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| 1 | Differential diagnosis of benign and malignant branch duct intraductal papillary mucinous neoplasm using contrastenhanced endoscopic ultrasonography显示文摘AIM: To elucidate the role of contrast-enhanced endoscopic ultrasonography(CE-EUS) in the diagnosis of branch duct intraductal papillary mucinous neoplasm(BD-IPMN).METHODS: A total of 50 patients diagnosed with BDIPMN by computed tomography(CT) and endoscopic ultrasonography(EUS) at our institute were included in this study. CE-EUS was performed when mural lesions were detected by EUS. The diagnostic accuracy for identifying mural nodules(MNs) was evaluated by CT, EUS, and EUS combined with CE-EUS. In the patients who underwent resection, the accuracy of measuring MN height with each imaging modality was compared. The cut-off values to diagnose malignant BD-IPMNs based on MN height for each imaging modality were determined using receiver operating characteristic curve analysis.RESULTS: Fifteen patients were diagnosed with BD-IPMN with MNs and underwent resection. The remaining 35 patients were diagnosed with BD-IPMN without MNs and underwent follow-up monitoring. The pathological findings revealed 14 cases with MNs and one case without. The accuracy for diagnosing MNs was 92% using CT and 72% using EUS; the diagnostic accuracy increased to 98% when EUS and CE-EUS were combined. The accuracy for measuring MN height significantly improved when using CE-EUS compared with using CT or EUS(median measurement error value, CT: 3.3 mm vs CE-EUS: 0.6 mm, P < 0.05; EUS: 2.1 mm vs CE-EUS: 0.6 mm, P < 0.01). A cut-off value of 8.8 mm for MN height as measured by CE-EUS improved the accuracy of diagnosing malignant BDIPMN to 93%. CONCLUSION: Using CE-EUS to measure MN height provides a highly accurate method for differentiating benign from malignant BD-IPMN. | Hirofumi Harima Seiji Kaino Shuhei Shinoda Michitaka Kawano Shigeyuki Suenaga Isao Sakaida | 2015 | World Journal of Gastroenterology2015，21，20： | 12 |
| 2 | Two-Dimensional Super High Density Multi-Fiber Connector显示文摘We have developed 32-fiber and 60-fiber super high density multi fiber connector. This 32-fiber connector can be applicable for single-mode fiber and 60-fiber connector for multi-mode fiber. We have also established PC (physical contact) connection technology by optimizing polishing condition and clamping force. | Takashi Shigenaga Katsuki Suematsu Masao Shinoda Takayuki Ando | 2003 | 光学学报2003，23，S1： | 6 |
| 3 | Colon perforation due to antigenemia-negative cytomegalovirus gastroenteritis after liver transplantation: A case report and review of literature显示文摘BACKGROUND Cytomegalovirus(CMV) remains a critical complication after solid-organ transplantation. The CMV antigenemia(AG) test is useful for monitoring CMV infection. Although the AG-positivity rate in CMV gastroenteritis is known to be low at onset, almost all cases become positive during the disease course. We treated a patient with transverse colon perforation due to AG-negative CMV gastroenteritis, following a living donor liver transplantation(LDLT).CASE SUMMARY The patient was a 52-year-old woman with decompensated liver cirrhosis as a result of autoimmune hepatitis who underwent a blood-type compatible LDLT with her second son as the donor. On day 20 after surgery, upper and lower gastrointestinal endoscopy(GE) revealed multiple gastric ulcers and transverse colon ulcers. The biopsy tissue immunostaining confirmed a diagnosis of CMV gastroenteritis. On day 28 after surgery, an abdominal computed tomography revealed transverse colon perforation, and simple lavage and drainage were performed along with an urgent ileostomy. Although the repeated remission and aggravation of CMV gastroenteritis and acute cellular rejection made the control of immunosuppression difficult, the upper GE eventually revealed an improvement in the gastric ulcers, and the biopsy samples were negative for CMV. The CMV-AG test remained negative, therefore, we had to evaluate the status of the CMV infection on the basis of the clinical symptoms and GE.CONCLUSION This case report suggests a monitoring method that could be useful for AGnegative CMV gastroenteritis after a solid-organ transplantation. | Takahiro Yokose Hideaki Obara Masahiro Shinoda Yutaka Nakano Minoru Kitago Hiroshi Yagi Yuta Abe Yohei Yamada Kentaro Matsubara Go Oshima Shutaro Hori Sho Ibuki Hisanobu Higashi Yuki Masuda Masanori Hayashi Miho Kawaida Takehiko Mori Takumi Fujimura Ken Hoshino Kaori Kameyama Tatsuo Kuroda Yuko Kitagawa | 2019 | World Journal of Gastroenterology2019，25，15： | 5 |
