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| 1 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 2 | 金刚石中的冰-Ⅶ相包裹体:来自地球深部地幔的含水流体证据显示文摘水在地球内部不同圈层的存在形态、分布、含量以及全球水循环一直以来都是固体地球科学研究的前沿热点问题之一。冰-Ⅶ相作为水的一种高压相,目前已经被国际矿物学会认定为一种新矿物。 | Tschauner O Huang S Greenberg E Prakapenka V B Rossman G R Shen A H Zhang D Newville M Lanzirotti A Tait K 张宝华 | 2018 | 矿物岩石地球化学通报2018，37，6： | 4 |
| 3 | 基于工作地点的分组干预对高血压控制的影响:一项随机临床研究显示文摘基于工作地点的干预可能为一种管理高血压的有效方法。但是目前缺少针对中国工作人群高血压控制情况的研究。本研究旨在评估基于工作地点的多组分别干预策略对改善血压控制的影响。研究设计及受试者:研究者在2013年1月至2014年12月于中国20个城区的60个工作地点进行了一系列高血压管理的随机临床试验。工作地点随机分为干预组(n=40)和对照组(n=20)。每个工作地点的受试者都需要完成一项横断面调查。 | 袁源(摘译) 叶鹏(审校) Wang Z Wang X Shen Y Li S Chen Z Zheng C Kang Y Jiang L Hao G Chang C Gao R | 2020 | 中华高血压杂志2020，28，6： | 3 |
| 4 | Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility:a case-control analysis显示文摘The BRCA1 Associated RING Domain(BARD1) gene has been identified as a high penetrance gene for breast cancer, whose germline and somatic mutations were reported in both non-BRCA1/2 hereditary site-specific and sporadic breast cancer cases. BARD1 plays a crucial role in tumor repression, along with its heterodimeric partner BRCA1. In the current study, we tested the hypothesis that common non-synonymous polymorphisms in BARD1 are associated with breast cancer susceptibility in a case-control study of 507 patients with incident breast cancer and 539 frequency-matched cancer-free controls in Chinese women. We genotyped all three common(minor allele frequency (MAF) > 0.10) non-synonymous polymorphisms(Pro24Ser, Arg378Ser, and Val507Met) in BARD1. We found that the BARD1 Pro24Ser variant genotypes(24Pro/Ser and 24Ser/Ser) and Arg378Ser variant homozygote 378Ser/Ser were associated with a significantly decreased breast cancer risk, compared with their wild-type homozygotes, respectively. Furthermore, a significant locus-locus interaction was evident between Pro24Ser and Arg378Ser (P-int = 0.032). Among the 378Ser variant allele carriers, the 24Pro/Pro wild-type homozygote was associated with a significantly increased breast cancer risk (adjusted OR = 1.81, 95% CI = 1.11-2.95), but the subjects having 24Pro/Ser or Ser/Ser variant genotypes had a significantly decreased risk(adjusted OR = 0.74, 95% CI = 0.56-0.99). In stratified analysis, this locus-locus interaction was more evident among subjects without family cancer history, those with positive estrogen receptor (ER) and individuals with negative progesterone receptor(PR). These findings indicate that the potentially functional polymorphisms Pro24Ser and Arg378Ser in BARD1 may jointly contribute to the susceptibility of breast cancer. | Huo, X Hu, Z. B Zhai, X. J Wang, Y Wang, S Wang, X. C Qin, J. W Chen, W. S Jin, G. F Liu, J. Y Gao, J Wei, Q. Y Wang, X. R Shen, H. B | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 3 |
| 5 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，： | 3 |
| 6 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，1971： | 2 |
| 7 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and nonstationary time series analysis显示文摘 | Huang N E Shen Z Long S R | | 0，，1971： | 2 |
| 8 | Studies on the toxic effects of pentachlorophenol on the biological activity of anaerobic granular sludge 显示文摘 | Liu X W He R Shen D S | 2008 | J Environ Manage2008，88，： | 1 |
| 9 | Growth inhibition of prostate cancer cells by epigallocatechin gallate in the presence of Cu^2+显示文摘 | Yu H N Yin J J Shen S R | 2004 | J Agric Food Chem2004，52，3： | 1 |
| 10 | Photocatalytic degradation of methylene blue by a combination of TiO2 and actived carbon fibers显示文摘 | YU R S GUAN R B SHEN W Z | 2005 | Journal of Colloid and Interface Science2005，282，1： | 1 |
| 11 | 显示文摘 | Shen Y Q Zhu S P Zheng F Q Pelton R | 2000 | Macromolecules2000，33，： | 1 |
| 12 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and nonstationary time series analysis 显示文摘 | Huang N E Zheng Shen Long S R | 1998 | Proceedings of the Royal Society A : Mathematical Physical and Engineering Sciences1998，454，1971： | 1 |
| 13 | The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings Of The Royal Society of London Series A-Mathematical Physical And Engineering Sciences1998，454，： | 1 |
| 14 | The empirical modedecomposition and the Hilbert spectrum for nonlinear andnon-stationary time series analysis显示文摘 | HUANG N E SHEN Z LONG S R | 1998 | Proceedings of theRoyal Society of London1998，454，1： | 1 |
| 15 | Coal use,stove improvement,and adult pneumonia mortality in Xuanwei,China :a retrospective cohort study显示文摘 | SHEN Min CHAPMAN R S VERMEULEN R | 2009 | Environmental HealthPerspectives2009，117，2： | 1 |
| 16 | The empirical mode decomposition and the Hilbert spectrum for non- linear and non- stationary time series analysis显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society of London Series A: Mathematical Physical and Engineering Sciences1998，454，： | 1 |
| 17 | The empirical mode 34 decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society A1998，，454： | 1 |
| 18 | The empirical mode decompo- sition and hilbert spectrum for nonlinear and nonstationary time series analysis显示文摘 | Huang N E Shen Z Long S R | 1998 | Proceedings of the Royal Society of London SERIESA1998，454，： | 1 |
| 19 | Improving tunneling junction in amorphous silicon tandem solar cells 显示文摘 | Shen D S Schropp R E I Chathem H | 1990 | Applied Physics Letters1990，56，： | 1 |
| 20 | The empir- ical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis 显示文摘 | Huang N E Shen Zheng Long S R | 1998 | Proceeding of the Royal Society A: Mathematical Phys- ical & the Engineering Sciences1998，，： | 1 |
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