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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | INFLUENCE OF PREPARATIVE HISTORY ON STRUCTURE AND PROPERTIES OF SODIUM ALUMINATE SOLUTIONS显示文摘It has been found that samples of sodium aluminate solutions with the same composition but different preparative history may have difTerent structure and physico-chemical properties.The structure of sodium-bearing aluminate solutions change very slowly during the storage after preparation.Sodium aluminate solutions contain several ammunium-bearing anisons such as Al(OH)^(-)_(4),Al(OH)^(3-)_(6)and[(HO)_(3)Al-O-Al(OH)_(3)]^(2-),etc.These anions can convert to each other but the reactions are very slow owing to the formation or breakage of covalent Al-O bond.Hence the ratio between these anions approaches equilibrium very slowly after the preparation,and the structure or properties of these solution samples before equilibrium is reached depend on their preparative histosive. | Chen Nianyi Liu Miaoxiu Yang Jinxiu Chi Likuan | 1992 | Transactions of Nonferrous Metals Society of China1992，2，2： | 8 |
| 3 | Elevated plasma levels of selective cytokines in COVID-19 patients reflect viral load and lung injury显示文摘A recent outbreak of pneumonia in Wuhan,China was found to be caused by a 2019 novel coronavirus(2019-nCoV or SARS-CoV-2 or HCoV-19).We previously reported the clinical features of 12 patients with2019-n Co V infections in Shenzhen,China.To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-n Co V,we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients.Thirty-eight out of the 48 measured cytokines in the plasma of 2019-n Co V-infected patients were significantly elevated compared to healthy individuals.Seventeen cytokines were linked to 2019-nCoV loads.Fifteen cytokines,namely M-CSF,IL-10,IFN-α2,IL-17,IL-4,IP-10,IL-7,IL-1 ra,G-CSF,IL-12,IFN-γ,IL-1α,IL-2,HGF and PDGF-BB,were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of2019-n Co V infections by calculating the area under the curve of the receiver-operating characteristics.Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines,some of which could be potential biomarkers of disease severity of 2019-n Co V infections.These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease.Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized. | Yingxia Liu Cong Zhang Fengming Huang Yang Yang Fuxiang Wang Jing Yuan Zheng Zhang Yuhao Qin Xiaoyun Li Dandan Zhao Shunwang Li Shuguang Tan Zhaoqin Wang Jinxiu Li Chenguang Shen Jianming Li Ling Peng Weibo Wu Mengli Cao Li Xing Zhixiang Xu Li Chen Congzhao Zhou William J Liu Lei Liu Chengyu Jiang | 2020 | National Science Review2020，7，6： | 6 |
| 4 | The effect of slight to minor biodegradation on C_6 to C_7 light hydrocarbons in crude oils: a case study from Dawanqi Oilfield in the Tarim Basin,NW China显示文摘Light hydrocarbons(LHs) are one of the main petroleum fractions in crude oils, and carry much information regarding the genetic origin and alteration of crude oils. But secondary alterations—especially biodegradation—have a significant effect on the composition of LHs in crude oils. Because most of the LHs affected in oils underwent only slight biodegradation(rank 1 on the biodegradation scale), the variation of LHs can be used to describe more the refined features of biodegradation. Here,23 crude oils from the Dawanqi Oilfield in the Tarim Basin, NW China, eleven of which have been biodegraded to different extents, were analyzed in order to investigate the effect of slight to minor biodegradation on C_6–C_7 LHs.The study results showed that biodegradation resulted in the prior depletion of straight-chained alkanes, followed by branched alkanes. In slight and minor biodegraded oils,such biodegradation scale could not sufficiently affect C_6–C_7cycloalkanes. For branched C_6–C_7 alkanes, generally,monomethylalkanes are biodegraded earlier than dimethylalkanes and trimethylalkanes, which indicates that branched alkanes are more resistant to biodegradation, with the increase of substituted methyl groups on parent rings.The degree of alkylation is one of the primary controlling factors on the biodegradation of C_6–C_7 LHs. There is a particular case: although 2,2,3-trimethylbutane has a relative higher alkylation degree, 2,2-dimethylpentane is more resistant to biodegradation than 2,2,3-trimethylbutane. 