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| 1 | Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis显示文摘全身的硬化(SSc ) ,自体免疫的疾病,可以由于 IL4R/mTOR 小径的激活引起重要 osteopenia。间充质的干细胞移植(MSCT ) 能改善在经由导致有免疫力的忍耐的 SSc 的有免疫力的混乱。然而, MSCT 是否在 SSc 救 osteopenia 显型,是未知的。这里,我们证明 MSCT 能有效地改善在由 rescuing 的 SSc 老鼠的 osteopenia 损害了接受者骨头髓 MSC 的系区别。机械学地,我们证明施主 MSC 在 SSc 老鼠把 miR-151-5p 转移到接受者骨头髓 MSC 禁止 IL4R 表示,这样提高 osteogenic 区别和还原剂 adipogenic 区别的 downregulating mTOR 小径激活。而且, miR-151-5p 的全身的交货能够在 SSc 老鼠的 rescuing osteopenia,损害骨头髓 MSC,紧密的皮,和有免疫力的混乱,建议那 miR-151-5p 可以是为 SSc 治疗的一个特定的目标。我们发现在把 miRNAs 转移到接受者干细胞改善识别 MSCT 的一个以前未被认出的角色经由 rescuing 的 osteopenia 一条非编码的 RNA 小径。 | Chider Chen Dandan Wang Alireza Moshaverinia Dawei Liu Xiaoxing Kou Wenjing Yu Ruili Yang Lingyun Sun Songtao Shi | 2017 | Cell Research2017，27，4： | 26 |
| 2 | Circulating apoptotic bodies maintain mesenchymal stem cell homeostasis and ameliorate osteopenia via transferring multiple cellular factors显示文摘 | Dawei Liu Xiaoxing Kou Chider Chen Shiyu Liu Yao Liu Wenjing Yu Tingting Yu Ruili Yang Runci Wang Yanheng Zhou Songtao Shi | 2018 | Cell Research2018，28，9： | 17 |
| 3 | A subset of IL-17+ mesenchymal stem cells possesses anti-Candida albicans effect显示文摘骨头髓间充质的干细胞(MSC ) 与深刻 immunomodulatory 性质包括出生后的祖先房间的一张异构的人口,例如 Foxp3 + 的 upregulation 规章的 T 房间(Tregs ) 和 Th17 房间的 downregulation。然而,它是未知的是否不同 MSC subpopulations 拥有 immunomodulatory 的一样的范围功能。这里,我们证明生产 IL-17 的单个导出殖民地的 MSC 的一个子集与体积 MSC 人口不同因为它不能 upregulate Tregs, downregulate Th17 房间,或改善在一只大肠炎老鼠的疾病显型当模特儿。机械学地,我们揭示那 IL-17,由这些 MSC 生产了,激活 NFκ B 小径到 downregulate TGF-β在 MSC 的生产,导致基于 MSC 的 immunomodulation 的废除。而且,我们显示出那 NFκ B 能直接绑在 TGF-β倡导者区域将调整 TGF-β在 MSC 的表示。而且,这些 IL-17 + MSC 在 C 在 vitro 和治疗学的效果拥有 anti-Candida albicans 生长效果。感染 albicans 的老鼠。在摘要,这研究证明 MSC 包含能够禁止 C 的一个 IL-17 + 子集。albicans 生长,而是 attenuating 经由 NFκ 的基于 MSC 的免疫力的抑制; TGF-β 的调停 B 的 downregulation;。 | Ruili Yang Yi Liu Peyman Kelk Cunye Qu Kentaro Akiyama Chider Chen Ikiru Atsuta WanJun Chen Yanheng Zhou Songtao Shi | 2013 | Cell Research2013，23，1： | 8 |
| 4 | Novel Ag nanocrystals based dental resin composites with enhanced mechanical and antibacterial properties显示文摘The aim of this work was to investigate the effect of trace addition of oleic acid coated Ag nanocrystals(Ag NCs) on mechanical and antibacterial properties of dental resin composites.Composites(70 wt%of silica loading) with 25 ppm,50 ppm,75 ppm and 100 ppm(wt) Ag NCs were prepared and the composite without Ag NCs served as a control.The experimental results showed that the addition of Ag NCs significantly improved the strength and modulus of the resin composite without compromising the shade.For the composite with 50 ppm Ag NCs,fiexural strength(140.3 MPa),modulus(13.2 GPa)and compressive strength(347.2 MPa) were increased by 4.1%,22.2%,13.3%,respectively,compared with the control.The antibacterial test demonstrated that trace Ag NCs provided the resin composites with an antibacterial effect.Such strong and antibacterial dental resin composites might be advantageous to prevent secondary caries and be potential for future clinical applications. | Fengwei Liu Ruili Wang Yuyuan Shi Xiaoze Jiang Bin Sun Meifang Zhu | 2013 | Progress in Natural Science:Materials International2013，23，6： | 5 |
| 5 | Prediction of major adverse cardiac events is the first critical task in the management of immune checkpoint inhibitor-associated myocarditis显示文摘Dear Editor,The application of immune checkpoint inhibitors(ICIs),anti-tumor immunotherapy unleashing the host immune system to eradicate tumor cells,has revolutionized the treatment of various advanced cancers and showed remarkable anti-tumor effects[1].However,emphasis must be placed on fatal immune-related adverse events(irAEs),especially some fulminant irAEs like ICI-related cardiovascular AEs[2,3].However,due to the low rate of cardiovascular AEs,little is known about the effective methods for evaluating the risk of catastrophic cardiac events in ICI-associated myocarditis and its management[4,5]. | Yan Xu Yanjun Song Xiaoyan Liu Yuequan Shi Yingxian Liu Hao Qian Xiaoxing Gao Minjiang Chen Ruili Pan Jing Zhao Wei Zhong Wei Wu Mengzhao Wang | 2022 | Cancer Communications2022，42，9： | 3 |
