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| 1 | 卒中后口咽吞咽困难的治疗显示文摘 卒中患者吞咽困难的患病率正在逐渐增加,目前对吞咽困难的管理多采用多学科的管理方法.但是,在临床上普遍使用的治疗方法均缺乏证据基础,需要随机试验来证实其效果.这篇综述主要关注卒中后的口咽吞咽困难.神经科学与神经刺激研究的相关结果,为探讨吞咽及卒中后吞咽恢复机制提供了新的契机.经颅磁刺激研究的成果,为临床使用这一方法促进卒中后口咽吞咽困难的恢复提供了坚实的基础.…… | Vanoo Jayasekeran Emilia Michou Shaheen Hamdy 张婧 | 2007 | 中国卒中杂志2007，2，3： | 14 |
| 2 | Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis显示文摘AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial peritonitis.METHODS:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human albumin.All patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic cultures.Patients were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) subgroups.All patients performed an end of treatment ascitic PMNL count.Patients were considered improved when:PMNLs decreased to < 250 cells/mm 3,no growth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic therapy.RESULTS:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,respectively.Patients in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] counts.Ascitic fluid culture was positive in 32% of cases.Cefotaxime failed in 19% of patients;of these patients,11(100%) responded to meropenem and 6(75%) responded to levofloxacin.Two patients with failed levofloxacin therapy were treated according to the in vitro culture and sensitivity(one case was treated with vancomycin and one case was treated with ampicillin/sulbactam).In group Ⅱ the meropenem subgroup had higher LDH(range:108-860 IU/L vs 120-491 IU/L,P = 0.042) and PMNL counts(range:957-23 822 cell/mm 3 vs 957-15 222 cell/mm 3,P = 0.000) at initiation of the alternative antibiotic therapy;there was no significant difference in the studied parameters between patients responsive to meropenem and patients responsive to levofloxacin at the end of therapy(mean ± SD:316.01 ± 104.03PMNLs/mm 3 vs 265.63 ± 69.61 PMNLs/mm 3,P = 0.307).The isolated organisms found in group Ⅱ were;enterococci,acinetobacter,expanded-spectrum β-lactamase producing Escherichia coli,β-lactamase producing Enterobacter and Staphylococcus aureus.CONCLUSION:Empirical treatment with cefotaxime is effective in 81% of cases;meropenem is effective in cefotaxime-resistant cases. | Ahmed Abouelkhair Badawy Tarik Ibrahim Zaher Samar Mahmoud Sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly | 2013 | World Journal of Gastroenterology2013，19，8： | 13 |
| 3 | Evidence-based consensus on the diagnosis, prevention and management of hepatitis C virus disease显示文摘Hepatitis C virus(HCV) is a potent human pathogen and is one of the main causes of chronic hepatitis round the world. The present review describes the evidencebased consensus on the diagnosis, prevention and management of HCV disease. Various techniques, for the detection of anti-HCV immunoglobulin G immunoassays, detection of HCV RNA by identifying virus-specific molecules nucleic acid testings, recognition of core antigen for diagnosis of HCV, quantitative antigenassay, have been used to detect HCV RNA and core antigen. Advanced technologies such as nanoparticlebased diagnostic assays, loop-mediated isothermal amplification and aptamers and Ortho trak-C assay have also come to the front that provides best detection results with greater ease and specificity for detection of HCV. It is of immense importance to prevent this infection especially among the sexual partners, injecting drug users, mother-to-infant transmission of HCV, household contact, healthcare workers and people who get tattoos and piercing on their skin. Management of this infection is intended to eradicate it out of the body of patients. Management includes examining the treatment(efficacy and protection), assessment of hepatic condition before commencing therapy, controlling the parameters upon which dual and triple therapies work, monitoring the body after treatment and adjusting the co-factors. Examining the treatment in some special groups of people(HIV/HCV co-infected, hemodialysis patients, renal transplanted patients). | Mahrukh Akbar Shaheen Muhammad Idrees | 2015 | World Journal of Hepatology2015，7，3： | 9 |
