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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | In vitro study of radiosensitization by β-Elemene in A549 cell line from adenocarcinoma of lung显示文摘在 A549 房间由 β-Elemene 探索效果和收音机促进感受性的可能的机制在试管内的目的从肺的腺癌排队。A549 房间从肺的腺癌衬里的方法被选择让学习由使用 MTT 试金决定抑制比率。词法变化,生长曲线,克隆效率,师的索引被观察。房间周期和 apoptosis 率的变化被 FCM 和基因 P53 的表情分析, Bcl-2 被检测。结果在照耀和 β-Elemene 下面的组的繁殖活动显著地被压制,它的克隆的效率和师的索引也衰退了。在照耀和 β-Elemene 下面的组的 apoptosis 率在 48 h 和 72 h 是显著地更高的,它被 FCM 分析。没有 Bcl-2 的 P53 的表达式在照耀和 β-Elemene 下面在这个组被观察,在仅仅在第 48 小时的 β-Elemene 下面的组指,当没有 p53 的 Bcl-2 的表达式仅仅在照耀下面在这个组被观察,控制组织时。结论 β-Elemene 擅长收音机促进感受性,它的机制可能与 P53, Bcl-2 的下面规定和导致的 apoptosis 的起来规定相关。 | Hao Jiang Shenglin Ma Jianguo Feng | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，1： | 17 |
| 3 | Epidermal growth factor receptor (EGFR) T790M mutation identified in plasma indicates failure sites and predicts clinical prognosis in non-small cell lung cancer progression during first-generation tyrosine kinase inhibitor therapy: a prospective observational study显示文摘Introduction:Plasma circulating tumor DNA(ctDNA)is an ideal approach to detecting the epidermal growth factor receptor(EGFR)T790M mutation,which is a major mechanism of resistance to first-generation EGFR-tyrosine kinase inhibitor(TKI)therapy.The present study aimed to explore the association of ctDNA-identified T790M mutation with disease failure sites and clinical prognosis in non-small cell lung cancer(NSCLC)patients.Methods:Patients who progressed on first-generation TKIs were categorized into failure site groups of chest limited(CF),brain limited(BF)and other(OF).Amplification refractory mutation system(ARMS)and droplet digital PCR(ddPCR)were used to identify the T790M mutation in ctDNA.Prognosis was analyzed with Kaplan-Meier methods.Results:Overall concordance between the two methods was 78.3%.According to both ARMS and ddPCR,patients in the OF group had a significantly higher rate of T790M mutation than did patients in the BF and CF groups(P<0.001),and a significantly higher T790M mutation rate was also observed in OF-group patients than in those in the CF and BF groups(P<0.001).AZD9291 was found to be an excellent treatment option and yielded the longest survival for T790M+patients in all groups who had progressed on EGFR-TKIs;for other treatments,the prognosis of T790M−patient subgroups varied.Conclusions:The present study demonstrates that T790M mutation in ctDNA is associated with failure sites for NSCLC patients after EGFR-TKI therapy and indicates that both failure site and T790M mutational status greatly influ-ence treatment selection and prognosis. | Shirong Zhang Lucheng Zhu Bing Xia Enguo Chen Qiong Zhao Xiaochen Zhang Xueqin Chen Xufeng Chen Shenglin Ma | 2018 | Cancer Communications2018，38，1： | 12 |
| 4 | Highly selective ethylbenzene production through alkylation of dilute ethylene with gas phase-liquid phase benzene and transalkylation feed显示文摘A novel industrial process was designed for the highly selective production of ethylbenzene. It comprised of a reactor vessel, vapor phase ethylene feed stream, benzene and transalkylation feed stream. Especially the product stream containing ethylbenzene was used to heat the reactor vessel, which consisted of an alkylation section, an upper heat exchange section, and a bottom heat exchange section. In such a novel reactor, vapor phase benzene and liquid phase benzene were coexisted due to the heat produced by isothermal reaction between the upper heat exchange section and the bottom heat exchange section. The process was demonstrated by the thermodynamic analysis and experimental results. In fact, during the 1010 hour-life-test of gas phase ethene with gas phase-liquid phase benzene alkylation reaction, the ethene conversion was above 95%, and the ethylbenzene selectivity was above 83% (only benzene