| 6 | Effect of immunopotentiator of the Chinese herbal medicine on the quantity of T lymphocyte in chicken显示文摘In order to study the mechanism of immunopotentiator,the quantity of T lymphocyte was observed.Total 240 1-day chikens were divided into 3 groups randomly:one contrast group and two groups being drunk immunopotentiator according to the concentration 10 mL·L^(-1) and 5 mL·L^(-1) lasting for 48 d.The number of T lymphocyte in blood was measured by E-rosette when the chikens were at 12-,24-,36-,and 48-day.The results showed that the percent of T lymphocyte in the trial group was obviously higher than that of the contrast,and the 10 mL·L^(-1) group was higher than that of the 5 mL·L^(-1) group;the quantity distribution of T lymphocyte in intestinal mucosa lymphoid tissue of 14-day,21-day chiken was surveyed in the contrast group and the 10 mL·L^(-1) group with the method of routine histology-slices and ANAE,the results showed that the quantity of T lymphocyte in the 10 mL·L^(-1) group was significantly higher than that of the contrast,which indicated that immunopotentiator increased markedly the quantity of T lymphocyte,and the 10 mL·L^(-1) group was higher than that of the 5 mL·L^(-1) group. | SHI Qiumei SHEN Ping GAO Guisheng ZHAO Ruili TANG Shengling | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，2： | 1 |
| 7 | Lipoic acid attenuates high fat diet-induced chronic oxidative stress and immunosuppression in mice jejunum: A microarray analysis显示文摘 | Jue Cui Guowei Le Ruili Yang Yonghui Shi | 2009 | Cellular Immunology2009，，1： | 1 |
| 8 | Apoptotic vesicles ameliorate lupus and arthritis via phosphatidylserine-mediated modulation of T cell receptor signaling显示文摘Mesenchymal stem cells(MSCs)influence T cells in health,disease and therapy through messengers of intercellular communication including extracellular vesicles(EVs).Apoptosis is a mode of cell death that tends to promote immune tolerance,and a large number of apoptotic vesicles(apoVs)are generated from MSCs during apoptosis.In an effort to characterize these apoVs and explore their immunomodulatory potential,here we show that after replenishing them systemically,the apoV deficiency in Fas mutant mice and pathological lymphoproliferation were rescued,leading to the amelioration of inflammation and lupus activity.ApoVs directly interacted with CD4^(+)T cells and inhibited CD25 expression and IL-2 production in a dose-dependent manner.A broad range of Th1/2/17 subsets and cytokines including IFNγ,IL17A and IL-10 were suppressed while Foxp3^(+)cells were maintained.Mechanistically,exposed phosphatidylserine(PtdSer/PS)on apoVs mediated the interaction with T cells to disrupt proximal T cell receptor signaling transduction.Remarkably,administration of apoVs prevented Th17 differentiation and memory formation,and ameliorated inflammation and joint erosion in murine arthritis.Collectively,our findings unveil a previously unrecognized crosstalk between MSC apoVs and CD4^(+)T cells and suggest a promising therapeutic use of apoVs for autoimmune diseases. | Runci Wang Meng Hao Xiaoxing Kou Bingdong Sui Maria Laura Sanmillan Xiao Zhang Dawei Liu Jun Tian Wenjing Yu Chider Chen Ruili Yang Lingyun Sun Yi Liu Claudio Giraudo Deepak A.Rao Nan Shen Songtao Shi | 2023 | Bioactive Materials2023，，7： | 1 |
| 9 | The Game Analysis on Risks of Logistics Enterprises Participate in Logistics Finance 显示文摘 | Shi Ruili Guo Chunxiang | 2011 | Advanced Materi- al2011，，： | 1 |
| 10 | Triconstituent Co-assembly to ordered mesostructured polyme>silica and carbon-silica nanoeomposites and large-Pore mesoporous carbons with high surface areas显示文摘 | Liu Ruili Shi Yifeng Wan Ying | 2006 | J Am Chem Soc2006，128，11： | 1 |
| 11 | Effect of somatostatin analog on high-fat diet-induced syndrome: Involvement of reactive oxygen species 显示文摘 | LI W SHI Yonghui YANG Ruili | 2010 | Peptides2010，4，31： | 1 |