2,2-Dimethylpentane is the most resistant to biodegradation in branched C_6–C_7 alkanes. Furthermore, the 2-methylpentane/3-methylpentane and 2-methylhexane/3-methylhexane ratios decreased steadily with increasing biodegradation,which implies that isomers of bilateral methyl groups are more prone to bacterial attack relative to mid-chain isomers. The position of the alkyls on the carbon skeleton is also one of the critical factors controlling the rate of biodegradation. With increasing biodegradation, Mango's LH parameters K1 values decrease and K2 values increase,the values of n-heptane and isoheptane decrease, and the indices of methylcyclohexane and cyclohexane increase.LH parameters should be applied cautiously for the biodegraded oils. Because biodegraded samples belong to slight or minor biodegraded oils, the values of n-heptane and isoheptane from Dawanqi Oilfield can better reflect and determine the ‘‘Biodegraded'' zone. When the heptane value is 0–21 and the isoheptane value is 0–2.6, the crude oil in Dawanqi Oilfield is defined as the ‘‘Biodegraded'' zone. | Lu Yang Chunming Zhang Meijun Li Jing Zhao Xuening Qi Jinxiu Du | 2016 | Acta Geochimica2016，35，2： | 5 |
| 5 | Adipose-derived stem cells inhibit dermal fibroblast growth and induce apoptosis in keloids through the arachidonic acid-derived cyclooxygenase-2/prostaglandin E2 cascade by paracrine显示文摘Background:The clinical features of keloids consist of aberrant proliferation,secretion,differentiation and apoptosis of keloid dermis-derived fibroblasts(KFBs).Notably,the apoptosis rate of KFBs is lower than the proliferation rate.Though the anti-fibrotic effect of adipose-derived stem cells(ADSCs)on keloids has become a hot topic of research,the exact anti-fibrotic mechanism of the paracrine effect remains unclear.This study aimed to find out how the conditioned medium of ADSCs(ADSC-CM)exerts an anti-fibrotic effect in KFBs.Methods:KFBs and ADSCs were extracted and cultured.Then,ADSC-CM was prepared.Whether ADSC-CM could inhibit KFB growth and induce apoptosis was verified by the use of a cell counting kit-8,an 5-Ethynyl-2-deoxyuridine(Edu)kit and flow cytometry.The expressions of cyclooxygenase-1(COX-1),COX-2,caspase 3 and B-cell lymphoma-2(Bcl-2)in ADSC-CM-cultured KFBs were tested by real-time PCR and western blotting.To clarify the role of COX-2 in ADSC-CM-induced KFB apoptosis,a specific COX-2 inhibitor,celecoxib,was applied to KFBs cultured in ADSC-CM.Moreover,we tested the production of arachidonic acid(AA)and prostaglandin E2(PGE2)by ELISA.Then,we established a keloid transplantation model in a nude mouse to validate the therapeutic effect in vivo.Results:The proliferation ability of KFBs cultured in ADSC-CM was found to be weakened and apoptosis was significantly increased.Caspase 3 expression was significantly upregulated and Bcl-2 was downregulated in ADSC-CM-cultured KFBs.Furthermore,ADSC-CM strikingly elevated COX-2 mRNA and protein expressions,but COX-1 expression was unaltered.COX-2 inhibitors reduced ADSC-CM-induced apoptosis.Additionally,COX-2 inhibition blocked the elevation of caspase 3 and reversed the decrease in Bcl-2 expression.ADSC-CM increased PGE2 levels by 1.5-fold and this effect was restrained by COX-2 inhibition.In the nude mouse model,expressions of AA,COX-2 and PGE2 were higher in the translated keloid tissues after ADSC-CM injection than in the controls.Conclusions:We showed activation of the COX-2/PGE2 cascade in KFBs in response to ADSC-CM.By employing a specific COX-2 inhibitor,COX-2/PGE2 cascade activation played a crucial role in mediating the ADSC-CM-induced KFB apoptosis and anti-proliferation effects. | Jinxiu Yang Shiyi Li Leren He Minliang Chen | 2021 | Burns & Trauma2021，9，1： | 4 |
