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| 1 | Equal Efficacy of Endoscopic and Surgical Cystogastrostomy for Pancreatic Pseudocyst Drainage in a Randomized Trial显示文摘 | Shyam Varadarajulu Ji Young Bang Bryce S. Sutton Jessica M. Trevino John D. Christein C. Mel Wilcox | 2013 | Gastroenterology2013，，： | 6 |
| 2 | c-Met signaling in the development of tumorigenesis and chemoresistance: Potential applications in pancreatic cancer显示文摘Pancreatic ductal adenocarcinoma is the 4th leading cause of cancer deaths in the United States.The majority of patients are candidates only for palliative chemotherapy,which has proven largely ineffective in halting tumor progression.One proposed mechanism of chemoresistance involves signaling via the mesenchymalepithelial transition factor protein(MET),a previously established pathway critical to cell proliferation and migration.Here,we review the literature to characterize the role of MET in the development of tumorigenesis,metastasis and chemoresistance,highlighting the potential of MET as a therapeutic target in pancreatic cancer.In this review,we characterize the role of c-Met in the development of tumorigenesis,metastasis and chemoresistance,highlighting the potential of c-Met as a therapeutic target in pancreatic cancer. | Daniel Delitto Eva Vertes-George Steven J Hughes Kevin E Behrns Jose G Trevino | 2014 | World Journal of Gastroenterology2014，20，26： | 6 |
| 3 | Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity显示文摘 | F. Ann Ran Patrick D. Hsu Chie-Yu Lin Jonathan S. Gootenberg Silvana Konermann Alexandro E. Trevino David A. Scott Azusa Inoue Shogo Matoba Yi Zhang Feng Zhang | 2013 | Cell2013，，2： | 4 |
| 4 | Molecular therapeutic strategies targeting pancreatic cancer induced cachexia显示文摘Pancreatic cancer(PC) induced cachexia is a complex metabolic syndrome associated with significantly increased morbidity and mortality and reduced quality of life. The pathophysiology of cachexia is complex and poorly understood. Many molecular signaling pathways are involved in PC and cachexia. Though our understanding of cancer cachexia is growing, therapeutic options remain limited. Thus, further discovery and investigation of the molecular signaling pathways involved in the pathophysiology of cachexia can be applied to development of targeted therapies. This review focuses on three main pathophysiologic processes implicated in the development and progression of cachexia in PC, as well as their utility in the discovery of novel targeted therapies. Skeletal muscle wasting is the most prominent pathophysiologic anomaly in cachectic patients and driven by multiple regulatory pathways. Several known molecular pathways that mediate muscle wasting and cachexia include transforming growth factor-beta(TGF-β), myostatin and activin, IGF-1/PI3 K/AKT, and JAK-STAT signaling. TGF-β antagonism in cachectic mice reduces skeletal muscle catabolism and weight loss, while improving overall survival. Myostatin/activin inhibition has a great therapeutic potential since it plays an essential role in skeletal muscle regulation. Overexpression of insulin-like growth factor binding protein-3(IGFBP-3) leads to increased ubiquitination associated proteolysis, inhibition of myogenesis, and decreased muscle mass in PC induced cachexia. IGFBP-3 antagonism alleviates muscle cell wasting.Another component of cachexia is profound systemic inflammation driven by pro-cachectic cytokines such as interleukin-6(IL-6), tumor necrosis factoralpha(TNF-α), and interferon gamma(INF-γ). IL-6 antagonism has been shown to reduce inflammation, reduce skeletal muscle loss, and ameliorate cachexia. While TNF-α inhibitors are clinically available, blocking TNF-α signaling is not effective in the treatment of cancer cachexia. Blocking the synthesis or action of acute phase reactants and cytokines is a feasible therapeutic strategy, but no anti-cytokine therapies are currently approved for use in