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| 1 | Synthesis and Characterization of a Silica-Based Drug Delivery System for Spinal Cord Injury Therapy显示文摘Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy. | Guodong Sun Shenghui Zeng Xu Liu Haishan Shi Renwen Zhang Baocheng Wang Changren Zhou Tao Yu | 2019 | Nano-Micro Letters2019，11，2： | 1 |
| 2 | Crystal structures of main proteases of SARS-CoV-2 variants bound to a benzothiazole-based inhibitor显示文摘Main protease(Mpro)serves as an indispensable factor in the life cycle of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as well as its constantly emerging variants and is therefore considered an attractive target for antiviral drug development.Benzothiazole-based inhibitors targeting Mpro have recently been investigated by several groups and proven to be promising leads for coronaviral drug development.In the present study,we determine the crystal structures of a benzothiazole-based inhibitor,YH-53,bound to Mpro mutants from SARS-CoV-2 variants of concern(VOCs)or variants of interest(VOIs),including K90R(Beta,B.1.351),G15S(Lambda,C.37),Y54C(Delta,AY.4),M49I(Omicron,BA.5)and P132H(Omicron,B.1.1.529).The structures show that the benzothiazole group in YH-53 forms a C-S covalent bond with the sulfur atom of catalytic residue Cys145 in SARSCoV-2 Mpro mutants.Structural analysis reveals the key molecular determinants necessary for interaction and illustrates the binding mode of YH-53 to these mutant Mpros.In conclusion,structural insights from this study offer more information to develop benzothiazole-based drugs that are broader spectrum,more effective and safer. | Jiqing Luo Weiwei Wang Haihai Jiang Wenwen Li Pei Zeng Jie Wang Xuelan Zhou Xiaofang Zou Shenghui Chen Qisheng Wang Jin Zhang Jian Li | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 3 | Preparation of Bioactive Calcium Phosphate Coatingon Porous C/C Substrate by a Novel Deposition Technique显示文摘A novel heat substrate technique,high frequency inductive heat deposition(IHD),was introduced to coat porous carbon materials,C/C and carbon felt to improve their bioactivity.The morphologies, composition and microstructure of the resulting coatings were examined by scanning electron microscopy(SEM), energy dispersive spectra(EDS),X-ray diffractometer(XRD)and Fourier transform infrared spectroscopy (FTIR).The results show that,the calcium phosphate consisted of non-stoichiometric,CO3-containing and plate-like octacalcium phosphate(Ca 8-x H 2 (PO 4 ) 6 ,OCP)could uniformly cover the entire porous surfaces of carbon materials.Good adhesion of the coating to carbon material substrates was observed. | XIONG Xinbo ZENG Xierong LI Xiaohua Xie Shenghui ZOU Chunli | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 0 |
| 4 | Photo-thermal synergistic excitation:Feasible strategy to detect ethanol for wide bandgap ZIF-8at low work temperature显示文摘Zeolitic Imidazolate Framework-8(ZIF-8)material was prepared by chemical precipitation method.The microstructure and physical properties of the as-prepared samples were characterized by XRD,BET,FESEM and UV spectrophotometer.The self-made four-channel measurement device was used to test the gas sensitivity of ZIF-8 material toward ethanol gas under photo-thermal synergistic excitation.The results showed that the sample was typical ZIF-8(E_(g)=4.96 eV)with a regular dodecahedron shape and the specific surface is up to 1793 m^(2)/g.The as-prepared ZIF-8 has a gas response value of 55.04 to 100 ppm ethanol at 75℃ and it shows good gas sensing selectivity and repeated stability.The excellent gas sensitivity can be attributed to the increase of free electron concentration in the ZIF-8 conduction band by photo-thermal synergistic excitation,and the large specific surface area of ZIF-8 material provides more active sites for gas-solid surface reaction.The reaction mechanism of ZIF-8 material under multi-field excitation was also discussed. | Shuhao Shi Qian Du Ming Hou Xiaolei Ye Li Yang Shenghui Guo Jianhong Yi Ullah Ehsan Hongbo Zeng | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 5 | An Iron-Based High-Entropy Alloy with Highly Efficient Degradation for p-Nitrophenol显示文摘High-entropy alloys(HEAs)have attracted widespread attention due to their excellent mechanical properties.However,their functional properties arising from the supersaturated solid solution state can be improved.Advanced oxidation processes(AOPs)are considered to be an effective method for decomposing organic pollutants,and HEAs are proposed as effective candidates for AOP catalysts.Currently,several HEAs used for organic pollutant degradation are prepared through mechanical alloying.In this work,FeAlCoNi and FeAlCoNiB Fenton-like catalysts were prepared by single roll melt spinning and subsequent ball milling techniques.We found that the FeAlCoNiB HEA exhibits highly efficient degradation for p-nitrophenol(p-NP).The degradation efficiency of FeAlCoNiB is 120 times higher than that of FeAlCoNi,which confirms that boron