| 6 | Identifying human body states by using a flexible integrated sensor显示文摘Flexible sensors are required to be lightweight,compatible with the skin,sufficiently sensitive,and easily integrated to extract various kinds of body vital signs during continuous healthcare monitoring in daily life.For this,a simple and low-cost flexible temperature and force sensor that uses only two carbon fiber beams as the sensing layer is reported in this work.This simple,flexible sensor can not only monitor skin temperature changes in real time but can also extract most pulse waves,including venous waves,from most parts of the human body.A pulse diagnostic glove containing three such flexible sensors was designed to simulate pulse diagnostic methods used in traditional Chinese medicine.Wearable equipment was also designed in which four flexible sensors were fixed onto different body parts(neck,chest,armpit,and fingertip)to simultaneously monitor body temperature,carotid pulse,fingertip artery pulse,and respiratory rate.Four important physiological indicators—body temperature(BT),blood pressure(BP),heart rate(HR),and respiratory rate(RR)—were extracted by the wearable equipment and analyzed to identify exercise,excited,tired,angry,and frightened body states. | Ying Jin Guoning Chen Kete Lao Songhui Li Yong Lu Yufeng Gan Zhundong Li Jiajia Hu Jingcheng Huang Jinxiu Wen Honggui Deng Min Yang Zhiming Chen Xiaoyan Hu Baowen Liang Jianyi Luo | 2020 | npj Flexible Electronics2020，4，1： | 2 |
| 7 | Cu^2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance显示文摘Nowadays,drug-resistant microbes are becoming a serious clinical problem threatening people's health and life.An timicrobial peptides(AMPs)are believed to be pote ntial alter natives of con-ventional antibiotics to combat the threat of drug-resistant microbes.However,the susceptibility of AMPs toward proteases is one of the major problems limiting their clinical use.In the present study,we reported the effect of Cu^2+on the bioactivity of AMP HMPI.We found that the addition of Cu^2+could improve the protease resistance of AMP HMPI without affecting its bioactivity.Notably,after the binding of Cu^2+with HMPI,the hemolytic activity of HMPI was greatly decreased.In additi on,our results also demonstrated that the addition of Cu^2+in creased the production of reactive oxygen species in the fun gal cells,which may be a suppleme nt for the antifungal activity of HMPI.In con elusion,the introduction of Cu^2+may provide an inorganic strategy to improve the stability and decrease the hemolytic activity of AMP HMPI,while maintaining its antifungal activity. | Jinxiu Peng Yang Yang Ping Zhao Shuai Qiu Fengjing Jia Jiayi Wang Xiaolei Liang Ahmed Shabbir Chaudhry Peihan Xu Wenjin Yan Zhaoqing Xu Kairong Wang | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 2 |
| 8 | Characteristics of Tight Reservoir in Shahezi Formation of Zhaozhou Area in Songliao Basin显示文摘Through the statistical analysis of reservoir physical property,thin slice,scanning electron microscopy and mercury injection experiment data of Shahezi formation in Zhaozhou area,there are two main directions of provenance systems.One from central uplift belt in western,and other from slope zone in eastern.Reservoirs roughly grow in sandstone which in fan-delta in | LI Chenhui YANG Jinxiu | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 2 |
