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| 1 | Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing显示文摘Many human genetic diseases,including Hutchinson-Gilford progeria syndrome(HGPS),are caused by single point mutations.HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene.Base editors(BEs)composed of a cytidine deaminase fused to CRISPR/Cas9 nickase are highly efficient at inducing C to T base conversions in a programmable manner and can be used to generate animal disease models with single amino-acid substitutions.Here,we generated the first HGPS monkey model by delivering a BE mRNA and guide RNA(gRNA)targeting the LMNA gene via microinjection into monkey zygotes.Five out of six newborn monkeys carried the mutation specifically at the target site.HGPS monkeys expressed the toxic form of lamin A,progerin,and recapitulated the typical HGPS phenotypes including growth retardation,bone alterations,and vascular abnormalities.Thus,this monkey model genetically and clinically mimics HGPS in humans,demonstrating that the BE system can efficiently and accurately generate patient-specific disease models in non-human primates. | Fang Wang Weiqi Zhang Qiaoyan Yang Yu Kang Yanling Fan Jingkuan Wei Zunpeng Liu Shaoxing Dai Hao Li Zifan Li Lizhu Xu Chu Chu Jing Qu Chenyang Si Weizhi Ji Guang-Hui Liu Chengzu Long Yuyu Niu | 2020 | Protein & Cell2020，11，11： | 11 |
| 2 | X-Mechanics——An endless frontier显示文摘In contrast to the conventional wisdom that mechanics is a relatively mature subject, the new manifestation of mechanics in an extended or crossed form is unfolding. Mechanics is now powering all subjects, from physical sciences, life sciences to social sciences. We name this new phase for the development of mechanics X-Mechanics. The present article outlines the contents of X-Mechanics from four aspects: cross media, cross scales, cross compliances, and cross cyber/physical spaces. X-Mechanics constitutes an endless frontier of science and technology. | Wei Yang HongTao Wang TieFeng Li ShaoXing Qu | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，1： | 6 |
| 3 | RATE DEPENDENT STRESS-STRETCH RELATION OF DIELECTRIC ELASTOMERS SUBJECTED TO PURE SHEAR LIKE LOADING AND ELECTRIC FIELD显示文摘The performance of dielectric elastomer(DE) transducers is significantly affected by viscoelastic relaxation-induced electromechanical dissipations.This paper presents an experimental study to obtain the rate dependent stress-stretch relation of DE membranes(VHB TM 9473) subjected to pure shear like loading and electric loading simultaneously.Stretching rate dependent behavior is observed.The results also show that the tensile force decreases as the voltage increases.The observations are compared with predictions by a viscoelastic model of DE.This experiment may be used for further studies of dynamic electromechanical coupling properties of DEs. | Shaoxing Qu Ke Li Tiefeng Li Hanqing Jiang Miao Wang Zhenhua Li | 2012 | Acta Mechanica Solida Sinica2012，25，5： | 5 |
| 4 | Pneumatically Actuated Soft Robotic Arm for Adaptable Grasping显示文摘 | Zhe Chen Xueya Liang Tonghao Wu Tenghao Yin Yuhai Xiang Shaoxing Qu | 2018 | Acta Mechanica Solida Sinica2018，31，5： | 5 |
| 5 | Functional hydrogel coatings显示文摘Hydrogels—natural or synthetic polymer networks that swell in water—can be made mechanically,chemically and electrically compatible with living tissues.There has been intense research and development of hydrogels for medical applications since the invention of hydrogel contact lenses in 1960.More recently,functional hydrogel coatings with controlled thickness and tough adhesion have been achieved on various substrates.Hydrogel-coated substrates combine the advantages of hydrogels,such as lubricity,biocompatibility and anti-biofouling properties,with the advantages of substrates,such as stiffness,toughness and strength.In this review,we focus on three aspects of functional hydrogel coatings:(i)applications and functions enabled by hydrogel coatings,(ii)methods of coating various substrates with different functional hydrogels with tough adhesion,and(iii)tests to evaluate the adhesion between functional hydrogel coatings and substrates.Conclusions and outlook are given at the end of this review. | Junjie Liu Shaoxing Qu Zhigang Suo Wei Yang | 2021 | National Science Review2021，8，2： | 4 |
