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| 1 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 2 | China's treatment regimen for fulminant myocarditis is bringing wonderful achievement to the world显示文摘Fulminant myocarditis is characterized by acute and severe inflammation with injury of myocardium globally. It has a fulminant course and high in-hospital mortality rate of up to50%-70%. It onsets rapidly after viral infection and progresses to hypotension. | Jing Zhang Weijian Hang Rutai Hui Qiong Zhao Shashank S.Desai | 2019 | Science China(Life Sciences)2019，62，2： | 8 |
| 3 | Predicting enhancer-promoter interaction from genomic sequence with deep neural networks显示文摘Background:In the human genome,distal enhancers are involved in regulating target genes through proximal promoters by forming enhancer-promoter interactions.Although recently developed high-throughput experimental approaches have allowed us to recognize potential enhancer-promoter interactions genome-wide,it is still largely unclear to what extent the sequence-level information encoded in our genome help guide such interactions.Methods:Here we report a new computational method (named 'SPEID') using deep learning models to predict enhancer-promoter interactions based on sequence-based features only,when the locations of putative enhancers and promoters in a particular cell type are given.Results:Our results across six different cell types demonstrate that SPEID is effective in predicting enhancerpromoter interactions as compared to state-of-the-art methods that only use information from a single cell type.As a proof-of-principle,we also applied SPEID to identify somatic non-coding mutations in melanoma samples that may have reduced enhancer-promoter interactions in tumor genomes.Conclusions^ This work demonstrates that deep learning models can help reveal that sequence-based features alone are sufficient to reliably predict enhancer-promoter interactions genome-wide. | Shashank Singh Yang Yang Barnabas Poczos Jian Ma | 2019 | Frontiers of Electrical and Electronic Engineering in China2019，7，2： | 8 |
| 4 | Endoscopic resolution and recurrence of gastric antral vascular ectasia after serial treatment with argon plasma coagulation显示文摘AIM To evaluate long-term endoscopic resolution and recurrence rate of gastric antral vascular ectasia(GAVE) after argon plasma coagulation(APC) treatment.METHODS This was an IRB-approved retrospective single center study that included patients endoscopically treated for GAVE between 1/1/2008 to 12/31/2014. The primary and secondary end points of the study were rate of endoscopic resolution of GAVE after APC treatment and recurrence rate of GAVE after endoscopic resolution, respectively. Endoscopic resolution of GAVE was defined as no endoscopic evidence of GAVE after treatment with APC. Recurrence of GAVE was defined as endoscopic reappearance of GAVE after prior resolution.RESULTS Twenty patients met the study criteria. Median age(range) of the patients was 59.5 years(42-74 years). GAVE was associated with underlying cirrhosis in 16(80%) patients. Indications for initial esophagogastroduodenoscopy(EGD) included hematemesis and/or melena(9/20, 45%), iron deficiency anemia(6/20, 30%), screening or surveillance of varices(4/20, 20%), and occult gastrointestinal bleeding(1/20, 5%). The patients were treated with a total of 55 APC sessions(range 1-7 sessions). Successful endoscopic resolution of GAVE wasachieved in 8 out of 20 patients(40%). There was no correlation between number of treatment sessions and GAVE treatment success(P = NS). Recurrence of GAVE was noted on a subsequent EGD in 2 out of 8 patients(25%) with prior endoscopic resolution of GAVE. Median follow-up period for the study population was 627 d(range 63-1953 d).CONCLUSION Endoscopic resolution rate of GAVE was low(40%) with a 25% recurrence rate after treatment with APC. These rates suggest that APC treatment of GAVE may not be optimal in many circumstances. | Shashank Garg Bilal Aslam Nicholas Nickl | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，6： | 5 |
