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| 1 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 2 | The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility显示文摘Objective: To examine the effect of pSer9-GSK-3β on breast cancer and to determine whether the underlying metabolic and immunological mechanism is associated with ROS/eIF2B and natural killer(NK) cells.Methods: We employed TWS119 to inactivate GSK-3β by phosphorylating Ser9 and explored its effect on breast cancer and NK cells. The expression of GSK-3β, natural killer group 2 member D(NKG2D) ligands, eIF2B was quantified by PCR and Western blot. We measured intracellular reactive oxygen species(ROS) and mitochondrial ROS using DCFH-DA and MitoSOX^(TM) probe,respectively, and conducted quantitative analysis of cellular respiration on 4T1 cells with mitochondrial respiratory chain complex Ⅰ/Ⅲ kits.Results: Our investigation revealed that TWS119 downregulated NKG2D ligands(H60 a and Rae1), suppressed the cytotoxicity of NK cells, and promoted the migration of 4T1 murine breast cancer cells. Nevertheless, LY290042, which attenuates p-GSK-3β formation by inhibiting the PI3K/Akt pathway, reversed these effects. We also found that higher expression of p Ser9-GSK-3β induced higher levels of ROS, and observed that abnormality of mitochondrial respiratory chain complex Ⅰ/Ⅲ function induced the dysfunction of GSK-3β-induced electron transport chain, naturally disturbing the ROS level. In addition, the expression of NOX3 and NOX4 was significantly up-regulated, which affected the generation of ROS and associated with the metastasis of breast cancer. Furthermore, we found that the expression of pSer535-eIF2B promoted the expression of NKG2D ligands(Mult-1 and Rae1) following by expression of pSer9-GSK-3β and generation of ROS.Conclusions: The PI3K/Akt/GSK-3β/ROS/eIF2B pathway could regulate NK cell activity and sensitivity of tumor cells to NK cells,which resulted in breast cancer growth and lung metastasis. Thus, GSK-3β is a promising target of anti-tumor therapy. | Fengjiao Jin Zhaozhen Wu Xiao Hu Jiahui Zhang Zihe Gao Xiao Han Junfang Qin Chen Li Yue Wang | 2019 | Cancer Biology & Medicine2019，16，1： | 20 |
| 3 | Intestinal Microbiota in Early Life and Its Implications on Childhood Health显示文摘Trillions of microbes reside in the human body and participate in multiple physiological and pathophysiological processes that affect host health throughout the life cycle. The microbiome is hallmarked by distinctive compositional and functional features across different life periods.Accumulating evidence has shown that microbes residing in the human body may play fundamental roles in infant development and the maturation of the immune system. Gut microbes are thought to be essential for the facilitation of infantile and childhood development and immunity by assisting in breaking down food substances to liberate nutrients, protecting against pathogens, stimulating or modulating the immune system, and exerting control over the hypothalamic–pituitary–adrenal axis.This review aims to summarize the current understanding of the colonization and development of the gut microbiota in early life, highlighting the recent findings regarding the role of intestinal microbes in pediatric diseases. Furthermore, we also discuss the microbiota-mediated therapeutics that can reconfigure bacterial communities to treat dysbiosis. | Lu Zhuang Haihua Chen Sheng Zhang Jiahui Zhuang Qiuping Li Zhichun Feng | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 16 |
| 4 | Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion显示文摘 | Qinggan Ni Jiahui Chen Xia Li Xiaodong Xu Nannan Zhang Ang Zhou Bin Zhou Qian Lu Zhong Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 9 |
