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| 1 | Intracellular HMGB1 as a novel tumor suppressor of pancreatic cancer显示文摘尽管有最近的进展, oncogenic K 地岬驾驶的胰腺的 ductal 腺癌(PDAC ) 在最致命的人的癌症之中留在现代医学。PDAC 的致病对内在的染色体不稳定性和外来的发炎激活部分可归因。然而,在在胰腺的 tumorigenesis 的这二个事件之间的分子的连接充分还没被建立了。这里,我们证明(HMGB1 ) 细胞内部的高活动性组盒子 1 显著地压制 oncogenic 由禁止染色体的 K-Ras-driven 胰腺的 tumorigenesis 调停不稳定性的支持 inflammatory nucleosome 版本。任何一个单身者的有条件的基因脱离或在胰的 HMGB1 的两等位基因在出生使老鼠变为极其敏感到先锋损害的 oncogenic K-Ras-driven 开始,包括胰腺的 intraepithelial 瘤, intraductal 乳突的 mucinous 瘤,和 mucinous 膀胱的瘤。在胰的 HMGB1 的损失与染色体重新整理和 telomere 畸形描绘的氧化 DNA 损坏和 chromosomal 不稳定性被联系。这些导致煽动性的 nucleosome 版本并且宣传 K-Ras-driven 胰腺的 tumorigenesis。细胞外的 nucleosomes 支持 interleukin 6 (IL-6 ) 由渗入 macrophages/neutrophils 的分泌物并且提高在胰腺的损害表明激活的 oncogenic K 地岬。到 IL-6 或 histone H3 或为先进 glycation 的受体的大美人的抵销的抗体结束产品都限制表明激活的 K 地岬,阻止癌症开发和转移 / 侵略,并且延长在 Pdx1-Cre 的动物幸存; K 地岬 G12D/+;Hmgb1/ 鼠标。由 glycyrrhizin 的 HMGB1 损失的药理学抑制在煽动性的条件下面在老鼠限制 oncogenic K-Ras-driven tumorigenesis。减少在 PDAC 病人的 HMGB1 的原子、全部的细胞的表示与差的全面幸存相关,在 PDAC 与预示、治疗学的关联作为新奇肿瘤 suppressor 支持细胞内部的 HMGB1。 | Rui Kang Yangchun Xie Qiuhong Zhang Wen Hou Qingping Jiang Shan Zhu Jinbao Liu Dexing Zeng Haichao Wang David L Bartlet Timothy R Billiar Herbert J Zeh III Michael T Lotze Daolin Tang | 2017 | Cell Research2017，27，7： | 22 |
| 2 | Temperature action and effect of concrete-filled steel tubular bridges:A review显示文摘Concrete-filled steel tube(CFST)has been widely applied in bridges due to its excellent structural and constructional performance.In CFST bridges,temperature action is not only an important but also a special load that must be considered in bridge design,construction and structural evaluation.This paper presents an overview on current researches of the temperature action and effect of CFST bridges.The historical and spatial characteristics as well as corresponding influencing factors of temperature distributions are summarized,and classifications of temperature actions are also reviewed.Results show that in-depth investigations of the contributions of temperature influencing factors can help to effectively reduce the adverse temperature effects on CFST bridges in the design stage.Due to the lack of long-term measurements and insufficient use of historical meteorological data,research on the representative value along with correlation analysis of CFST temperature actions and meteorological parameters have to be further carried out.In the meanwhile,a decomposition method of temperature distribution is proposed based on structural effects of CFST bridges in this paper.The decomposed temperature actions can be used for more accurate effect calculation than traditional temperature action classification method,especially for CFST truss bridges.At last,specific temperature action patterns still need to be investigated in some of the special problems,such as longitudinal temperature differences along the CFST arch rib and thermal debonding in the CFST interface.Further investigations are required on the accurate simulation of temperature distribution of CFST bridges considering the shading effects of components and terrain. | Jiang Liu Yongjian Liu Chenyu Zhang Qiuhong Zhao Yi Lyu Lei Jiang | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，2： | 15 |
