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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Establishment and Preliminary Application of a Rapid Fluorescent Focus Inhibition Test (RFFIT) for Rabies Virus显示文摘The World Health Organization (WHO) standard assay for determining levels of the rabies virus neutralization antibody (RVNA) is the rapid fluorescent focus inhibition test (RFFIT), which is used to evaluate the immunity effect after vaccination against rabies. For RFFIT, CVS-11 was used as the challenge virus, BSR cells as the adapted cells, and WHO rabies immunoglobulin (WHO STD) as the reference serum in this study. With reference to WHO and Pasteur RFFIT procedures, a micro-RFFIT procedure adapted to our laboratory was produced, and its specificity and reproducibility were tested. We tested levels of RVNA in human serum samples after immunization with different human rabies vaccines (domestic purified Vero cell rabies vaccine (PVRV) and imported purified chick embryo cell vaccine (PCECV)) using different regimens (Zagreb regimen and Essen regimen). We analyzed the levels of RVNA, and compared the immune efficacy of domestic PVRV and imported PCECV using different immunization regimens. The results showed that the immune efficacy of domestic PVRV using the Zagreb regimen was as good as that of the imported PCECV, but virus antibodies were generated more rapidly with the Zagreb regimen than with the Essen regimen. The RFFIT procedure established in our laboratory will enhance the comprehensive detection ability of institutions involved in rabies surveillance in China. | Pengcheng Yu Xinjun Lv Xinxin Shen Qing Tang Guodong Liang | 2013 | Virologica Sinica2013，28，4： | 11 |
| 3 | Mars Orbiter magnetometer of China’s First Mars Mission Tianwen-1显示文摘As one of the seven scientific payloads on board the Tianwen-1 orbiter,the Mars Orbiter Magnetometer(MOMAG)will measure the magnetic fields of and surrounding Mars to study its space environment and the interaction with the solar wind.The instrument consists of two identical triaxial fluxgate magnetometer sensors,mounted on a 3.19 meter-long boom with a seperation of about 90 cm.The dual-magnetometers configuration will help eliminate the magnetic field interference generated by the spacecraft platform and payloads.The sensors are controlled by an electric box mounted inside the orbiter.Each magnetometer measures the ambient vector magnetic field over a wide dynamic range(to 10,000 nT per axis)with a resolution of 1.19 pT.Both magnetometers sample the ambient magnetic field at an intrinsic frequency of 128 Hz,but will operate in a model with alternating frequency between 1 and 32 Hz to meet telemetry allocations. | Kai Liu XinJun Hao YiRen Li TieLong Zhang ZongHao Pan ManMing Chen XiaoWen Hu Xin Li ChengLong Shen YuMing Wang | 2020 | Earth and Planetary Physics2020，4，4： | 2 |
| 4 | Generation and characterization of neutralizing human recombinant antibodies against antigenic site II of rabies virus glycoprotein显示文摘 | Lina Sun Zhe Chen Li Yu Jingshuang Wei Chuan Li Jing Jin Xinxin Shen Xinjun Lv Qing Tang Dexin Li Mifang Liang | 2012 | Applied Microbiology and Biotechnology2012，，2： | 1 |
| 5 | Modeling Strategies for Reconfigurable Assembly System显示文摘 | Yu Jianfeng Yin Yuehong Shen Xinjun | 2003 | Assembly Automation2003，13，3： | 1 |
| 6 | Modeling strateg ies for reconfigurable assembly system, Assembly Automatio显示文摘 | Yu Jianfeng Yin Yuehong Shen Xinjun Chen Zhaoneng | 2003 | Assem bly Automation2003，13，3： | 1 |
| 7 | A twin projection support vector machine for data regression显示文摘 | Peng Xinjun Xu Dong Shen Jindong | 2014 | Neurocom- puting2014，138，： | 1 |
| 8 | A low-energy ion spectrometer with half-space entrance for three-axis stabilized spacecraft显示文摘A low-energy ion spectrometer(LEIS) for use aboard three-axis stabilized spacecraft has been developed to measure ion energy per charge distribution in three-dimensional space with good energy-, angular-and temporal-resolutions. For the standard top-hat electrostatic analyzer used widely in space plasma detection, three-axis stabilized spacecraft makes it difficult to obtain complete coverage of all possible ion arrival directions. We have designed angular scanning deflectors supplementing to a cylindrically symmetric top-hat electrostatic analyzer to provide a half-space field of view as 360°×90°(–45°–+45°), and fabricated the LEIS flight model for detecting magnetospheric ions in geosynchronous orbit. The performance of this payload has been evaluated in detail by a series of simulation and environmental tests, and the payload has also been calibrated through laboratory experiments using a low-energy ion source. The results show that capabilities of the LEIS payload are in accordance with the requirements of a magnetospheric mission. | HU RenXiang SHAN Xu YUAN GuangYuan WANG ShuWen ZHANG WeiHang QI Wei CAO Zhe LI YiRen CHEN ManMing YANG XiaoPing WANG Bo SHAO SiPei LI Feng ZHONG XiaoQing FAN Dan HAO XinJun FENG ChangQing SU ZhenPeng SHEN ChengLong LI Xin DAI GuYue QIU BingLin PAN ZongHao LIU Kai XU ChunKai LIU ShuBin AN Qi ZHANG TieLong WANG YuMing CHEN XiangJun | 2019 | Science China(Technological Sciences)2019，62，6： | 1 |
