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| 1 | Human colorectal cancer-specific CCAT1-L IncRNA regulates long-range chromatin interactions at the MYC locus显示文摘人的 8q24 基因沙漠包含多重 enhancers 形式织物特定的远程的染色质与 MYC oncogene 循环,但是染色质在 MYC 地点循环怎么被调整,仍然保持糟糕理解。这里,我们表明那长 noncoding RNA (lncRNA ) , CCAT1-L,从一个地点在人的 colorectal 癌症明确地被抄录 MYC 在上游的 515 kb。这 lncRNA 在 MYC transcriptional 规定起一个作用并且支持远程的染色质循环。重要地, CCAT1-L 地点位于强壮的超级提高以内并且离 MYC 空间地靠近。CCAT1-L 击倒在 MYC 倡导者和它的 enhancers 之间的减少的远程的相互作用。另外, CCAT1-L 与 CTCF 交往并且在这些环区域调制染色质符合构造。这些结果揭示一个重要角色一以前在在 MYC 地点的基因规定的 unannotated lncRNA。 | Jian-Feng Xiang Qing-Fei Yin Tian Chen Yang Zhang Xiao-Ou Zhang Zheng Wu Shaofeng Zhang Hai-Bin Wang Junhui Ge Xutiua Lu Li Yang Ling-Ling Chen | 2014 | Cell Research2014，24，5： | 67 |
| 2 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 3 | A new stationary droplet evaporation model and its validation显示文摘The liquid droplet evaporation character is important for not only combustion chamber design process but also high-accuracy spray combustion simulation. In this paper, the suspended droplets' evaporation character was measured in a quiescent high-temperature environment by micro high-speed camera system. The gasoline and kerosene experimental results are consistent with the reference data. Methanol, common kerosene and aviation kerosene droplet evaporation characteristics, as well as their evaporation rate changing with temperature, were obtained. The evaporation rate experimental data were compared with the prediction result of Ranz-Marshall boiling temperature model(RMB), Ranz-Marshall low-temperature model(RML), drift flux model(DFM), mass analogy model(MAM), and stagnant film model(SFM). The disparity between the experimental data and the model prediction results was mainly caused by the neglect of the natural convection effect, which was never introduced into the droplet evaporation concept. A new droplet evaporation model with consideration of natural convection buoyancy force effect was proposed in this paper. Under the experimental conditions in this paper, the calculation results of the new droplet evaporation model were agreed with the experimental data for kerosene, methanol and other fuels, with less than 20% relative deviations. The relative deviations between the new evaporation model predictions for kerosene and the experimental data from the references were within 10%. | Fang WANG Jie YAO Shaofeng YANG Rui LIU Jie JIN | 2017 | Chinese Journal of Aeronautics2017，30，4： | 5 |
| 4 | Clinical curative effect of fuzi-cake-separated moxibustion for preventing dysuria after operation for lower limb fracture显示文摘OBJECTIVE: To assess the clinical curative effect of fuzi-cake-separated moxibustion at Zhongji(CV 3)and Guanyuan(CV 4) for preventing dysuria after internal fixation of lower limb fractures.METHODS: Sixty patients conforming to the inclusion standards were randomly divided into a treatment group(n=30) and a control group(n=30).Fuzi-cake-separated moxibustion was performed at Guanyuan(CV 4) and Zhongji(CV 3), 20 min at a time, twice a day, for 3 days before operation in the treatment group. No fuzi-cake-separated moxibustion was performed in the control group. After treatment, the score for symptoms of first urination, urinary time, urinary volume, 24 h remaining urinary volume, incidence of uroschesis, and rate of controlling dysuria were compared to evaluate the curative effect of preventing post-operative dysuria.RESULTS: The score for symptoms of first urination,24 h remaining urinary volume(maximum 120 m L vs 250 m L, and less than 10 m L in 24 cases vs 15 cases), and the rate of controlling dysuria(83.34% vs30%) were significantly better(P<0.05, P<0.05, and P<0.001, respectively) in the treatment compared with the control group. There was no statistical difference(P>0.05) between the two groups in first post-operative urinary time, urinary volume, or incidence of 24 h uroschesis.CONCLUSION: Fuzi-cake-separated moxibustion at Zhongji(CV 3) and Guanyuan(CV 4) can better prevent post-operative dysuria, effectively promote the functional restoration of the urinary bladder,and control the incidence of post-operative dysuria. | Yan Yue Lijun Tao Jianqiao Fang Qi Xie Shaofeng He Chunxia Huang Xueming Yang | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 4 |
