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| 1 | Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease显示文摘AIM: To identify pathologic features associated with this 'ulcerative colitis(UC)-like' subgroup of Crohn's disease(CD).METHODS: Seventeen subjects diagnosed as having UC who underwent proctocolectomy(RPC) from 2003-2007 and subsequently developed CD of the ileal pouch were identified. UC was diagnosed based on preoperative clinical, endoscopic, and pathologic studies. Eighteen patients who underwent RPC for UC within the same time period without subsequently developing CD were randomly selected and used as controls. Pathology reports and histological slides were reviewed for a wide range of gross and microscopic pathological features, as well as extent of disease. The demographics, gross description and histopathology of the resection specimens were reviewed and compared between the two groups. RESULTS: Patients with 'UC-like' CD were on average 13 years younger than those with 'true' UC(P < 0.01). More severe disease in the proximal involved region and active ileitis with/without architectural distortion were observed in 6 of 17(35%) and 7 of 17(41%) 'UC-like' CD cases, respectively, but in none of the 'true' UC cases(P < 0.05). Active appendicitis occurred in 8 of 16(50%) 'UC-like' CD cases but in only two(11%) 'true' UC cases(P < 0.05). Conspicuous lamina propria neutrophils were more specific for 'UClike' CD(76% vs 22%, P < 0.05). In addition, prominent lymphoid aggregates tended to be more common in 'UC-like' CD(P = 0.07). The 'true' UC group contained a greater number of cases with severe activity(78% vs 47%). Therefore, the features more commonly seen in 'UC-like' CD were not due to a more severe disease process. Crohn's granulomas and transmural inflammation in non-ulcerated areas were absent in both groups.CONCLUSION: More severe disease in the proximal involved region, terminal ileum involvement, active appendicitis, and prominent lamina propria neutrophils may be morphological factors associated with 'UC-like' CD. | Samuel D James Paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi | 2014 | World Journal of Gastroenterology2014，20，36： | 4 |
| 2 | ATP-induced changes in energy status and membrane integrity of harvested litchi fruit and its relation to pathogen resistance 显示文摘 | YI C QU H X JIANG Y M SHI J DUAN X W JOYCE D C LI Y B | 2008 | Journal of Phytopathology2008，156，： | 1 |
| 3 | Cerebral amyloid angiopathy and de- mentia显示文摘 | Tian J Shi J Mann D M | 2004 | Panminerva Med2004，46，： | 1 |
| 4 | Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling显示文摘 | Tang DZ Hou W Zhou Q Zhang M Holz J Sheu TJ Li TF Cheng SD Shi Q Harris SE Chen D Wang YJ | 2010 | J Bone Miner Res2010，25，6： | 1 |
| 5 | Genetic control of rice plant architecture under domestication 显示文摘 | Jin J Huang W Gao J Yang J Shi M Zhu M Luo D Lin H | 2008 | Nature Genetics2008，40，11： | 1 |
| 6 | Runoff ero- sion process on different underlying surfaces from dis- turbed soils in the Three Gorges Reservoir Area, China 显示文摘 | PENG X D SHI D M JIANG D | 2014 | CATENA2014，123，12： | 1 |
| 7 | Template-imprinted nanostructured surface for protein recognition 显示文摘 | Shi H Q Tsai W B Garrison M D | 1999 | Nature1999，398，： | 1 |
| 8 | 显示文摘 | SHI H Q TSAI W B GARRISSON M D | 1999 | Nature1999，398，： | 1 |
| 9 | Brand and product integration in horizontal mergers and ~quisitions 显示文摘 | VU D A SHI Y J GREGORY M | 2010 | European Journal of International Management2010，4，1： | 1 |
| 10 | 查看详情显示文摘 | Dong W Y Sun Y J Lee C W Hua W M Lu X C Shi Y F Zhang S C Chen J M Zhao D Y | | 0，，： | 1 |
| 11 | 查看详情显示文摘 | Wang J M Feng H Q Sun J F Shi D H | | 0，，： | 1 |
| 12 | Segmentation of greenvegetation of crop canopy images based on mean shift andfisher linear discriminant显示文摘 | Zheng L Y Shi D M Zhang J T | 2010 | Pattern Recognition Letters2010，31，： | 1 |
| 13 | Observation of circulating turnout cells in patients with non-small cell lung cancer by real-time fluorescent quantitative reverse transcriptase-polymerase chain reaction in peroperative period显示文摘 | Ge M J Shi D Wu QC | 2006 | J Cancer Res Clin Oncol2006，，4： | 1 |
| 14 | Synthetic peptides derived from SARS coronavirus S protein with diagnostic and therapeutic potential 显示文摘 | Lu W Wu X D Shi M D | 2005 | FEBS Letters2005，579，： | 1 |
| 15 | The 132-adrenergic receptor and Her2 comprise a positive feedback loop in human breast cancer cells 显示文摘 | Shi M Liu D Duan H | 2011 | Breast Cancer Res Treat2011，125，2： | 1 |
| 16 | Results of a global phaseII study with crizotinib in advanced ALK-positivenon-small lung cancer(NSCLC)显示文摘 | Kim D W Ahn M J Shi Y | 2012 | J Clin Oncol2012，30，15： | 1 |
| 17 | Changes in hepatitis B virus DNA levels and liver function after transcatheter arterial chemoembolization of hepatocellular carcinoma显示文摘 | Lao XM Wang D Shi M | | 0，，： | 1 |
| 18 | Contrast enhancement based on a novel homogeneity measurement显示文摘 | Cheng H D Xue M Shi X | 2003 | Pattern Recognition2003，36，11： | 1 |
| 19 | Template-imprinted Nanostructured Surfaces for Protein Recognition显示文摘 | Shi H Q Tsai W B Garrison M D | 1999 | Nature1999，398，： | 1 |
| 20 | Study on the tribological properties of surfactant-modified MoS2 micrometer spheres as an additive in liquid paraffin显示文摘 | Zhou X D Wu D M Shi H Q | 2007 | Tribology International2007，40，： | 1 |
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