| 9 | Facile synthesis of spinel LiNi_(0.5)Mn_(1.5)O_(4) as 5.0 V-class high-voltage cathode materials for Li-ion batteries显示文摘LiNi_(0.5)Mn_(1.5)O_(4) and LiMn_(2)O_(4) with novel spinel morphology were synthesized by a hydrothermal and postcalcination process.The synthesized LiMn_(2)O_(4) particles(5–10 lm)are uniform hexahedron,while the LiNi_(0.5)Mn_(1.5)O_(4) has spindle-like morphology with the long axis 10–15 lm,short axis 5–8 lm.Both LiMn_(2)O_(4) and LiNi_(0.5)Mn_(1.5)O_(4) show high capacity when used as cathode materials for Li-ion batteries.In the voltage range of 2.5–5.5 V at room temperature,the LiNi_(0.5)Mn_(1.5)O_(4) has a high discharge capacity of 135.04 mA·h·g^(-1) at 20 mAg^(-1),which is close to 147 mA·h·g^(-1)(theoretical capacity of LiNi_(0.5)Mn_(1.5)O_(4)).The discharge capacity of LiMn_(2)O_(4) is 131.08 mA·h·g^(-1) at 20 mAg^(-1).Moreover,the LiNi_(0.5)Mn_(1.5)O_(4) shows a higher capacity retention(76%)compared to that of LiMn_(2)O_(4)(61%)after 50 cycles.The morphology and structure of LiMn_(2)O_(4) and LiNi_(0.5)Mn_(1.5)O_(4) are well kept even after cycling as demonstrated by SEM and XRD on cycled LiMn_(2)O_(4) and LiNi_(0.5)Mn_(1.5)O_(4) electrodes. | Xueyi Guo Chenlin Yang Jinxiu Chen Qinghua Tian Hongmei Zhang Guoyong Huang | 2021 | Chinese Journal of Chemical Engineering2021，34，11： | 2 |
| 10 | Application of WSS in Mined Tunnel Crossing under the Existing Shield Tunnel显示文摘 | Daoyuan Wang Jinxiu Yuan Yang ZHeng etc | 2014 | Advanced Materials Research2014，839，8： | 1 |
| 11 | Active-site and interface engineering of cathode materials for aqueous Zn–gas batteries显示文摘Aqueous rechargeable Zn–gas batteries are regarded as promising energy storage and conversion devices due to their high safety and inherent environmental friendliness.However,the energy efficiency and power density of Zn–gas batteries are restricted by the kinetically sluggish cathode reactions,such as oxygen evolution reaction(OER)during charging and oxygen reduction reaction(ORR)/carbon dioxide reduction reaction(CO_(2)RR)/nitrogen reduction reaction(NRR)/nitric oxide reduction reaction(NORR)during discharge.In this review,battery configurations and fundamental reactions in Zn–gas batteries are first introduced,including Zn–air,Zn-CO_(2),Zn-N_(2),and Zn-NO batteries.Afterward,recent advances in active site engineering for enhancing the intrinsic catalytic activities of cathode catalysts are summarized.Subsequently,the structure and surface regulation strategies of cathode materials for optimizing the three-phase interface and improving the performance of Zn–gas batteries are discussed.Finally,some personal perspectives for the future development of Zn–gas batteries are presented. | Wenxian Liu Jinxiu Feng Tianran Wei Qian Liu Shusheng Zhang Yang Luo Jun Luo Xijun Liu | 2023 | Nano Research2023，16，2： | 1 |
| 12 | Colonization and development of the gut microbiome in calves显示文摘Colonization and development of the gut microbiome are crucial for the growth and health of calves.In this review,we summarized the colonization,beneficial nutrition,immune function of gut microbiota,function of the gut barrier,and the evolution of core microbiota in the gut of calves of different ages.Homeostasis of gut microbiome is beneficial for nutritional and immune system development of calves.Disruption of the gut microbiome leads to digestive diseases in calves,such as diarrhea and intestinal inflammation.Microbiota already exists in the gut of calf fetuses,and the colonization of microbiota continues to change dynamically under the influence of various factors,which include probiotics,diet,age,and genotype.Colonization depends on the interaction between the gut microbiota and the immune system of calves.The abundance and diversity of these commensal microbiota stabilize and play a critical role in the health of calves. | Yufeng Du Ya Gao Mingyang Hu Jinxiu Hou Linhai Yang Xianghuang Wang Wenjuan Du Jianxin Liu Qingbiao Xu | 2023 | Journal of Animal Science and Biotechnology2023，14，4： | 1 |
