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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | 金刚石中的冰-Ⅶ相包裹体:来自地球深部地幔的含水流体证据显示文摘水在地球内部不同圈层的存在形态、分布、含量以及全球水循环一直以来都是固体地球科学研究的前沿热点问题之一。冰-Ⅶ相作为水的一种高压相,目前已经被国际矿物学会认定为一种新矿物。 | Tschauner O Huang S Greenberg E Prakapenka V B Rossman G R Shen A H Zhang D Newville M Lanzirotti A Tait K 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 4 |
| 3 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 4 | Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease显示文摘 | R Duara D A. Loewenstein E Potter J Appel M T. Greig R Urs Q Shen A Raj B Small W Barker E Schofield Y Wu H Potter | 2008 | Neurology2008，，24： | 2 |
| 5 | Heme oxygenase-1 gene transfer prevents CD95/FasL-mediated apoptosis and improves liver allograft survival via carbon monoxide signaling pathway显示文摘 | Ke B Shen XD Buelow R | 2002 | Transplant Proc2002，34，5： | 1 |
| 6 | Photocatalytic degradation of methylene blue by a combination of TiO2 and actived carbon fibers显示文摘 | YU R S GUAN R B SHEN W Z | 2005 | Journal of Colloid and Interface Science2005，282，1： | 1 |
| 7 | 查看详情显示文摘 | J R Sun F X Hu B G Shen | | 0，，： | 1 |
| 8 | Event-triggered distributed state estimation with packet dropouts through sensor networks显示文摘 | D R Ding Z D Wang B Shen | 2015 | IET Control Theory and Applications2015，9，13： | 1 |
| 9 | Intestinal response to myeloablative chemotherapy in piglets 显示文摘 | Pontoppidan P L Shen R L Petersen B L | 2014 | Experimental Biology & Medicine2014，239，1： | 1 |
| 10 | Histone deacetylases modulate vascular smooth muscle cell migration induced by cyclic mechanical strain显示文摘 | Yan Z Q Yao Q P Zhang M L Qi Y X Guo Z Y Shen B R | 2009 | J Biomeeh2009，42，： | 1 |
| 11 | TLR3signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71infection显示文摘 | Zhu K Yang J Luo K Yang C Zhang N Xu R Chen J Jin M Xu B Guo N Wang J Chen Z Cui Y Zhao H Wang Y Deng C Bai L Ge B Qin C F Shen H Yang C F Leng Q | 2015 | PLoS Pathog2015，11，10： | 1 |
| 12 | The genome of the platyfish, Xiphophorus maculatus, provides insights into evolutionary adaptation and several complex traits显示文摘 | Schartl M Walter R B Shen Y | 2013 | Nature Genetics2013，45，5： | 1 |
| 13 | Geodetic measurememt of crustal motion in southwest China显示文摘 | King R W Shen P Burchfiel B C | 1997 | Geology1997，25，： | 1 |
| 14 | Kidney-specific cadherin, a specific marker for the distal portion of the nephron and related renal neoplasms显示文摘 | Shen SS Krishna B Chirala R | 2005 | Mod Pathol2005，18，： | 1 |
| 15 | 查看详情显示文摘 | F X Hu B G Shen J R Sun X X Zhang | | 0，，： | 1 |
| 16 | Bulk ferromagnetic glasses prepared by flux melting and water quenching显示文摘 | SHEN T D SCHWARZ R B | | 0，，1： | 1 |
| 17 | 查看详情显示文摘 | Xu Z Sheng L Shen R Wang B Xing D Y | | 0，，： | 1 |
| 18 | 显示文摘 | Hu F X Shen B G Sun J R | 2000 | Appl Phys Lett2000，76，： | 1 |
| 19 | Extraction of Cr(Ⅲ)and other metals from tannery sludge by mineral acids显示文摘 | Shen S B Tyagi R D Blais J F | 2001 | Environ Technol2001，22，9： | 1 |
| 20 | Synthesis and evaluation of shrinkage reducing admixture for cementitious materials 显示文摘 | Bian R B Shen J | 2005 | Cement and Concrete Resarch2005，35，4： | 1 |
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