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| 1 | Activation of disease resistance against Botryosphaeria dothidea by downregulating the expression of MdSYP121 in apple显示文摘In plants,the vesicle fusion process plays a vital role in pathogen defence.However,the importance of the vesicle fusion process in apple ring rot has not been studied.Here,we isolated and characterised the apple syntaxin gene MdSYP121.Silencing the MdSYP121 gene in transgenic apple calli increased tolerance to Botryosphaeria dothidea infection;this increased tolerance was correlated with salicylic acid(SA)synthesis-related and signalling-related gene transcription.In contrast,overexpressing MdSYP121 in apple calli resulted in the opposite phenotypes.In addition,the results of RNA sequencing(RNA-Seq)and quantitative real-time PCR(qRT-PCR)assays suggested that MdSYP121 plays an important role in responses to oxidation–reduction reactions.Silencing MdSYP121 in apple calli enhanced the expression levels of reactive oxygen species(ROS)-related genes and the activity of ROS-related enzymes.The enhanced defence response status in MdSYP121-RNAi lines suggests that syntaxins are involved in the defence response to B.dothidea.More importantly,we showed that MdSYP121 forms a soluble N-ethylmaleimide-sensitive factor attachment protein receptor(SNARE)complex with MdSNAP33,and the complex may participate in regulating resistance to B.dothidea.In conclusion,by regulating the interaction of SA pathway and oxidation–reduction process,MdSYP121 can influence the pathogen infection process in apple. | Xiaowen He Yanhong Huo Xiuxia Liu Qianqian Zhou Shouqian Feng Xiang Shen Baohua Li Shujing Wu Xuesen Chen | 2018 | Horticulture Research2018，5，1： | 3 |
| 2 | Effects of ZrO_2 on the structure and magnetic properties of CoPt thin films显示文摘[CoPt 1.5 nm/ZrO2 x nm]10 multilayer films were deposited on glass substrates by magnetron sputtering and then an-nealed in vacuum at 600°C for 30 min. Their structures and magnetic properties were investigated as a function of ZrO2 content. The results show that the grain size and coercivity first increase and then decrease with the increase in ZrO2 content. The maximum coercivity and grain size are obtained at 37 vol.% of ZrO2. The content of ZrO2 in the film plays an impor-tant role in the separation of CoPt grains and in the reduction of intergrain exchange interaction. On the basis of the studies of angular dependent coercivity, it is found that the magnetization reversal of CoPt films with (111) texture is different from either the domain wall motion or the S-W type of rotation mode. | SHEN Xiaohua XU Xiaohong JIANG Fengxian LV Baohua TIAN Baoqiang JIN Tao | 2007 | Rare Metals2007，26，1： | 2 |
| 3 | In-situ polymerized cross-linked binder for cathode in lithium-sulfur batteries显示文摘Volume expansion and polysulfide shuttle effect are the main barriers for the commercialization of lithium-sulfur(Li-S) battery.In this work,we in-situ polymerized a cross-linked binder in sulfur cathode to solve the aforementioned problems using a facile method under mild conditions.Polycarbonate diol(PCDL),triethanolamine(TEA) and hexamethylene diisocyanate(HDI) were chosen as precursors to prepare the cross-linked binder.The in-situ polymerized binder(PTH) builds a strong network in sulfur cathode,which could restrain the volume expansion of sulfu r.Moreover,by adopting functional groups of oxygen atoms and nitrogen atoms,the binder could effectively facilitate transportation of Li-ion and adsorb polysulfide chemically.The Li-S battery with bare sulfur and carbon/sulfur composite cathodes and cross-linked PTH binder displays much better electrochemical performance than that of the battery with PVDF.The PTH-bare S cathode with a mass loading of 5.97 mg/cm^2 could deliver a capacity of 733.3 mAh/g at 0.2 C,and remained 585.5 mAh/g after 100 cycles.This in-situ polymerized binder is proved to be quite effective on restraining the volume expansion and suppressing polysulfide shuttle effect,then improving the electrochemical performance of Li-S battery. | Heng Ye Danni Lei Lu Shen Bin Ni Baohua Li Feiyu Kang Yan-Bing He | 2020 | Chinese Chemical Letters2020，31，2： | 2 |