| 5 | Pathology of atherosclerotic coronary artery disease in the young Indian population显示文摘Atherosclerotic coronary artery disease (CAD) is of great concern in young adults because of its potential to cause great incapacitation.This arena of cardiology has gained importance in South Asian countries,particularly India due to increased prevalence that is related to traditional risk factors,altered life styles and inherent risk factors.In this study,we sought to evaluate,at autopsy,the pathology of atherosclerotic CAD in young patients with ischemic heart disease (IHD).A 10-year retrospective autopsy-based study was carried out in a large tertiary-care centre and patients aged ≤45 years with IHD were selected.Out of 545 autopsied cases of IHD,95 patients (17.4%) were young.Among these 95 patients,84 (88.4%) had IHD related to atherosclerotic CAD;the youngest patient was 18years old.Predictably there was sole involvement of left anterior descending artery and the presence of fibrous plaques.Irrespective of the plaque morphology,the commonest complication was thrombosis produced by plaque erosion seen in 36.9% of patients.Acute coronary insufficiency was noted in 52 patients (61.9%),while healed infarctions were surprisingly noted in 28 patients (33.3%).Screening for IHD in the young population may help to improve prognosis by detecting subclinical disease,although more studies are necessary to establish reference limits for this young population.Additional research must also focus on treatment concerns that are specific to young patients. | Pradeep Vaideeswar Shashank Tyagi Saranya Singaravel | 2019 | Forensic Sciences Research2019，4，3： | 4 |
| 6 | Prediction of vibrations induced by trains on line 8 of Beijing metro显示文摘This paper mainly discusses the problem of ground-borne vibrations due to the planned line 8 of Beijing metro which passes under the National Measurement Laboratory.A lot of vibration sensitive equipments are placed in the laboratory.It is therefore necessary to study the impact of vibrations induced by metro trains on sensitive equipments and important to propound a feasible vibration mitigation measure.Based on the coupled periodic finite element-boundary element (FE-BE) method,a 3D dynamic track-tunnel-soil interaction model for metro line 8 has been used to predict vibrations in the free field induced by trains running at variable speeds between 30 km/h and 80 km/h.Four types of track structures commonly used on the Beijing metro network have been considered:(1) high resilience direct fixation fasteners,(2) Vanguard fasteners,(3) a floating slab track and (4) a floating ladder track.For each of these track types,the vibration isolation efficiency has been compared.The results of the numerical study can be used to predict vibrations in nearby buildings and to decide upon effective vibration countermeasures. | De-yun DING Shashank GUPTA Wei-ning LIU Geert LOMBAERT Geert DEGRANDE | 2010 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2010，11，4： | 4 |
| 7 | Emerging targets in cancer drug resistance显示文摘Drug resistance is a complex phenomenon that frequently develops as a failure to chemotherapy during cancer treatment.Malignant cells increasingly generate resistance to various chemotherapeutic drugs through distinct mechanisms and pathways.Understanding the molecular mechanisms involved in drug resistance remains an important area of research for identification of precise targets and drug discovery to improve therapeutic outcomes.This review highlights the role of some recent emerging targets and pathways which play critical role in driving drug resistance. | Shashank Kumar Prem Prakash Kushwaha Sanjay Gupta | 2019 | Cancer Drug Resistance2019，2，2： | 3 |
| 8 | Bilateral sequential femoral neck stress fractures in young adult with HIV infection on antiretroviral therapy: A case report显示文摘BACKGROUND Femoral neck stress fractures are rarely encountered among young adults and are often associated with either repetitive excessive loading or underlying bone pathology.Preliminary research has indicated human immunodeficiency virus(HIV)/antiretroviral therapy(ART)as predisposing agents to osteopenia and osteoporosis related complications.We report a case of HIV/ART induced insufficiency fracture in a resource limited setting in Central India.Our aim is to increase awareness and promote screening of HIV/ART related osteopenia and osteoporosis in order to prevent catastrophic orthopaedic complications.CASE SUMMARY A 35-year-old HIV positive male presented with a stress fracture of left femoral neck.The patient was on ART and reported no comorbidities.He went on to be