| 9 | Identification of three kinds of Plumeria flowers by DNA barcoding and HPLC specific chromatogram显示文摘DNA barcoding and HPLC specific chromatogram were used to identify three kinds of Plumeria flowers respectively. DNAs extracted from the three Plumeria species were amplified by PCR with universal primers, and the psb A-trn H region was selected. All the amplified products were sequenced and the results were analyzed by MEGA 5.0. Chemometric methods including principal components analysis and hierarchical clustering analysis were conducted on the SAS 9.0 software to demonstrate the variability among samples. In conclusion, the psb A-trn H of all samples were successfully amplified from total DNA and sequenced. These three varieties of Plumeria can be differentiated by the psb A-trn H region and clustered into three groups respectively through building neighbor joining tree, which conformed to their germplasm origins. However, it was hard to distinguish them by HPLC specific chromatograms combined with chemometrics analysis. These indicated that DNA barcoding was a promising and reliable tool for the identification of three kinds of Plumeria flowers compared to HPLC specific chromatogram generally used. It could be treated as a powerful complementary method for traditional authentication,especially for those varieties which are difficult to be identified by conventional chromatography. | Leilei Zhao Xiaoxue Yu Jie Shen Xinjun Xu | 2018 | Journal of Pharmaceutical Analysis2018，8，3： | 1 |
| 10 | First results of the low energy ion spectrometer onboard a Chinese geosynchronous satellite显示文摘A Chinese geosynchronous satellite was launched on June 23,2020.It carried a plasma detection package to monitor the space environment around the orbit.Here we report the inflight performance of a low energy ion spectrometer(LEIS),one of the primary instruments in the plasma detection package,and its initial observations in flight.Benefiting from the state-of-the-art design of a top-hat electrostatic analyzer cooperated with angular scanning deflectors,three-dimensional measurement of ions in space with a large field of view of 360°×90°and a wide energy range from 50 eV to 25 keV per charge has been achieved.The differential energy flux spectra of ions around the orbit have shown clear signatures of surface charging and storm/substorm ion injections.The occurrence of surface charging could be caused by the lack of photoemission at the Earth's eclipse(near the midnight)or the storm energetic electron injection at the dawn sector.The present results demonstrated a good performance of the LEIS payload in flight for monitoring the space ion environment around the orbit.In situ measurements of the LEIS payload provide us an opportunity to understand the magnetospheric ion dynamics and forecast the associate space weather impacts. | SHAN Xu MIAO Bin CAO Zhe SUN ZhenYu LI YiRen LIU Kai GUO XingYu QU SanBiao SU ZhenPeng SHEN ChengLong PAN ZongHao LI Xin HAO XinJun YANG XiaoPing TIAN Chao JIANG Yu LIU ShuBin AN Qi CHEN XiangJun WANG YuMing | 2023 | Science China(Technological Sciences)2023，66，5： | 0 |
| 11 | In-flight calibration of the magnetometer on the Mars orbiter of Tianwen-1显示文摘Mars orbiter magnetometer(MOMAG)is one of seven science payloads onboard Tianwen-1’s orbiter.Unlike most of the satellites,Tianwen-1’s orbiter is not magnetically cleaned,and the boom where placed the magnetometer’s sensors is not long enough.These pose many challenges to the magnetic field data processing.In this study,we introduce the in-flight calibration process of the Tianwen-1/MOMAG.The magnetic interference including spacecraft generated dynamic field and the slowlychanging zero offsets are cleaned in sequence.Then the calibrated magnetic field data are compared with the data from the Mars atmosphere and volatile Evolutio N(MAVEN).We find that some physical structures in the solar wind are consistent between the two data sets,and the distributions of the magnetic field strength in the solar wind are very similar.These results suggest that the in-flight calibration of the MOMAG is successful and the MOMAG provides reliable data for scientific research. | ZOU ZhuXuan WANG YuMing ZHANG TieLong WANG GuoQiang XIAO SuDong PAN ZongHao ZHANG ZhouBin YAN Wei DU Yang CHI YuTian CHENG Long WU ZhiYong HAO XinJun LI YiRen LIU Kai CHEN ManMing SU ZhenPeng SHEN ChengLong XU MengJiao GUO JingNan | 2023 | Science China(Technological Sciences)2023，66，8： | 0 |
| 12 | The Mars orbiter magnetometer of Tianwen-1:in-flight performance and first science results显示文摘The Mars Orbiter MAGnetometer(MOMAG)is a scientific instrument onboard the orbiter of China’s first mission for Mars—Tianwen-1.Since November 13,2021,it has been recording magnetic field data from the solar wind to the magnetic pile-up region surrounding Mars.Here we present its in-flight performance and first science results,based on its first one and one-half months’data.Comparing these early MOMAG observations to the magnetic field data in the solar wind from NASA’s Mars Atmosphere and Volatile EvolutioN(MAVEN)mission,we report that the MOMAG magnetic field data are at the same level in magnitude,and describe the same magnetic structures with similar variations in three components.We recognize 158 clear bow shock(BS)crossings in these MOMAG data;their locations match well statistically with the modeled average BS.We also identify and compare five pairs of datasets collected when Tianwen-1’s orbiter and the MAVEN probe made simultaneous BS crossings.These BS crossings confirm the global shape of modeled BS,as well as the south-north asymmetry of the Martian BS.Two cases presented in this paper suggest that the BS is probably more dynamic at flank than near the nose.So far,MOMAG performs well,and provides accurate magnetic field vectors.MOMAG is continuously scanning the magnetic field surrounding Mars.Data from MOMAG’s measurements complement data from MAVEN and will undoubt edly advance our understanding of the plasma environment of Mars. | YuMing Wang TieLong Zhang GuoQiang Wang SuDong Xiao ZhuXuan Zou Long Cheng ZongHao Pan Kai Liu XinJun Hao YiRen Li ManMing Chen ZhouBin Zhang Wei Yan ZhenPeng Su ZhiYong Wu ChengLong Shen YuTian Chi MengJiao Xu JingNan Guo Yang Du | 2023 | Earth and Planetary Physics2023，7，2： | 0 |
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