| 4 | An ultrathin and continuous Li_4Ti_5O_(12) coated carbon nanofiber interlayer for high rate lithium sulfur battery显示文摘Severe capacity fading and poor high rate performance of lithium sulfur(Li–S) battery caused by 'shuttle effect' and low conductivity of sulfur hampers its further developments and applications. Li_4Ti_5O_(12) (LTO)possesses high lithium ion conductivity, and it is also can be used as an active adsorbent for polysulfide. Herein, fine LTO particle coated carbon nanofibers(CNF) were prepared and a conductive network both for electron and lithium ion was built, which can greatly promote the electrochemical conversion of polysulfide and improve the rate performance of Li–S batteries. Meanwhile, a quantity of adsorption sites is constructed by defects of the surface of LTO-CNF membrane to effectively immobilize polysulfide. The multifunctional LTO-CNF interlayer could impede the shuttle effect and enhance comprehensive electrochemical performance of Li–S batteries, especially high rate performance. With such LTO-CNF interlayer,the Li–S battery presents a specific capacity of 641.9 mAh/g at 5 C rate. After 400 cycles at 1 C, a capacity of 618.0 mAh/g is retained. This work provides a feasible strategy to achieve high performance of Li–S battery for practical utilization. | Decheng An Lu Shen Danni Lei Lehong Wang Heng Ye Baohua Li Feiyu Kang Yan-Bing He | 2019 | Journal of Energy Chemistry2019，28，4： | 2 |
| 5 | A preliminary study on sediment flux in the Changjiang Delta during the Postglacial period 显示文摘 | Li Baohua Li Congxian Shen Huanting | 2003 | Science in China ( Series D)2003，46，7： | 1 |
| 6 | Fabrication and characteristics of nano LiFePO 4 /C composites with high capacity and high rate using nano Fe 2 O 3 as raw materials显示文摘 | BaoHua Rong YanWen Lu XueWen Liu QingLin Chen Kun Tang HuaZhen Yang XingYun Wu Fei Shen YanBin Chen YueFeng Tang YanFeng Chen | 2014 | Nano Energy2014，，： | 1 |
| 7 | News media use, credibility, and efficacy: an analysis of media participation intention in China显示文摘 | Fei Shen Ye Lu Steve Guo Baohua Zhou | 2011 | Chinese Journal of Communication2011，，4： | 1 |
| 8 | Liver resection versus liver transplantation for hepatocellular carcinoma within the Milan criteria based on estimated microvascular invasion risks显示文摘Background:Preoperative prediction of microvascular invasion(MVI)in hepatocellular carcinoma(HCC)may optimize individualized treatment decision-making.This study aimed to investigate the prognostic differences between HCC patients undergoing liver resection(LR)and liver transplantation(LT)based on predicted MVI risks.Methods:We analysed 905 patients who underwent LR,including 524 who underwent anatomical resection(AR)and 117 who underwent LT for HCC within the Milan criteria using propensity score matching.A nomogram model was used to predict preoperative MVI risk.Results:The concordance indices of the nomogram for predicting MVI were 0.809 and 0.838 in patients undergoing LR and LT,respectively.Based on an optimal cut-off value of 200 points,the nomogram defined patients as high-or low-risk MVI groups.LT resulted in a lower 5-year recurrence rate and higher 5-year overall survival(OS)rate than LR among the high-risk patients(23.6%vs 73.2%,P<0.001;87.8%vs 48.1%,P<0.001)and low-risk patients(19.0%vs 45.7%,P<0.001;86.5%vs 