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| 1 | Multi-Wavelength Ultra-Weak Fiber Bragg Grating Arrays for Long-Distance Quasi-Distributed Sensing显示文摘Fiber Bragg grating(FBG)array,consisting of a number of sensing units in a single optical fiber,can be practically applied in quasi-distributed sensing networks.Serious signal crosstalk occurring between large-serial of identical FBGs,however,has limited the further increase in the number of sensing units,thus restricting applications only for short-distance sensing networks.To reduce the signal crosstalk,we design two novel types of 10-kilometer-long FBG arrays with 10000 equally spaced gratings,written on-line using a customized grating inscription system,which is affiliated to a drawing tower.Main factors causing signal crosstalk,such as spectral shadowing and multiple reflections,are firstly investigated in theory.Consistent with the theoretical findings,experimental results are proving that ultra-weak(the reflectivity of—40 dB)and multi-wavelength gratings of a number more than 10000 can be readily identified,with satisfied low crosstalk.The maximum attenuation of grating signal and minimum signal-to-noise ratio(SNR)in a single-wavelength array are 10.69 dB and 5.62 dB,respectively.As a comparison,by increasing the number of central wavelengths to three,the attenuation can be effectively reduced to 5.54dB and the minimum SNR has been improved to 8.14 dB.The current study significantly enhances the multiplexing capacity of FBG arrays and demonstrates promising potentials for establishing large-capacity quasi-distributed sensing networks. | Wenjing GAO Jianxia LIU Huiyong GUO Xin JIANG Shaofa SUN Haihu YU | 2022 | Photonic Sensors2022，12，2： | 1 |
| 2 | A novel monoacylglycerol lipase-targeted^(18)F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network显示文摘Monoacylglycerol lipase(MAGL)constitutes a serine hydrolase that orchestrates endocannabinoid homeostasis and exerts its function by catalyzing the degradation of 2-arachidonoylglycerol(2-AG)to arachidonic acid(AA).As such,selective inhibition of MAGL represents a potential therapeutic and diagnostic approach to various pathologies including neurodegenerative disorders,metabolic diseases and cancers.Based on a unique 4-piperidinyl azetidine diamide scaffold,we developed a reversible and peripheral-specific radiofluorinated MAGL PET ligand[^(18)F]FEPAD.Pharmacokinetics and binding studies on[^(18)F]FEPAD revealed its outstanding specificity and selectivity towards MAGL in brown adipose tissue(BAT)–a tissue that is known to be metabolically active.We employed[^(18)F]FEPAD in PET studies to assess the abundancy of MAGL in BAT deposits of mice and found a remarkable degree of specific tracer binding in the BAT,which was confirmed by post-mortem tissue analysis.Given the negative regulation of endocannabinoids on the metabolic BAT activity,our study supports the concept that dysregulation of MAGL is likely linked to metabolic disorders.Further,we now provide a suitable imaging tool that allows non-invasive assessment of MAGL in BAT deposits,thereby paving the way for detailed mechanistic studies on the role of BAT in endocannabinoid system(ECS)-related pathologies. | Ran Cheng Masayuki Fujinaga Jing Yang Jian Rong Ahmed Haider Daisuke Ogasawara Richard S.Van Tuo Shao Zhen Chen Xiaofei Zhang Erick R.Calderon Leon Yiding Zhang Wakana Mori Katsushi Kumata Tomoteru Yamasaki Lin Xie Shaofa Sun Lu Wang Chongzhao Ran Yihan Shao Benjamin Cravatt Lee Josephson Ming-Rong Zhang Steven H.Liang | 2022 | Acta Pharmacologica Sinica2022，43，11： | 0 |
| 3 | From imines to amides via NHC-mediated oxidation显示文摘The unprecedented NHC-mediated oxidation of imines to amides is described.This protocol features broad substrate scope and allows rapid assembly of amides in good to high yields.Notably,this process includes not only the umpolung of imines,but also the discovery of NHC-bound 1,2-dioxetane intermediates. | Shaofa Sun Donghui Guo Fangyi Li Jian Wang | 2022 | Organic Chemistry Frontiers2022，9，2： | 0 |
| 4 | Structure-activity relationship of pyrazol-4-ylpyridine derivatives and identification of a radiofluorinated probe for imaging the muscarinic acetylcholine receptor M4显示文摘There is an accumulating body of evidence implicating the muscarinic acetylcholine receptor4(M4)in schizophrenia and dementia with Lewy bodies,however,a clinically validated M4positron emission tomography(PET)radioligand is currently lacking.As such,the aim of this study was to develop a suitable M4PET ligand that allows the non-invasive visualization of M4in the brain.Structure-activity relationship studies of pyrazol-4-yl-pyridine derivates led to the discovery of target compound 12—a subtype-selective positive allosteric modulator(PAM).The radiofluorinated analogue,[18F]12,was synthesized in 28±10%radiochemical yield,>37 GBq/μmol and an excellent radiochemical purity>99%.Initial in vitro autoradiograms on rodent brain sections were performed in the absence of carbachol and showed moderate specificity as well as a low selectivity of[18F]12 for the M4-rich striatum.However,in the presence of carbachol,a significant increase in tracer binding was observed in the rat striatum,which was reduced by>60%under blocking conditions,thus indicating that orthosteric ligand interaction is required for efficient binding o f[18F]12 to the allosteric site.Remarkably,however,the presence of carbachol was not required for high specific binding in the non-human primate(NHP)and human striatum,and did not further improve the specificity and selectivity of[18F]12 in higher species.These results pointed towards significant species-differences and paved the way for a preliminary PET study in NHP,where peak brain uptake of[18F]12 was found in the putamen and temporal cortex.In conclusion,we report on the identification and preclinical development of the first radiofluorinated M4PET radioligand with promising attributes.The availability of a clinically validated M4PET radioligand harbors potential to facilitate drug development and provide a useful diagnostic tool for non-invasive imaging. | Ahmed Haider Xiaoyun Deng Olivia Mastromihalis Stefanie K.Pfister Troels E.Jeppesen Zhiwei Xiao Vi Pham Shaofa Sun Jian Rong Chunyu Zhao Jiahui Chen Yinlong Li Theresa R.Connors April T.Davenport James B.Daunais Vahid Hosseini Wenqing Ran Arthur Christopoulos Lu Wang Celine Valant Steven H.Liang | 2023 | Acta Pharmaceutica Sinica B2023，13，1： | 0 |
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