| 13 | Laboratory Diagnosis and Monitoring the Viral Shedding of SARS-CoV-2 Infection显示文摘The worldwide epidemic of coronavirus disease 2019(COVID-19)is ongoing.Rapid and accurate detection of the causative virus SARSCoV-2 is vital for the treatment and control of COVID-19.In this study,the comparative sensitivity of different respiratory specimen types were retrospectively analyzed using 3,552 clinical samples from 410 COVID-19 patients confirmed by Guangdong CDC(Center for Disease Control and Prevention).Except for bronchoalveolar lavage fluid(BALF),the sputum possessed the highest positive rate(73.4%–87.5%),followed by nasal swabs(53.1%–85.3%)for both severe and mild cases during the first 14 days after illness onset(d.a.o.).Viral RNA could be detected in all BALF samples collected from the severe group within 14 d.a.o.and lasted up to 46 d.a.o.Moreover,although viral RNA was negative in the upper respiratory samples,it was also positive in BALF samples in most cases from the severe group during treatment.Notably,no viral RNA was detected in BALF samples from the mild group.Despite typical ground-glass opacity observed via computed tomographic scans,no viral RNA was detected in the first three or all upper respiratory tract specimens from some COVID-19 patients.In conclusion,sputum is most sensitive for routine laboratory diagnosis of COVID-19,followed by nasal swabs.Detection of viral RNA in BALF improves diagnostic accuracy in severe COVID-19 patients. | Yang Yang Minghui Yang Jing Yuan Fuxiang Wang Zhaoqin Wang Jinxiu Li Mingxia Zhang Jinli Wei Ling Peng Gary Wong Haixia Zheng Weibo Wu Chenguang Shen Mingfeng Liao Kai Feng Jianming Li Qianting Yang Juanjuan Zhao Lei Liu Yingxia Liu | 2020 | The Innovation2020，1，3： | 1 |
| 14 | Porous Fe-Mn-O nanocomposites:Synthesis and supercapacitor electrode application显示文摘Transition metal oxide micro-/nanostructures demonstrate high potential applications in energy storage devices. Here, we report a facile synthesis of highly homogeneous oxide composites with porous structure via a coordination polymer precursor, which was prepared with the assistance of tartaric acid.The typical product, Fe-Mn-O composite was demonstrated here. The obtained Fe-Mn-O product was systemically characterized by X-ray powder diffraction, scanning electron microscopy, transmission electron microscopy, elemental mapping analysis, and X-ray photoelectron spectroscopy. It was demonstrated that the Fe-Mn-O nanocomposite shows interconnected porous structure, in which iron,manganese, and oxygen are uniformly distributed. In addition, the Fe-Mn-O nanocomposite was then fabricated as capacitor electrodes. Operating in an aqueous neutral solution, the Fe-Mn-O composite electrodes showed an wide working potential window from 0.2 to 1.0 V(vs. SCE), and a specific capacitance of 86.7 Fg^(-1)or 0.4 Fcm^(-2)at a constant current density of 1 Ag^(-1)with good cycle life. This study offers a new precursor approach to prepare porous metal oxide composites, which would be applied in energy-storage/conversion devices, catalysts, sensors, and so on. | Guoxing Zhu Jing Yang Yuanjun Liu Xulan Xie Zhenyuan Ji Jinxiu Yin Xiaoping Shen | 2016 | Progress in Natural Science:Materials International2016，26，3： | 0 |