| 5 | Diclofop-methyl affects microbial rhizosphere community and induces systemic acquired resistance in rice显示文摘Diclofop-methyl(DM),a widely used herbicide in food crops,may partly contaminate the soil surface of natural ecosystems in agricultural area and exert toxic effects at low dose to nontarget plants.Even though rhizosphere microorganisms strongly interact with root cells,little is known regarding their potential modulating effect on herbicide toxicity in plants.Here we exposed rice seedlings(Xiushui 63) to 100 μg/L DM for 2 to 8 days and studied the effects of DM on rice rhizosphere microorganisms,rice systemic acquired resistance(SAR) and rice-microorganisms interactions.The results of metagenomic 16 S rDNA Illumina tags show that DM increases bacterial biomass and affects their community structure in the rice rhizosphere.After DM treatment,the relative abundance of the bacterium genera Massilia and Anderseniella increased the most relative to the control.In parallel,malate and oxalate exudation by rice roots increased,potentially acting as a carbon source for several rhizosphere bacteria.Transcriptomic analyses suggest that DM induced SAR in rice seedlings through the salicylic acid(but not the jasmonic acid) signal pathway.This response to DM stress conferred resistance to infection by a pathogenic bacterium,but was not influenced by the presence of bacteria in the rhizosphere since SAR transcripts did not change significantly in xenic and axenic plant roots exposed to DM.The present study provides new insights on the response of rice and its associated microorganisms to DM stress. | Si Chen Xingxing Li Michel Lavoie Yujian Jin Jiahui Xu Zhengwei Fu Haifeng Qian | 2017 | Journal of Environmental Sciences2017，29，1： | 8 |
| 6 | Strain hardening behavior of Mg-Y alloys after extrusion process显示文摘The strain hardening is an effective mode of enhancing mechanical properties in alloys.In this work,the strain hardening behaviors of Mg-xY(x=1,2,and 3 wt%)after extrusion process was investigated using uniaxial tensile tests.Results suggest that the Mg-xY alloys are composed ofα-Mg with a little amount of Mg24Y5 phase.The average grain size reduces from 19.8μm to 12.2μm as the Y content adds from 1 wt%to 2 wt%.Nevertheless,when Y content reaches 3 wt%,the grain size reaches to 12.9μm,which is close to that of Mg-2Y.The strain hardening rate decreases from 883 MPa to 798 MPa at(σ-σ0.2)=40 MPa,and Mg-2Y and Mg-3Y have the similar strain hardening response.Moreover,Mg-1Y shows an obvious ascending stage after the steep decreasing stage,which is mainly caused by the activation of twinning.The strain hardening behavior of Mg-xY is explained based on understanding the roles of the deformation mechanisms via deformation microstructure analysis and Visco-Plastic Self Consistent(VPSC)model.The variation of strain hardening characteristics with increasing Y content is related to the effects of grain size and texture. | Chaoyue Zhao Ziyan Li Jiahui Shi Xianhua Chen Teng Tu Zhu Luo Renju Cheng Andrej Atrens Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 6 |
| 7 | Surgical treatment of gastric cancer:Current status and future directions显示文摘Surgery is the most important and effective method for the treatment of gastric cancer.Since the first gastrectomy in the early 19th century,surgical treatment of gastric cancer has undergone more than 100 years of development.With the increasing understanding of gastric cancer and the promotion of a series of clinical trials,the concept of gastric cancer surgery has evolved from the initial'bigger is better'to today’s'standardized surgery'and is developing towards individualized surgery focusing on accurate resection and quality of life.This trend has had a tremendous impact on the development of surgical treatments,such as minimally invasive surgeries,functionpreserving surgeries,and the optimal extent of lymph node dissection.Understanding the development and current status of gastric cancer surgery and exploring the remaining academic controversies are goals that every gastric surgeon should constantly pursue.However,how should gastric cancer surgery develop in the future?What opportunities and challenges will we encounter?In this review,we elaborate on the development and current status of gastric cancer surgery based on a series of clinical studies and discuss the controversy in the development of gastric cancer surgery. | Jiahui Chen Zhaode Bu Jiafu Ji | 2021 | Chinese Journal of Cancer Research2021，33，2： | 6 |