PC. Metabolic alterations such as increased energy expenditure and gluconeogenesis, insulin resistance, fat tissue browning, excessive oxidative stress, and proteolysis with amino acid mobilization support tumor growth and the development of cachexia. Current innovative nutritional strategies for cachexia management include ketogenic diet, utilization of natural compounds such as silibinin, and supplementation with ω3-polyunsaturated fatty acids. Elevated ketone bodies exhibit an anticancer and anticachectic effect. Silibinin has been shown to inhibit growth of PC cells, induce metabolic alterations, and reduce myofiber degradation. Consumption of ω3-polyunsaturated fatty acids has been shown to significantly decrease resting energy expenditure and regulate metabolic dysfunction. | Anastasiya Yakovenko Miles Cameron Jose Gilberto Trevino | 2018 | World Journal of Gastrointestinal Surgery2018，10，9： | 4 |
| 5 | Randomized trial comparing fanning with standard technique for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic mass lesions显示文摘 | J. Bang S. Magee J. Ramesh J. Trevino S. Varadarajulu | 2013 | Endoscopy2013，，： | 3 |
| 6 | Randomized trial comparing the 22-gauge aspiration and 22-gauge biopsy needles for EUS-guided sampling of solid pancreatic mass lesions显示文摘 | Ji Young Bang Shantel Hebert-Magee Jessica Trevino Jayapal Ramesh Shyam Varadarajulu | 2012 | Gastrointestinal Endoscopy2012，，2： | 2 |
| 7 | Polymerization of vinyl acetate in ternary microemulsions stabilized with hexadecyhrimethylammonium bromide显示文摘 | LOPEZ R G TREVINO M E SALAZAR L V | 1997 | Polymer Bulletin1997，38，4： | 1 |
| 8 | c-Src regulates constitutive and EGF-mediated VEGF expression in pancreatic tumor cells through activation of phosphatidyl inositol-3 kinase and p38 MAPK显示文摘 | Summy JM Trevino JG Baker CH | 2005 | Pancreas2005，31，： | 1 |
| 9 | Speaking Up to Higher-Ups:How Supervisors and Skip-Level Leaders Influence Employee Voice 显示文摘 | DETERT J R TREVINO L K | 2010 | Organization Science2010，21，1： | 1 |
| 10 | Refinement of the structure of solid nitromethane显示文摘 | Trevino SF Prince E Hubbard C R | 1980 | ] Chem Phys1980，73，： | 1 |
| 11 | 查看详情显示文摘 | Stillahn J M Trevino K J Fisher E R | | 0，，： | 1 |
| 12 | Media Symbolism, Media Richness, and Media Choice in Organizations: A Symbolic lnteractionist Perspective 显示文摘 | Trevino L K Daft R L Lengel R H | 1987 | Communication Research1987，14，5： | 1 |
| 13 | Moral disen- gagement in ethical decision making: a study of anteced- ents and outcomes显示文摘 | Detert J R Trevino L K Sweitzer V L | 2008 | Journal of Applied Psychology2008，93，2： | 1 |
| 14 | Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice显示文摘 | Trevino MB Mazur-Hart D Machida Y | 2015 | Molecular endocrinology2015，29，： | 1 |
| 15 | New inorganic spinel oxides for use as negative electrode materials in future lithiumion batteries 显示文摘 | Robertson A D Trevino L Tukamoto H | 1999 | J Power Sources1999，8182，： | 1 |
| 16 | 'Moral person and moral manager: How executives develop a reputation for ethical leasership' 显示文摘 | TREVINO L K HARTMAN L P BROWN M | 2000 | California Management Review2000，42，4： | 1 |
| 17 | Ethical Decision Makingin Organizations:A Person-situation Interactionist Model显示文摘 | Trevino L K | 1986 | Academy of Management Review1986，，03： | 1 |
| 18 | The conjugate conduction-natural convection heat transfer along a thin vertical plate with non-uniform internal heat generation显示文摘 | Mendez F Trevino C | 2000 | Int J Heat Mass Transfer2000，43，12： | 1 |
| 19 | Argatroban anticoagulation in patients with heparin-induced thrombocytopenia requiring renal replacement therapy显示文摘 | Reddy BV Grossman EJ Trevino SA | 2005 | Ann Pharmacother2005，39，10： | 1 |
| 20 | Effect of sulfateon methanol degradation in thermophilic(55°C)methanogenic UASB reactors显示文摘 | Vallero MVG Trevino R H M Paulo P L | 2003 | Enzyme and Microbial Technology2003，32，6： | 1 |
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