successfully managed surgically.However,during work-up osteopenia of the contralateral proximal femur was recognised using Singh’s Index.Six months post-op the patient presented with right-sided femoral-neck stress fracture.At this stage the patient was nonconcordant with ART and denied surgical fixation.CONCLUSION In the absence of co-morbidities,several mechanisms of HIV/antiretroviral therapy may have played a role in predisposing our patient towards such a presentation.We recommend routine screening all HIV-infected patients for osteopenia,especially in younger individuals.In low resource settings and district hospitals,pelvis radiograph&Singh’s index can be used for screening. | Saisunder Shashank Chaganty Deeptiman James | 2019 | World Journal of Orthopedics2019，10，6： | 3 |
| 9 | Perils of Rib Fractures显示文摘 | Sharma Om P Oswanski Michael F Jolly Shashank Lauer Sherry K Dressel Rhonda Stombaugh Heather A | 2008 | The American Surgeon2008，，4： | 2 |
| 10 | Lineage relationship of CD8^+ T cell subsets is revealed by progressive changes in the epigenetic landscape显示文摘 | Joseph G. Crompton Manikandan Narayanan Suresh Cuddapah Rahul Roychoudhuri Yun Ji Wenjing Yang Shashank J. Patel Madhusudhanan Sukumar Douglas C. Palmer Weiqun Peng Ena Wang Francesco M. Marincola Christopher A. Klebanoff Keji Zhao John S. Tsang Luca Gatt-inoni Nicholas P. Restifo | 2016 | Cellular & Molecular Immunology2016，13，4： | 2 |
| 11 | Self-referenced measurements of the dielectric properties of metals using terahertz time-domain spectroscopy via the excitation of surface plasmon-polaritons显示文摘We present experimental measurements that show direct determination of the dielectric properties of various metals relevant to plasmonics.In contrast to traditional measurements that typically rely on transmission and reflectance measurements,we launch surface plasmon-polaritons on a variety of different substrates and measure the propagation properties using terahertz time-domain spectroscopy.Surprisingly,we find that the extracted values for the dielectric constant for these metals differ by orders of magnitude from published data.In order to validate the obtained results,we separately measure the 1∕e decay length,both along the propagation direction and normal to the metal surface,and show that the results are fully self-consistent with experimental data.The generality of the measurement technique makes it a useful tool to estimate the properties not only of planar conducting substrates but also a wide variety of more complex plasmonic structures. | Shashank Pandey Shuchang Liu Barun Gupta Ajay Nahata | 2013 | Photonics Research2013，1，4： | 2 |
| 12 | Reconstruction of post-traumatic upper extremity soft tissue defects with pedicled flaps: An algorithmic approach to clinical decision making显示文摘Purpose:Pedicled flaps are still the workhorse flaps for reconstruction of upper limb soft tissue defects in many centers across the world. They are lifeboat options for coverage in vessel deplete wounds. In spite of their popularity existing algorithms are limited to a particular region of upper limb;a general algorithm involving entire upper limb which helps in clinical decision making is lacking. We attempt to propose one for the day to day clinical practice.Methods:A retrospective analysis of patients who underwent pedicled flaps for coverage of post-traumatic upper extremity (arm, elbow, forearm, wrist & hand) soft tissue defects within the period of January 2016 to October 2017 was performed. Patients were divided into groups according to the anatomical location of the defects. The flaps performed for different anatomical regions were enlisted. Demographic data and complications were recorded. An algorithm was proposed based on our experience, with a particular emphasis made to approach to clinical decision making.Results:Two hundred and twelve patients were included in the study. Mean age was 27.3 years (range: 1-80 years), 180 were male, and 32 were female. Overall flap success rate was 98%, the following complications were noted marginal flap necrosis requiring no additional procedure other than local wound care in 32 patients (15%), partial flap necrosis requiring flap advancement or extra flap in 15 patients (7%), surgical site infection in 11 patients (5%), flap dehiscence requiring re-suturing in 5 patients (2.4%), total flap necrosis 4 patients (2%).Conclusion:The proposed algorithm allows a reliable and consistent method for addressing diverse soft tissue defects in the upper limb with high success rate. | Ravikiran Naalla Shashank Chauhan Aniket Dave Maneesh Singhal | 2018 | Chinese Journal of Traumatology2018，21，6： | 2 |