| 8 | Research and Development of Indoor Positioning显示文摘Indoor positioning systems have been sufficiently researched to provide location information of persons and devices.This paper is focused on the current research and further development of indoor positioning.The standard evolution and industry development are summarized.There are various positioning systems according to the scenarios,cost and accuracy.However,there is a basic positioning system framework including information extraction,measurement and calculation.In particular,the detailed positioning technologies mainly including cellular positioning and Local Area Network(LAN) positioning are listed and compared to provide a reference for practical applications.Finally,we summarize the challenges of indoor positioning and give a3-phase evolution route. | Qi Liu Jiahui Qiu Yi Chen | 2016 | China Communications2016，13，S2： | 5 |
| 9 | Solvent-free nanocasting toward universal synthesis of ordered mesoporous transition metal sulfide@N-doped carbon composites for electrochemical applications显示文摘Transition metal sulfides (TMSs) have a wide range of applications owing to their intriguing properties.Significant efforts have been devoted to nanostructuring TMSs to enhance their properties and performance,still there is a high need in general synthesis of TMS nanostructures.Herein,for the first time,a simple solvent free reactive nanocasting approach that integrates solid precursor loading,in-situ sulfuration and carbonization into a single heating step is developed for the universal synthesis of ordered mesoporous TMS@N-doped carbon composites (denoted as OM-TMS@NCs) with methionine (Met) and metal chlorides as the precursors and the mesoporous silica (SBA-15) as the hard template.A series of OM-TMS@NCs with a hexagonal mesostructure,ultra-high surface areas (430-754 m2·g-1),large pore volumes (0.85-1.32 cm3·g-1),and unique TMS stoichiometries,including MoS2,Fe7S8,Co9S8,NiS,Cu7S4 and ZnS,are obtained.Two distinct structure configurations,namely,highly dispersed ultrathin TMS nanosheets within NCs and TMS@NC co-nanowire arrays,can be obtained depending on different metals.The structure evolution of the OM-TMS@NCs over the solvent-free nanocasting process is studied in detail for a deep understanding of the synthesis.As demonstrations,these materials are promising for electrocatalytic hydrogen evolution reaction and lithium ion storage with high performances. | Jiahui Zhu Zhi Chen Lin Jia Yuqi Lu Xiangru Wei Xiaoning Wang Winston Duo Wu Na Han Yanguang Li Zhangxiong Wu | 2019 | Nano Research2019，12，9： | 5 |
| 10 | A Survey of Bitmap Index Compression Algorithms for Big Data显示文摘With the growing popularity of Internet applications and the widespread use of mobile Internet, Internet traffic has maintained rapid growth over the past two decades. Internet Traffic Archival Systems(ITAS) for packets or flow records have become more and more widely used in network monitoring, network troubleshooting, and user behavior and experience analysis. Among the three key technologies in ITAS, we focus on bitmap index compression algorithm and give a detailed survey in this paper. The current state-of-the-art bitmap index encoding schemes include: BBC, WAH, PLWAH, EWAH, PWAH, CONCISE, COMPAX, VLC, DF-WAH, and VAL-WAH. Based on differences in segmentation, chunking, merge compress, and Near Identical(NI) features, we provide a thorough categorization of the state-of-the-art bitmap index compression algorithms. We also propose some new bitmap index encoding algorithms, such as SECOMPAX, ICX, MASC, and PLWAH+, and present the state diagrams for their encoding algorithms. We then evaluate their CPU and GPU implementations with a real