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| 1 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 2 | Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial显示文摘 | Xin Shelley Wang Laurence D Rhines Almon S Shiu James N Yang Ugur Selek Ibrahima Gning Ping Liu Pamela K Allen Syed S Azeem Paul D Brown Hadley J Sharp David C Weksberg Charles S Cleeland Eric L Chang | 2012 | Lancet Oncology2012，，4： | 2 |
| 3 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 4 | Pediatrics:diagnosis of neuroblastoma显示文摘 | Sharp S E Gelfand M J Shulkin B L | 2011 | Semin Nucl Med2011，41，5： | 1 |
| 5 | Analysis of protein solvent accessible surfaces by photochemical oxidation and mass spectrometry显示文摘 | SHARP J S BECKER J M HETTICH R L | | 0，，3： | 1 |
| 6 | Compiler transformations for high-performance computing 显示文摘 | Bacon D F Graham S L Sharp O J | 1994 | ACM Computing Surveys1994，26，4： | 1 |
| 7 | Computer identification of symptomatic deep venous thrombosis associated with peripherally inserted venous catheters 显示文摘 | Evans R S Linford L H Sharp J H | 2007 | AMIA Annu Symp Proc2007，，： | 1 |
| 8 | 100 consecutive minimally invasive Heller myotomies: Lessons learned 显示文摘 | SHARP KW KHAITAN L SCHOLZ S | 2002 | Ann Surg2002，235，5： | 1 |
| 9 | Who defaults from colposcopy? A multi-centre, population-based, prospective cohort study of predic- tors of non-attendance for follow-up among women with low-grade ab- normal cervical cytology显示文摘 | Sharp L Cotton S Thornton A et at | 2012 | European Journal of Obstetrics & Gyne- cology and Reproductive Biology2012，165，2： | 1 |
| 10 | Chronic inter- mittent hypoxia increases sympathetic control of blood pressure: role of neuronal activity in the hypothalamic paraventricular nucle- us显示文摘 | Sharpe A L Calderon A S Andrade M A | 2013 | Am J Physiol Heart Circ Physiol2013，305，12： | 1 |
| 11 | The adenoma-carcinoma sequence and prospects for the prevention of colorectal neoplasia显示文摘 | Cotton S Sharp L Little J | 1996 | Crit Rev Oncog1996，7，56： | 1 |
| 12 | The impact of seasonal variations in DOC arising from a moorland peat catchment on coagulation with iron and aluminium salts显示文摘 | SHARP E L PARSONS S A JEFFERSON B | 2006 | Environmental Pollution2006，140，： | 1 |
| 13 | Effect of low-frequency pulsatile flow on expression of osteoblastic genes by bone marrow stromal cells显示文摘 | Sharp L A Lee Y W Goldstein A S | 2009 | Ann Biomed Eng2009，37，3： | 1 |
| 14 | beta-hydroxy-beta-methylbutyrate(HMB)supplementation in humans is safe and may decrease cardiovascular risk factors显示文摘 | Nissen S Sharp RL Panton L | 2000 | J Nutr2000，130，8： | 1 |
| 15 | Further Investigation of the Invivo Pharmacological Properties of the Putative 5-HT1a Antagonist, BMY 7378 显示文摘 | Sharp T Backus L I Hjorth S etal | 1990 | Eur J Pharmacol1990，176，3： | 1 |
| 16 | Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin显示文摘 | Holmes J L Sharp S Y Hobbs S | 2008 | Cancer Res2008，68，4： | 1 |
| 17 | Conserved structure and function of the Arabidopsis flowering time gene CONSTANS in Brassica napus显示文摘 | Robert L S Robson F Sharpe A | 1998 | Plant Molecular Biology1998，37，： | 1 |
| 18 | A Monoclinic Post-stishovite polymorph of silica in the shergotty meteorite 显示文摘 | Goresy El A Dubrovinsky L Sharp T G Saxena S K Chen M | 2000 | Science2000，288，： | 1 |
| 19 | 100 consecutive minimally invasive Heller myotomies: lessons learned 显示文摘 | Sharp KW Khaitan L Schulz S | 2002 | Ann Surg2002，235，5： | 1 |
| 20 | 1231-MIBG scintigraphy and 18F-FDG PET in neuroblastoma显示文摘 | Sharp S E Shulkin B L Gelfand M J | 2009 | J Nucl Med2009，50，8： | 1 |
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