| 6 | A FINITE ELEMENT METHOD FOR DIELECTRIC ELASTOMER TRANSDUCERS显示文摘We present a finite element method for dielectric elastomer(DE) transducers based on the nonlinear field theory of DE.The method is implemented in the commercial finite element software ABAQUS,which provides a large library functions to describe finite elasticity.This method can be used to solve electromechanical coupling problems of DE transducers with complex configurations and under inhomogeneous deformation. | Shaoxing Qu Zhigang Suo | 2012 | Acta Mechanica Solida Sinica2012，25，5： | 3 |
| 7 | A chemo-mechanical model for fully-coupled lithiation reaction and stress generation in viscoplastic lithiated silicon显示文摘Development of stresses in silicon(Si) anodes of lithium-ion batteries is strongly affected by its mechanical properties. Recent experiments reveal that the mechanical behavior of lithiated silicon is viscoplastic, thereby indicating that lithiation-induced mechanical stresses are dependent on the lithiation reaction rate. Experimental evidence also accumulates that the rate of lithiation reaction is conversely affected by the magnitude of mechanical stresses. These experimental observations demonstrate that lithiation reaction and stress generation in silicon anodes are fully coupled. In this work, we formulate a chemo-mechanical model considering the two-way coupling between lithiation reaction and viscoplastic deformation in silicon nanoparticle anodes.Based on the model, the position of the lithiation interface, the interface velocity, and the lithiation-induced stresses can be solved simultaneously via numerical methods. The predicted interface velocity is in line with experimental measurements reported in the literature. We demonstrate that the lithiation-induced stress field depends on the lithiation reaction through two parameters:the migration velocity and the position of the lithiation interface. We identify a stress-mitigation mechanism in viscoplastic silicon anodes: the stress-regulated lithiation reaction at the interface serves as a 'brake' to reduce the interface velocity and mitigate the lithiation-induced stresses, protecting the Si nanoparticle anode from being subjected to excessive mechanical stresses. | BUREBI Yi Ming JIA Zheng QU ShaoXing | 2019 | Science China(Technological Sciences)2019，62，8： | 2 |
| 8 | A NUMERICAL STUDY OF INDENTATION WITH SMALL SPHERICAL INDENTERS显示文摘The finite element method for the conventional theory of mechanism-based strain gradient plasticity is used to study the indentation size effect. For small indenters (e.g.,radii on the order of 10 μm),the maximum allowable geometrically necessary dislocation (GND) density is introduced to cap the GND density such that the latter does not become unrealistically high. The numerical results agree well with the indentation hardness data of iridium. The GND density is much larger than the density of statistically stored dislocations (SSD) underneath the indenter,but this trend reverses away from the indenter. As the indentation depth (or equivalently,contact radius) increases,the GND density decreases but the SSD density increases. | Jiang Qin Shaoxing Qu Xue Feng Yonggang Huang Jianliang Xiao Keh-Chih Hwang | 2009 | Acta Mechanica Solida Sinica2009，22，1： | 1 |
| 9 | Design and analysis of an untethered micro flapping robot which can glide on the water显示文摘Flapping-wing flying insects possess various advantages,such as high agility and efficiency.The design and manufacture of insect-scale flapping-wing micro aerial vehicle(FWMAV)have attracted increasing attention in recent decades.Due to the limitations of size and weight,the FWMAV with an onboard battery which can fully mimic insect flight has not been achieved.In this work,we design and fabricate a highly integrated flapping-wing microrobot named Robomoth.The Robomoth consists of a carbon chassis,customized power and control devices,and two piezoelectric ceramic actuators symmetrically distributed in the thorax and controlled individually.It weighs 2.487 g,spans 5.9 cm in length,possesses 9 cm of wingspan,and carries a 0.355 g rechargeable lithium battery.We demonstrate the mobility of the Robomoth through untethered gliding and making turns on the water surface.A simplified dynamic model of the flapping system is proposed to explain the relationship between the driving frequency and the flapping amplitude.The Robomoth is one new untethered bioinspired flapping-wing robot that can perform stable water surface motion,which holds potential applications such as search and rescue on the water.The robot can also provide insight for designing insect-scale flying vehicles. | CHEN YanHong LIU YiDe LIU TaiShan LI Hua QU ShaoXing YANG Wei | 2022 | Science China(Technological Sciences)2022，65，8： | 0 |
