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| 1 | Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation显示文摘许多干细胞人口被他们的本地微型环境(壁龛) 紧调整,它包括 stromal 房间的不同类型。然而,很少对壁龛亚群并列地由决定干细胞命运的机制被知道。这里,我们识别那 Yki,关键河马小径部件,为护卫房间(EC ) 是必要的在在果蝇卵巢支持 germline 区别的功能。我们发现那个刺猬(Hh ) 发信号首先从帽子房间发出,支持 EC 的功能肘脉 interruptus (Ci ) ,表明受动器的 Hh,禁止河马 kinase 的行为串联活动。机械学地,我们发现 Ci 竞争地与 Hpo 交往并且损害表明复杂形成的 Hpo-Wts,从而支持的 Yki 原子本地化。Ci 的行动保证发信号在 EC 反对 Sd/Tgi/Vg-mediated 缺省压抑的有效 Yki。这研究揭开解释壁龛房间的亚群怎么协调经由表明串音的 Hh 河马决定干细胞命运的机制,并且提高我们发信号的 oncogenic Yki/YAP 的机械学的规定的理解。 | Chaoyi Li Lijuan Kan Yan Chen Xiudeng Zheng Weini Li Wenxin Zhang Lei Cao Xiaohui Lin Shanming Ji Shoujun Huang Guoqiang Zhang Xiaohui Liu Yi Tao Shian Wu Dahua Chen | 2015 | Cell Research2015，25，10： | 5 |
| 2 | Prevalence, risk factors, and survival associated with pulmonary hypertension and heart failure among patients with underlying coronary artery disease: a national prospective, multicenter registry study in China显示文摘Background: Coronary artery disease (CAD) is the commonest cause of heart failure (HF), whereas pulmonary hypertension (PH) has not been established or reported in this patient population. Therefore, we assessed the prevalence, risk factors, and survival in CAD-associated HF (CAD-HF) complicated with PH.Methods: Symptomatic CAD-HF patients were continuously enrolled in this prospective, multicenter registry study. Echocardiography, coronary arteriography, left and right heart catheterization (RHC), and other baseline clinical data were recorded. Patients were followed up and their survival was recorded.Results: One hundred and eighty-two CAD-HF patients were enrolled, including 142 with HF with a preserved ejection fraction (heart failure with preserved ejection fraction [HFpEF];left ventricular ejection fraction [LVEF] ≥50%) and 40 with a reduced ejection fraction (heart failure with reduced ejection fraction [HFrEF];LVEF < 50%). PH was diagnosed with RHC in 77.5% of patients. Patients with PH showed worse hemodynamic parameters and higher mortality. HFrEF-PH patients had worse survival than HFpEF-PH patients. CAD-HF patients with an enlarged left ventricular end-diastolic diameter and reduced hemoglobin were at higher risk of PH. Nitrate treatment reduced the risk of PH. Elevated creatinine and mean pulmonary arterial pressure (mPAP), diastolic pressure gradient (DPG) ≥7 mmHg, and previous myocardial infarction (MI) entailed a higher risk of mortality in CAD-HF patients with PH.Conclusions: PH is common in CAD-HF and worsens the hemodynamics and survival in these patients. Left ventricle enlargement and anemia increase the risk of PH in CAD-HF. Patients may benefit from nitrate medications. Renal impairment, elevated mPAP, DPG ≥7 mmHg, and previous MI are strong predictors of mortality in CAD-HF-PH patients.Trial Registration: ClinicalTrials.gov, NCT02164526. | Li Huang Lingpin Pang Qing Gu Tao Yang Wen Li Ruilin Quan Weiqing Su Weifeng Wu Fangming Tang Xiulong Zhu Jieyan Shen Jingzhi Sun Guangliang Shan Changming Xiong Shian Huang Jianguo He | 2022 | Chinese Medical Journal2022，，15： | 4 |
| 3 | Integrating GAbased time-scale feature extractions with SVMs for stock index forecasting显示文摘 | Shian Chang Huang Tung Kuang Wu | 2008 | Expert Systems with Applications2008，35，： | 1 |
| 4 | Sorption kinetics of selected volatile organic compounds in humin 显示文摘 | Yang- Hsin Shih Shian -Chee Wu | 2002 | Environmental Toxicology and Chemistry2002，21，10： | 1 |
| 5 | Wet-resilient graphene aerogel for thermal conductivity enhancement in polymer nanocomposites显示文摘Three-dimensional(3 D)graphene-based aerogels have significant potential for adsorption,sensors,and thermal management applications.However,their practical applications are limited by their disorganized structure and ultra-low resilience after compression.Some methods can realize a well-aligned structure,however,they involve high costs and complex technology.Herein,a 3 D graphene hybrid aerogel with an anisotropic open-cell and well-oriented structure is realized by unidirectional freeze casting,which combines the‘soft’(e.g.graphene oxide,Tween-80)and‘hard’(e.g.graphene assembly)components to realize full recovery after flattening.A graphene aerogel annealed at a moderate temperature(200℃)can possess superhydrophilicity and outstanding wet-resilience properties,including after being pressed under40 MPa.Furthermore,the graphene aerogel annealed at a high temperature of 1500℃exhibits excellent thermal conductivity enhancement efficiency in polydimethylsiloxane(PDMS).The resultant nanocomposites clearly demonstrate anisotropic thermal conductivity and promising applications as thermal interface materials.This strategy offers new insights into the design and fabrication of 3 D multifunctional graphene aerogels. | Ying Lin Jin chen Shian Dong Guangning Wu Pingkai Jiang Xingyi Huang | 2021 | Journal of Materials Science & Technology2021，，24： | 1 |
| 6 | The influence of relative humidity on the adsorption of toluene by soils interpretation with the adsorption energy distribution functions 显示文摘 | Chen Chih yu Wu Shian thee | 1998 | Chemosphere1998，37，8： | 1 |
| 7 | Inhibition of invasion and angiogenesis by zinc chelating agent disulfiram显示文摘 | Shian S G Kao Y R Wu F Y etal | 2003 | Molecular Pharmacology2003，64，： | 1 |
| 8 | Justifying video -assisted thoracic surgery for spontaneous hemopneumothorax 显示文摘 | WU Yieheng LU Ming shian YEH Chihsiao | 2002 | Chest2002，122，2： | 1 |
| 9 | Inhibition of invasion and angiogenesis by zinc-chelating agent disulfiram显示文摘 | Shian SG Kao YR Wu FY | 2003 | Mol Pharmacol2003，64，5： | 1 |
| 10 | Multimode lasing from the microcavity of an octagonal quasi-crystal based on holographic polymer-dispersedliquid crystals显示文摘 | Ming Shian Li Andy Ying-Guey Fuh Shing-Trong Wu | 2012 | Opt Letters2012，37，15： | 1 |
| 11 | Late initiation of renal replacement therapy is associated with worse outcomes in acute kidney injury af-ter major abdominal surgery显示文摘 | Shian CC Wu VC Li WY | 2009 | Crit Care2009，13，5： | 1 |
| 12 | Free amino acids and peptides asrelated to antioxidant properties in protein hydrolysates of mackerel (scomber austriasicus)显示文摘 | Wu HC Chen HM Shian CY | 2003 | Food Research International2003，36，： | 1 |
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