| 4 | Validation of a novel imaging approach using multi-slice CT and cone-beam CT to follow-up on condylar remodeling after bimaxillary surgery显示文摘The main goal of this study was to introduce a novel three-dimensional procedure to objectively quantify both inner and outer condylar remodelling on preoperative multi-slice computed tomography(MSCT) and postoperative cone-beam computed tomography(CBCT) images. Second, the reliability and accuracy of this condylar volume quantification method was assessed. The mandibles of 20 patients(11 female and 9 male) who underwent bimaxillary surgery were semi-automatically extracted from MSCT/CBCT scans and rendered in 3D. The resulting condyles were spatially matched by using an anatomical landmark-based registration procedure.A standardized sphere was created around each condyle, and the condylar bone volume within this selected region of interest was automatically calculated. To investigate the reproducibility of the method, inter-and intra-observer reliability was calculated for assessments made by two experienced radiologists twice five months apart in a set of ten randomly selected patients. To test the accuracy of the bone segmentation, the inner and outer bone structures of one dry mandible, scanned according to the clinical set-up, were compared with the gold standard, micro-CT. Thirty-eight condyles showed a significant(P<0.05) mean bone volume decrease of 26.4% ± 11.4%(502.9 mm^3± 268.1 mm^3). No significant effects of side, sex or age were found. Good to excellent(ICC>0.6) intra-and inter-observer reliability was observed for both MSCT and CBCT. Moreover, the bone segmentation accuracy was less than one voxel(0.4 mm) for MSCT(0.3 mm ± 0.2 mm) and CBCT(0.4 mm ± 0.3 mm), thus indicating the clinical potential of this method for objective follow-up in pathological condylar resorption. | laura ferreira pinheiro nicolielo jeroen van dessel eman shaheen carolina letelier marina codari constantinus politis ivo lambrichts reinhilde jacobs | 2017 | International Journal of Oral Science2017，9，3： | 7 |
| 5 | 咽腔电刺激在神经源性吞咽障碍中的应用——从基础实验到临床研究显示文摘神经源性吞咽障碍是一种常见的神经系统疾病的并发症,预后差且治疗方法有限。因此,将神经刺激的基础研究转化为临床应用成为当务之急。本文重点介绍咽腔电刺激(pharyngeal electrical stimulation,PES)技术在人类吞咽运动系统中的治疗应用,阐明咽腔电刺激调控吞咽功能的机制,通过大量研究结果证明该刺激能够增加咽部运动皮质的兴奋性,该技术在神经源性吞咽障碍已经完成和正在进行的临床研究也可窥见一斑。尽管目前的研究结果提示咽腔电刺激技术是一种具有广阔临床应用前景的神经调控干预手段,但仍需要进行更多的临床研究,以便充分地探索其潜在用途。 | Shaheen Hamdy 张梦清 窦祖林 | 2020 | 中华物理医学与康复杂志2020，42，1： | 6 |
| 6 | Molecular study on Y chromosome microdeletions in Egyptian males with idiopathic infertility显示文摘Aim:To determine the frequency of genetic deletions within the azoospermia factors in Egyptian infertile males.Methods:The Yq microdeletions in 33 infertile males with undetectable chromosomal anomalies were examined by mutiplex polymerase chain reaction (PCR).Deletions were confirmed using single PCR amplifications.Results:Four out of the total 33 (12%) men had Yqll microdeletions,thus supporting the average reported figures in other populations.Three of those 4 cases had single short tandem sequence deletions with discrete histological findings of their testes.Single sY272 deletion within AZFc was associated with Sertoli cell only syndrome,whereas a patient with isolated sY84 deletion within AZFa had immature testicular structure.The remaining case had a large deletion in AZFa-c and short stature.Conclusion:The present study supports the hypothesis that the Yq11 encompasses genetic determinants of stature besides genes controlling spermatogenesis.(Asian J Androl 2004 Mar;6:53-57) | Mostafa K. El Awady Sohair F. El Shater Ehab Ragaa Khaled Atef Ibrahim M. Shaheen Nagwa A. Megiud | 2004 | Asian Journal of Andrology2004，6，1： | 6 |
