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| 1 | Nutritional support in chronic liver disease and cirrhotics显示文摘The liver is a major organ and an essential componentin maintaining an appropriate nutritional status in healthy individuals through metabolism of protein, carbohydrates, and fat. In individuals with chronic liver disease(CLD), along with a number of other essen-tial functions that the liver serves, its role in nutrition maintenance is severely impaired. Common causes of CLD include hepatitis C, alcoholic liver disease, and non-alcoholic liver disease. Amongst this population, the most common manifestation of impaired nutritional maintenance is protein-calorie malnutrition. Aside from inherent abnormalities in metabolism, such as malab-sorption and maldigestion, CLD can be associated with anorexia as well as increased metabolic requirements, all of which contribute to a state of malnutrition. Given the systemic implications and impact on prognosis of malnutrition, proper nutritional assessment is essential and can be achieved through a thorough history and physical, as well as biochemical investigations and anthropometry as needed. Following an appropriate assessment of a patient's nutritional status, an approach to management can be decided upon and is based on the extent of malnutrition which directly reflects the severity of disease. Management options can be grossly separated into enteral and parenteral nutrition. The former is usually sufficient in the form of oral supplements in less severe cases of malnutrition, but as the CLD worsens, parenteral nutrition becomes necessary. With appropriate assessment and early intervention, many of the complications of CLD can be avoided, and ultimately better outcomes can be achieved. | Ravi Shergill Wajahat Syed Syed Ali Rizvi Ikjot Singh | 2018 | World Journal of Hepatology2018，10，10： | 17 |
| 2 | Approach to pseudomyxoma peritonei显示文摘Pseudomyxoma peritonei(PMP) is a mucinous tumour of the appendix that spreads into the peritoneal cavity in the form of gelatinous deposits. The incidence of PMP is believed to be approximately 1-3 out of a million per year. Nonetheless, due to its indolent nature, it is usually discovered at an advanced stage and severely impacts quality of life. Curative treatment for PMP is complete cytoreductive surgery(CRS) with hyperthermic intraperitoneal chemotherapy(HIPEC). An extensive literature review was conducted searching EMBASE, MEDLINE, Pub Med, and Google Scholar databases for PMP in aims to delineate a clinical approach to diagnosis and treatment. Literature was limited to the years 2007-2018. We found the 5-year overall survival with CRS and HIPEC estimated to be between 23%-82% and rates of major complications as high as 24%. Therefore, it is important to appropriately stage and select patients that should undergo CRS with HIPEC. Modalities like MDCT radiological scores have been shown to have sensitivity and specificity of 94% and 81%, respectively, in being able to predict resectability and survival. Despite treatment, the disease often recurs. Tumor markers have significant potential for establishing prognosis preoperatively, and this paper will review the most recent evidence in support of them. | Syed Ali Rizvi Wajahat Syed Ravi Shergill | 2018 | World Journal of Gastrointestinal Surgery2018，10，5： | 15 |
| 3 | Controversies in the treatment of Crohn’s disease: The case for an accelerated step-up treatment approach显示文摘The ideal treatment strategy for Crohn’s disease (CD) remains uncertain, as does the optimal endpoint of therapy. Top-down versus step-up describes two different approaches: early use of immunomodulators and biological agents in the former versus initial treatment with steroids in the latter, with escalation to immunomodulators or biological drugs in patients proven to be steroid refractory or steroid dependent. Top-down therapy has been associated with higher rates of mucosal healing. If mucosal healing proves to be associated with better long-term outcomes, such as a decreased need for hospitalization and surgery, top-down therapy may be the better approach for many patients. The main concern with the top-down approach is the toxicity of the immunomodulators and biological agents, which have been linked with