feed) and even higher than 99% (benzene plus transalkylation feed). At the same time, the xylene content in the ethylbenzene was less than 100 ppm when the reaction was carried out under the reaction conditions of 140-185 °C of temperature, 1.6-2.1 MPa of pressure, 3.0-5.5 of benzene/ethylene mole ratio, 4-6 v% of transalkylation feed/(benzene+transalkylation feed), 0.19-0.27 h-1 of ethene space velocity, and 1000 g of 3998 catalyst loaded. Thus, compared with the conventional ethylbenzene synthesis route, the transalkylation reactor could be omitted in this novel industrial process. | Shenglin Liu Fucun Chen Sujuan Xie Peng Zeng Xiyan Du Longya Xu | 2009 | Journal of Natural Gas Chemistry2009，18，1： | 11 |
| 5 | Thermal and hydrothermal stabilities of the alkali-treated HZSM-5 zeolites显示文摘有 micro-mesopore 的 HZSM-5 沸石层次孔被准备了由碱处理,和他们的热、热水的稳定性合成以后用 DTA, XRD,和 NH 3-TPD 描述技术被学习。比作未修改的沸石,因为 desilication 引起的中央毛孔的介绍,对待碱的 ZSM-5 沸石的热、热水的稳定性稍微被败坏。不过,对待碱的沸石框架能被维持直到温度增加了到 1175 ° C。 | Yuning Li Dong Liu Shenglin Liu Wei Wang Sujuan Xie Xiangxue Zhu Longya Xu | 2008 | Journal of Natural Gas Chemistry2008，17，1： | 10 |
| 6 | The Late Carboniferous–Early Permian Ocean-Continent Transition in the West Junggar,Central Asian Orogenic Belt: Constraints from Columnar Jointed Rhyolite显示文摘The West Junggar of the western Central Asian Orogenic Belt is one of the typical regions in the term of ocean subduction, contraction and continental growth in the Late Paleozoic. However, it is still controversial on the exact time of ocean-continent transition so far. This study investigates rhyolites with columnar joint in the West Junggar for the first time.Based on zircon U-Pb dating, we determined that the ages of the newly-discovered rhyolites are between 303.6 and 294.5 Ma, belonging to Late Carboniferous–Early Permian, which is the oldest rhyolite with columnar joint preserved in the world at present. Geochemical results show that the characteristics of the major element compositions include a high content of SiO_2(75.78–79.20 wt%) and a moderate content of Al_2O_3(12.21–13.19 wt%). The total alkali content(K_2O +Na_2O) is 6.14–8.05 wt%, among which K_2O is 2.09–4.72 wt% and the rate of K_2O/Na_2O is 0.38–3.05. Over-based minerals such as Ne, Lc, and Ac do not appear. The contents of TiO_2(0.09–0.24 wt%), CaO(0.15–0.99 wt%) and MgO(0.06–0.18 wt%) are low. A/CNK=0.91–1.68, A/NK=1.06–1.76, and as such, these are associated with the quasi-aluminum-weak peraluminous high potassium calc-alkaline and some calc-alkaline magma series. These rhyolites show a significant negative Eu anomaly with relative enrichment of LREE and LILE(Rb, Ba, Th, U, K) and depletion of Sr, HREE and HFSE(Nb, Ta, Ti, P). These rhyolites also have the characteristics of an A2-type granite, similar to the Miaoergou batholith,which indicates they both were affected by post-orogenic extension. Combining petrological, zircon U-Pb dating and geochemical characteristics of the rhyolites, we conclude that the specific time of ocean-continent transition of the West Junggar is the Late Carboniferous–Early Permian. | XU Shenglin CHEN Xuanhua LI Tingdong SHI Jianjie DING Weicui LI Bing HUANG Penghui ZHANG Yiping ZHANG Yaoyao MA Feizhou | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 9 |
| 7 | Functional Imaging of Breast Tissue and Clinical Application显示文摘A novel approach to image hemoglobin concentration(ΔD_ hb) and oxygen saturation (ΔD_ oxy) of breast tissue is presented. The scenograph of dual-wavelength (760 and 850 nm) near infrared lights through breast tissue is acquired by high sensitive charge coupled device (CCD) camera. The evaluation criterion of the difference of ΔD_ hb and ΔD_ oxy between detected and referenced breast tissue can be obtained by a calculation formula without complicate caculation. This approach is applied to clinic detection in breast tissue. The ongoing clinical experiments indicate that malignant tumor usually exhibits characterize of “higher ΔD_ hb and lower ΔD_ oxy”, while benign lesion often shows “lower ΔD_ hb and higher ΔD_ oxy” or other characters. So it is useful to assist the diagnosis of breast disease. | LI Kaiyang LIU Shenglin | 2006 | Wuhan University Journal of Natural Sciences2006，11，2： | 8 |