| 10 | Preface to the'Soft Matter Mechanics'Special Issue of Acta Mechanica Solida Sinica显示文摘Different from ordinary solids,liquids and gases,soft matter is a subfield of condensed matter comprising a complexity of physical states and softness that are easily modulated by external stimuli and/or thermal flue tu at ions,with the featured sensitivity to tiny perturbations from the environment.The soft matter research is considered to be“the science of the 21st century,”which is rapidly evolving and growing at the interfaces of mechanics,physics,biology,material science,chemistry,etc. | Jin Qian Tongqing Lu Shaoxing Qu | 2019 | Acta Mechanica Solida Sinica2019，32，5： | 0 |
| 11 | Inclusion Size Effect on Mechanical Properties of Particle Hydrogel Composite显示文摘Particle hydrogel composite(PHC)combines the characteristics of at least two mat erials and has pot ential applications in many fields.Different functions require the particle size to range from nanometer to millimeter,which has a noticeable effect on the mechanical properties of the hydrogel composites.In this paper,the mechanical properties of silica-inlaid PAAM hydrogel are measured with various particle diameters from 75 nm to 50|im.Experimental results show no obvious size effect on the mechanical properties of PHC when the particle diameter falls in micron scale.However,as the particle size decreases to nanoscale,the modulus of the PHC begins to increase rapidly.The size-irrelevant moduli and stress fields of PHCs with random and uniform particle distributions under different loading conditions are obtained based on the finite element method.Meanwhile,the toughening mechanism and the failure of the PHC are investigated.The size-irrelevant modulus of the PHC is also predicted by the equivalent inclusion theory.Finally,the interaction between the hydrogel polymer chains and the particles is described from the microscopic point of view,requiring the nanoscale size-dependent theory and new experimental approach to further explore the mechanical proper ties of PHC. | Xiaocheng Hu Shaoxing Qu | 2019 | Acta Mechanica Solida Sinica2019，32，5： | 0 |
| 12 | Preface:Mechanics of soft materials and lexible structures显示文摘Soft materials and lexible structures have become essential and hot topic,which is expected to signiicantly promote the research and development of current mechanics,physics,chemistry and life science.Furthermore,the soft materials and lexible structures have attracted enthusiastic attentions due to their great potential and practical applications in deployable structures,morphing structures,sensors,actuators,health-monitoring etc. | Haibao Lu Shaoxing Qu Xiqiao Feng | 2021 | Acta Mechanica Sinica2021，37，5： | 0 |
| 13 | Editorial: Mechanics of soft materials, structures and systems显示文摘The concept of soft matter was first introduced by P.G.de Gennes in his acceptance speech for the Nobel Physics Prize in 1991.In mechanics community,however,people usually prefer using soft material instead of soft matter to describe the material whose energy associated with thermal motion is comparative to the interaction energy.Unlike in the conventional con densed matter,entropy plays an important and even determinative role in soft materials.This particular characteristic of soft material gives birth to very complex and kaleidoscopic systems,such as liquid crystals,polymers,colloids,granular materials,and biological systems.Soft materials have many vagarious properties,including strong reaction to weak stimulus,nonlinear response,self-assembly,to name a few,which fully embody the complexities and particularities in multi-scale compositions,structures and interactions.The luxuriant multi-discipline nature and wide applications of soft materials have successfully intrigued both scientists and engineers worldwide. | Chaofeng L Wen Chen Jinxiong Zhou Shaoxing Qu Weiqiu Chen | 2013 | Theoretical & Applied Mechanics Letters2013，3，5： | 0 |
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