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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 3 | JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling(摘要)显示文摘 | Bai, J Zhang, J Wu, J Shen, L Zeng, J Ding, J Wu, Y Gong, Z Li, A Xu, S Zhou, J Li, G | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 4 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 5 | Geometric phase in spin precession and the adiabatic approximation 显示文摘 | Ni G J Chen S Q Shen Y L | 1995 | Phys Lett1995，197，： | 2 |
| 6 | Analysis of cognitive radio spectrum access with optimal channel reservation 显示文摘 | ZHU X SHEN L YUM T S | 2007 | IEEE Communication Letters2007，11，4： | 1 |
| 7 | Endothelial ceils stimulate self-renewal and expand neurogenesis of neural stem cells显示文摘 | SHEN Q GODERIE S K JIN L | 2004 | Science2004，304，5675： | 1 |
| 8 | Tape-Arabidopsis Sandwich - a simpler Arabidopsis protoplast isolation method 显示文摘 | Wu F H Shen S C Lee L Y | 2009 | Plant Methods2009，5，16： | 1 |
| 9 | Nuclear magnetic resonance studies of 5,7-dihydroxyflavonoids 显示文摘 | Shen C C Chang Y S Ho L K | 1993 | Phytochem1993，34，3： | 1 |
| 10 | Synthesis and antibacterial activities of quaternary ammonium salt of chitosan显示文摘 | Jia Z S Shen D F Xu W L | 2001 | Carbohydrate Res2001，333，1： | 1 |
| 11 | Proximity algorithms for the L1/TV image denoising model显示文摘 | Micchelli C A Shen L X Xu Y S | 2011 | Advances in Com- putational Mathematics2011，34，4： | 1 |
| 12 | Morphology and mechanical properties of intermetallic compounds in SnAgCu solderjoints显示文摘 | Chandra Rao B S S Weng J Shen L | 2010 | MicroelectronEngineering2010，87，11： | 1 |
| 13 | One-stop hybrid coronary revascularization versus coronary artery bypass grafting and percutaneous coronary intervention for the treatment of multivessel coronary artery disease: 3-year follow-up results from a single institution显示文摘 | Shen L Hu S Wang H | 2013 | J Am Coll Cardiol2013，61，： | 1 |
| 14 | Particle stick- ing behavior near the throat of a low-NOx Lxial-swirl coal burner 显示文摘 | Li Z Q Zeng L Y Zhao G B Shen S P Zhang F C | 2011 | Applied Energy2011，88，： | 1 |
| 15 | Estimation of crowd density based on wavelet and support vector machine显示文摘 | Li X H Shen L S Li H Q | 2006 | Transactions of the Institute of Measurement and Control2006，28，3： | 1 |
| 16 | Nitrogen transfer of fuel-N in chemical looping combustion 显示文摘 | Song T Shen L H Xiao J Chen D Q Gu H M Zhang S W | 2012 | Combustion and Flame2012，159，3： | 1 |
| 17 | Fission trakc dating of Mesozoic sandstone and its tectonic significance in the Eastern Si chuan basin, China显示文摘 | Shen C B Mei L F Xu S H | 2009 | Radiation Measurements2009，44，： | 1 |
| 18 | Effect of ultrasonic vibration on fluid-to-particle convective heat transfer coefficients显示文摘 | Sastry S K Shen G Q Blaisdell J L | 1989 | Journal of Food Science1989，54，4： | 1 |
| 19 | Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation显示文摘 | SHEN L YAN P S | 2004 | Proc Natl Acad Sci USA2004，101，： | 1 |
| 20 | Hippocampal CA1 kindling but not long-term potentiation disrupts spatial memory performance显示文摘 | Leung L S Shen B | 2006 | Learn Mem2006，13，1： | 1 |
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