| 7 | Synthesis of ion imprinted polymers for selective recognition and separation of rare earth metals显示文摘Lanthanide-ion imprinted polymers(L-IIPs) were synthesized by stoichiometric amounts of rare earth ions and the cavities in the polymers were created for the corresponding lanthanide ions. The maximum sorption capacities were estimated to be 125.3, 126.5, 127.6, 128.2 and 129.1 mg/g for Pr, Nd, Sm, Eu and Gd, respectively at p H 6. In the selectivity study, the L-IIPs exhibited good selectivity to the specific rare earth ions in the presence of coexisting cations. The imprinting results were found to be excellent with some rare earth ions over other competitor rare earth ions with the same charges and close ionic radius. | Mashitah M.Yusoff Nik Rohani Nik Mostapa Md Shaheen Sarkar Tapan Kumar Biswas Md Lutfor Rahman Sazmal Effendi Arshad Mohd Sani Sarjadi Ajaykumar D.Kulkarni | 2017 | Journal of Rare Earths2017，35，2： | 6 |
| 8 | Post-transplantation lymphoproliferative disorders:Current concepts and future therapeutic approaches显示文摘Transplant recipients are vulnerable to a higher risk of malignancy after solid organ transplantation and allogeneic hematopoietic stem-cell transplant.Posttransplant lymphoproliferative disorders(PTLD)include a wide spectrum of diseases ranging from benign proliferation of lymphoid tissues to frank malignancy with aggressive behavior.Two main risk factors of PTLD are:Firstly,the cumulative immunosuppressive burden,and secondly,the oncogenic impact of the Epstein-Barr virus.The latter is a key pathognomonic driver of PTLD evolution.Over the last two decades,a considerable progress has been made in diagnosis and therapy of PTLD.The treatment of PTLD includes reduction of immunosuppression,rituximab therapy,either isolated or in combination with other chemotherapeutic agents,adoptive therapy,surgical intervention,antiviral therapy and radiotherapy.In this review we shall discuss the prevalence,clinical clues,prophylactic measures as well as the current and future therapeutic strategies of this devastating disorder. | Fedaey Abbas Mohsen El Kossi Ihab Sakr Shaheen Ajay Sharma Ahmed Halawa | 2020 | World Journal of Transplantation2020，10，2： | 6 |
| 9 | Efficient removal of heavy metals from electroplating wastewater using polymer ligands显示文摘(hydroxamic 酸) Poly, -poly(amidoxime) chelating ligands 被综合从 poly (甲基 acrylate-co-acrylonitrile ) 为把有毒的金属离子从工业废水移开的 grafted 相思树纤维素。这些 ligands 显示出更高的吸附能力到铜(2.80 mmol 湩浩浵椠 ? 湯 ? 牯敤 ? 浳污敬 ? 桴湡洠獯 ?硥獩楴杮愠杬牯瑩浨 | Md. Lutfor RAHMAN Shaheen M. SARKAR Mashitah Mohd YUSOFF | 2016 | Frontiers of Environmental Science & Engineering2016，10，2： | 5 |
| 10 | Graphene oxide-based hydrogels as a nanocarrier for anticancer drug delivery显示文摘Graphene oxide (GO) possesses excellent mechanical strength,biocompatibility,colloidal stability,large surface area and high adsorption capability.It has driven to cancer nanotechnology to defeat cancer therapy obstacles,via integration into three-dimensional (3D) hydrogel network with biocompatible polymers as nanocomposites carrier,and controllable release of anticancer drugs.Specifically,the surface of GO affords π-π stacking and hydrophilic interactions with anticancer drugs.Additionally,modification of GO with various polymers such as natural and synthetic polymers enhances its biodegradability,drug loading,and target delivery.In this review,GO based hydrogels research accomplishments are reviewed on the aspects of crosslinking strategies,preparation methods,the model drug,polymer conjugation and modification with targeting ligands.Moreover,swelling kinetics,drug release profile and biological activity in vivo and in vitro are discussed.The biocompatibility of GO based hydrogels