| 5 | The toxic effect of solubilizing excipients on Tetrahymena thermophila BF_5 growth investigated by microcalorimetry显示文摘The toxic effect of different solubilizing excipients on the growth and metabolism of Tetrahymena thermophila BF5(T.t.BF5) at various concentrations was investigated by microcalorimetry.The thermogenic curves of T.t.BF5 growth were determined at 28°C,and were evaluated by dynamic parameters.The results indicated that the values of growth rate constant(k),maximum power(P1,P2),peak time(T1,T2) and total quantity of heat(Q) varied for different excipients.There was a good linear relationship between k and concentrations(r>0.95,P<0.01).5% inhibition concentration(IC5) of poloxamer 188,Tween 80,PEG 600,PEG 400 and Tween 20 was 2.18,1.07,1.35,0.58,and 0.045 mg/mL,respectively.After the principal component analysis(PCA),Q,k and P1 could characterize the effect of these excipients on T.t.BF5 growth.Comprehensive evaluation indicated that compared with the control group,poloxamer 188 had the weakest toxicity and Tween 20 had the strongest toxicity. | ZHANG ShaoFeng YAN Dan TANG HuiYing YANG Ming WANG YueSheng XIAO XiaoHe | 2010 | Chinese Science Bulletin2010，55，18： | 4 |
| 6 | Temperature inferential control of a reactive distillation column with double reactive sections显示文摘Temperature inferential control (TIC) is studied for a reactive distillation column with double reactive sections (RDC-DRSs) processing a hypothetical two-stage consecutive reversible reaction (A + B■C + D, C + B■E + D with αD > αB > αC > αA > αE). Because of the complicated dynamic behaviors, the controlled stages by sensitivity analysis lead to great steady-state deviations (SSDs) in top and bottom product purities. Since TIC involves considerably reduced settling times in comparison with direct composition control, small SSDs in product qualities correspond generally to small transient deviations (TDs) in product qualities. An objective function that measures SSDs in product qualities is formulated to represent the performance of a TIC system and an iterative procedure is devised to search for the best control configuration. The application of the procedure to the RDC-DRS gives considerably suppressed TDs and SSDs in top and bottom product qualities as compared with the one by sensitivity analysis. The method is simpler in principle and less computationally intensive than the current practice. These striking outcomes show the effectiveness of the proposed principle for the development of TIC systems for complicated reactive distillation columns. | Lijing Zang Kejin Huang Ting Guo Yang Yuan Haisheng Chen Liang Zhang Xing Qian Shaofeng Wang | 2019 | Chinese Journal of Chemical Engineering2019，27，4： | 4 |
| 7 | Combustion mechanism and control approaches of underground coal fires:a review显示文摘With the large-scale mining of coal resources,the huge economic losses and environmental problems caused by underground coal fires have become increasingly prominent,and the research on the status quo and response strategies of underground coal fires is of great significance to accelerate the green prevention and control of coal fires,energy conservation and emission reduction.In this paper,we summarized and sorted out the research status of underground coal fires,focused on the theoretical and technical issues such as underground coal fire combustion mechanism,multiphysics coupling effect of coal fire combustion,fire prevention and extinguishing technology for underground coal fires,and beneficial utilization technology,and described the latest research progress of the prevention and control for underground coal fire hazards.Finally,the key research problems in the field of underground coal fire hazards prevention and control were proposed in the direction of the basic theory,technology research,comprehensive management and utilization,with a view to providing ideas and solutions for the management of underground coal fires. | Yuntao Liang Yalan Yang Sida Guo Fuchao Tian Shaofeng Wang | 2023 | International Journal of Coal Science & Technology2023，10，2： | 3 |
