| 1 | VAV2 is required for DNA repair and implicated in cancer radiotherapy resistance显示文摘Radiotherapy remains the mainstay for treatment of various types of human cancer;however,the clinical efficacy is often limited by radioresistance,in which the underlying mechanism is largely unknown.Here,using esophageal squamous cell carcinoma(ESCC)as a model,we demonstrate that guanine nucleotide exchange factor 2(VAV2),which is overexpressed in most human cancers,plays an important role in primary and secondary radioresistance.We have discovered for the first time that VAV2 is required for the Ku70/Ku80 complex formation and participates in non-homologous end joining repair of DNA damages caused by ionizing radiation. | Weiling Liu Chuanwang Miao Shaosen Zhang Yachen Liu Xiangjie Niu Yiyi Xi Wenjia Guo Jiahui Chu Ai Lin Hongjin Liu Xinyu Yang Xinjie Chen Ce Zhong Yuling Ma Yuqian Wang Shihao Zhu Shuning Liu Wen Tan Dongxin Lin Chen Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 3 | Analysis of tight oil accumulation conditions and prediction of sweet spots in Ordos Basin: A case study显示文摘Tight sandstone reservoirs are widely developed in the Mesozoic Yanchang Formation of the Ordos Basin,China.There is a lack of understanding on the sedimentary setting,source-reservoir relationship and oil accumulation conditions in this area.In this study,through the comprehensive analysis of the distri-bution of tight oil,we evaluated the properties and petrological features of reservoir,geochemical characteristics of source rocks,the source-reservoir relationship,as well as the trapping,preservation and accumulation conditions of tight oil in the Chang 7 Member,and predicted the sweet spots of tight oil in the study area.The results show that the Chang 7 Member is a typical low-porosity and ultra-low permeability reservoir with great tightness,small pore throat and high capillary pressure,and must have been of near-source accumulation.The source rocks are mainly developed in the Chang 7_(3) submember,and the reservoirs mainly occur in the Chang 7_(1) and Chang 7_(2) submembers,forming a combination mode of“lower source rock and upper reservoir”.Sandbodies with good connectivity and fractures being well developed in local areas are the main hydrocarbon transport systems.The abnormal high pressure caused by hydrocarbon generation and pressurization is the main driving force of tight oil accumulation.The mode of hydrocarbon transportation is dominated by the vertical or lateral migration from under-lying source rocks or adjacent source rocks to reservoirs within a short distance.Following the integrated evaluation of lithology,physical properties and oil saturation of reservoirs and geochemical character-istics of source rocks,we grouped the sweet spots of Chang 7 Member into three types:Type I,Type II and Type III.Among others,the Type I sweet spots are the best in terms of porosity,permeability and source rock thickness and hydrocarbon enrichment which should be the focus of oilfield development.This study lays an important foundation for the economic and efficient development of tight oil in the Chang 7 Member of Heshui area,and has important implications on tight sandstone reservoirs in other regions of Ordos Basin in China. | Ying Tang Shihao Tan Ruifei Wang Hao Wang Chunming Xia Kaiyun Chen | 2022 | Energy Geoscience2022，3，4： | 0 |
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