| 8 | Exceptional groups of Lie type and flag-transitive triplanes显示文摘A triplane is a ( v, k, 3)-symmetric design. Let G be a subgroup of the full automorphism group of a triplane D. In this paper we prove that if G is flag-transitive and point-primitive, then the socle of G cannot be a simple exceptional group of Lie type. | ZHOU ShengLin & DONG HuiLi Department of Mathematics, South China University of Technology, Guangzhou 510640, China | 2010 | Science China Mathematics2010，53，2： | 7 |
| 9 | Building an IPv6 address generation and traceback system with NIDTGA in Address Driven Network显示文摘In the design and construction process of Next Generation Internet, it is important to identify the source of each IP packet forwarding accurately, especially for the support of precise fine-grained management,control, traceability and improving the trustworthiness of the Internet. This paper designed a scalable Network Identity(NID) scheme for the Internet users, proposed NIDTGA(Network Identity and Time Generated Address), an IPv6 address generation algorithm embedded NID and time information, then designed and implemented an IPv6 address generation and traceback system based on NIDTGA. The design of NIDTGA, which reflects the length, time and owner attributes of the IP address, can be a good support to ADN(Address Driven Network). At the same time, by embedding the key elements of user identity and time in the IPv6 address,and by taking into account both the traceability and privacy, NIDTGA can provide a technical basis for the establishment of the network trust mechanism, and achieve the traceability of security event. | LIU Ying REN Gang WU JianPing ZHANG ShengLin HE Lin JIA YiHao | 2015 | Science China Chemistry2015，58，12： | 7 |
| 10 | P-doped BN nanosheets decorated graphene as the functional interlayer for Li–S batteries显示文摘Lithium–sulfur(Li–S)batteries have attracted much attention due to their ultrahigh theoretical specific capacity.However,serious capacity attenuation caused by shuttle effect still inhibits the performance improvement.Herein,a modified separator consists of the few-layer graphene as a highly conductive network and stable scaffold to support P-doped boron nitride(denoted as BN-P@GO)as the functional interlayer of Li–S batteries.The cell with the interlayer provides an initial discharge capacity as high as1045.3 mAh g^-1,and retains a high reversible capacity of 728.7 mAh g^-1 at 1 C after 500 cycles with a capacity decay of 0.061%per cycle.Moreover,the rate capability is also superior to cells with BN@GO or BN-P interlayers,i.e.reversible capcity of 457.9 mAh g^-1 even at 3 C.The excellent electrochemical performance is ascribed to the synergistic effect of physical barrier and chemical adsorption for dissolved polysulfides provided by the modified layer.Furhtermore,it also mitigates the polarization and promotes kinetic reactions of the cells.This work provides a concise and effective method for commercialization of lithium–sulfur batteries. | Jing Zhang Wenzhe Ma Zhenyu Feng Fangfang Wu Denghu Wei Baojuan Xi Shenglin Xiong | 2019 | Journal of Energy Chemistry2019，28，12： | 7 |
| 11 | Sporadic groups and flag-transitive triplanes显示文摘Let D be a triplane, i.e., a 2-(v,k,3) symmetric design, and G be a subgroup of the full automorphism group of D. In this paper we prove that if G is flag-transitive point-primitive, then the socle of G cannot be a sporadic simple group. | ZHOU ShengLin DONG HuiLi | 2009 | Science China Mathematics2009，52，2： | 7 |
