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| 1 | The Axin/TNKS complex interacts with KIF3A and is required for insulin-stimulated GLUT4 translocation显示文摘由葡萄糖 transporter GLUT4 的刺激胰岛素的葡萄糖举起在整个身体的葡萄糖动态平衡起一个中央作用,哪个导致类型 2 糖尿病的 dysregulation。然而,调整刺激胰岛素的葡萄糖举起的分子的部件和机制仍然保持大部分不清楚。这里,我们证明 Axin 与 ADP-ribosylase tankyrase 交往 2 (TNKS2 ) 并且 kinesin 马达蛋白质 KIF3A,响应胰岛素形成为 GLUT4 translocation 关键的第三的建筑群。特定到血浆膜的复杂稀释刺激胰岛素的 GLUT4 translocation 的单个部件击倒。重要地, TNKS2 −/− 老鼠展出减少的胰岛素敏感和更高的血葡萄糖层次什么时候在 fasting 以后的 re-fed。机械学地,我们证明当胰岛素不在时, Axin, TNKS 和 KIF3A 与 trans-Golgi 网络上的 GLUT4 是 co 局部性的。胰岛素处理压制 TNKS 的 ADP-ribosylase 活动,导致在自动数据处理 ribosylation 和 ubiquitination 的减小 Axin 和 TNKS,和建筑群的并发的稳定。Akt 的抑制,胰岛素发信号的主要受动器 kinase,废除调停胰岛素的复杂稳定。我们因此阐明了直接在刺激胰岛素的 GLUT4 translocation 与马达蛋白质 kinesin 被联系的新蛋白质建筑群。 | Hui-Ling Guo Cixiong Zhang Qi Liu Qinxi Li Guili Lian Di Wu Xuebin Li Wei Zhang Yuemao Shen Zhiyun Ye Slau-Yong Lin Sheng-Cai Lin | 2012 | Cell Research2012，22，8： | 4 |
| 2 | Natural product sciences: an integrative approach to the innovations of plant natural products显示文摘The study on plant natural products not only helps us understand that their structural diversity is the inevitable result of plant species diversity, but also helps us understand certain rules and unity of the inevitable connection between the two. The diversity and complexity of chemical structures of many natural products are beyond imagination before we elucidated their structures.The question that follows is what is the biological significance of these natural products. Intrigued by the relationship between plant resources, natural products and biological functions, the Hao laboratory has taken an integrative approach that employs tools and knowledge from multi-disciplines, including natural product chemistry, chemical ecology and chemical biology, to unveil the effects of plant natural products on plant resistance to diseases, and environmental acclimations. Collaborating with cell biologists, the research has resulted in discovery of new mechanisms of cellular signaling and lead compounds. | Yuemao Shen Xiaojiang Hao | 2020 | Science China(Life Sciences)2020，63，11： | 2 |
| 3 | Chemical and Genetic Diversity of Some Ligularia Species (Compositae) in Northwestern Yunnan and Southwestern Sichuan of China显示文摘 | Chiaki Kuroda Ryo Hanait Xun Gong Yuemao Shen Motoo Tori | 2005 | 复旦学报(自然科学版)2005，44，5： | 1 |
| 4 | Lysohexaenetides A and B,linear lipopeptides from Lysobacter sp.DSM 3655 identified by heterologous expression in Streptomyces显示文摘Lysobacter harbors a plethora of cryptic biosynthetic gene clusters(BGCs),albeit only a limited number have been analyzed to date.In this study,we described the activation of a cryptic polyketide synthase(PKS)/nonribosomal peptide synthetase(NRPS)gene cluster(lsh)in Lysobacter sp.DSM 3655 through promoter engineering and heterologous expression in Streptomyces sp.S001.As a result of this methodology,we were able to isolate two novel linear lipopeptides,lysohexaenetides A(1)and B(2),from the recombinant strain S001-lsh.Furthermore,we proposed the biosynthetic pathway for lysohexaenetides and identified LshA as another example of entirely iterative bacterial PKSs.This study highlights the potential of heterologous expression systems in uncovering cryptic biosynthetic pathways in Lysobacter genomes,particularly in the absence of genetic manipulation tools. | XU Qiushuang ZOU Haochen PAN Chen WANG Haoxin SHEN Yuemao LI Yaoyao | 2023 | Chinese Journal of Natural Medicines2023，21，6： | 1 |
| 5 | Challeng the potential of chemical defenses from antimicrobial activities显示文摘 | Lu Chunhua Shen Yuemao | 2004 | Bioessays2004，26，7： | 1 |
| 6 | A pentanor- triterpenoid with a novel carbon skeleton and a new pregnane from Trichilia connaroides 显示文摘 | Zhang Huaping Wu Shaohua Shen Yuemao | 2003 | Can J Chem2003，81，： | 1 |
| 7 | Harnessing the potential of chemical defenses from antimicrobial activities显示文摘 | Chunhua Lu Yuemao Shen | 2004 | BioEssays2004，26，7： | 1 |
| 8 | T-he Chemistry and Biochemistry of Spiraea japonica Complex显示文摘 | Shen Yuemao Li Ling | 2003 | Current Medicinal Chemistry2003，10，1： | 1 |
| 9 | Effect of salinity on the growth,biological activity and secondary metabolites of some marine fungi显示文摘The study investigated the effects of salinity on growth,antimicrobial activities and secondary metabolites of 47 marine filamentous fungi isolated from the East China Sea near the western shore of the Taiwan Straits.The results indicate that NaCl promoted the growth up to 91.5% of test strains.However,only 14.9% of them showed a significant increase of antimicrobial activity against Candida albicans.When incubated in different concentrations of NaCl,the colony growth, antimicrobial activities and composition of secondary metabolites of the strain Ty01b-8 of Penicillium sp.varied.Treatment with KCl also showed a similar effect.An alkaloid isolated from the fermentation broth of Ty01b-8 was identified as chrysogine,inhibition activity of which against Hela cells was 15.05% at 20 μ g/ml,and yield was 4.4 and 4.9 times higher in 3 percent and 6 percent NaCl treatments,respectively, compared with the non-salt culture condition. These findings prove that salinity is an important factor influencing growth and secondary metabolites of some marine fungi,which can be used to screen for new metabolites from marine fungi,and to enhance their metabolites production in industrial fermentation. | HUANG Jingjing LU Chunhua QIAN Xiaoming HUANG Yaojian ZHENG Zhonghui SHEN Yuemao | 2011 | Acta Oceanologica Sinica2011，30，3： | 1 |
| 10 | Secondary metabolites of Aspergillus sp. F1, a commensal fungal strain of Trewia nudiflora显示文摘 | Ting Lin Chunhua Lu Yuemao Shen | 2009 | Natural Product Research2009，，1： | 1 |
| 11 | Secondary metabolites from endophytic Streptomyces aureofaciens CMUAc 130 and their antifungal activity显示文摘 | Thongchai T Lu Chunhua Shen Yuemao | 2005 | Microbiology2005，151，： | 1 |
| 12 | Water-soluble constituents from Cal- licarpa pedunculata显示文摘 | Lu Chunhua Shen Yuemao | 2008 | Chin J Nat Med2008，6，3： | 1 |
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