| 3 | Constrained large-eddy simulation and detached eddy simulation of flow past a commercial aircraft at 14 degrees angle of attack显示文摘With the development of computational power and numerical algorithms,computational fluid dynamics(CFD) has become an important strategy for the design of aircraft,which significantly reduces the reliance on wind-tunnel and flight tests.In this paper,we conducted a numerical investigation on the flow past a full commercial aircraft at Mach number 0.2 and 14 degrees angle of attack by means of Reynolds-averaged Navier-Stokes(RANS),detached-eddy simulation(DES) and our newly developed constrained large-eddy simulation(CLES).The objective of this paper is to study the capability of these models in simulating turbulent flows.To our knowledge,this is the first large-eddy simulation method for full commercial aircraft simulation.The results show that the CLES can predict the mean statistical quantities well,qualitatively consistent with traditional methods,and can capture more small-scale structures near the surface of the aircraft with massive separations.Our study demonstrates that CLES is a promising alternative for simulating real engineering turbulent flows. | CHEN ShiYi CHEN YingChun XIA ZhenHua QU Kun SHI YiPeng XIAO ZuoLi LIU QiuHong CAI QingDong LIU Feng LEE Cunbiao ZHANG RiKui CAI JinSheng | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，2： | 14 |
| 4 | Wheat powdery mildew resistance gene Pm64 derived from wild emmer (Triticum turgidum var.dicoccoides) is tightly linked in repulsion with stripe rust resistance gene Yr5显示文摘Stripe rust and powdery mildew are both devastating diseases for durum and common wheat.Pyramiding of genes conferring resistance to one or more diseases in a single cultivar is an important breeding approach to provide broader spectra of resistances in wheat improvement. A new powdery mildew resistance gene originating from wild emmer(Triticum turgidum var.dicoccoides) backcrossed into common wheat(T. aestivum) line WE35 was identified. It conferred an intermediate level of resistance to Blumeria graminis f. sp. tritici isolate E09 at the seedling stage and a high level of resistance at the adult plant stage. Genetic analysis showed that the powdery mildew resistance in WE35 was controlled by a dominant gene designated Pm64. Bulked segregant analysis(BSA) and molecular mapping indicated that Pm64 was located in chromosome bin 2 BL4-0.50–0.89. Polymorphic markers were developed from the corresponding genomic regions of Chinese Spring wheat and wild emmer accession Zavitan to delimit Pm64 to a 0.55 cM genetic interval between markers WGGBH1364 and WGGBH612, corresponding to a 15 Mb genomic region on Chinese Spring and Zavitan 2 BL, respectively. The genetic linkage map of Pm64 is critical for fine mapping and cloning. Pm64 was completely linked in repulsion with stripe rust resistance gene Yr5. Analysis of a larger segregating population might identify a recombinant line with both genes as a valuable resource in breeding for resistance to powdery mildew and stripe rust. | Deyun Zhang Keyu Zhu Lingli Dong Yong Liang Genqiao Li Tilin Fang Guanghao Guo Qiuhong Wu Jingzhong Xie Yongxing Chen Ping Lu Miaomiao Li Huaizhi Zhang Zhenzhong Wang Yan Zhang Qixin Sun Zhiyong Liu | 2019 | The Crop Journal2019，7，6： | 8 |
| 5 | Assessment of structural stability in Bohai Sea area based on AHP-GDM model显示文摘The AHP-GDM model is used for the assessment of structural stability, with the Bohai Sea area as an example. In this model, the credit degree of each expert is calculated through the assessment matrix based on the similarity and diversity of vector. The comprehensive opinions of expert panel are quantitatively obtained by considering the effect of credit degree. According to the geological structural setting, the Bohai Sea is divided into twelve assessment zones of structural stability by non-uniform element method. The structural stability grade of each zone is obtained on the basis of the latest geophysical data, earthquake statistical data, and the information of fault activities, current stress field and crustal deformation. The results show that there are one relatively stable area, three relatively