Internet trace from CAIDA. Finally, we summarize and discuss the future direction of bitmap index compression algorithms. Beyond the application in network security and network forensic, bitmap index compression with faster bitwise-logical operations and reduced search space is widely used in analysis in genome data, geographical information system, graph databases, image retrieval, Internet of things, etc. It is expected that bitmap index compression will thrive and be prosperous again in Big Data era since 1980s. | Zhen Chen Yuhao Wen Junwei Cao Wenxun Zheng Jiahui Chang Yinjun Wu Ge Ma Mourad Hakmaoui Guodong Peng | 2015 | Tsinghua Science and Technology2015，20，1： | 5 |
| 11 | Research on Mobile Internet Mobile Agent System Dynamic Trust Model for Cloud Computing显示文摘This paper analyzes the reasons for the formation of security problems in mobile agent systems, and analyzes and compares the security mechanisms and security technologies of existing mobile agent systems from the perspective of blocking attacks. On this basis, the host protection mobile agent protection technology is selected, and a method to enhance the security protection of mobile agents (referred to as IEOP method) is proposed. The method first encrypts the mobile agent code using the encryption function, and then encapsulates the encrypted mobile agent with the improved EOP protocol IEOP, and then traces the suspicious execution result. Experiments show that using this method can block most malicious attacks on mobile agents, and can protect the integrity and confidentiality of mobile agents, but the increment of mobile agent tour time is not large. | Weijin Jiang Yang Wang Yirong Jiang Jiahui Chen Yuhui Xu Lina Tan | 2019 | China Communications2019，16，7： | 5 |
| 12 | Life Cycle Assessment of PHEV显示文摘 | Chen Yisong Hu Xu Liu Jiahui | 2017 | 汽车技术2017，，9： | 5 |
| 13 | Nuclear miR-665 aggravates heart failure via suppressing phosphatase and tensin homolog transcription显示文摘Although numerous miRNAs have been discovered,their functions in the different subcellular organelles have remained obscure.In this study,we found that miR-665 was enriched in the nucleus of cardiomyocytes,and then investigated the underlying role of nuclear miR-665 in heart failure.RNA fluorescence in situ hybridization assays in human heart tissue sections and primary cardiomyocytes showed that miR-665 was localized in the nucleus of cardiomyocytes.Increased expression of nuclear miR-665 was observed not only in the cardiomyocytes isolated from the heart of mice treated in vivo by transverse aortic constriction(TAC),but also in phenylephrine(PE)-treated cultured cardiomyocytes in vitro.To further explore the role of miR-665 in heart failure,a type 9 recombinant adeno-associated virus(rAAV)system was employed to manipulate the expression of miR-665 in mice.Overexpression of miR-665 aggravated TAC-induced cardiac dysfunction,while down-expression of miR-665 showed opposite effects.Bioinformatic prediction and biological validation confirmed that the PTEN(phosphatase and tensin homolog)gene was one of the targets of miR-665 in the nucleus.Furthermore,restoring PTEN expression significantly eliminated the destructive effects of miR-665 over-expression in TAC-induced cardiac dysfunction.Our data showed that nuclear miR-665 aggravates heart failure via inhibiting PTEN expression,which provided a therapeutic approach for heart failure. | Jiahui Fan Xudong Zhang Xiang Nie Huaping Li Shuai Yuan Beibei Dai Jiabing Zhan Zheng Wen Jiangang Jiang Chen Chen Daowen Wang | 2020 | Science China(Life Sciences)2020，63，5： | 4 |
