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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 3 | Detrital Zircon U-Pb Geochronology from Greywackes in the Niujuanzi Ophiolitic Mélange, Beishan Area, NW China: Provenance and Tectonic Implications显示文摘The Niujuanzi ophiolitic mélange represents the remnant of oceanic crust between the Dunhuang massif and Mingshui-Hanshan massif. Greywacke from different tectonic slices in the Niujuanzi ophiolitic mélange were analyzed for detrital zircon U-Pb geochronology, trace elements and whole-rock trace elements to infer their provenance and the evolution of the Niujuanzi Ocean. Sample N-76 s containing Carboniferous spores has the youngest zircon age of 323 Ma, while sample N-85 s without fossils has the youngest zircon age of 449 Ma. The two samples were deposited no earlier than 323 and 449 Ma, respectively. The greywackes are depleted in large ion lithophile elements, and are relatively enriched in high field strength elements. The age spectra and trace element concentrations indicate that the sediments may have been deposited near the trench. The Hf, U, and Yb contents of zircons from sample N-76 s vary widely, whereas those from sample N-85 s have a narrow range. Sample N-76 s contains both continental and oceanic zircons, while sample N-85 s contains only continental zircons. The sediments were derived from the continental arc and accretionary wedge. The Paleozoic oceanic crust zircons have ages of 430–500 Ma, indicating the timing of the expansion of the HongliuheNiujuanzi-Xichangjing Ocean expansion. The oldest Paleozoic continental zircon has an age of 470 Ma, suggesting that the northward subduction of the oceanic crust may have started at that time. | Shengdong Wang Kexin Zhang Bowen Song Shucai Li Jianxing Li Jiyuan Yu Jianjun Bu | 2018 | Journal of Earth Science2018，29，1： | 8 |
| 4 | Advances in lung cancer screening and early detection显示文摘Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health worldwide.Two randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer screening.However,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation exposure.This review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related issues.Second,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is presented.Third,current explorations of strategies for suspected malignancy are summarized.Overall,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer. | Caichen Li Huiting Wang Yu Jiang Wenhai Fu Xiwen Liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He Wenhua Liang | 2022 | Cancer Biology & Medicine2022，19，5： | 6 |
| 5 | Nonlinear Contact Between Inner Walls of Deep Sea Pipelines in Buckling Process显示文摘In order to study buckling propagation mechanism in deep sea pipelines, the contact between pipeline's inner walls in buckling process was studied. A two-dimensional ring model was used to represent the pipeline and a nonlinear spring model was adopted to simulate the contact between inner walls. Based on the elastoplastic constitutive relationship and the principle of virtual work theory, the coupling effect of pipeline's nonlinear large deformation and wall contact was included in the theoretical analysis with the aid of MATLAB, and the application scope of the theoretical model was also discussed. The calculated results show that during the loading process, the change in external pressure is closely related to the distribution of section stress, and once the walls are contacting each other, the external pressure increases and then remains stable after it reaches a specific value. Without fracture, the pipeline section will stop showing deformation. The results of theoretical calculations agree well with those of numerical simulations. Finally, in order to ensure reliability and accuracy of the theoretical results, the collapse pressure and propagation pressure were both verified by numerical simulations and experiments. Therefore, the theoretical model can be used to analyze pipeline's buckling deformation and contact between pipeline's inner walls, which forms the basis for further research on three-dimensional buckling propagation. | MA Weilin YU Jianxing ZHOU Qingji XIE Bin CAO Jing LI Zhibo | 2015 | Journal of Ocean University of China2015，14，1： | 4 |
| 6 | Application of computational fluid dynamics simulation for submarine oil spill显示文摘Computational fluid dynamics(CFD) codes are being increasingly used in the simulation of submarine oil spills.This study focuses on the process of oil spills, from damaged submarine pipes, to the sea surface, using numerical models. The underwater oil spill model is developed, and a description of the governing equations is proposed,along with modifications required for the particalization of the control volume. Available experimental data were introduced to evaluate the validity of the CFD predictions, the results of which proved to be in good agreement with the experimental data. The effects of oil leak rate, leak diameter, current velocity, and oil density are investigated, by the validated CFD model, to estimate the undersea leakage time, the lateral migration distance,and surface diffusion range when the oil reaches the sea surface. Results indicate that the leakage time and lateral migration distance increase with decreasing leak rates and leak diameter, and increase with increasing current velocity and oil density. On the other hand, a large leak diameter, high density, high leak rate, or fast currents result in a greater surface diffusion range. The findings and analysis presented here will provide practical predictions of oil spills, and guidance for emergency rescues. | YANG Zhenglong YU Jianxing LI Zhigan CHEN Haicheng JIANG Meirong CHEN Xi | 2018 | Acta Oceanologica Sinica2018，37，11： | 3 |