sub-stable areas, six relatively sub-unstable areas and two relatively unstable areas. The assessment results of non-uniform element method are very close with those of uniform grid method with size of 0.25° in longitude direction and 0.14° in latitude direction. However the workload of non-uniform element method is only 1/16 of the latter. Compared with traditional assessment methods of structural stability, a more objective and reliable assessment result can be obtained by combining non-uniform element method and AHP-GDM model. | XIU Zongxiang LIU Baohua XIE Qiuhong LI Xishuang LIU Chenguang PEI Yanliang ZHENG Yanpeng | 2013 | Acta Oceanologica Sinica2013，32，4： | 8 |
| 6 | Microstructure and mechanical properties of Mg-4.0Zn alloy reinforced by NiO-coated CNTs显示文摘Mg-4.0Zn alloy composite reinforced by NiO-coated CNTs(NiO@CNTs) was synthesized by combining ball-milling and a casting process. The yield strength(YS) and elongation to failure of the composite were dramatically increased by 44.9% and 38.6%, respectively, compared to its alloy counterpart. The significantly enhanced mechanical properties of the as-synthesized composite are mainly ascribed to an improved interfacial bond, grain refinement and good dispersion of CNTs in the matrix via. coating NiO on CNTs.It is shown that the NiO-nanolayer on the CNTs significantly enhances the interfacial bonding strength and effectively prevents the agglomeration of CNTs. NiO@CNTs are, therefore, expected to be a highly sustainable and dispersible reinforcement for magnesium matrix composites with superior performance. | Qiuhong Yuan Xiaoshu Zeng Yanchun Wang Lan Luo Yan Ding Dejiang Li Yong Liu | 2017 | Journal of Materials Science & Technology2017，33，5： | 8 |
| 7 | Systemic induction of H_(2)O_(2) in pea seedlings pretreated by wounding and exogenous jasmonic acid显示文摘Pea seedlings (Pisum sativum L.) were used as materials to test the timings and compartments of hydrogen peroxide (H2O2) triggered by wounding and exogenous jasmonic acid (JA). The results showed that H2O2 could be systemically induced by wounding and exogenous JA. H2O2 increased within 1 h and reached the peak 3―5 h after wounding in either the wounded leaves or the unwounded leaves adjacent to the wounded ones and the inferior leaves far from the wounded ones. After this, H2O2 decreased and recovered to the control level 12 h after wounding. The activities of antioxidant enzymes, however, were rapidly increased by wounding. Diphenylene iodonium (DPI), an inhibitor of NADPH oxidase, could significantly inhibit H2O2 burst that was mediated by wounding and exogenous JA. Assay of H2O2 subcellular location showed that H2O2 in response to wounding and exogenous JA was predominantly accumulated in plasma membrane, cell wall and apoplasmic space. Numerous JA (gold particles) was found via immu- nogold electron microscopy to be located in cell wall and phloem zones of mesophyll cell after wounding. | LIU Yan 1,2 , HUANG Weidong 1 , ZHAN Jicheng 1 & PAN Qiuhong 1 1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China 2. College of Agronomy, Inner Mongolia Agricultural University, Huhhot 010019, China | 2005 | Science China(Life Sciences)2005，48，3： | 7 |
