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| 1 | Basic and clinical study of increased effect of partial anti-tumor agents by infusing sodium bicarbonate through target artery显示文摘Objective: To observe the influence of pH value on the proliferation of LAK cells and on the killing effect of rIL-2, IFN-ɑ2b, TNF-α, LAK cells and doxorubicin on malignant tumor cells, and investigate the possibility of increasing the efficacy of rIL-2 or IFN-ɑ2b and doxorubicin by infusing sodium bicarbonate (NaHCO3) through target arteries. Methods: Separating single nucleus cells from peripheral blood of healthy men, and observing the influence of pH on the activation of single nucleus cells by rIL-2. MTT assay was used to measure the killing effect of rIL-2, IFN-ɑ2b and TNF-α on 7404 cells and the increased effect of doxorubicin on rIL-2 and IFN-ɑ2b, the cytotoxity of LAK cells in different pH. Forty-two patients with advanced primary liver cancer were obtained by stratified random, NaHCO3, rIL-2/IFN-ɑ2b and doxorubicin were infused through target arteries. The efficacy was estimated after two cycles. Results: The conditions of pH 7.3 and pH 7.6 in vitro helped the proliferation of LAK cells and the killing effect of rIL-2, IFN-ɑ2b and LAK cells on 7404 cells. In the condition of pH 6.8 there was almost no killing effect for LAK cells. In the condition of pH 7.0, 7.2, 7.4 and 7.6, the killing rate of TNF-α to 7404 cells increased by degrees, and in pH 7.4 the killing effect was the optimum. After two cycles treatments in the 42 patients with advanced primary liver cancer, the response rate (CR+PR) was 88% (37/42). The median overall response and median overall survival were increased , and no complication associated with infusing sodium bicarbonate was observed. Conclusion: The killing effect of rIL-2, IFN-ɑ2b, TNF-α and doxorubicin on malignant tumor cells was enhanced by increasing the pH value. | Pingsheng Fan Shicun Wang Lin Xiu Jide Li Kehai Feng Feihu Chen Xinmin Lin Jiansheng Zhuang | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，1： | 3 |
| 2 | Effect of aqueous extract of Sanweitanxiang powder on calcium homeostasis protein expression in ischemic-reperfusion injury rat heart显示文摘OBJECTIVE: To investigate the underlying mechanism of reduced myocardial ischemia-reperfusion (I/R) injury in rats using the traditionalTibetan medicine Sanweitanxiang powder (SWTX). METHODS: Rats were randomly divided into six groups (n=10) as follows: (a) propranolol dinitrate control group, given propranolol dinitrate 0.02 g/kg for 10 days before I/R, (b) SWTX with a high dose group, given SWTX 1.5 g/kg for 10 days before I/R, (c) SWTX with a medium dose group, given SWTX 1.25 g/kg for 10 days before I/R, (d) sham group (Sham), in which the rat heart was exposed by pericardiotomy but without I/R, (e) SWTX with a low dose group, given SWTX 1.0 g/kg for 10 days before I/R, and (f) I/R injury group. Rats were intragastrically pretreated with propranolol dinitrate orSWTX. After that, the operation to cause ischemia and reperfusion was conducted.The histopathologic changes of rat hearts were observed by hematoxylin and eosin staining and transmission electron microscopy. Ca2+ homeostasis protein expression was determined by western blot. RESULTS: After SWTX pretreatment, the development of ultrastructural pathological changes from IR injury was attenuated. A decrease in the expression of B-cell lymphoma 2 associated X protein, and an increase in the expression of B-cell lymphoma 2 were observed. An increased activation of extracellular signal regulated kinases were found. Compared with the sham group, the expression of sarcoplasmic reticulum calcium-ATPase, phospholamban, and calsequestrin were all up-regulated after pretreatment with SWTX. CONCLUSION: The protective mechanism of SWTX pretreatment on myocardial I/R injury might be related to its effect on maintaining the balance of calcium homeostasis in rat heart. | Mei Yang Shuna Zhang Shicun Ren Jinjun Wang Haixia Yun Sheng Yong Dejun Zhang Quanyu Yang Yiying Kou Dianxiang Lu Rili Ge | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 3 | The Epidemiological Investigation and Intelligent Analytical System for foodborne disease显示文摘 | Ligui Wang Yuanyong Xu Yong Wang Shicun Dong Zhidong Cao Wen Zhou Hailong Sun Donghui Huo Hui Zhang Yansong Sun Liuyu Huang Zhengquan Yuan Dajun Zeng Hongbin Song | 2010 | Food Control2010，，11： | 1 |
| 4 | "Joint Development": An Ad Hoc Solution to the South China Sea Dispute显示文摘 | WU Shicun | 2007 | 中国海洋法学评论(中英文版)2007，，2： | 0 |
| 5 | Application of China's Land Resources Satellites in Natural Disaster Emergency显示文摘In recent years,natural disasters especially earthquakes,landslides,debris flow,forest fires and other major natural disaster events have occured frequently in China,causing many casualties and loss of property.With the rapid development and application,remote sensing technology has played a very important role in disaster rescue and post-disaster rebuilding.Remote sensing technology is used to obtain images of | Xia Guofu Huang Shicun | 2014 | Aerospace China2014，15，3： | 0 |
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