| 12 | Bonding VSe2 ultrafine nanocrystals on graphene toward advanced lithium-sulfur batterie显示文摘Lithium–sulfur batteries have been attracting considerable research attention due to their high energy densities and low costs. However, one of their main challenges is the undesired shuttling of polysulfides, causing rapid capacity degradation. Herein, we report the first example of sulfiphilic VSe2 ultrafine nanocrystals immobilized on nitrogen-doped graphene to modify the battery separator for alleviating the shuttling problem. VSe2 nanocrystals provide numerous active sites for chemisorption of polysulfides as well as benefit the nucleation and growth of Li2S. Furthermore, the kinetic reactions are accelerated which is confirmed by higher exchange current density and higher lithium ion diffusion coefficient. And the first-principles calculations further show that the exposed sulfiphilic planes of VSe2 boost the redox of Li2S. When used as separators within the lithium sulfur batteries, the cell indicates greatly enhanced electrochemical performances with excellent long cycling stability and exceptional rate capability up to 8 C. Moreover, it delivers a higher areal capacity of 4.04 mAh·cm^−2 as well as superior cycling stability with sulfur areal loading up to 6.1 mg·cm^−2. The present strategy can encourage us in engineering novel multifunctional separators for energy-storage devices. | Wenzhi Tian Baojuan Xi Yu Gu Qiang Fu Zhenyu Feng Jinkui Feng Shenglin Xiong | 2020 | Nano Research2020，13，10： | 6 |
| 13 | Flexible and stable 3D lithium metal anodes based on self-standing MXene/COF frameworks for high-performance lithium-sulfur batteries显示文摘Lithium metal(Li)is believed to be the ultimate anode for lithium-ion batteries(LIBs)owing to the advantages of high theoretical capacity,the lowest electrochemical potential,and light weight.Nevertheless,issues such as uncontrollable growth of Li dendrites,large volume changes,high chemical reactivity,and unstable solid electrolyte interphase(SEI)hinder its rapid development and practical application.Herein a stable and dendrite-free Li-metal anode is obtained by designing a flexible and freestanding MXene/COF framework for metallic Li.COF-LZU1 microspheres are distributed among the MXene film framework.Lithiophilic COF-LZU1 microspheres as nucleation seeds can promote uniform Li nucleation by homogenizing the Li^(+)flux and lowering the nucleation barrier,finally resulting in dense and dendrite-free Li deposition.Under the regulation of the COF-LZU1 seeds,the Coulombic efficiency of the MXene/COF-LZU1 framework and electrochemical stability of corresponding symmetric cells are obviously enhanced.Li-S full cells with the modified Li-metal anode and sulfurized polyacrylonitrile(S@PAN)cathode also exhibited a superior electrochemical performance. | Chuanliang Wei Yusheng Wang Yuchan Zhang Liwen Tan Yi Qian Yuan Tao Shenglin Xiong Jinkui Feng | 2021 | Nano Research2021，14，10： | 5 |
| 14 | Distribution Characteristics of Sulfur and the Main Harmful Trace Elements in China's Coal显示文摘摘要:在中国支持干净的煤资源的合理发展和使用,数据在上地区性并且在中国煤的硫,砷和另外的有害元素的年龄分发广泛地被收集,为内容测试了,并且分析。在西北的中国的煤被描绘由对低极其硫的底层;在北中国的太原形成的煤主要有高硫的内容;山西形成的被低硫煤主要描绘;并且在南部的中国的晚二叠的煤有全面的更高的硫内容;另外的区域有低硫煤。在中国的煤的体积的有害踪迹元素的平均内容类似于在北美洲的煤和世界的其余部分的相应内容,而各种各样的元素的内容( Hg , Sb 和 Se )在到在外壳中的相应百分比的大小是不同的。元素 Cr 的平均内容, Se,公司,, U,而在对在 N 中国的早二叠的年龄近来含碳的煤的 Hg 和 CI 的平均内容最高,在在 S 中国的晚二叠的煤的 Br 在这个国家评价第一。在早、中间的侏罗记煤的 Mn 的平均内容在 NW 中国是更高的。在一些煤的有害元素的高内容应该在煤的发展和利用引起特别担心两个。 | TANG Shuheng SUN Shenglin QIN Yong JIANG Yaofa WANG Wenfeng | 2008 | Acta Geologica Sinica(English Edition)2008，82，3： | 5 |