| 8 | Runout prediction and dynamic characteristic analysis of a potential submarine landslide in Liwan 3-1 gas field显示文摘A large number of submarine landslides with different scales have been identified in the canyon area of the submarine pipeline route of Liwan 3-1 gas field. There is still much chance that submarine slope failures would happen, and the following mass movement would present great risk to the submarine pipeline. In view of this, a numerical prediction method based on Eulerian-Eulerian two-phase flow model is introduced to simulate the mass movement of potential submarine landslides. The sliding soil and ambient water are respectively simulated by Herschel-Bulkley rheology model and Newtonian fluid model. The turbulence is simulated using the k-e model. Compared with both the experiment data and Bing result, the two-phase flow model shows a good accuracy, and its result is more close to the actual situation; the dynamic coupling between soil and ambient water can be effectively simulated and the phenomena of hydroplaning and head detachment can be obtained.Finally, the soil movement of a potential submarine landslide is simulated as an example, according to the seismic profile in the canyon area. The result shows that the hydroplaning occurs during the movement process. The runout distance calculated by the two-phase flow model is 877 m, which is 27.1% larger than the Bing result.However, the peak front velocity of soil is relative small, with a maximum value of 8.32 m/s. The Bing program with a simple and rapid process can be used for a preliminary evaluation, while the two-phase flow model is more appropriate for an accurate assessment. | XIU Zongxiang LIU Lejun XIE Qiuhong LI Jiagang HU Guanghai YANG Jianghui | 2015 | Acta Oceanologica Sinica2015，34，7： | 6 |
| 9 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 10 | Mapping stripe rust resistance genes by BSR-Seq:YrMM58 and YrHY1 on chromosome 2AS in Chinese wheat lines Mengmai 58 and Huaiyang 1 are Yr17显示文摘Stripe rust(yellow rust), caused by Puccinia striiformis f. sp. tritici(PST),is one of the most devastating fungal diseases in common wheat(Triticum aestivum L.) in China and worldwide. Resistance breeding is the most effective strategy to control diseases in crop plants. Chinese wheat lines Mengmai 58 and Huaiyang 1 are highly resistant to PST race CYR34(V26) at the adult plant stage. To genetically map the underlying resistance genes we developed segregating populations by crossing Mengmai 58 and Huaiyang 1 with the susceptible cultivar Nongda 399. The stripe rust resistances in Mengmai 58 and Huaiyang 1 were both controlled by single dominant genes, provisionally designated YrMM58 and YrHY1, respectively. Bulked segregant RNA-Seq(BSR-Seq) analysis showed that YrMM58 and YrHY1 were located in the same distal ~16 Mb region on chromosome 2 AS.Comparative genomics analysis with the physical map of Aegilops tauschii proved useful for developing additional markers to saturate the genetic linkage map. YrMM58 and YrHY1 were mapped to the distal end of chromosome arm 2 AS, with the closest marker WGGB148 being 7.7 cM and 3.8 cM from the resistance gene, which was considered to be Yr17. These markers can be used in marker-assisted selection. | Yong Wang Huaizhi Zhang Jingzhong Xie Bingmin Guo Yongxing Chen Huaiyu Zhang Ping Lu Qiuhong Wu Miaomiao Li Deyun Zhang Guanghao Guo Jian Yang Panpan Zhang Yan Zhang Xicheng Wang Hong Zhao Tingjie Cao Zhiyong Liu | 2018 | The Crop Journal2018，6，1： | 5 |
| 11 | Ultrathin ZnS nanosheet/carbon nanotube hybrid electrode for high-performance flexible all-solid-state supercapacitor显示文摘为在便携电子学的申请的灵活、容易可配置的 supercapacitors 表演伟人诺言。在这研究, multiwall C nanotubes (CNT ) 与层次 ultrathin 装饰了锌硫化物(ZnS ) nanosheets (ZnS@CNT ) 经由一个灵巧的方法被综合。产生 ZnS@CNT 电极,它交付 347.3 F | Xiaoyi Hou Tao Peng Jinbing Cheng Qiuhong Yu Rongjie Luo Yang Lu Xianming Liu Jang-Kyo Kim Jun He Yongsong Luo | 2017 | Nano Research2017，10，8： | 4 |