| 14 | The double face of miR-320:cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction显示文摘MicroRNAs(miRNAs)are aberrantly expressed in the pathophysiologic process of heart failure(HF).However,the functions of a certain miRNA in different cardiac cell types during HF are scarcely reported,which might be covered by the globe effects of it on the heart.In the current study,Langendorff system was applied to isolate card io myocytes(CMs)and cardiac fibroblasts(CFs)from transverse aortic constriction(TAC)-induced mice.Slight increase of miR-320 expression was observed in the whole heart tissue of TAC mice.Interestingly,miR-320 was significantly elevated in CMs but decreased in CFs from TAC mice at different time points.Then,recombinant adeno-associated virus 9 with cell-type-specific promoters were used to manipulate miR-320 expressions in vivo.Both in vitro and in vivo experiments showed the miR-320 overexpression in CMs exacerbated cardiac dysfunction,whereas overexpression of miR-320 in CFs alleviated cardiac fibrosis and hypertrophy.Mechanically,downstream signaling pathway analyses revealed that miR-320 might induce various effects via targeting PLEKHM3 and IFITM1 in CMs and CFs,respectively.Moreover,miR-320 mediated effects could be abolished by PLEKHM3 re-expression in CMs or IFITM1 re-expression in CFs.Interestingly,miR-320 treated CFs were able to indirectly affect CMs function,but not vice versa.Meanwhile,upstream signaling pathway analyses showed that miR-320 expression and decay rate were rigorously manipulated by Ago2,which was regulated by a cluster of cell-type-specific TFs distinctively expressed in CMs and CFs,respectively.Together,we demonstrated that miR-320 functioned differently in various cell types of the heart during the progression of HF. | Xudong Zhang Shuai Yuan Huaping Li Jiabing Zhan Feng Wang Jiahui Fan Xiang Nie Yan Wang Zheng Wen Yanghui Chen Chen Chen Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 4 |
| 15 | Trimetallic PtRhNi alloy nanoassemblies as highly active electrocatalyst for ethanol electrooxidation显示文摘尽管 nanostructures 广泛地基于高贵金属合金被利用在(电镀物品) 催化作用,他们的低温度的合成由于金属先锋的不同 Nernst 平衡潜力仍然是庞大的挑战。此处,我们用一个简单混合 cyanogel 减小方法与悦耳的 Pt/Rh 比率描述 trimetallic PtRhNi 合金 nanoassemblies (PtRhNi 言论集) 的成功的合成并且提供他们的化学作文,形态学,和结构的详细描述。另外, PtRhNi 言论集的电气化学的性质被周期的 voltammetry 检验,揭示在乙醇氧化反应(EOR ) 的作文依赖者 electrocatalytic 活动。比作商业磅黑人 electrocatalyst,优化的磅 3 Rh 1 Ni 2-ANAs 显示显著地在碱的媒介提高了 EOR electrocatalytic 性能。 | Huimin Liu Jiahui Li Lijuan Wang Yawen Tang Bao Yu Xia Yu Chen | 2017 | Nano Research2017，10，10： | 4 |
| 16 | Evolutionary Dynamics Modeling of Symbolic Social Network Structure Equilibrium显示文摘The use of symbol attributes on the side of symbolic social networks to analyze,understand,and predict the topology,function,and dynamic behaviour of complex networks,and has important theoretical significance for personalized recommendations,attitude prediction,user feature analysis,and clustering and application value.However,due to the huge scale of online social networks,this poses a challenge to traditional symbolic social network analysis methods.Based on the theory of structural equilibrium,this paper studies the evolutionary dynamics of symbolic social networks,proposes the energy function of weak structural equilibrium theory,and uses the evolution of evolutionary algorithms to obtain the weak imbalance of the network.The simulation experiment results show that the calculation method in this paper can get the optimal solution faster.It provides an idea for the study of real and complex social networks. | Weijin Jiang Sijian Lv Yirong Jiang Jiahui Chen Fang Ye Xiaoliang Liu | 2020 | China Communications2020，17，10： | 4 |
| 17 | In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect显示文摘In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank’s solution. In vitro cytotoxicity test showed that Mg69Zn27Ca4 metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original φ6 mm to φ3.35 ± 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. | Junxiu Chen Jiahui Dong Huameng Fu Haifeng Zhang Lili Tan Dewei Zhao Ke Yang | 2019 | Journal of Materials Science & Technology2019，35，10： | 4 |