70.0%,P=0.002).The hazard ratios(HRs)of LT vs LR for recurrence and OS were 0.18(95%confidence interval[CI],0.09–0.37)and 0.12(95%CI,0.04–0.37)among the high-risk patients and 0.37(95%CI,0.21–0.66)and 0.36(95%CI,0.17–0.78)among the low-risk patients.LT also provided a lower 5-year recurrence rate and higher 5-year OS rate than AR among the high-risk patients(24.8%vs 63.5%,P=0.001;86.7%vs 65.7%,P=0.004),with HRs of LT vs AR for recurrence and OS being 0.24(95%CI,0.11–0.53)and 0.17(95%CI,0.06–0.52),respectively.The 5-year recurrence and OS rates between patients undergoing LT and AR were not significantly different in the low-risk patients(19.4%vs 28.3%,P=0.129;85.7%vs 77.8%,P=0.161).Conclusions:LT was superior to LR for patients with HCC within the Milan criteria with a predicted high or low risk of MVI.No significant differences in prognosis were found between LT and AR in patients with a low risk of MVI. | Pinghua Yang Fei Teng Shilei Bai Yong Xia Zhihao Xie Zhangjun Cheng Jun Li Zhengqing Lei Kui Wang Baohua Zhang Tian Yang Xuying Wan Hao Yin Hao Shen Timothy M Pawlik Wan Yee Lau Zhiren Fu Feng Shen | 2023 | Gastroenterology Report2023，11，1： | 1 |
| 9 | A rapid and accurate UPLC/MS/MS method for the simultaneous determination ofzolpidem and its main metabolites in biological fluids and its application in aforensic context显示文摘 | Yan Shi Ping Xiang Baohua Shen Min Shen | 2012 | Journal of Chromatography B2012，911，： | 1 |
| 10 | Screening for volatile sulphur compounds in a fatal accident case显示文摘Acute fatal poisoning due to the inhalation of toxic gas frequently occurs in China.Volatile sulphur compounds(VSCs)are toxic to humans.In fatal poisoning investigations,such as those in industrial settings,a number of VSCs,including methanethiol(MT),dimethyl sulphide(DMS),dimethyl disulphide(DMDS)and dimethyl trisulphide(DMTS),can coexist.To date,there is limited data regarding these compounds in post-mortem cases.In the present study,we report toxicological findings in a fatal accident case with two victims.Headspace gas chromatography/flame ionization detector with two columns of different polarities was utilized to screen MT,DMS,DMDS and DMTS in blood.The limits of detection in both methods were 0.05 mg/mL.No sulphur compounds were detected in the blood samples of the two victims.DMS and DMDS were detected in the lungs at concentrations of 0.5 and 1.3 mg/g and 2.2 and 4.1 mg/g,respectively.DMDS liver concentrations were 2.5 and 6.5 mg/g.In addition to hydrogen sulphide,screening for additional VSCs could help establish the cause of death. | Ping Xiang Huosheng Qiang Baohua Shen Min Shen | 2017 | Forensic Sciences Research2017，2，4： | 1 |
| 11 | nitiation of ER Body Formation and Indole Glucosinolate Metabolism by the Plastidia Retrograde Signaling Metabolite, MEcPP显示文摘植物发展了紧调整的发信号的网络反应并且适应包含的发信号的中心的环境不安,而是性质仍然是一个谜。我们以前建立了那 methylerythritol cyclodiphosphate (MEcPP ) , plastidial isoprenoids 的一位先锋并且一压力特定后退表明代谢物,为高顺序的适应功能启用细胞的重新调整。这里,我们明确地证明 MEcPP 支持二个 Brassicaceae 特定的特点,也就是 endoplasmic 蜂窝胃(嗯) 身体形成和吲哚 glucosinolate (IG ) 的正式就职新陈代谢有选择地,经由关键管理者 NAI1 为的 transcriptional 规定嗯身体形成 ? 并且为 IG 生合成的 MYB51/122 ) 。MEcPP 的特性被正式就职的缺乏进一步证实创伤可诱导嗯象由另外的改变的 methylerythritol 磷酸盐小径酶的 IG 一样的身体基因。基因分析揭示了这些特点的调停 MEcPP 的 COI1 依赖的正式就职。而且,发信号的 MEcPP 作为 bioactive 结束产品通过 nitrile 修饰符 protein1 和简单 nitriles 的 suppressor, ESM1,和生产的减小的正式就职集成 IG 的生合成和水解作用。调查结果位置 ? plastidial 代谢物, MEcPP 作为开始中心, transducing 发信号调整硬连线的基因电路的活动扩展 phytochemical 差异并且改变为第二等的代谢物的功能要求的联系 subcellular 结构,从而定制植物压力回答。 | Jin-Zheng Wang Baohua Li Yanmei Xiao Yu Ni Haiyan Ke Panyu Yang Amancio de Souza Marta Bjornson Xiang He Zhouxin Shen Gerd Ulrich Balcke Steve P. Briggs Alain Tissier Daniel J. Kliebenstein Katayoon Dehesh | 2017 | Molecular Plant2017，10，11： | 1 |