| 8 | Investigation and Analysis of Understory Vegetation in Casuarina equisetifolia Forests in Northern Hainan Province显示文摘Understory vegetation in the Casuarina equisetifolia forests at different ages was sampled and analyzed fi rstly, and then the structural features, biomass, and distribution characteristics of carbon stock of the understory vegetation, as well as the quantity and thickness of the understory litter were studied. The results show that the understory vegetation in the C. equisetifolia forests is mainly composed of herbaceous plants, and there are nearly no shrubs in the study area. Moreover, the quantity of herbaceous plants rises obviously with the increase of forest age. There is a big difference between the woodlands at different ages in total biomass of herbaceous plants, and the maximum of total biomass can be found in 15-year-old woodland, reaching 1.68 t/hm^2; the biomass of overground parts of herbaceous plants is higher than that of underground parts. There is a big difference between the woodlands at different ages in thickness of the understory litter, and the thickness of understory litter in 10-yearold woodland is the highest, reaching 6.67 cm. The maximum quantity of the understory litter has reached 14.69 t/hm^2, and the thickness of the half decomposed litter is larger than that of the undercomposed litter in most woodlands. | XUE Yang YANG Zhongyang WANG Xiaoyan SU Shaofeng LIN Zhipan XU Lina | 2016 | Journal of Landscape Research2016，8，3： | 2 |
| 9 | Crystal-KMC: Parallel Software for Lattice Dynamics Monte Carlo Simulation of Metal Materials显示文摘Kinetic Monte Carlo(KMC) is a widely used method for studying the evolution of materials at the microcosmic level. At present, while there are many simulation software programs based on this algorithm, most focus on the verification of a certain phenomenon and have no analog-scale requirement, so many are serial in nature. The dynamic Monte Carlo algorithm is implemented using a parallel framework called SPPARKS, but it does not support the Embedded Atom Method(EAM) potential, which is commonly used in the dynamic simulation of metal materials. Metal material — the preferred material for most containers and components — plays an important role in many fields, including construction engineering and transportation. In this paper, we propose and describe the development of a parallel software program called Crystal-KMC, which is specifically used to simulate the lattice dynamics of metallic materials. This software uses MPI to achieve a parallel multiprocessing mode, which avoid the limitations of serial software in the analog scale. Finally, we describe the use of the parallel-KMC simulation software Crystal-KMC in simulating the diffusion of vacancies in iron, and analyze the experimental results. In addition, we tested the performance of Crystal-KMC in 'meta-Era' supercomputing clusters, and the results show the Crystal-KMC parallel software to have good parallel speedup and scalability. | Jianjiang Li Peng Wei Shaofeng Yang Jie Wu Peng Liu Xinfu He | 2018 | Tsinghua Science and Technology2018，23，4： | 2 |