infectious complications as well as an increased risk of lymphoma. It is unlikely that one strategy will be best for all patients given the underlying heterogeneity of CD presentation and severity. Ultimately, we must weigh the safety and efficacy of the therapies with the risks of the disease itself. Unfortunately our ability to risk stratify patients at diagnosis remains rudimentary. The purpose of this paper is to review the data that supports or refutes the differing treatment paradigms in CD, and to provide a rationale for an approach, termed the 'accelerated step-up' approach, which attempts to balance the risks and benefits of our currently available therapies with the risk of disease related complications as we understand them in 2008. | Amandeep K Shergill Jonathan P Terdiman | 2008 | World Journal of Gastroenterology2008，14，17： | 4 |
| 4 | The Role of Endoscopy in the Assessment and Treatment of Esophageal Cancer显示文摘 | J.A. Evans D.S. Early V. Chandraskhara K.V. Chathadi R. Fanelli D.A. Fisher K. Foley J.H. Hwang T.L. Jue S. Pasha R. Sharaf A. Shergill J.A. Dominitz B.D. Cash | 2012 | Gastrointestinal Endoscopy2012，，： | 2 |
| 5 | Guidelines for endoscopy in pregnant and lactating women显示文摘 | Amandeep K. Shergill Tamir Ben-Menachem Vinay Chandrasekhara Krishnavel Chathadi G. Anton Decker John A. Evans Dana S. Early Robert D. Fanelli Deborah A. Fisher Kimberly Q. Foley Norio Fukami Joo Ha Hwang Rajeev Jain Terry L. Jue Khalid M. Khan Jennifer L | 2012 | Gastrointestinal Endoscopy2012，，1： | 2 |
| 6 | Gender differences in white matter microstructure显示文摘 | Kanaan R.A Allin M Picchioni M Barker G.J Daly E Shergill S.S McGuire P.K | | 0，，： | 1 |
| 7 | Greenlight prostatectomy: a challenge to the gold standard? A review of KTP photoselective vaporization of the prostate显示文摘 | Ahmed HU Thwaini A Shergill IS | 2007 | Surg Laparosc Endosc Percutan Tech2007，17，3： | 1 |
| 8 | Long-term follow-up after retroperitoneal laparoscopic decortication of symptomatic renal cysts显示文摘 | THWAINI A SHERGILL I S ARYA M | 2007 | Urol Int2007，79，4： | 1 |
| 9 | Applicability, tolerability and efficacy of preemptive antiviral therapy in hepatitis C- infected patients undergoing liver transplantation 显示文摘 | Shergill AK Khalili M Straley S | 2005 | Am J Transplant2005，5，1： | 1 |
| 10 | Ephrin B2/Eph B4 pathway in hepatic stellate cells stimulates?Erk-dependent VEGF production and sinusoidal endothelial cell recruitment显示文摘 | Das A Shergill U Thakur L | 2010 | Am J Physiol Gastrointest Liver Physiol2010，298，6： | 1 |
| 11 | Luteinising hormone re- leasing hormone analogues in the treatment of prostate cancer 显示文摘 | Gommersall LM Hayne D Shergill IS | 2002 | Expert opinion on pharmacotherapy2002，3，12： | 1 |
| 12 | Cyclicalmicromove-ment and fracture healing显示文摘 | Noordeen MH Lavy CB Shergill NS | 1995 | J Bone Join SurgBr1995，77，4： | 1 |
| 13 | Tract-specific anisot- ropy measurements in diffusion tensor imaging显示文摘 | Kanaan RA Shergill SS Barker GJ | 2006 | Psychiatry Res2006，146，1： | 1 |
| 14 | 显示文摘 | SHERGILL I S WILLIAMSON M | 2005 | Expert Rev Mol Diagn2005，5，： | 1 |
| 15 | Randomized trial of standard versus magnetic endoscope imaging colonoscopes for unsedated colonoscopy显示文摘 | Amandeep K. Shergill Kenneth R. McQuaid Arn DeLeon Michelle McAnanama Janak N. Shah | 2012 | Gastrointestinal Endoscopy2012，，5： | 1 |
| 16 | Intimal prevents arterial and venous thrombosis in canine model of deep vessel wall injury 显示文摘 | Hennan JK Hong TT Shergill AK | 2002 | J Pharmacol Exp Ther2002，301，3： | 1 |
| 17 | Basic principles of real-time quantitative PCR显示文摘 | Shergill I S Williamson M | 2005 | Expert RevMol Diagn2005，5，2： | 1 |
| 18 | Greenlight prostatectomy: a challenge to the gold standard? A review of KTP photoselective vaporization of the prostate显示文摘 | Ahmed HU Thwaini A Shergill IS | 2007 | Surg Laparosc Endosc Percutan Tech2007，17，3： | 1 |
| 19 | Applicability, tolerability and efficacy of preemptive antiviral therapy in hepatitis C infected patients undergoing liver transplantation显示文摘 | Shergill AK Khalili M Straley S | 2005 | Am J Transplant2005，5，1： | 1 |
| 20 | Sleep-disordered Breathing in neuromuscular disease显示文摘 | Guilleminault C Shergill RP | 2002 | Curr Treat Options Neurol2002，4，2： | 1 |
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