| 15 | Diode Laser Soldering Technology of Fine Pitch QFP Devices显示文摘The laser provides a controllable means of supplying localized energy for solder joint formation and is a valuable tool in electronics manufacture.Diode laser soldering for fine pitch QFP devices were carried out with Sn-Ag-Cu lead-free solder and Sn-Pb solder respectively,and the mechanical properties of micro-joints of the QFP devices were tested and studied by STR-1000 micro-joints tester.The results indicate that sound QFP micro-joints without bridging or solder ball are gained by means of diode laser soldering method with appropriate laser processing parameters,and the pitch of the QFP devices is as fine as to 0.4mm.Tensile strength of QFP micro-joints increases gradually with the increase of laser output power,the maximum tensile strength presents when the laser output power increase to a certain value.The results also indicate that the mechanical properties of QFP micro-joints soldered by diode laser soldering system are better than those of QFP micro-joints soldered by IR reflow soldering method.The experimental results may provide a theory guide for investigation of diode laser soldering. | XUE Songbai ZHANG Liang HAN Zongjie WANG Jianxin YU Shenglin | 2011 | Chinese Journal of Mechanical Engineering2011，24，5： | 5 |
| 16 | Anthocyanin profi les and color properties of red wines made from Vitis davidii and Vitis vinifera grapes显示文摘Spine grape(Vitis davidii Foex.)is an important wild grape species native to China.Fifteen red spine grape clones and three red Vitis vinifera grape varieties were used to evaluate the differences in the anthocyanin profiles and color properties of wines made from V.davidii and V.vinifera grapes.Among spine wines,‘Junzi#2’wine had the highest total phenolic and total anthocyanin,‘Xiangzhenzhu’wine had the highest total flavonoids,and‘Junzi#1’wine had the highest total tannin.The anthocyanin compositions of all of the spine wines were dominated by Mv-3,5-diglucoside.The total individual anthocyanin contents in spine wines,except‘Gaoshan#5’,‘Junzi#5055’,‘Junzi#5061’,and‘Junzi#5044’,were signifi cantly higher than in V.vinifera wines.Most of the spine wines had a stronger red intensity and a brighter chroma with a bluer hue than V.vinifera wines.Correlation analysis revealed that the color properties were closely related to the anthocyanin composition.These results suggest that wines made from spine grapes may be useful for the wine industry for their color properties and high individual anthocyanin contents. | Yanlun Ju La Yang Xiaofeng Yue Yunkui Li Rui He Shenglin Deng Xin Yang Yulin Fang | 2021 | Food Science and Human Wellness2021，10，3： | 5 |
| 17 | Preparation and properties of novel PIPD fibers显示文摘Poly[2, 6-diimidazo (4,5-b:4’,5’-e) pyridinylene-1,4(2,5-dihydroxy) phenylen] (PIPD) was synthesized and the obtained PIPD/ PPA dope was directly spun into fibers via a dry-jet wet-spinning process for the first time. The obtained polymers were mainly characterized by ATR-FTIR and dynamic contact angle analysis. FTIR spectrum of the PIPD fibers indicates that the product was consistent with the target product. The contact angle measurements show that the wetting process of water on PIPD fibers is apparently faster than that on PBO fibers. The axial compression bending test indicates that PIPD fibers showed larger compressive strength compared with that of PBO fibers under the same axial compressive load. Meanwhile, the TGA test results indicate that the PIPD fibers have excellent thermal stability. | ZHANG Tao JIN JunHong YANG ShengLin LI Guang JIANG JianMing | 2010 | Chinese Science Bulletin2010，55，36： | 5 |