| 12 | Elevated Kir2.1/nuclear N2ICD defines a highly malignant subtype of non-WNT/SHH medulloblastomas显示文摘Medulloblastoma(MB)is one of the most common childhood malignant brain tumors(WHO grade IV),traditionally divided into WNT,SHH,Group 3,and Group 4 subgroups based on the transcription profiles,somatic DNA alterations,and clinical outcomes.Unlike WNT and SHH subgroup MBs,Group 3 and Group 4 MBs have similar transcriptomes and lack clearly specific drivers and targeted therapeutic options.The recently revised WHO Classification of CNS Tumors has assigned Group 3 and 4 to a provisional non-WNT/SHH entity.In the present study,we demonstrate that Kir2.1,an inwardly-rectifying potassium channel,is highly expressed in non-WNT/SHH MBs,which promotes tumor cell invasion and metastasis by recruiting Adam10 to enhance S2 cleavage of Notch2 thereby activating the Notch2 signaling pathway.Disruption of the Notch2 pathway markedly inhibited the growth and metastasis of Kir2.1-overexpressing MB cell-derived xenograft tumors in mice.Moreover,Kir2.1^(high)/nuclear N2ICD^(high)MBs are associated with the significantly shorter lifespan of the patients.Thus,Kir2.1^(high)/nuclear N2ICD^(high)can be used as a biomarker to define a novel subtype of non-WNT/SHH MBs.Our findings are important for the modification of treatment regimens and the development of novel-targeted therapies for non-WNT/SHH MBs. | Yan-Xia Wang Haibo Wu Yong Ren Shengqing Lv Chengdong Ji Dongfang Xiang Mengsi Zhang Huimin Lu Wenjuan Fu Qing Liu Zexuan Yan Qinghua Ma Jingya Miao Ruili Cai Xi Lan Bin Wu Wenying Wang Yinhua Liu Dai-Zhong Wang Mianfu Cao Zhicheng He Yu Shi Yifang Ping Xiaohong Yao Xia Zhang Peng Zhang Ji Ming Wang Yan Wang Youhong Cui Xiu-Wu Bian | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 0 |
| 13 | The evaluation of voting rules based on voting networks:Weber problem with support domain显示文摘This study focuses on improving the Weber model to obtain a more optimised solution, by whichwe can measure effectively the quality of the voting rules. By introducing the voter’s supportingdomain and the candidate’s supported degree to depict the emotional factors of voters and thereal voting network, we propose the concept of validity for a candidate. Upon the traditionalWeber model, two improved models are presented and the corresponding global optimal candidateis used as the evaluation benchmark for the voting rules. The experiments show that theoptimal solution of the two models has better robustness in complex voting networks, can beused as a standard to evaluate the voting rules. When the support degree of voter is the mainfactor, the Condorcet rule is optimal in most cases, and when the validity of the candidate is takenas the main factor, the Approval rule must be the best. | Chunxiang Guo Yinjie Zhang Ruili Shi Dongzhi Wang | 2021 | Journal of Control and Decision2021，8，4： | 0 |
| 14 | Genome-wide identification,characterization,and expression analysis of aluminum-activated malate transporter genes(ALMTs)in Gossypium hirsutum L.显示文摘Aluminum-activated malate transporters(ALMT)are widely involved in plant growth and metabolic processes,including adaptation to acid soils,guard cell regulation,anion homeostasis,and seed development.Although ALMT genes have been identified in Arabidopsis,wheat,barley,and Lotus japonicus,little is known about its presence in Gossypium hirsutum L.In this study,ALMT gene recognition in diploid and tetraploid cotton were done using bioinformatics analysis that examined correlation between homology and evolution.Differentially regulated ALMT genetic profile in G.hirsutum was examined,using RNA sequencing and qRT-PCR,during six fiber developmental time-points,namely 5 d,7 d,10 d,15 d,20 d,and 25 d.We detected 36 ALMT genes in G.hirsutum,which were subsequently annotated and divided into seven sub-categories.Among these ALMT genes,34 had uneven distribution across 14/26 chromosomes.Conserved domains and gene structure analysis indicated that ALMT genes were highly conserved and composed of exons and introns.The GhALMT gene expression profile at different DPA(days post anthesis)in different varieties of G.hirsutum is indicative of a crucial role of ALMT genes in fiber development in G.hirsutum.This study provides basis for advancements in the cloning and functional enhancements of ALMT genes in enhancing fiber development and augmenting high quality crop production. | QUANWEI LU YUZHEN SHI RUILI CHEN XIANGHUI XIAO PENGTAO LI JUWU GONG RENHAI PENG YOULU YUAN | 2022 | BIOCELL2022，46，5： | 0 |
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