is also discussed from the perspective of its nano-bio interfaces.Apart from that,the clinical potential of GO based hydrogels and its major challenges are addressed in detail.Finally,this review concludes with a summary and invigorating future perspectives of GO based hydrogels for anticancer drug delivery.It is anticipated that this review can stimulate a new research gateway to facilitate the development of anticancer drug delivery by harnessing the unique properties of GO based hydrogels,such as large surface area,chemical purity,high loading capacity of drug,chemical stability,and the nature of lipophilic for cell membrane penetration. | Abdullah A.Ghawanmeh Gomaa A.M.Ali H.Algarni Shaheen M.Sarkar Kwok Feng Chong | 2019 | Nano Research2019，12，5： | 5 |
| 11 | Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children显示文摘AIM: To identify the prevalence, risk factors and manifestations of asymptomatic hepatitis C virus (HCV) infection in Egyptian children. METHODS: Children at the age of 1-9 years were screened for HCV antibodies and alanine aminotransferase (ALT) levels. Every child with elevated ALT and/or detectable HCV antibodies was tested for HCV RNA by RT-PCR and compared with two negative controls for risk factors and signs and symptoms of liver disease.RESULTS: We screened 1042 children, six of them had elevated ALT, negative HCV antibody and positive RNA, likely representing acute hepatitis C cases. Fifteen children were HCV seropositive, 5 of them were HCV RNA positive. Asymptomatic HCV infection was present in 2.02% (positive results for either HCV antibodies or HCV-RNA or both). Symptoms such as diarrhea, abdominal pain, history of fatigue and school absence because of illness and risk factors such as dental care were significantly more common among HCV positive cases than among controls. None of the HCV positive children was diagnosed as having signs of advanced liver disease upon clinical or ultrasonographic examination. CONCLUSION: Asymptomatic HCV infection is detectable in 2.02% Egyptian children. | MS El-Raziky M El-Hawary G Esmat AM Abouzied N El-Koofy N Mohsen S Mansour A Shaheen M Abdel Hamid H El-Karaksy | 2007 | World Journal of Gastroenterology2007，13，12： | 4 |
| 12 | Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management显示文摘Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using 'top-down' care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed. | Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris Paul Jordan Kenneth Manas Felix Becker Jonathan Steven Alexander | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 4 |
| 13 | Enhanced thermoelectric performance of CoSbS_(0.85)Se_(0.15) by point defect显示文摘In this study, we report the effect of Zn doping on the thermoelectric properties of Co_(1-x)Zn_xSbS_(0.85)Se_(0.15)solid solutions(x = 0, 0.02, 0.05, 0.08). The results show the dimensionless figure of merit(zT) increases from 0.17 to 0.34 at 875 K for Co_(0.95)Zn_(0.05)SbS_(0.85)Se_(0.15) sample, due to the noticeable decrease in the lattice thermal conductivity by introducing point defect, which is further confirmed by an analysis based on the Debye-CallawayKlemens model. Meanwhile, the thermoelectric power factor is maintained at high temperatures. This work highlights the important role of point defect in improving the thermoelectric performance of CoSbS-based compounds. | Shan-Shan Zhang Ding-Feng Yang Nusrat Shaheen Xing-Chen Shen Dan-Dan Xie Yan-Ci Yan Xu Lu Xiao-Yuan Zhou | 2018 | Rare Metals2018，37，4： | 4 |
