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| 1 | Endoscopic closure of a gastrocolic fistula using the over-the-scope-clip-system显示文摘Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemo-clips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough tensile force to keep fibrotic defects larger than 5 mm approximated. Herein we present a case of successful endoscopic closure of a gastrocolic fistula in a severely malnourished patient with complex post-surgical upper GI anatomy. We strongly believe that this device is a major breakthrough for the management of various types of discontinuity defects or fistulas. In addition, we show the usefulness of placing a direct jejunostomy using the double balloon enteroscopy (DBE) technique during the same procedure. The concept of providing direct jejunal feedings while allowing for upper gas-trointestinal bowel rest to promote the healing of the minimally invasive endoscopic operation is novel. Thus, our case is unique and exemplifies the utility of mini-mally invasive endoscopic endoluminal surgery. | Klaus Mnkemüller Shajan Peter Basem Alkurdi Jayapal Ramesh Daniel Popa C Mel Wilcox | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 5 |
| 2 | Multipurpose use of the ‘bear claw’ (over‐the‐scope‐clip system) to treat endoluminal gastrointestinal disorders显示文摘 | Klaus M?nkemüller Shajan Peter Jay Toshniwal Daniel Popa Marzena Zabielski Richard D. Stahl Jayapal Ramesh C. Mel Wilcox | 2014 | Digestive Endoscopy2014，，3： | 4 |
| 3 | Evolving screening and surveillance techniques for Barrett's esophagus显示文摘Barrett's esophagus(BE) is a change in the esophageal lining and is known to be the major precursor lesion for most cases of esophageal adenocarcinoma(EAC).Despite an understanding of its association with BE for many years and the falling incidence rates of squamous cell carcinoma of the esophagus, the incidence for EAC continues to rise exponentially. In association with this rising incidence, if the delay in diagnosis of EAC occurs after the onset of symptoms,then the mortality at 5 years is greater than 80%. Appropriate diagnosis and surveillance strategies are therefore vital for BE. Multiple novel optical technologies and other advanced approaches are being utilized to assist in making screening and surveillance more cost effective. We review the current guidelines and evolving techniques that are currently being evaluated. | David Steele Kondal Kyanam Kabir Baig Shajan Peter | 2019 | World Journal of Gastroenterology2019，25，17： | 3 |
| 4 | Carbon dioxide accumulation during analgosedated colonoscopy: Comparison of propofol and midazolam显示文摘AIM: To characterize the profiles of alveolar hypoventilation during colonoscopies performed under sedoanalgesia with a combination of alfentanil and either midazolam or propofol. METHODS: Consecutive patients undergoing routine colonoscopy were randomly assigned to sedation with either propofol or midazolam in an open-labeled design using a titration scheme. All patients received 4 μg/kg per body weight alfentanil for analgesia and 3 L of supplemental oxygen. Oxygen saturation (SpO 2 ) was measured by pulse oximetry (POX), and capnography (PcCO 2 ) was continuously measured using a combined dedicated sensor at the ear lobe. Instances of apnea resulting in measures such as stimulation of the patient, a chin lift, a mask maneuver, or withholding of sedation were recorded. PcCO 2 values (as a parameter of sedation-induced hypoventilation) were compared between groups at the following distinct time points: baseline, maximal rise, termination of the procedure and 5 min after termination of the procedure. The number of patients in both study groups who regained baseline PcCO 2 values (± 1.5 mmHg) five minutes after the procedure was determined.RESULTS: A total of 97 patients entered this study. The data from 14 patients were subsequently excluded for clinical procedure-related reasons or for technical problems. Therefore, 83 patients (mean age 62 ± 13 years) were successfully randomized to receive propofol (n = 42) or midazolam (n = 41) for sedation. Most of the patients were classified as American Society of Anesthesiologists (ASA) Ⅱ [16 (38%) in the midazolam group and 15 (32%) in the propofol group] and ASA Ⅲ [14 (33%) and 13 (32%) in the midazolam and propofol groups, respectively]. A mean dose of 5 (4-7) mg of Ⅳ midazolam and 131 (70-260) mg of Ⅳ propofol was used during the procedure in the corresponding study arms. The mean SpO 2 at baseline (%) was 99 ± 1 for the midazolam group and 99 ± 1 for the propofol group. No cases of hypoxemia (SpO 2 < 85%) or apnea were recorded. However, an increase in PcCO 2 that indicated alveolar hypoventilation occurred in both groups after administration of the