| 13 | Strain–temperature hysteresis in concrete under cyclic freeze–thaw conditions显示文摘 | Shashank Bishnoi Taketo Uomoto | 2008 | Cement and Concrete Composites2008，，5： | 2 |
| 14 | Integrative taxonomy of the Plain-backed Thrush(Zoothera mollissima)complex(Aves,Turdidae)reveals cryptic species,including a new species显示文摘Background: The Plain-backed Thrush Zoothera mollissima breeds in the Himalayas and mountains of central China. It was long considered conspecific with the Long-tailed Thrush Zoothera dixoni, until these were shown to be broadly sympatric.Methods: We revise the Z. mollissima–Z. dixoni complex by integrating morphological, acoustic, genetic(two mitochondrial and two nuclear markers), ecological and distributional datasets.Results: In earlier field observations, we noted two very different song types of 'Plain-backed' Thrush segregated by breeding habitat and elevation. Further integrative analyses congruently identify three groups: an alpine breeder in the Himalayas and Sichuan, China('Alpine Thrush'); a forest breeder in the eastern Himalayas and northwest Yunnan(at least), China('Himalayan Forest Thrush'); and a forest breeder in central Sichuan('Sichuan Forest Thrush'). Alpine and Himalayan Forest Thrushes are broadly sympatric, but segregated by habitat and altitude, and the same is probably true also for Alpine and Sichuan Forest Thrushes. These three groups differ markedly in morphology and songs. In addition, DNA sequence data from three non-breeding specimens from Yunnan indicate that yet another lineage exists('Yunnan Thrush'). However, we find no consistent morphological differences from Alpine Thrush, and its breeding range is unknown. Molecular phylogenetic analyses suggest that all four groups diverged at least a few million years ago, and identify Alpine Thrush and the putative 'Yunnan Thrush' as sisters, and the two forest taxa as sisters. Cytochrome b divergences among the four Z. mollissima sensu lato(s.l.) clades are similar to those between any of them and Z. dixoni, and exceed that between the two congeneric outgroup species. We lectotypify the name Oreocincla rostrata Hodgson, 1845 with the Z. mollissima sensu stricto(s.s.) specimen long considered its type. No available name unambiguously pertains to the Himalayan Forest Thrush.Conclusions: The Plain-backed Thrush Z. mollissima s.l. comprises at least three species: Alpine Thrush Z. mollissima s.s., with a widespread alpine breeding distribution; Sichuan Forest Thrush Z. griseiceps, breeding in central Sichuan forests; and Himalayan Forest Thrush, breeding in the eastern Himalayas and northwest Yunnan(at least), which is described herein as a new species. 'Yunnan Thrush' requires further study. | Per Alstrom Pamela C.Rasmussen Chao Zhao Jingzi Xu Shashank Dalvi Tianlong Cai Yuyan Guan Ruiying Zhang Mikhail V.Kalyakin Fumin Lei Urban Olsson | 2016 | Chinese Birds2016，，1： | 2 |
| 15 | Platelets: Linking Hemostasis and Cancer显示文摘 | Shashank Jain John Harris Jerry Ware | 2010 | Arteriosclerosis, Thrombosis, and Vascular Biology2010，，12： | 1 |
| 16 | Intravenous immunoglobulin therapy in acute disseminated encephalomyelitis 显示文摘 | Pradhan S GuPta RP Shashank S | 1999 | J Neurol Sci1999，165，1： | 1 |
| 17 | Oral Nifedipine or Intravenous Labetalol for Hypertensive Emergency in Pregnancy: A Randomized Controlled Trial显示文摘 | Shashank Shekhar Chanderdeep Sharma Sita Thakur Suresh Verma | 2013 | Obstetrics & Gynecology2013，，5： | 1 |
| 18 | Magnetoelectric Effect in Composites of Magnetostrictive and Piezoelectric Materials显示文摘 | Jungho Ryu Shashank Priya Kenji Uchino Hyoun-Ee Kim | 2002 | Journal of Electroceramics2002，，2： | 1 |
| 19 | Parkinsonism due to pr- edominant involvement of substantia nigra in Japanese encephat- itis显示文摘 | Pradhan S Pandey N Shashank S | 1999 | Neurology1999，53，： | 1 |
| 20 | Gamma Knife surgery for intracranial arteriovenousmalformations in children: a retrospective study in 103 patients显示文摘 | Narayanam AN Shashank SH etal | 2007 | Neurosurg2007，107，： | 1 |
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