| 4 | Pre-hepatectomy type Ⅳ collagen 7S predicts post-hepatectomy liver failure and recovery显示文摘BACKGROUND Liver resection is an effective treatment for benign and malignant liver tumors.However,a method for preoperative evaluation of hepatic reserve has not yet been established.Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term recovery of hepatic reserve.When determining eligibility for hepatectomy,the underlying pathophysiology needs to be considered to determine if the functional hepatic reserve can withstand both surgery and any postoperative therapy.AIM To identify pre-hepatectomy factors associated with both early postoperative liver failure and long-term postoperative liver function recovery.METHODS This study was a retrospective cohort study.We retrospectively investigated 215 patients who underwent hepatectomy at our hospital between May 2013 and December 2016.Early post-hepatectomy liver failure(PHLF)was defined using the International Study Group of Liver Surgery’s definition of PHLF.Long-term postoperative recovery of liver function was defined as the time taken for serum total bilirubin and albumin levels to return to levels of<2 mg/dL and>2.8 g/dL,respectively,and the time taken for Child-Pugh score to return to Child-Pugh class A.RESULTS Preoperative type IV collagen 7S was identified as a significant independent factor associated with both PHLF and postoperative long-term recovery of liver function.Further analysis revealed that the time taken for the recovery of Child-Pugh scores and serum total bilirubin and albumin levels was significantly shorter in patients with type IV collagen 7S≤6 ng/mL than in those with type IV collagen 7S>6 ng/mL.In additional analyses,similar results were observed in patients without chronic viral hepatitis associated with fibrosis.CONCLUSION Preoperative type IV collagen 7S is a preoperative predictor of PHLF and longterm postoperative liver function recovery.It can also be used in patients without chronic hepatitis virus. | Masatsugu Ishii Osamu Itano Masahiro Shinoda Minoru Kitago Yuta Abe Taizo Hibi Hiroshi Yagi Ayano Takeuchi Hanako Tsujikawa Tokiya Abe Yuko Kitagawa | 2020 | World Journal of Gastroenterology2020，26，7： | 3 |
| 5 | Relapse of both small cell lung cancer and Lambert-Eaton myasthenic syndrome after a 13-year disease-free survival period显示文摘Lambert-Eaton myasthenic syndrome(LEMS) is a paraneoplastic syndrome and only 3%of small cell lung carcinoma(SCLC) patients have LEMS.Moreover,the recurrence of SCLC after a disease-free survival(DFS) of more than 10 years is rare.We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period.A 69-year-old man was diagnosed with LEMS and SCLC(cT0N2M0,stage ⅢA) 13 years ago.Chemoradiotherapy was performed and a complete response was achieved.With anticancer treatment,the LEMS symptoms was alleviated.At the age of 82 years,gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC.Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a long DFS period. | Fumio Asano Keisuke Watanabe Masaharu Shinkai Yoshitaka Tei Kei Mishina Mikiko Tanabe Hiroshi Ishii Masahiro Shinoda Tadasuke Shimokawaji Makoto Kudo Takeshi Kaneko | 2016 | Chinese Journal of Cancer2016，35，11： | 3 |
| 6 | Identification of a triterpenoid saponin from a crucifer,Barbarea vulgaris,as a feeding deterrent to the diamondback moth,Plutella xylostella显示文摘 | Shinoda T Nagao T Nakayama M | 2002 | J Chem Ecol2002，28，： | 2 |
| 7 | Fatty acid-binding protein 7 triggersα-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress显示文摘We previously show that fatty acid-binding protein 3(FABP3)triggersα-synuclein(Syn)accumulation and induces dopamine neuronal cell death in Parkinson disease mouse model.But the role of fatty acid-binding protein 7(FABP7)in the brain remains unclear.In this study we investigated whether FABP7 was involved in synucleinopathies.We showed that FABP7 was co-localized and formed a complex with Syn in Syn-transfected U251 human glioblastoma cells,and treatment with arachidonic acid(100 M)significantly promoted FABP7-induced Syn aggregation,which was associated with cell death.We demonstrated that synthetic FABP7 ligand 6 displayed a high affinity against FABP7 with Kd value of 209 nM assessed in 8-anilinonaphthalene-1-sulfonic acid(ANS)assay;ligand 6 improved U251 cell survival via disrupting the FABP7–Syn interaction.We showed that activation of phospholipase A2(PLA2)by psychosine(10 M)triggered oligomerization of endogenous Syn and FABP7,and induced cell death in both KG-1C human oligodendroglia cells and oligodendrocyte precursor cells(OPCs).FABP7 ligand 6(1 M)significantly decreased Syn oligomerization and aggregation thereby prevented KG-1C and OPC cell death.This study demonstrates that FABP7 triggersα-synuclein oligomerization through oxidative stress,while FABP7 ligand 6 can inhibit FABP7-induced Syn oligomerization and aggregation,thereby rescuing glial cells and oligodendrocytes from cell death. | An Cheng Yi-fei Wang Yasuharu Shinoda Ichiro Kawahata Tetsunori Yamamoto Wen-bin Jia Hanae Yamamoto Tomohiro Mizobata Yasushi Kawata Kohji Fukunaga | 2022 | Acta Pharmacologica Sinica2022，43，3： | 2 |