| 10 | Phase group synchronization between any signals and its physical characteristics显示文摘The phase group synchronization between any signals is further revealed,which is based on proposing the new concepts of the greatest common factor frequency,the least common multiple period,quantized phase shift resolution,equivalent phase comparison frequency and so on.Then the problem of phase comparison and processing between different frequency signals is solved and shown in detail.Using the basic principle and the variation law of group phase difference,the frequency stability better than 10-14/s can be easily obtained in the time&frequency measurement and control domain,and experimental results also show the phase relations between atomic energy level transition signal and the locked crystal oscillator signal in an active hydrogen atomic clock are strict phase group synchronization,and locked precision with 10-13/s can be reached based on phase group synchronization.The phase group synchronization can provide technical support to frequency linking among radio frequency,microwave and light frequency. | DU BaoQiang SHI LinLin CHEN YaoMing DONG ShaoFeng YANG ZhiGang CAO LingZhi GUO ShuTing | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，4： | 2 |
| 11 | Dynamic response of ultralight all-metallic sandwich panel with 3D tube cellular core to shallow-buried explosives显示文摘The underbody of a vehicle system, either military or civil, is typically made of a relatively thin metallic plate, thus vulnerable to mine blast attacks. To improve the blast resistance, a multitude of protective structures have been proposed as attachments to the thin plate. In the present study, a novel ultralight all-metallic sandwich panel with three-dimensional(3D) tube cellular cores mounted to the vehicle underbody was envisioned as such a protective system. A metallic substrate(mimicking vehicle bottom)was placed above the proposed sandwich panel to construct a sandwich-substrate combinative structure. A series of sandwich panels having 3D tube cellular cores were fabricated via argon protected welding and laser welding. Mechanical responses of the combinative structure subjected to the denotation of 6 kg TNT explosives shallow-buried in dry sand were experimentally measured. Full numerical simulations with the method of finite elements(FE) were subsequently carried out to explore the physical mechanisms underlying the observed dynamic performance and quantify the effects of key geometrical parameters and connection conditions of the protective system. The performance of the proposed sandwich panel under shallow-buried explosives was also compared with competing sandwich constructions having equal mass. Finally, a preliminary optimal design of the 3D tube cellular core was carried out. | ZHANG DuJiang ZHAO Zhen Yu DU ShaoFeng CHEN WeiJie YANG Fan NI ChangYe YANG ZhiKun LU TianJian | 2021 | Science China(Technological Sciences)2021，64，7： | 2 |
| 12 | Sympathetic Nerve Mediated Spinal Glia Activation Underlies Itch in a Cutaneous T-Cell Lymphoma Model显示文摘Dear Editor,Cancer-associated itch can be described as pruritus associated with malignancy.Although intractable itch associated with specific types of cancer afflicts patients badly,few effective treatments are available due to limited knowledge about the mechanisms of such itch.Globally,cancer-associated itch is an uncommon symptomin malignancy. | Fang Tong Qianru He Wan-Jie Du Huan Yang Dongping Du Shaofeng Pu Qingjian Han | 2022 | Neuroscience Bulletin2022，38，4： | 2 |
| 13 | Facile preparation of nano-g-C_(3)N_(4)/UiO-66-NH_(2) composite as sorbent for high-efficient extraction and preconcentration of food colorants prior to HPLC analysis显示文摘In this work,the nano-g-C_(3)N_(4)/Ui O-66-NH_(2)composite was prepared by one-step solvothermal method.The as-prepared composite was characterized by scanning electron microscopy,Brunner-Emmet-Teller measurement,energy dispersive spectrometer,X-ray diffraction,and Fourier transform infrared spectroscopy.By using nano-g-C_(3)N_(4)/Ui O-66-NH_(2)composite as sorbent,a dispersive solid-phase extraction coupled with high-performance liquid chromatography was developed to sensitive analysis of food colorants including tartrazine,amaranth,carmine,sunset yellow,allura red and bright blue.The experiment parameters including the amount of sorbent,adsorption time,the p H of adsorption solution,desorption time,desorption solvent,the p H of desorption solution as well as the proportion between desorption solvent and buffer solvent were investigated.Under the optimized conditions,the limits of detection(S/N=3) and limits of quantitation (S/N=10) were determined in the ranges of 0.08-0.8 and 0.2-2.0 ng/m L,respectively.With the developed sample pretreatment method,carmine and brilliant blue were determined from blueberry juice by HPLC-DAD.The contents were calculated as 1.53μg/m L and0.17μg/mL,respectively. | Xiaowan Zhang Yixin Yang Peige Qin Lizhen Han Wenli Zhu Shaofeng Duan Minghua Lu Zongwei Cai | 2022 | Chinese Chemical Letters2022，33，2： | 2 |
