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| 1 | Bevacizumab as a second- or later-line of treatment for metastatic colorectal cancer显示文摘AIM: To determine the efficacy of bevacizumab in patients with metastatic colorectal cancer (MCRC) who have failed prior chemotherapy without bevacizumab. METHODS: Between March 2002 and June 2010, 40 patients in South Korea with MCRC who were treated with bevacizumab plus chemotherapy as a second or later-line treatment were analyzed retrospectively for their overall response rate (ORR), overall survival (OS), and progression-free survival (PFS). The tumor responses were assessed using the RECIST (Response Evaluation Criteria in Solid Tumors) guidelines. RESULTS: All of the patients had progressed under prior chemotherapy without bevacizumab. Three patients (7.5%) exhibited an ORR, twenty one patients (52.5%) exhibited stable disease (SD), and fifteen patients (37.5%) exhibited disease progression. The median duration of the OS and PFS were 14.0 and 6.13 mo respectively. The median OSs were 16.60, 14.07 and 13.00 mo for second-line, third-line and fourth- or later-line treatments, respectively. The median PFSs were 7.23, 7.30 and 3.87 mo for the second-line, third-line and fourth- or later-line treatments, respectively. CONCLUSION: In patients with MCRC, bevacizumab combined chemotherapy may be beneficial during second- or later-line treatment. | Lee Chun Park Ho Sup Lee Seong Hoon Shin Seun Ja Park Moo In Park Sung Yong Oh Hyuk Chan Kwon Jin ho Baek Young Jin Choi Myoung Joo Kang Yang Soo Kim | 2012 | World Journal of Gastroenterology2012，18，10： | 3 |
| 2 | Synergistic Memory Impairment Through the Interaction of Chronic Cerebral Hypoperfusion and Amlyloid Toxicity in a Rat Model显示文摘 | Bo-Ryoung Choi Sang Rim Lee Jung-Soo Han Sang-Keun Woo Kyeong Min Kim Dong-Hee Choi Kyoung Ja Kwon Seol-Heui Han Chan Young Shin Jongmin Lee Chin-Sang Chung Seong-Ryong Lee Hahn Young Kim | 2011 | Stroke2011，，9： | 2 |
| 3 | Effects of bamboo charcoal and bamboo vinegar as antibiotic alternatives on growth performance, immune responses and fecal microflora population in fattening pigs显示文摘 | Gyo Moon CHU Cheol Kyu JUNG Hoi Yun KIM Ji Hee HA Jong Hyun KIM Min Seob JUNG Shin Ja LEE Yuno SONG Rashid Ismael Hag IBRAHIM Jae Hyeon CHO Sung Sill LEE Young Min SONG | 2012 | Animal Science Journal2012，，2： | 2 |
| 4 | A cost- effective VLSI Architecture for Anisotropic Texture Filtering in Limitited Memory Bandwidth 显示文摘 | SHIN H C LEE JA KIM IS | 2006 | IEEE Transactions on very Large Scale Integration (VLSI) Sysstems2006，14，3： | 1 |
| 5 | Matrix metalloproteinase-3 is activated by Omi/HtrA2 in dopaminergiccells: relevance to Parkinson's disease显示文摘 | Shin EJ Kim EM Lee JA | 2012 | Neurochem Int2012，60，3： | 1 |
| 6 | Chorea-ballista associated with nonketotic hyperglyeaemia or diabetic ketoacidosis: Characteristics of 25 patients in Korea 显示文摘 | Lee SH Shin JA Kim JH | 2011 | Diabetes Res Clin Pract2011，93，2： | 1 |
| 7 | Prenatal exposure to valproic acid increases the neural progenitor cell pool and induces macrocephaly in rat brain via a mechanism involving the GSK-3β/β-catenin pathway显示文摘 | Hyo Sang Go Ki Chan Kim Chang Soon Choi Se Jin Jeon Kyung Ja Kwon Seol-Heui Han Jongmin Lee Jae Hoon Cheong Jong Hoon Ryu Chong-Hyun Kim Kwang Ho Ko Chan Young Shin | 2012 | Neuropharmacology2012，，6： | 1 |
| 8 | Feganunaria mediates C-reactive protein- duced inflammatory responses of human vascular smooth muscle ceils activating NADPH oxidase 4 显示文摘 | Ryu J Lee CW Shin JA | 2007 | Cardiovase Res2007，75，3： | 1 |
| 9 | Production of lipase- catalyzed structured lipids from safflower oil with conjugated linoleic acid and oxidation studies with rosemary extracts 显示文摘 | Lee JH Shin JA Lee JH | 2004 | Food Research International2004，37，10： | 1 |
| 10 | FegammaRlla mediates C-reactive protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4显示文摘 | Lee CW Shin JA | 2007 | Cardiovase Res2007，75，3： | 1 |