functions effectively during the degradation process.FeAlCoNiB has a better degradation efficiency than pure iron powder and a degradation efficiency comparable to that of the amorphous Fe_(78)Si_(11)B_(11) alloy.Additionally,the degradation efficiency of FeAlCoNiB_(X) increases(k values from 0.13 to 0.55 min^(−1))when the boron content increases from an X value of 0.25 to 1.25.We speculate that Fe_(2)B favors the degradation process and promotes zero-valent iron to decompose organic pollutants through a galvanic cell effect.Possible p-NP degradation pathways are proposed after LC–MS analysis.This study provides a new series of HEA Fenton-like catalysts,which have the potential to be prepared into bulk devices for industrial applications. | Shenghui Xie Xiang Liao Xierong Zeng Haipeng Yang Liang He | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，10： | 0 |
| 6 | Water-soluble boron carbon oxynitride dots with excellent solid-state fluorescence and ultralong room-temperature phosphorescence显示文摘Developing metal-free and long lifetime room-temperature phosphorescence(RTP)materials has received tremendous interest due to their numerous potential applications,of which stable triplet-excited state is the core challenge.Here,boron carbon oxynitride(BCNO)dots,emitting stable blue fluorescence and green RTP,are reported for the first time.The obtained BCNO dots exhibit an unexpected ultralong RTP lifetime of 1.57 s,lasting over 8 s to naked eyes.The effective doping of carbon and oxygen elements in boron nitride(BN)actually provides a small energy gap between singlet and triplet states,facilitating the intersystem crossing(ISC)and populating of triplet excitons.The formation of compact cores via crystallization and effective inter-/intra-dot hydrogen bonds further stabilizes the excited triplet states and reduces quenching of RTP by oxygen at room temperature.Based on the water-soluble feature of BCNO dots,a novel advanced security ink is developed toward anti-counterfeiting tag and confidential information encryption.This study extends BCNO dots to rarely exploited phosphorescence fields and also provides a facile strategy to prepare ultralong lifetime metal-free RTP materials. | Shenghui Han Gang Lian Xiaoliang Zeng Zhaozhen Cao Qilong Wang Deliang Cui Ching-Ping Wong | 2020 | Nano Research2020，13，12： | 0 |
| 7 | Thermal Fatigue Behavior of SiC/MBAS Glass Coated Carbon/Carbon Composites显示文摘The thermal fatigue behavior of C/C composites coated with the SiC/MBAS glass (MoSi2 particle-containing boron aluminosilicate glass) coating, prepared by the two-step process of the pack cementation and procoating-sintering, was investigated in present paper. The experimental results indicated that the SiC/MBAS glass coating had an excellent thermal shock resistance in air at temperature up to 1873 K. During quick thermal cycle between 1873K and room temperature in air, the decrease of mass and mechanical property of the coated C/C composites was all slight. After thermal cycle for 50 times, the mass loss of the SiC/MBAS glass coated sample was only 0.22%; additionally, the remaining ratio of strength and modulus was no less than 95.2% and 99.4%, respectively. The decrease of the mechanical property during the thermal cycle was primarily due to the damnification of the fiber/matrix interfaces and the oxidation of the coated samples with oxygen. | Li Long Zeng Xierong Li Hejun Xiong Xinbo Xie Shenghui Zou Zizhao | 2009 | 稀有金属材料与工程2009，38，A03： | 0 |
| 8 | Sinorhizobium meliloti NtrX interacts with different regions of the visN promoter显示文摘The bacterial flagellum is a motile organelle consisting of a transmembrane multi-protein apparatus composed of the flagellins, the flagellin export complex, and the basal body with motor proteins. Flagellum biosynthesis is regulated by a hierarchical system in Escherichia coli [1]. Different from E. coli, Sinorhizobium meliloti, as a plant-symbiotic soil bacterium, induces the formation of nitrogen-fixing root nodules on the host plant alfalfa when combined nitrogen is limited. Sinorhizobium meliloti contains a ‘flagellum regulon’ that consists of 41 genes, including 10 chemotaxis (che) genes, 4 motor (mot) genes, 15 flg, flh, and fli genes encoding the components of the protein export complex and the basal body, 4 flagellin (fla) genes, and 4 unknown genes [1]. Similar to E. coli, flagellum biosynthesis in S. meliloti depends on a hierarchical system that is composed of the Class IA regulators, VisN and VisR, the Class IB regulator, Rem, Class II FliM, MotABC, and Class III flagellin and chemotaxis proteins [2]. Recently, several other regulators involved in flagellum biosynthesis have been reported, including the tow-component regulatory system ExoS/ChvI with the suppressor ExoR and the LuxR regulator ExpR in S. meliloti [3,4]. | Shuang Zeng Shenghui Xing Fang An Xinwei Yang Junhui Yan Liangliang Yu Li Luo | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 0 |
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