| 12 | Mapping a leaf senescence gene els1 by BSR-Seq in common wheat显示文摘Leaf senescence is normally the last stage of plant development. Early senescence of functional leaves significantly reduces the photosynthetic time and efficiency, seriously affecting grain yield and quality in wheat. Discovering genes responsible for early leaf senescence(els) are necessary for developing novel germplasms and cultivars with delayed leaf-senescence through molecular manipulation and marker assisted selection. In this study, we identified an early leaf senescence line M114 in a derivative of a wheat breeding population. Genetic analysis indicated that early leaf senescence in M114 is controlled by a single recessive gene, provisionally designated els1. By applying bulked segregant analysis and RNA-Seq(BSR-Seq), seven polymorphic markers linked to els1 were developed and the gene was located on chromosome arm 2 BS in a 1.5 c M genetic interval between markers WGGB303 and WGGB305. A co-segregating marker, WGGB302, provide a starting point for fine mapping and map-based cloning of els1. | Miaomiao Li Beibei Li Guanghao Guo Yongxing Chen Jingzhong Xie Ping Lu Qiuhong Wu Deyun Zhang Huaizhi Zhang Jian Yang Panpan Zhang Yan Zhang Zhiyong Liu | 2018 | The Crop Journal2018，6，3： | 3 |
| 13 | Space-Earth Integration Observation Based Environmental Emergency Monitoring and Management System Design显示文摘 | Tao Xie Rui Liu Qiuhong Hu | 2013 | 环境科学前沿(中英文版)2013，2，3： | 3 |
| 14 | The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen显示文摘Dear Editor,Rabbit hemorrhagic disease(RHD)is a fatal infectious disease that primarily affects adult rabbits and causes great economic losses in the rabbit industry(Mitro and Krauss,1993).The causative pathogen is rabbit hemorrhagic disease virus(RHDV),which belongs to the genus Lagovirus and the family Calicivirus(Moussa et al.,1992).In 1984,RHDV was first documented in China. | Ruibin Qi Chunchun Meng Jie Zhu Hang Li Qiuhong Miao Jingyu Tang Aoxing Tang Hongyuan Guo Chuncao Liu Chuanfeng Li Zongyan Chen Fang Wang Qinwen Zhang Guangqing Liu | 2022 | Virologica Sinica2022，37，4： | 3 |
| 15 | Effect of steam explosion and microbial fermentation on cellulose and lignin degradation of corn stover显示文摘 | Juan Chang Wei Cheng Qingqiang Yin Ruiyu Zuo Andong Song Qiuhong Zheng Ping Wang Xiao Wang Junxi Liu | 2011 | Bioresource Technology2011，，： | 3 |
| 16 | Cesium lead halide perovskite nanocrystals for ultraviolet and blue light blocking显示文摘Using cesium lead halide perovskite nanocrystals, CsPb(Cl/Br)3, as a light absorber, we report a highly effective UV and blue light blocking film. The CsPb(Cl/Br)3 nanocrystals are well dispersed in the ethyl cellulose(EC) matrix to compose a UV and blue light shielding film, and the absorption edge of the film is tunable by adjusting Cl to Br ratio using anion exchange. The CsPbCl2 Br-EC film exhibits a transmittance of 5% at 459 nm, 90% at 478 nm and 95% in the range of 500–800 nm, which makes it excellent for UV and blue light shielding. In addition, the as-prepared EC-CsPb(Cl/Br)3 film shows excellent photostability under UV irradiation. Results demonstrate that this EC-CsPb(Cl/Br)3 based materials with sharp absorbance edges, tunable blocking wavelength, and high photostability can be useful for the applications in UV and blue light blocking and optical filters. | Guihua Huang Yipeng Huang Wei Xu Qiuhong Yao Xiaofang Liu Caifeng Ding Xi Chen | 2019 | Chinese Chemical Letters2019，30，5： | 2 |
| 17 | Temperature rise and flow of Zr-based bulk metallic glasses under high shearing stress显示文摘Deformation of the bulk metallic glasses (BMGs) and the creation and propagation of the shear bands are closely interconnected.Shearing force was loaded on Zr 41.2 Ti 13.8 Cu 12.5 Ni 10.0 Be 22.5 (Vit.1) BMGs by cutting during the turning of the BMG rod.The temperature rise of alloy on the shear bands was calculated and the result showed that it could reach the temperature of the super-cooled liquid zone or exceed the melting point.The temperature rise caused viscous fluid flow and brought about the deformation of BMGs.This suggested that the deformation of BMGs was derived,at least to some extent,from the adiabatic shear temperature rise. | ZHANG WeiGuo MA MingZhen SONG AiJun LIANG ShunXing HAO QiuHong TAN ChunLin JING Qin LIU RiPing | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，11： | 2 |