| 11 | Early spatial changes in the posterior corneal surface after laser in situ keratomileusis显示文摘 | Lee DH Seo S Jeong KW Shin SC Vukich JA | | 0，，04： | 1 |
| 12 | Chorea-ballista associated with nonketotic hyperglycaemia or diabetic ketoacidosis: characteristics of 25 patients in Korea显示文摘 | Lee SH Shin JA Kim JH | 2011 | Diabetes Res Clin Pratt2011，93，： | 1 |
| 13 | FcgammaRIIa mediates C-reac five protein-induced inflammatory responses of human vascular smooth muscle cells by activating NADPH oxidase 4显示文摘 | Ryu J Lee CW Shin JA | 2007 | Cardiovasc Res2007，75，3： | 1 |
| 14 | Nanosized titanium dioxide enhanced inflammatory responses in the septic brain of mouse显示文摘 | Shin JA Lee E J Seo SM | 2010 | Neurosci2010，165，2： | 1 |
| 15 | Early spatial changes in the posterior corneal surface after laser in situ kera- tomileusis 显示文摘 | Lee DH Seo S Jeong KW Shin SC Vukich JA | 2003 | J Cataract Refract Surg2003，29，4： | 1 |
| 16 | Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia显示文摘 | Kyoung Ja Kwon Min Kyeong Kim Eun Joo Lee Jung Nam Kim Bo-Ryoung Choi Soo Young Kim Kyu Suk Cho Jung-Soo Han Hahn Young Kim Chan Young Shin Seol-Heui Han | 2014 | Journal of the Neurological Sciences2014，，： | 1 |
| 17 | Metabolomic and transcriptomic study to understand changes in metabolic and immune responses in steers under heat stress显示文摘Heat stress(HS)damages livestock by adversely affecting physiological and immunological functions.However,fundamental understanding of the metabolic and immunological mechanisms in animals under HS remains elusive,particularly in steers.To understand the changes on metabolic and immune responses in steers under HS condition,we performed RNA-sequencing and proton nuclear magnetic resonance spectroscopy-based metabolomics on HS-free(temperature humidity index[THI]value:64.92±0.56)and HS-exposed(THI value:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study clarifies the metabolic changes in 3 biofluids(rumen fluid,serum,and urine)and the immune responses observed in the peripheral blood mononuclear cells of HS-exposed steers.This integrated approach allowed the discovery of HS-sensitive metabolic and immunological pathways.The metabolomic analysis indicated that HS-exposed steers showed potential HS biomarkers such as isocitrate,formate,creatine,and riboflavin(P<0.05).Among them,there were several integrative metabolic pathways between rumen fluid and serum.Furthermore,HS altered mRNA expression and immune-related signaling pathways.A meta-analysis revealed that HS decreased riboflavin metabolism and the expression of glyoxylate and dicarboxylate metabolism-related genes.Moreover,metabolic pathways,such as the hypoxia-inducible factor-1 signaling pathway,were downregulated in immune cells by HS(P<0.05).These findings,along with the datasets of pathways and phenotypic differences as potential biomarkers in steers,can support more in-depth research to elucidate the interrelated metabolic and immunological pathways.This would help suggest new strategies to ameliorate the effects of HS,including disease susceptibility and metabolic disorders,in Jersey steers. | Jun Sik Eom Da Som Park Sang Jin Lee Bon-Hee Gu Shin Ja Lee Sang-Suk Lee Seon-Ho Kim Byeong-Woo Kim Sung Sill Lee Myunghoo Kim | 2022 | Animal Nutrition2022，，4： | 1 |
| 18 | Chorea-ballism associated with non-ketotic hyperglycaemia or diabetic ketoacidosis: Characteristics of 25 patients in Korea显示文摘 | Lee SH Shin JA Kim JH | 2011 | Diabetes Res Clin Pract2011，93，2： | 1 |
| 19 | Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin‐dependent kinase 5 activity in SH‐SY5Y neuroblastoma cells and primary neurons显示文摘 | Du‐Hyong Cho Eun Joo Lee Kyoung Ja Kwon Chan Young Shin Kee‐Ho Song Jung‐Hyun Park Inho Jo Seol‐Heui Han | 2013 | J Neurochem2013，，5： | 1 |
| 20 | Chorea-ballista associated with non- ketotic hyperglycaemia or diabetic ketoaeidesis: characteristics of 25 pa- tients in Korea显示文摘 | Lee SH Shin JA Kim JH | 2011 | Diabetes Res Clin Praet2011，93，2： | 1 |
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