| 12 | The size and temperature effects of coercivity for the magnetic nanowire : Monte Carlo simulation 显示文摘 | Zhong Kehua Zhang Zhicheng Shen Baohua | 2007 | Solid State Phenomena Vols2007，，： | 1 |
| 13 | Adsorption and desorption mechanisms on graphene oxide nanosheets: Kinetics and tuning显示文摘A knowledge of the adsorption and desorption behavior of sorbates on surface adsorptive site(SAS)is the key to optimizing the chemical reactivity of catalysts.However,direct identification of the chemical reactivity of SASs is still a challenge due to the limitations of characterization techniques.Here,we present a new pathway to determine the kinetics of adsorption/desorption on SASs of graphene oxide(GO)based on total internal reflectance fluorescence microscopy.The switching on and off of the fluorescent signal of SAS lit by carbon dots(CDs)was used to trace the adsorption process and desorption process.We find that sodium pyrophosphate(PPi)could increase the adsorption equilibrium of CDs thermodynamically and promote the substrate-assisted desorption pathway kinetically.At the single turnover level,it was disclosed that the species that can promote desorption may also be an adsorption promoter.Such discovery provides significant guidance for improving the chemical reactivity of the heterogeneous catalyst. | Xiaodan Qu Qiong Hu Zhongqian Song Zhonghui Sun Baohua Zhang Jialing Zhong Xuyou Cao Yuanjin Liu Bolin Zhao Zhenbang Liu Yujie Shen Yu Bao Zhenxin Wang Yuwei Zhang Li Niu | 2021 | The Innovation2021，2，3： | 0 |
| 14 | Analysis of the clinical characteristics and neonatal outcomes of seven cases of pregnancy luteoma discovered incidentally at cesarean section显示文摘Objective:In this study,we summarize the clinical characteristics and neonatal outcomes of patients with pregnancy luteomas that were identified incidentally at cesarean section in our hospital.We also provide a review of the existing literature relating to this condition.Methods:A total of seven cases of pregnancy luteoma were enrolled from our hospital into this retrospective study between March 2013 and February 2018.We then evaluated the clinical characteristics and neonatal outcomes of these patients.Results:All seven patients with pregnancy luteomas found incidentally during Cesarean sections at term as a result of obstetric indications.These masses were unilateral and ranged from 2 to 10 cm in size.All patients underwent partial ovariectomies or oophorocystectomy due to presumptive benign ovarian tumors.Two patients had gestational diabetes and one patient had gestational hypertension.One patient developed hirsutism and a deepened voice.Of the seven newborns,three were girls and four were boys.Physical examinations of the newborns were normal and no virilization was detected among the infant girls.Conclusion:Pregnancy luteoma may be more common than expected.Better strategies are now needed to educate obstetricians about the clinical features of pregnancy luteoma so that they can avoid unnecessary surgery. | Junhua Shen Lanlan Tang Genping Huang Xiaoxia Bai Baohua Li Zhengping Wang | 2021 | Gynecology and Obstetrics Clinical Medicine2021，1，2： | 0 |
| 15 | Gallbladder carcinoma with tumor thrombus in common bile duct: an unusual way of growing invasion显示文摘Objective: To summarize the experience of diagnosis and surgical treatment for a rare invasion manner of gallbladder carcinoma, which was combined with tumor thrombus in common bile duct (CBD). Methods: Between February 2003 and January 2005, 3 patients with gallbladder carcinoma who were identified of tumor thrombus in common bile duct in surgical procedure were retrospectively analyzed. Results: Abdominal ultrasound and magnetic resonance cholangiopancreatography (MRCP) were used for preoperative diagnosis. All 3 patients were given radical operations, which were composed of cholecystectomy, resection of the extrahepatic biliary duct, cuniform hepatectomy of gallbladder bed, skeletonization of the hepatoduodenal ligament, hilar choledochojejunostomy, and clearance of tumor thrombus from biell renal carcinoma. The patient has been doing well without any evidence of recurrence or metastasis for 6 months. | Yang Xinwei Yang Jue Man Xiaobo Zhang Baohua Shen Feng Wu Mengchao | 2012 | Journal of Medical Colleges of PLA(China)2012，27，1： | 0 |