| 18 | Projected Changes in Extreme High Temperature and Heat Stress in China显示文摘High temperature accompanied with high humidity may result in unbearable and oppressive weather. In this study,future changes of extreme high temperature and heat stress in China's Mainland are examined based on daily maximum temperature(T_x) and daily maximum wet-bulb globe temperature(T_w). T_w has integrated the effects of both temperature and humidity. Future climate projections are derived from the bias-corrected climate data of five general circulation models under the Representative Concentration Pathways(RCPs) 2.6 and 8.5 scenarios. Changes of hot days and heat waves in July and August in the future(particularly for 2020-50 and 2070-99), relative to the baseline period(1981-2010), are estimated and analyzed. The results show that the future T_x and T_w of entire China will increase by 1.5-5℃ on average around 2085 under different RCPs. Future increases in T_x and T_w exhibit high spatial heterogeneity, ranging from 1.2 to 6℃ across different regions and RCPs. By around 2085, the mean duration of heat waves will increase by 5 days per annum under RCP8.5. According to T_x, heat waves will mostly occur in Northwest and Southeast China, whereas based on T_w estimates, heat waves will mostly occur over Southeast China and the mean heat wave duration will be much longer than those from T_x. The total extreme hot days(T_x or T_w > 35℃) will increase by 10-30 days. Southeast China will experience the severest heat stress in the near future as extreme high temperature and heat waves will occur more often in this region, which is particularly true when heat waves are assessed based on T_w. In comparison to those purely temperature-based indices, the index T_w provides a new perspective for heat stress assessment in China. | Xingcai LIU Qiuhong TANG Xuejun ZHANG Siao SUN | 2018 | Journal of Meteorological Research2018，32，3： | 2 |
| 19 | Experimental and analytical studies on the stability of structural steel tube and coupler scaffolds without X-bracing显示文摘 | Hongbo Liu Qiuhong Zhao Xiaodun Wang Ting Zhou Dong Wang Jie Liu Zhihua Chen | 2009 | Engineering Structures2009，，4： | 2 |
| 20 | Adaptive fuzzy backstepping control for attitude stabilization of flexible spacecraft with signal quantization and actuator faults显示文摘In this study,the fault-tolerant attitude control of flexible spacecraft is investigated over digital communication channels,where a uniform quantizer is considered with respect to the sensor signals and controller indexes.Further,an adaptive fuzzy backstepping control strategy has been developed for the considered attitude stabilization issue,where the adaptive fuzzy logic method is used to approximate the rigid-flexible coupled nonlinearity of the spacecraft.In this design,the online adjusting quantizer parameters are injected into the controller gains to simultaneously compensate for the quantization errors and timevarying actuator faults.In the proposed control method,the attitude stabilization task is achieved in the presence of external disturbances,time-varying actuator faults,and signal quantization.Finally,the practical examples are compared to demonstrate the effectiveness of the proposed control strategy. | Qiuhong LIU Ming LIU Guangren DUAN | 2021 | Science China(Information Sciences)2021，64，5： | 2 |
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