| 14 | Synthesis and photoswitching properties of azobenzene liquid crystals with a pentafluorobenzene terminal显示文摘The fluorine-substituted benzoate ester rod-shaped liquid crystals containing an azobenzene side chain linked with terminal double bonds were synthesized and characterized.The mesophase and photoswitching properties were determined by polarizing optical microscopy(POM),differential scanning calorimetry(DSC) and UV-visible spectrometry.The rod-shaped compound 4a having an odd number of carbon atoms in the alkyl chains exhibits nematic phase and SmA type phase whereas compound 4b having an even number of carbon atoms showed only nematic phase.Both fluorinecontaining compounds 4c and 4d showed only SmA type phases.The photoswitching properties of these compounds showed a rate of trans to cis isomerization ranging 19-20 s,whereas reverse process took around 230 min in solution.These materials may be ideal in the field of optically rewritable applications where both on and off rates should be crucial. | Md Lutfor Rahman Gurumuthy Hegde Shaheen M.Sarkar Mashitah Mohd Yusoff | 2014 | Chinese Chemical Letters2014，25，12： | 4 |
| 15 | 泮托拉唑缩小静脉曲张套扎术后的套扎后溃疡大小:一项随机对照试验 | Shaheen N.J. Stuart E. Schmitz S.M. 杨瑗 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，7： | 3 |
| 16 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 17 | Quantum chemical investigation on photodegradation mechanisms of sulfamethoxypyridazine with dissolved inorganic matter and hydroxyl radical显示文摘Sulfamethoxypyridazine(SMP) is one of the commonly used sulfonamide antibiotics(SAs).SAs are mainly studied to undergo triplet-sensitized photodegradation in water under natural sunlight with other coexisting aquatic environmental organic pollutants.In this work,SMP was selected as a representative of SAs.We studied the mechanisms of triplet-sensitized photodegradation of SMP and the influence of selected dissolved inorganic matter,i.e.,anions(Br^-,Cl^-,and NO^-_3) and cations ions(Ca^(2+),Mg^(2+),and Zn^(2+)) on SMP photodegradation mechanism by quantum chemical methods.In addition,the degradation mechanisms of SMP by hydroxyl radical(OH·) were also investigated.The creation of SO_2 extrusion product was accessed with two different energy pathways(pathway-1 and pathway-2) by following two steps(step-I and step-II) in the tripletsensitized photodegradation of SMP.Due to low activation energy,the pathway-1 was considered as the main pathway to obtain SO_2 extrusion product.Step-II of pathway-1 was measured to be the rate-limiting step(RLS) of SMP photodegradation mechanism and the effect of the selected anions and cations was estimated for this step.All selected anions and cations promoted photodegradation of SMP by dropping the activation energy of pathway-1.The estimated low activation energies of different degradation pathways of SMP with OH·radical indicate that OH·radical is a very powerful oxidizing agent for SMP degradation via attack through benzene derivative and pyridazine derivative ring. | Shaheen Shah Ce Hao | 2017 | Journal of Environmental Sciences2017，29，7： | 3 |
| 18 | Feasibility, safety, acceptability, and yield of office-based, screening transnasal esophagoscopy (with video)显示文摘 | Anne F. Peery Toshitaka Hoppo Katherine S. Garman Evan S. Dellon Norma Daugherty Susan Bream Alejandro F. Sanz Jon Davison Melissa Spacek Diane Connors Ashley L. Faulx Amitabh Chak James D. Luketich Nicholas J. Shaheen Blair A. Jobe | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 19 | A Cost-Utility Analysis of Ablative Therapy for Barrett’s Esophagus显示文摘 | John M. Inadomi Ma Somsouk Ryan D. Madanick Jennifer P. Thomas Nicholas J. Shaheen | 2009 | Gastroenterology2009，，7： | 2 |
| 20 | Evaluation of serum biomarkers of fibrosis and injury in Egyptian patients with chronic hepatitis C显示文摘 | Gamal Esmat Mohamed Metwally Khalid R. Zalata Shahinaz Gadalla Mohamed Abdel-Hamid Amr Abouzied Abdel-Aziz Shaheen Maissa El-Raziky Hani Khatab Sherif El-Kafrawy Nabiel Mikhail Laurence S. Magder Nezam H. Afdhal G. Thomas Strickland | 2007 | Journal of Hepatology2007，，4： | 2 |
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