| 18 | TiO_2-doped Fe_3O_4 nanoparticles as high-performance Fenton-like catalyst for dye decoloration显示文摘Fenton reaction based on Fe2+-H2O2 system has been widely applied in water remediation, but the obvious drawbacks largely hinder its practical uses. Alternatively, heterogeneous nanomaterials with proper surface modification could be used as Fenton-like catalysts. Surface doping of Ti O2 could concentrate the pollutants surrounding the Fe3O4 catalyst, which might benefit the catalytic performance of Fe3O4. Herein, we reported that Ti O2-doped Fe3O4 nanoparticles(NPs) could be used as high-performance Fenton-like catalyst for dye decoloration in near neutral environment, where the doping of Ti O2 on Fe3O4 surface dramatically improved the catalytic activity of Fe3O4 in Fenton-like reaction. Ti O2-doped Fe3O4 NPs catalyzed the decomposition of H2O2 to oxidize methylene blue without external energy supply, resulting in effective decoloration. Ti O2-doped Fe3O4 NPs showed high catalytic activity under various p H values and even in the presence of radical scavenger. More catalysts and H2O2 would facilitate the decoloration. At higher temperature, the decoloration became faster and more effective. The implication to the environmental applications of Ti O2-doped Fe3O4 NPs is discussed. | YANG ShengTao YANG LiJun LIU XiaoYang XIE JingRu ZHANG XiaoLiang YU BaoWei WU RuiHan LI HongLiang CHEN LingYun LIU JiaHui | 2015 | Science China(Technological Sciences)2015，58，5： | 3 |
| 19 | 3D printing biomimeticmaterials and structures for biomedical applications显示文摘Over millions of years of evolution,nature has created organisms with overwhelming performances due to their unique materials and structures,providing us with valuable inspirations for the development of next-generation biomedical devices.As a promising new technology,3D printing enables the fabrication of multiscale,multi-material,and multi-functional threedimensional(3D)biomimetic materials and structures with high precision and great flexibility.The manufacturing challenges of biomedical devices with advanced biomimetic materials and structures for various applications were overcome with the flourishing development of 3D printing technologies.In this paper,the state-of-the-art additive manufacturing of biomimetic materials and structures in the field of biomedical engineering were overviewed.Various kinds of biomedical applications,including implants,lab-on-chip,medicine,microvascular network,and artificial organs and tissues,were respectively discussed.The technical challenges and limitations of biomimetic additive manufacturing in biomedical applications were further investigated,and the potential solutions and intriguing future technological developments of biomimetic 3D printing of biomedical devices were highlighted. | Yizhen Zhu Dylan Joralmon Weitong Shan Yiyu Chen Jiahui Rong Hanyu Zhao Siqi Xiao Xiangjia Li | 2021 | Bio-Design and Manufacturing2021，4，2： | 3 |
| 20 | A fluorescent Eu(Ⅲ) MOF for highly selective and sensitive sensing of picric acid显示文摘A metal-organic framework [Eu_3L_3(CH_3COO)_2(H_2O)_2(μ_3-OH)]·3 DMF,(EuL, H_2L=9H-carbazole-2,7-dicarboxylic acid,DMF=N,N-dimethylformamide) has been synthesized under solvothermal conditions and structurally characterized. In EuL,Eu_6O_8 clusters are four-bridged by carboxylates to form parallel-aligned Eu–O–C chains, which are further linked by the carbazole moieties of L^(2-) ligands to form the three-dimensional framework with rhombic channels. The EuL material with characteristic emission of Eu^(3+) ion exhibits significant luminescence quenching response for picric acid(PA) and the linear Stern-Volmer plot was observed in the concentration range of 0.05–0.15 mM with K_(sv) of 98074 M^(-1). As far as we know, this Ksv is among the highest values for COFs and MOFs in detection of PA. The excellent anti-interference ability and repeatability were also verified by experiments. Lastly, we investigated the luminescence quenching mechanism in the EuL sensing system. | Qianqian Chen Jiahui Cheng Jin Wang Liang Li Zhipeng Liu Xinhui Zhou Yujian You Wei Huang | 2019 | Science China Chemistry2019，62，2： | 3 |
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