| 7 | Optimal locating arrays for at most two faults显示文摘Locating arrays are of interest in generating software test suites to cover all t-way component interactions and locate interaction faults in component-based systems.Recently,Tang,Colbourn and Yin made an investigation into optimal locating arrays in the case where a single fault is to be located.They pointed out that when two or more faults were considered,matters would become rather complicated.To handle those cases generally seems challenging,but is well worth further research.In this paper,we establish a lower bound on the size of locating arrays with at most two faults,and then prove that optimal locating arrays meeting this bound can be equivalently characterized in terms of orthogonal arrays with prescribed properties.Using this characterization,we develop a number of constructions of optimal locating arrays.Two infinite series of optimal locating arrays are then obtained. | SHI Ce TANG Yu YIN JianXing | 2012 | Science China Mathematics2012，55，1： | 2 |
| 8 | A COVID-19 Outbreak Emerging in a Food Processing Company——Harbin City,Heilongjiang Province,China,January-February 2021显示文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)epidemic in China had been effectively controlled for several months,but as the ambient temperature dropped,large gathering-initiated epidemics occurred in northern China,including Hebei,Liaoning,and Jilin provinces. | Lei Hou Hao Zhou Nanxi Meng Xue Yu Xin Wang Tuo Wang Jianfeng Zhang Yan Wang Shie Li Shuzhen Guo Jianxing Yu Muxin Chen Wenhui Shi Ning Xiao Chao Yang Jianxiang Liu | 2021 | China CDC weekly2021，3，32： | 2 |
| 9 | Laboratory investigation into the oil diffusion from submarine pipeline under water flow显示文摘A physical model test has been conducted to study the oil diffusion from the submarine pipeline under water flow.The crude oil in the flume is spilled from a leakage point of the pipeline and diffused from the seabed to the surface. By the non-contact optical measuring technology, an image acquisition and data analysis system is designed to explore the spilled mechanism and characteristic. The oil trajectory, velocity and the rising time to the surface are obtained through this system. The influence of the water flow and the spilled discharge on the behavior of the spilled oil are analyzed from both qualitative and quantitative perspectives. The sensitivity study of the characteristic physical quantities to various factors are presented afterward. The spilled oil under water is mainly distributed in the form of the scattered particles with different sizes. The rising process of the oil can be divided into three stages: full, dispersion and aggregation period. The spilled discharge is the primary factor affecting the rising time of the oil particles. In the rising process of the oil particles, the vertical velocity of the oil is mainly affected by the spilled discharge, and the transverse velocity is more dependent on the water velocity. The deviation of the transverse oil velocity is much larger than that of the rising time and the vertical oil velocity. The study can provide a theoretical reference for the prediction system of oil spill emergency. | JIANG Meirong YU Jianxing LI Zhigang ZHONG Wenjun WU Zhaohui YU Yang | 2018 | Acta Oceanologica Sinica2018，37，11： | 2 |
| 10 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Benjamin J Cowling Lianmei Jin Eric HY Lau Qiaohong Liao Peng Wu Hui Jiang Tim K Tsang Jiandong Zheng Vicky J Fang Zhaorui Chang Michael Y Ni Qian Zhang Dennis KM Ip Jianxing Yu Yu Li Liping Wang Wenxiao Tu Ling Meng Joseph T Wu Huiming Luo Qun Li Yuelong | 2013 | The Lancet2013，，9887： | 1 |
| 11 | Modeling of multi-freedom ship motion in irregular waves with fuzzy neural networks 显示文摘 | YU Jianxing | 2002 | China Ocean Engineering2002，17，2： | 1 |
| 12 | The combinatorial construction for a class of optimal optical orthogonal codes显示文摘 | Tang Yu Yin Jianxing | 2002 | Science in China Series A: Mathematics2002，，10： | 1 |
| 13 | Civic Education and TransitionGovernance in China 显示文摘 | Yu Jianxing Feng Tao | 2010 | Peace review : a journal of socialjustice2010，，22： | 1 |
| 14 | Antimicrobial effect of chitooligosaccharides produced by chitosanase from pseudomonas CUY8显示文摘 | WANG Yan ZHOU Peigen YU Jianxing | 2007 | Asia Pac J Clin Nutr2007，16，1： | 1 |