first drug and was not detected with pulse oximetry alone. The mean interval between the initiation of sedation and the time when the PcCO 2 value increased to more than 2 mmHg was 2.8 ± 1.3 min for midazolam and 2.8 ± 1.1 min for propofol. The mean maximal rise was similar for both drugs: 8.6 ± 3.7 mmHg for midazolam and 7.4 ± 3.2 mmHg for propofol. Five minutes after the end of the procedure, the mean difference from the baseline values was significantly lower for the propofol treatment compared with midazolam (0.9 ± 3.0 mmHg vs 4.3 ± 3.7 mmHg, P = 0.0000169), and significantly more patients in the propofol group had regained their baseline value ± 1.5 mmHg (32 of 41vs 12 of 42,P = 0.0004). CONCLUSION: A significantly higher number of patients sedated with propofol had normalized PcCO 2 values five minutes after sedation when compared with patients sedated with midazolam. | Ludwig T Heuss Shajan Peter Sugandha Christoph Beglinger | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 5 | Data mining applied to wire-EDM process 显示文摘 | Shajan K Kamal M Shunmugam M S | 2003 | Journal of Material2003，142，1： | 1 |
| 6 | Helicobacter pylorl and gastric cancer:the causal relationship 显示文摘 | Shajan P Chrlstoph B | | Digestion0，75，1： | 1 |
| 7 | Somatostatin Analogues in the Treatment of Recurrent Bleeding from Gastrointestinal Vascular Malformations: An Overview and Systematic Review of Prospective Observational Studies显示文摘 | Colin Brown Venkataraman Subramanian C. Mel Wilcox Shajan Peter | 2010 | Digestive Diseases and Sciences2010，，： | 1 |
| 8 | Helicobacter pylori and gastric cancer:the causal relationship显示文摘 | Shajan P Christoph B | 2007 | Digestion2007，75，1： | 1 |
| 9 | Nutrient status mod- ulates the expression of nesfatin-1 encoding nucleo- bindin 2A and 2B mRNAs in zebrafish gut,liver and brain显示文摘 | Hater A Shajan S Unniappan S | 2015 | General and Comparative Endocrinology2015，215，： | 1 |
| 10 | Factors impacting treatment outcomes in the endoscopic management of walled‐off pancreatic necrosis显示文摘 | Ji Young Bang C Mel Wilcox Jessica Trevino Jayapal Ramesh Shajan Peter Muhammad Hasan Robert H. Hawes Shyam Varadarajulu | 2013 | J Gastroenterol Hepatol2013，，11： | 1 |
| 11 | Utility of double-balloon enteroscopy in patients with left ventricular assist devices and obscure overt gastrointestinal bleeding显示文摘 | Adam Edwards Klaus M?nkemüller Salpy Pamboukian James George C. Wilcox Shajan Peter | 2014 | Endoscopy2014，，11： | 1 |
| 12 | Helicobacter pylori and gastriccancer: the causal relationship 显示文摘 | Shajan P Christoph B | 2007 | Digestion2007，75，1： | 1 |
| 13 | Helicobacter pylori and Gastric Cancer: The Causal Relationship 显示文摘 | Shajan P Christoph B | 2007 | Digestion2007，75，1： | 1 |
| 14 | Endoscopist-Directed Administration of Propofol: A Worldwide Safety Experience显示文摘 | Douglas K. Rex Viju P. Deenadayalu Emely Eid Thomas F. Imperiale John A. Walker Kuldip Sandhu Anthony C. Clarke Lybus C. Hillman Akira Horiuchi Lawrence B. Cohen Ludwig T. Heuss Shajan Peter Christoph Beglinger James A. Sinnott Thomas Welton Magdy Rofail | 2009 | Gastroenterology2009，，4： | 1 |
| 15 | Helicobacter pylori and Gastric Cancer:The Causal Relationship显示文摘 | SHAJAN P CHRISTOPH B | 2007 | Digestion2007，75，1： | 1 |
| 16 | EUS-guided FNA of peritoneal carcinomatosis in patients with unknown primary malignancy显示文摘 | Shajan Peter Isam Eltoum Mohamad A. Eloubeidi | 2009 | Gastrointestinal Endoscopy2009，，6： | 1 |
| 17 | Nutrient sta- tus modulates the expression of Nesfatin-1 encoding nucleobindin 2A and 2B mRNAs in zebrafish gut,Iiv- er and brain显示文摘 | HATEF A SHAJAN S UNNIAPPAN S | 2014 | General and Comparative Endocrinol- ogy2014，215，： | 1 |
| 18 | Gastrointestinal Bleeding in Patients with Ventricular Assist Devices Is Highest Immediately After Implantation显示文摘 | Joshua B. French Salpy V. Pamboukian James F. George George B. Smallfield Jose A. Tallaj Robert N. Brown Melissa C. Smallfield James K. Kirklin William L. Holman Shajan Peter | 2013 | ASAIO Journal2013，，： | 1 |
| 19 | Somatostatin Analogues in the Treatment of Recurrent Bleeding from Gastrointestinal Vascular Malformations: An Overview and Systematic Review of Prospective Observational Studies显示文摘 | Colin Brown Venkataraman Subramanian C. Mel Wilcox Shajan Peter | 2010 | Digestive Diseases and Sciences2010，，8： | 1 |
| 20 | Endoscopist-Directed Administration of Propofol: A Worldwide Safety Experience显示文摘 | Douglas K. Rex Viju P. Deenadayalu Emely Eid Thomas F. Imperiale John A. Walker Kuldip Sandhu Anthony C. Clarke Lybus C. Hillman Akira Horiuchi Lawrence B. Cohen Ludwig T. Heuss Shajan Peter Christoph Beglinger James A. Sinnott Thomas Welton Magdy Rofail | 2009 | Gastroenterology2009，，4： | 1 |
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