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| 1 | Prion protein devoid of the octapeptide repeat region restores susceptibility to scrapie in PrP knockout mice显示文摘 | Flechsig E Shmerling D Hegyi I | 2000 | Neuron2000，27，： | 1 |
| 2 | Effect of chronic stress during early postnatal ontogeny on structural characteristics of the myocardium and glomerular apparatus of the kidneys in NISAG rats显示文摘 | SHMERLING M D FILYUSHINA E E KOROSTYSHEVSKAYA I M | 2003 | Bull Exp Biol Med2003，136，1： | 1 |
| 3 | The American College of Rheumatology criteria for the classification of systemic lupus erythematosus : strengths, weaknesses, and opportunities for improvement 显示文摘 | Smith EL Shmerling RH | 1999 | Lupus1999，8，： | 1 |
| 4 | Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions显示文摘 | Shmerling D Hegyi I Fischer M | 1998 | Cell1998，93，2： | 1 |
| 5 | A review of fibromyalgia 显示文摘 | Nampiaparampil DE Shmerling RH | 2004 | Am J Manag Care2004，10，： | 1 |
| 6 | The WNT1^(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV显示文摘The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies. | Nele Vollersen Wenbo Zhao Tim Rolvien Fabiola Lange Felix Nikolai Schmidt Stephan Sonntag Doron Shmerling Simon von Kroge Kilian Elia Stockhausen Ahmed Sharaf Michaela Schweizer Meliha Karsak Bjorn Busse Ernesto Bockamp Oliver Semler Michael Amling Ralf Oheim Thorsten Schinke Timur Alexander Yorgan | 2021 | Bone Research2021，9，4： | 1 |
| 7 | Expression of aminoterminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions显示文摘 | Shmerling D Hegyi I Fischer M | 1998 | Cell1998，93，： | 1 |
| 8 | Prion protein devoid of the octapeptide repeat region restores sus- ceptibility to scrapie in PrP knockout mice显示文摘 | Flechsig E Shmerling D Hegyi I | 2000 | Neu- ron2000，27，： | 1 |
| 9 | Structural char- acteristics of adenohypophysis in hypertensive ISIAH rats in early ontogeny显示文摘 | Buzueva II Filyushina EE Shmerling MI) | 2012 | Bull Exp Biol Med2012，152，3： | 1 |
| 10 | Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions显示文摘 | SHMERLING D HEGYI I FISCHER M | 1998 | Cell1998，93，： | 1 |
| 11 | Testing for anti-cyclic citrullinated peptide antibodies: is it time to set this genie free? 显示文摘 | Shmerling RH | 2009 | Arch Intern Med2009，169，： | 1 |
| 12 | Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions显示文摘 | Shmerling D Hegyi I Fischer M | 1998 | Cell1998，93，2： | 1 |
| 13 | The American College of Rheuma- tology criteria for the classification of systemic lupus erythemato- sus :strengths, weaknesses and opportunities for improvement 显示文摘 | Smith EL Shmerling RH | 1999 | Lupus1999，8，8： | 1 |
| 14 | CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice显示文摘 | Nguyen Hang Thi Thu Dalmasso Guillaume Torkvist Leif Halfvarson Jonas Yan Yutao Laroui Hamed Shmerling Doron Tallone Tiziano D’Amato Mauro Sitaraman Shanthi V Merlin Didier | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 15 | The benefit of nonpharmacologic therapy to treat symptomatic osteoarthritis显示文摘 | LEE YC SHMERLING RH | 2008 | Curr Rheumatol Rep2008，10，1： | 1 |
| 16 | Diangnostic tests for rheumatic disease: clinicalutility revisited显示文摘 | SHMERLING R H | 2005 | South Med2005，98，7： | 1 |
| 17 | The benefit of nonpharmacologic therapy to treat symptomatic osteoarthritis显示文摘 | Lee YC Shmerling RH | 2008 | Curr Rheumatol Rep2008，10，1： | 1 |
| 18 | Diagnoistic tests for rheumatic disease : clinical utility revisited显示文摘 | Shmerling RH | 2005 | South Med J2005，98，7： | 1 |
| 19 | Autoantibodies in systemic lupus erythematosus there before you know it显示文摘 | Shmerling R H | 2003 | N Engl J Med2003，349，16： | 1 |
| 20 | Autoantibodies in systemic lupus erythematosus there before you know it显示文摘 | Shmerling R H | 2003 | N Engl J Med2003，349，16： | 1 |
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