| 16 | YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths显示文摘N6-methyladenosine(m^(6)A)is a critical regulator in the fate of RNA,but whether and how m^(6)A executes its functions in different tissues remains largely obscure.Here we report downregulation of a crucial m^(6)A reader,YTHDF2,leading to tissue-specific programmed cell deaths(PCDs)upon fluorene-9-bisphenol(BHPF)exposure.Currently,Bisphenol A(BPA)substitutes are widely used in plastic manufacturing.Interrogating eight common BPA substitutes,we detected BHPF in 14%serum samples of pregnant participants.In a zebrafish model,BHPF caused tissue-specific PCDs triggering cardiac and vascular defects.Mechanistically,BHPF-mediated downregulation of YTHDF2 reduced YTHDF2-facilitated translation of m^(6)A-gch1 for cardiomyocyte ferroptosis,and decreased YTHDF2-mediated m^(6)A-sting1 decay for caudal vein plexus(CVP)apoptosis.The two distinct YTHDF2-mediated m^(6)A regulations and context-dependent co-expression patterns of gch1/ythdf2 and tnfrsf1a/ythdf2 contributed to YTHDF2-mediated tissue-specific PCDs,uncovering a new layer of PCD regulation.Since BHPF/YTHDF2-medaited PCD defects were also observed in mammals,BHPF exposure represents a potential health threat. | Jiebo Lin Guankai Zhan Jinfeng Liu Yasen Maimaitiyiming Zhiping Deng Baohua Li Kunhui Su Jiafeng Chen Siqi Sun Wanlin Zheng Xianghui Yu Feng He Xiaodong Cheng Lingfang Wang Bin Shen Ziqin Yao Xinquan Yang Jian Zhang Wentao He Hengyu Wu Hua Naranmandura Kao-Jung Chang Junxia Min Jun Ma Mikael Björklund Peng-Fei Xu Fudi Wang Chih-Hung Hsu | 2023 | National Science Review2023，10，12： | 0 |
| 17 | Interactions of human islet amyloid polypeptide with lipid structure of different curvatures显示文摘Curvature is one of the most important features of lipid membranes in living cells,which significantly influences the structure of lipid membranes and their interaction with proteins.Taken the human islet amyloid polypeptide(h IAPP),an important protein related to the pathogenesis of type II diabetes,as an example,we performed molecular dynamics(MD)simulations to study the interaction between the protein and the lipid structures with varied curvatures.We found that the lipids in the high curvature membrane pack loosely with high mobility.The h IAPP initially forms H-bonds with the membrane surface that anchored the protein,and then inserts into the membrane through the hydrophobic interactions between the residues and the hydrophobic tails of the lipids.h IAPP can insert into the membrane more deeply with a larger curvature and with a stronger binding strength.Our result provided important insights into the mechanism of the membrane curvature-dependent property of proteins with molecular details. | Le Mei Wenhui Shen Xuwei Wu Jie Liu Dechang Li Baohua Ji | 2020 | Theoretical & Applied Mechanics Letters2020，10，6： | 0 |
| 18 | Multiphase redistribution differences of polycyclic aromatic hydrocarbons (PAHs) between two successive sediment suspensions显示文摘连续沉积暂停经常发生在河口,然而,很少研究都没在不同暂停之中在有机化合物的版本行为探查进差别。这研究拿了多不的芳香的烃(哼) 同样典型的器官的沾染物并且与一个粒子乘火车模拟器(足) 调查了在二连续暂停之间的版本行为。结果证明连续沉积暂停降低了集中溶解经由便于重新吸附在 overlying 水里哼溶解哼到推迟的粒子上。快版本、慢版本的时期哼连续地在两暂停被观察。集中变化溶解在第二暂停哼通常是类似的与但是在第一暂停的 hysteretic 到那些。更精力旺盛的解吸附作用和重吸收哼在第二暂停被导致。连续沉积暂停显然减少了在 overlying 的矿物质作文和有机物的集中流水,它显著地影响多相的分发哼。 | Rufeng LI Chenghong FENG Dongxin WANG Baohua LI Zhenyao SHEN | 2016 | Frontiers of Environmental Science & Engineering2016，10，2： | 0 |