| 15 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Benjamin J Cowling Lianmei Jin Eric HY Lau Qiaohong Liao Peng Wu Hui Jiang Tim K Tsang Jiandong Zheng Vicky J Fang Zhaorui Chang Michael Y Ni Qian Zhang Dennis KM Ip Jianxing Yu Yu Li Liping Wang Wenxiao Tu Ling Meng Joseph T Wu Huiming Luo Qun Li Yuelong | 2013 | The Lancet . 2013 (9887)2013，，9887： | 1 |
| 16 | Thermal effects on fracture toughness of cracked straight-through Brazilian disk green sandstone and granite显示文摘Cracked straight-through Brazilian disc(CSTBD) samples prepared using two rock materials were used for thermal treatment from room temperature to 700℃. Uniaxial splitting experiments were performed using an automatic electro-hydraulic servo press to study the evolution laws of physical and fracture properties of different deep rock materials under high-temperature geological conditions. The fracture characteristics were measured using an industrial camera and digital image correlation technology to analyze the effect of high temperature on fracture properties and failure modes of the CSTBD samples after different thermal treatments. The micro-damage properties of green sandstone and granite materials were obtained using a scanning electron microscope(SEM). The following conclusions were drawn from the test results:(1) With the increasing temperature, the fracture characteristics of green sandstone and granite change from brittle fracture to plasticity fracture, the longitudinal wave velocity of granite decreases sharply at 600℃, and the damage factor reaches 0.8748 at 700℃.(2) The fracture toughness of green sandstone and granite decreases with increasing temperature;however, the decreasing range of granite is larger than that of green sandstone.(3) As the temperature increases, the fracture morphologies of green sandstone and granite materials become rougher, whereas thermal damage cracks of granite and intergranular fractures inside sandstone as well as pores of sandstone increase.(4) The crack tip opening displacement and peak strain corresponding to peak load increase with the temperature. | Lei Zhou Weiting Gao Liyuan Yu Zheming Zhu Jianxing Chen Xingkai Wang | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，5： | 1 |
| 17 | Fuzzy comprehensive evaluation method on flood-control risk consequence assessment of bridge 显示文摘 | Wang Hongwei Hu Changyu Yu Jianxing | 2012 | Affective Computing and Intelligent Interaction2012，137，3： | 1 |
| 18 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 19 | Comparative epidemiology of human infections with avian influenza A H7N9 and H5N1 viruses in China: a population-based study of laboratory-confirmed cases显示文摘 | Benjamin J Cowling Lianmei Jin Eric HY Lau Qiaohong Liao Peng Wu Hui Jiang Tim K Tsang Jiandong Zheng Vicky J Fang Zhaorui Chang Michael Y Ni Qian Zhang Dennis KM Ip Jianxing Yu Yu Li Liping Wang Wenxiao Tu Ling Meng Joseph T Wu Huiming Luo Qun Li Yuelong | 2013 | 2013 (9887)2013，，9887： | 1 |
| 20 | Asian,regional,and national burdens of respiratory tract cancers and associated risk factors from 1990 to 2019:A systematic analysis for the global burden of disease study 2019显示文摘Background:Respiratory cancer is the leading cause of cancer-related deaths worldwide,but its statistics vary between the East and West.This study aimed to estimate the burdens of tracheal,bronchus,and lung(TBL)cancer and larynx cancer and their attributable risks from 1990 to 2019 in Asia,and at regional and national levels.Methods:This research evaluated the incidence,mortality,years lived with disability,years of life lost,and disability-adjusted life years(DALYs)for respiratory tract cancers using the Global Burden of Diseases,Injuries,and Risk Factors Study(GBD)2019 database.Age-standardized rates were calculated for TBL cancer from 1990 to 2019,adjusted for smoking and socio-demographic index(SDI).Deaths from TBL cancer and larynx cancer attributable to each risk factor were estimated for 33 Asian countries.Results:The age-standardized incidence and death rates for TBL cancer in Asia declined from 2010 to 2019,while the incidence rate of larynx cancer increased.Smoking was the leading specific risk factor for deaths from both TBL and larynx cancers.The burden of TBL cancer in Asian countries was influenced by SDI and smoking,particularly among males in Central Asia.Deaths,DALYs,and incidences of larynx cancer in East Asia had not changed significantly over the past 30 years,but showed slight downward trends in males and both sexes combined,and an upward trend in females in recent years.Conclusions:The past decade saw increases in numbers of incident cases and deaths from TBL cancer and larynx cancer in Asia.SDI and smoking were the main factors influencing the disease burden of TBL cancer in Asian countries.This study highlights the need for tailored cancer control programs to address the burden of respiratory tract cancers in different Asian countries. | Ran Zhong Xiuyu Cai Jianfu Li Peiling Chen Runchen Wang Xinting Li Feng Li Shan Xiong Caichen Li Huiting Wang Yang Xiang Shuting Zhan Ziwen Yu Haixuan Wang Chunyan Li Lixuan Lin Wenhai Fu Xin Zheng Shen Zhao Kang Zhang Jianxing He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，4： | 1 |
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