示文摘 | Ariane V Z Sergio C Carmen I P | 2014 | Food Control2014，46，1： | 1 |
| 4 | Decreased nitric oxide pro- duction in the rat brain after chronic arsenic exposure显示文摘 | Sergio Z Francisca PS Juan MD | 2006 | Neuro- chem Res2006，31，： | 1 |
| 5 | 查看详情显示文摘 | Guendalina M.C Sergio H Li Z | | 0，，： | 1 |
| 6 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants显示文摘 | Emanuela Z Sergio G Alessandra B | 2004 | Meat Science2004，66，： | 1 |
| 7 | IRREGULAR WAVELET FRAMES AND GABOR FRAMES显示文摘Given g∈L 2(R n), we consider irregular wavelet systems of the form {λ n2 jg(λ jx-kb)} j∈Z,k∈Z n, where λ j>0 and b>0. Sufficient conditions for the wavelet system to constitute a frame for L 2(R n) are given. For a class of functions g∈L 2(R n) we prove that certain growth conditions on {λ j} will lead to frames, and that some other types of sequences exclude the frame property. We also give a sufficient condition for a Gabor system {e 2πib(j,x)g(x-λ k)} j∈Z n,k∈Z to be a frame. | Ole Christensen Sergio Favier Felipe Zó | 2001 | Analysis in Theory and Applications2001，17，3： | 1 |
| 8 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants 显示文摘 | Emanuela Z Sergio G Alessandra B | 2004 | Meat Science2004，66，： | 1 |
| 9 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants显示文摘 | EMANUELA Z SERGIO G ALESSANDRA B | 2004 | Meat Science2004，66，2： | 1 |
| 10 | Blockage ofdopaminergic D2 receptors produces decrease of REM but not of slow wave sleep in rats after REM sleep deprivation显示文摘 | Marcelo MSL Angela BR Andressa S Monica LA Adriano Z Sílvio MZ Maria ABFV Sergio T | | 0，，： | 1 |
| 11 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants 显示文摘 | Emanuela Z Sergio G Alessandra B | 2004 | Meat Science2004，66，： | 1 |
| 12 | Wind erosion quantity and quality of an antic haplustoll of the semi-arid pampas of Argentina显示文摘 | DANIEL E B TED M Z SERGIO A | 2007 | Journal of Arid Environments2007，69，： | 1 |
| 13 | Tacrolimus-associated posterior reversible encephalopathy syndrome after allogeneic haematopoietic stem cell transplantation显示文摘 | RAYMOND W GUILLERMO Z SERGIO A | | 0，，01： | 1 |
| 14 | Information Sharing through Inter-organisational Systems in Local Government 显示文摘 | Alinaghi Z B Muhammad K Sergio C | 2013 | Transforming Government : People Process and Policy2013，7，2： | 1 |
| 15 | Detection of Pathologic Prion Protein in the Olefactory Epithelium in Sporadic Creutzfeldt-Jakob Disease显示文摘 | Gianluigi Z Sergio F Franco C | 2003 | NeEngland Journal of Medicine2003，8，348： | 1 |
| 16 | Lipolysis and lipid oxidation in fermented sausages depending on different processing conditions and different antioxidants显示文摘 | Emanuela Z Sergio G Alessandra | | 0，，： | 1 |
| 17 | Steel moment frames resolution of recent seismic detailing and material shape issues显示文摘 | Nestor I Sergio Z | 2002 | Journal of Constructional Steel Research2002，58，1： | 1 |
| 18 | Decreased nitric oxide production in the rat brain after chronic arsenic exposure 显示文摘 | Sergio Z Francisca PS Juan M D | 2006 | Neurochem Res2006，31，： | 1 |
| 19 | Primate β -defensins - structure, function and evolution 显示文摘 | SERGIO C NIKOLINKA A IGOR Z | 2005 | Current Protein and Peptide Science2005，6，1： | 1 |
| 20 | In situ X-ray diffraction investigation of thermal decomposition of wood cellulose 显示文摘 | Gerald A Z Wolfgang W Sergio S F | 2007 | J Anal Appl Pyrolysis2007，80，： | 1 |
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