| 15 | The Stability of Imitation Dynamics with Continuously Distributed Delays显示文摘This paper investigates imitation dynamics with continuously distributed delay.In realistic technological,economic,and social environments,individuals are involved in strategic interactions simultaneously while the influences of their decision-making may not be observable instantaneously.It shows that there exists a time delay effect.Different distributions of delay are further considered to efficiently lucubrate the stability of interior equilibrium in the imitation dynamics with continuous distributions of delay in the two-strategy game contexts.Precisely,when the delay follows the uniform distributions and Gamma distributions,the authors present that interior equilibrium can be asymptotically stable.Furthermore,when the probability density of the delay is general density,the authors also determine a sufficient condition for stability derived from the expected delay.Last but not least,the interested but uncomplicated Snowdrift game is utilized to demonstrate our theoretical results. | FANG Caiya YANG Hui PI Jinxiu WU Wenjun | 2023 | Journal of Systems Science & Complexity2023，36，5： | 0 |
| 16 | A brief history of wheat utilization in China显示文摘Wheat is one of the most important crops in both China and the world, and its domestication can be traced back to ~10000 years ago.However, the history of its origin and utilization in China remains highly ambiguous.Drawing upon the most recent results of taxonomic, genetic, archeological and textual studies focused on the wheat in prehistory, this paper argues that wheat was not domesticated but introduced into China in the late fifth millennium BP.In the subsequent centuries,this exotic crop was quickly utilized as a staple food in northwest China.In contrast, it was not adopted as a staple in the Central Plains until the Han Dynasty(202 BCE–220 CE), which was mainly as a consequence of the living environment, population and innovations in food processing technology. | Minxia LU Liang CHEN Jinxiu WANG Ruiliang LIU Yang YANG Meng WEI Guanghui DONG | 2019 | Frontiers of Agricultural Science and Engineering2019，6，3： | 0 |
| 17 | Research on Dynamic Discovery Model of User Interest Based on Time and Space Vector显示文摘 | Jinxiu Lin Zhaoxin Zhang Lejun Chi Yang Wang | 2018 | 国际计算机前沿大会会议论文集2018，，2： | 0 |
| 18 | Similarities and Differences between Marine and Continental Shale Gas显示文摘Shale is composed of the fine particle size less than0.0039mm debris,clay and organic matters(Zhou Wen,Wang Hao,2013).Having sheet bedding.Based on the formation of environment,divide the organic-rich shale into marine organic-rich shales,The continental coal organic-rich shales and the lake facies shales.The successful development of shale gas resources in oil | XUE Song LU Shuangfang XUE Haitao YANG Jinxiu TANG Mingming LIU Shuang | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
| 19 | Seismic Features of Marine Gas Hydrates in Offshore Northwest Africa显示文摘1 Introduction Gas hydrates are also called methane hydrates or clathrate hydrates,commonly known as'combustible ice',which are present in permafrost,continental slope,shallow sea,platform,etc.Gas hydrates(clathrate hydrates)are crystalline solid structures consisting of water and small molecules such as CO2,N2,CH4,H2,etc.which are | LIU Shuang LU Shuangfang YANG Jinxiu ZHANG Yanian | 2015 | Acta Geologica Sinica(English Edition)2015，89，A01： | 0 |
| 20 | 三阴性乳腺癌基因组与转录组全景图:亚型及治疗策略显示文摘文章简介三阴性乳腺癌(triple-negative breast cancer,TNBC)是雌激素受体、孕激素受体和HER-2均为阴性的一群乳腺癌,缺乏有效靶向治疗,预后差,是乳腺癌学界的世界性难题。近年的研究表明TNBC是一个异质性很强的群体,为更全面而深入地认识这类疾病,寻找精准治疗的突破口,研究团队全面分析了465例原发性三阴性乳腺癌(TNBC)队列的临床、基因组学和转录组学数据。 | Yi-Zhou Jiang Ding Ma Chen Suo Jinxiu Shi Mengzhu Xue Xin Hu Yi Xiao Ke-Da Yu Yi-Rong Liu Ying Yu Yuanting Zheng Xiangnan Li Chenhui Zhang Pengchen Hu Jing Zhang Qi Hua Jiyang Zhang Wanwan Hou Luyao Ren Ding Bao Bingying Li Jingcheng Yang Ling Yao Wen-Jia Zuo Shen Zhao Yue Gong Yi-Xing Ren Ya-Xin Zhao Yun-Song Yang Zhenmin Niu Zhi-Gang Cao Daniel G.Stover Claire Verschraegen Virginia Kaklamani Anneleen Daemen John R.Benson Kazuaki Takabe Fan Bai Da-Qiang Li 王鹏 石乐明 黄薇 邵志敏 | 2020 | 科学新闻2020，，2： | 0 |
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