| 14 | Adsorption of malachite green on micro and mesoporous rice husk-based activecarbon显示文摘 | Guo Yupeng Yang Shaofeng Fu Wuyou | 2003 | Dyes and Pigments2003，56，： | 1 |
| 15 | The preparation and mechanism studies of rice husk based porous carbon 显示文摘 | GUO Yupeng YANG Shaofeng YU Kaifeng | 2002 | Materials Chemistry and Physics2002，74，： | 1 |
| 16 | Preparation of rutile titania nanocrystals by liquid method at room temperature显示文摘 | YANG Shaofeng LIU Yanhua GUO Yupeng | 2002 | Mater Chem Phys2002，77，： | 1 |
| 17 | Efficacy on rabbits with arrhythmia: needling acupoint of Neiguan(PC6) at shallow or deep depth, and retaining needles for 10, 20, or 30 min显示文摘OBJECTIVE:To compare the effects of Neiguan(PC6)acupuncture at different depths and retention time on arrhythmia duration,myocardial tissue morphology,mRNA expression level of L-type calcium channelα1C subunit and Ca^(2+)-Mg^(2+)-At Pase activity in tachirrhythmia model of rabbits.METHODS:The tachyarrhythmia model was made by intravenous injection of barium chloride into the ears of rabbits.A total of 56 healthy adult male New Zealand big-eared white rabbits,apply the random number table method,divided into normal control group(group A),model group(group B),shallow needling Neiguan(PC6)10 min group(group C),shallow needling Neiguan(PC6)20 min group(group D),shallow needling Neiguan(PC6)30 min group(group E),deep needling Neiguan(PC6)10 min group(group F),deep needling Neiguan(PC6)20 min group(group G),deep needling Neiguan(PC6)30 min group(group H),7 animals in each group.Electrocardiograms were used to collect the duration of arrhythmia;hematoxylin-eosin staining method was performed on myocardial tissue,RT-PCR tested the expression ofα1C subunit mRNA,and the activity of Ca^(2+)-Mg^(2+)-ATPase were quantified by phosphorus determination method.RESULTS:The duration of arrhythmia in each acupuncture treatment group was shortened to varying degrees.Compare to the model group,the tissue damage from barium chloride inducing was improved in the acupuncture group.Compared to the model group,except for group E,most treatment groups had varying degrees of improvement with significantly down-regulated L-type calcium channelα1C subunit mRNA expressions level and increased Ca^(2+)-Mg^(2+)-ATPase activity.CONCLUSIONS:The effect of acupuncture at Neiguan(PC6)with different depths and retention time can reduce the duration of arrhythmia induced by barium chloride relatively,improve the induced pathological changes,down regulate L-type calcium channelα1C subunit mRNA expressions level and increase Ca^(2+)-Mg^(2+)-ATPase activity.Both the shallow and deep tissues of Neiguan(PC6)may be involved in transmitting acupuncture information.There is an optimal induction period for shallow needling at Neiguan(PC6)to reach the best therapeutic effect. | GU Chunling CHENG Kai YANG Shouqin RAN Shaofeng TAI Hengyap GAO Xiaofeng PANG Dandan | 2021 | Journal of Traditional Chinese Medicine2021，41，6： | 1 |
| 18 | The preparation and mechanism studies of rice husk based porous carbon显示文摘 | GOU Yupeng YANG Shaofeng YU Kaifeng | 2002 | Mater Chem Phys2002，74，2： | 1 |
| 19 | Preparation of Rutile Titania Nanocrystals by Liquid Method at Room Tem- perature 显示文摘 | Yang Shaofeng Liu Yanhua Guo Yupeng | 2003 | Mater Chem Phys2003，77，2： | 1 |
| 20 | An electrocatalyst with anti-oxidized capability for overall water splitting显示文摘 | Chang Yu Huawei Huang Si Zhou Xiaotong Han Changtai Zhao Juan Yang Shaofeng Li Wei Guo Bowen An Jijun Zhao Jieshan Qiu | 2018 | Nano Research2018，11，6： | 1 |
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