| 18 | s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide显示文摘Hand-foot skin reaction(HFSR),among the most significant adverse effects of sorafenib,has been limiting the clinical benefits of this frontline drug in treating various malignant tumors.The mechanism underlying such toxicity remains poorly understood,hence the absence of effective intervention strategies.In the present study,we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor(s-HBEGF)mediates the crosstalk between vascular endothelial cells and keratinocytes.Mechanistically,s-HBEGF released from vascular endothelial cells activates the epidermal growth factor receptor(EGFR)on keratinocytes and promotes the phosphorylation of c-Jun N-terminal kinase 2(JNK2),which stabilizes sirtuin 1(SIRT1),an essential keratinization inducer,and ultimately gives rise to HFSR.The administration of s-HBEGF in vivo could sufficiently induce hyper-keratinization without sorafenib treatment.Furthermore,we report that HBEGF neutralization antibody,Sirtl knockdown,and a classic SIRTI inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model.It is noteworthy that nicotinic acid,a prodrug of nicotinamide,could substantially reverse the sorafenib-induced HFSR in ten patients in a preliminary clinical study.Collectively,our findings reveal the mechanism of vascular endothelial cell-promoted keratinization in keratinocytes and provide a potentially promising therapeutic strategy for the treatment of sorafenib-induced HFSR. | Peihua Luo Hao Yan Xueqin Chen Ying Zhang Ziying Zhao Ji Cao Yi Zhu Jiangxia Du Zhifei Xu Xiaochen Zhang Su Zeng Bo Yang Shenglin Ma Qiaojun He | 2020 | Cell Research2020，30，9： | 5 |
| 19 | Introduction of fluorin into PBO polymer chains:Toward higher thermal stability and lower dielectric constant显示文摘A series of novel fluorinated benzoxazole polymers (6FPBO's) with high thermal stability and low dielectric constant were synthesized by copolymerization of 1,3-diamino-4, 6-dihydroxybenzene dihy-drochloride (DAR), 1,4-benzenedicarboxylic acid (PTA) and various amount of 4'4- (hexafluoroisopro-pylidene) bis (benzoic acid) (BIS-B-AF) in the medium of polyphosphoric acid (PPA). 6FPBO fibers were then obtained via dry-jet wet-spinning technique and characterized by means of Fourier transform infrared (FTIR) spectra, thermogravimetric analysis (TGA), single fiber tensile testing machine and scanning electron microscopy (SEM). FTIR spectrum of 6FPBO fibers indicated that the fluorine groups had been incorporated into PBO molecular chains successfully. TGA curves revealed that 6FPBO fibers possessed high thermal stability just as pure PBO fibers. Moreover, dielectric constant spectrum of 6FPBO exhibited that the polymers had low dielectric constant, especially in the range of high- frequency. | ZHANG Tao HU DaYong JIN JunHong YANG ShengLin LI Guang JIANG JianMing | 2009 | Science China(Technological Sciences)2009，52，1： | 4 |
| 20 | Immobilizing VN ultrafine nanocrystals on N-doped carbon nanosheets enable multiple effects for high-rate lithium-sulfur batteries显示文摘The exploitation of new sulfiphilic and catalytic materials is considered as the promising strategy to overcome severe shuttle effect and sluggish kinetics conversion of lithium polysulfides within lithium-sulfur batteries.Herein,we design and fabricate monodisperse VN ultrafine nanocrystals immobilized on nitrogen-doped carbon hybrid nanosheets(VN@NCSs)via an one-step in-situ selftemplate and self-reduction strategy,which simultaneously promotes the interaction with polysulfides and the kinetics of the sulfur conversion reactions demonstrated by experimental and theoretical results.By virtue of the multifunctional structural features of VN@NCSs,the cell with ultrathin VN@NCSs(only 5 pm thickness)modified separator indicates improved electrochemical performances with long cycling stability over 1,000 cycles at 2 C with only 0.041%capacity decay per cycle and excellent rate capability(787.6 mAh g^(-1) at 10 C).Importantly,it delivers an areal reversible capacity of 3.71 mAh cm^(-2) accompanied by robust cycling life. | Ning Song Baojuan Xi Peng Wang Xiaojian Ma Weihua Chen Jinkui Feng Shenglin Xiong | 2022 | Nano Research2022，15，2： | 4 |
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