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136篇 您的检索式：作者名="Sharon B"

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	题名	作者	年代	出处	被引量
1	Chemical conjugation of a novel antibody interleukin 2 immunoconjugate against c erbB 2 product显示文摘Objective To develop a new chemical method to produce a monoclonal antibody (MoAb) 520C9/recombinant human interleukin 2 (rhIL 2) conjugate Methods MoAb 520C9 reactive with the protooncogene c erbB 2 product P185 was chemically conjugated with rhIL 2 by using a simple two step method First, the rhIL 2 was activated by Sulfosuccinimidyl 4 [N maleimidomethyl] cyclohexane 1 carboxylate, a heterobifunctional linker, and N succinimidyl s acetylthioacetate was introduced onto 520C9 Then SATA on the 520C9 was reacted with the maleimide group on the activated rhIL 2 to generate 520C9 rhIL 2 immunoconjugate Results The immunoconjugate retained the antigen binding activity compared to the respective native antibody as determined by an indirect live cell binding assay The immunoconjugate also possessed IL 2 activity as measured by the standard CTLL 2 cells proliferation assay and the stimulation of human peripheral blood mononuclear cells (PBMCs) into lymphokine activated killer cells Conclusion Our method of conjugation of rhIL 2 to 520C9 preserves the binding activity of the antibody and the cytokine function of IL 2 This simple and efficient method of conjugation should be applicable to other types of MoAbs and recombinant	李君 Sharon E Lee Marie Belciug David B Ring Cheuk S Kwok	2000	Chinese Medical Journal2000，，2：	3
2	Pharmacokinetics of melamine in pigs following intravenous administration显示文摘	RONALD E B GEOF S SHARON E M	2008	Food and Chemical Toxicology2008，46，：	1
3	Why customers stay:measuring the underlying dimensions of services switching costs and managing their differential stra-tegic outcomes显示文摘	Michael A J David L M Sharon E B	2002	Journal of Business Research2002，55，6：	1
4	How Do Entrepreneurs Organize Firms Under Conditions of Uncertainty? 显示文摘	Sharon A Alvarez Jay B Barney	2005	Journal of Management2005，31，5：	1
5	Effects of culture density , conditioned medium and feeder cultures on microspore embryogenesis in Brassica napus L 显示文摘	Huang B Sharon B	1990	cv Topas Plant Cell Reports1990，8，：	1
6	Echocardiogr aphic evaluation of the cardiovascular effects of short-duration spaceflight显示文摘	John B Charles Jeanne M Riddle	1991	J Clin Pharmacol1991，31，10：	1
7	Perceived barriers to medicalerror reporting: an exploratory investigation 显示文摘	Claudia L Uribe Sharon B Schweikhart	2002	Joural of Healthcare Management2002，47，4：	1
8	Emergence of antiviral resistance during oral valgancielovir treatment of an infant with congenital cytomegalovirus (CMV) infection显示文摘	Choi KY Sharon B Balfour HH Jr	2013	J Clin Virol2013，57，4：	1
9	Staphylococcal toxic shock syndrome erythroderma is associated with superantigenieity and hypersensitivity 显示文摘	JOHN C C NIERMANN M SHARON B	2009	Clin Infect Dis2009，49，12：	1
10	Outcome of Ilizrov ankle arthro- desis 显示文摘	Sharon E Shlomo P Noam B	2007	Foot Ankle Int2007，8，：	1
11	Lysosomal protease pathways to apoptosis 显示文摘	Stoka V Turk B Sharon L	2001	Biolo Chem2001，276，：	1
12	Regeneration of blueberry plantlets from leaf segment显示文摘	SHARON G B CHEE K CHIN C	1988	Hortseience1988，23，4：	1
13	The flypaper effect revisited : an econometric Explanation 显示文摘	Megdal Sharon B	1987	The Review of Economics and Statistics1987，，：	1
14	Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction显示文摘	Geza S B Sharon P Yvonne L	1992	Clin Chem1992，38，11：	1
15	Use of Surface Electromyography to Estimate Neck Muscle Activity显示文摘	CAROLYN M SOMMERICH SHARON M B JOINES et a1	2000	J Electromyogr Kinesioi2000，10，：	1
16	Regeneration of blueberry plantlets from leaf segments显示文摘	Sharon C B Chin C K Jelenkovic G	1988	HortScience1988，23，4：	1
17	Proteolysis in Caenorhabditis elegans sex determination: cleavage of TRA-2A by TRA-3 显示文摘	Sharon B S Patricia E K	2000	Genes and Development2000，14，：	1
18	The Effect of Work Climate on Critical Employee and Customer Outcomes: An Employee - level Analysis 显示文摘	MAHN H Y SHARON E B JAEBEOM S	2001	International Journal of Service Industry Management2001，12，5：	1
19	Foodborne Campylobacter: Infections, Metabolism, Pathogenesis and Reservoirs显示文摘	Epps Sharon V R Harvey Roger B Hume Michael E Phillips Timothy D Anderson Robin C Nisbet David J	2013	International Journal of Environmental Research and Public Health2013，，12：	1
20	Reexamination of the age limit for defining when Puberty is precocious in girls in the united states: implications for evalution and treatment 显示文摘	Paul B Kaplowitz MD Sharon E	1999	Pediatrics1999，4，4：	1

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