| 19 | Effects of co-exposure to lead and manganese on learning and memory deficits显示文摘Lead(Pb) and manganese(Mn) are common neurotoxins. However, individuals are subject to co-exposures in real life, and it is therefore important to study these metals in combination. Weaning Sprague-Dawley rats were given ad libitum access to drinking water solutions containing Pb(100 mg/L), Mn(2.5 mg/m L) or a mixture, and each treatment had its own minocycline(50 mg/(kg·day)) supplement group. The results showed a significant difference in spatial memory and induction levels of hippocampal long-term potentiation(LTP) in all exposure groups when compared with controls. The combined-exposure group exhibited the most pronounced effect when compared with each of the single-metal exposure groups.Microglia displayed activation at day 3 after exposure alone or in combination, while astrocytes showed activation at day 5, accompanied by decreased expression levels of GLAST,GLT-1, and GS. Furthermore, the levels of glutamate in the synaptic cleft increased significantly. When microglial activation was inhibited by minocycline, the activation of astrocytes and the expression of GLAST, GLT-1, and GS were both reversed. In addition, upon minocycline treatment, hippocampal LTP impairment and cognitive injury were significantly alleviated in each of the exposure groups. These results suggest that combined exposure to Pb and Mn can cause greater effects on cognition and synaptic plasticity when compared to single-metal exposure groups. The reason may involve abnormal activation of microglia leading to excessive regulation of astrocytes, resulting in glutamate reuptake dysfunction in astrocytes and leading to perturbed cognition and synaptic plasticity. | Ruili Guan Tao Wang Xiaoru Dong Kejun Du Juan Li Fang Zhao Jie Xu Bin Li Gang Zheng Xuefeng Shen Baohua Cao Jing Wang Michael Aschner Mingchao Liu Rui Chen | 2022 | Journal of Environmental Sciences2022，34，11： | 0 |
| 20 | Separation and Preliminary Identification of Intestinal Probiotics of Laying Hens显示文摘[Objective] The paper was to isolate and identify probiotics in the intestine of laying hens. [Method] The intestinal probiotics in laying hens at peak period were isolated using conventional separation methods; the physical and chemical properties of target strains and in vitro antibacterial effects were measured. Moreover, the safety test of chicks was conducted. [Result] Four strains of lactobacillus were isolated from the jejunum of laying hens, including Lactobacillus plantarum, Bacillus acidophilus, L. delbrueckii subsp. Delbrueckii and L. delbrueckii subsp. Lactis, and their inhibition zone diameters were 18.30, 16.07, 11.45, 17.26 mm, respectively. One strain of Lactobacillus, L. brevis, was isolated from the cecum, with the inhibition zone diameter of 10.26 mm. Three strains of bacillus were isolated from the cecum, including Bacillus subtilis, B. cereus and B. licheniformis, and their inhibition zone diameters were 9.25, 8.46 and 8.37 mm, respectively. Daily drinking 2 billion units of viable bacteria was the safe dosage for chicks. [Conclusion] Eight strains of probiotics had certain inhibitory effect on Escherichia coli O_2, and had no toxic side effects to chicks. Lactobacillus had strong antibacterial effect on E. coli O_2, while the antibacterial effect of bacillus was relatively weak. | Guo Shijin Zhang Zhimei Fu Shijun Mo Ling Zhang Ying Shen Zhiqiang Huang Baohua | 2018 | Animal Husbandry and Feed Science2018，10，1： | 0 |
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