| 8 | Environmental investigation of potentially pathogenic Vibrio parahaemolyticus in the Seto-Inland Sea, Japan显示文摘 | Muhammad Jahangir Alam Ken-Ichi Tomochika Shin-Ichi Miyoshi Sumio Shinoda | 2002 | FEMS Microbiology Letters2002，，1： | 2 |
| 9 | Effects of grazing and precipitation variability on vegetation dynamics in a Mongolian dry steppe显示文摘Aims Grazing and water availability are the primary drivers of vegetation dynamics in grazing-dominated regions of Mongolia with a semi-arid climate and frequent droughts.Nomadic animal husbandry still plays a large part in the economy of Mongolia,but more variable precipitation regime and increase in livestock number have severely affected grassland ecosystems through overgrazing,leading to pasture degradation.This study aimed to examine the effects of grazing exclusion,interannual variation of plant-available precipitation(PAP)and their interaction on the aboveground biomass(AGB)of each dominant species,the AGB of annual species and the total AGB in a Mongolian dry steppe,using long-term field data.Methods To detect the effect of grazing on vegetation dynamics,vegetation surveys were conducted in a non-grazed exclosure zone and a fully grazed area outside the exclosure.We assessed the effects of grazing,PAP and their interaction on AGB parameters using a generalized linear model.A detrended correspondence analysis(DCA)was used to visualize the effects of grazing and PAP on the AGB of each species.Important Findings Grazing,PAP and their interaction had significant effects on AGB.The effect of grazing on AGB was larger with higher precipitation and higher amounts of AGB(i.e.forage)while AGB was strongly limited in drought years,which resulted in a smaller grazing effect.The current year PAP had the highest impact(r=0.88,P<0.01)on AGB.The dominance of annual species was characterized by the amount of PAP in the current and preceding years:annuals dominated in wet years that followed consecutive dry years.The DCA Axis 1 reflected the variation of AGB with interannual variation of PAP while the DCA Axis 2 differentiated the grazing effect.The DCA scatter diagram based on species score illustrated that Artemisia adamsii(an unpalatable herb)was clearly linked to grazing disturbance whereas palatable perennials such as Agropyron cristatum,Stipa krylovii and Cleistogenes squarrosa were related to grazing abandonment and wetter conditions.In brief,number of livestock,hence the grazing impacts on vegetation dynamic in this region could have driven by forage availability,which is mainly controlled by current-year PAP. | Tserenpurev Bat-Oyun Masato Shinoda Yunxiang Cheng Yadamjav Purevdorj | 2016 | Journal of Plant Ecology2016，9，5： | 2 |
| 10 | Evidence for a primary cortical origin of a middle latency auditory evoked potential in cats显示文摘 | Kaga K Hink R F Shinoda Y | 1980 | Electrcencephalogr Clin Neurophysiol1980，53，34： | 2 |
| 11 | The influence of donor age on liver regeneration and hepatic progenitor cell populations显示文摘 | Yoshihiro Ono Shigeyuki Kawachi Tetsu Hayashida Masatoshi Wakui Minoru Tanabe Osamu Itano Hideaki Obara Masahiro Shinoda Taizo Hibi Go Oshima Noriyuki Tani Kisyo Mihara Yuko Kitagawa | 2011 | Surgery2011，，2： | 2 |
| 12 | New bimodal pore catalyst for Fiseher-Tropsch synthesis显示文摘 | Shinoda M Zhang Y Yoneyama Y | 2004 | Fuel Process Tech2004，86，： | 1 |
| 13 | Effect of bias enhanced nucleation on the nucleation density of diamond in microwave plasma CVD 显示文摘 | Ma Y Tsunami T Shinoda N | 1995 | Diamond Relat Mater1995，4，： | 1 |
| 14 | Paracrine up regulation of VEGF receptor mRNA in endothelial cells by hypoxia-exposed Hep G2 cells显示文摘 | Suzuki H Seto K Shinoda YM | 1999 | Am J Physiol Gastrointest Liver Physiol1999，276，11： | 1 |
| 15 | Daytime hypoxemia, sleep-disordered breathing,and laryngopharyngeal findings in multiple system atrophy显示文摘 | Shimohata T Shinoda H Nakayama H | 2007 | Arch Neurol2007，64，： | 1 |
| 16 | Changes in P2X3receptor expression in the trigeminal ganglion following monoarthritis of the temporomandibular joint in rats显示文摘 | Shinoda M Ozaki N Asai H | 2005 | Pain2005，116，1： | 1 |
| 17 | Survival of Lactobacillus helveticus strain CP53 in the human gastrointestinal tract 显示文摘 | SHINODA T KUSUDA D | 2001 | Applied Microbiology2001，32，： | 1 |
| 18 | Influence of the Indian Ocean dipole on atmospheric subseasonal variability显示文摘 | SHINODA T HAN W | 2005 | J Climate2005，18，18： | 1 |
| 19 | Acarbose improves fibrinolytic activity in patients with impaired glucose tolerance显示文摘 | Shinoda Y Iuoue I Nakano T | 2006 | Metabolism2006，55，7： | 1 |
| 20 | Recent development of friction stir welding-new solid state joining technology 显示文摘 | SHINODA S TAKESHI M | 2001 | International Journal Mater Product Technol2001，2，： | 1 |
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