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| 1 | Bacteremia in hemodialysis patients显示文摘Infection is a common complication and is the second leading cause of death in hemodialysis patients. The risk of bacteremia in hemodialysis patients is 26-fold higher than in the general population, and 1/2-3/4 of the causative organisms of bacteremia in hemodialysis patients are Gram-positive bacteria. The ratio of resistant bacteria in hemodialysis patients compared to the general population is unclear. Several reports have indicated that hemodialysis patients have a higher risk of methicillin-resistant Staphylococcus aureus infection. The most common site of infection causing bacteremia is internal prostheses; the use of a hemodialysis catheter is the most important risk factor for bacteremia. Although antibiotic lock of hemodialysis catheters and topical antibiotic ointment can reduce catheter-related blood stream infection(CRBSI), their use should be limited to necessary cases because of the emergence of resistant organisms. Systemic antibiotic administration and catheter removal is recommended for treating CRBSI, although a study indicated the advantages of antibiotic lock and guidewire exchange of catheters over systemic antibiotic therapy. An infection control bundle recommended by the Center for Disease Control and Prevention succeeded in reducing bacteremia in hemodialysis patients with either a catheter or arteriovenous fistula. Appropriate infection control can reduce bacteremia in hemodialysis patients. | Masashi Suzuki Nobuhiko Satoh Motonobu Nakamura Shoko Horita George Seki Kyoji Moriya | 2016 | World Journal of Nephrology2016，5，6： | 14 |
| 2 | Hyperglycemia is a significant prognostic factor of hepatocellular carcinoma after curative therapy显示文摘AIM:To evaluate whether metabolic factors are related to distant recurrence of hepatocellular carcinoma(HCC) and survival after curative treatment.METHODS:This retrospective study included 344 patients whose HCC was treated curatively by radiofrequency ablation(RFA) therapy.The mean age was 67.6 years and the mean observation period was 4.04 years.The etiological background of liver disease was hepatitis B virus infection in 30,hepatitis C virus infection in 278,excessive alcohol drinking in 9,and other in 27 patients.The Child-Pugh classification grade was A(n = 307) or B(n = 37).The number of HCC nodules was one in 260,two in 61,and three in 23 patients.For surveillance of HCC recurrence after curative therapy with RFA,patients were radiologically evaluated every 3 mo.Factors associated with distant recurrence of HCC or survival were studied.RESULTS:Inadequate maintenance of blood glucose in diabetic patients was associated with higher incidence of distant recurrence.The 1-,2-,and 3-year recurrence rates were significantly higher in diabetic patients with inadequate maintenance of blood glucose compared with the others:50.6% vs 26.8%,83.5% vs 54.4%,and 93.8% vs 73.0%,respectively(P = 0.0001).Inadequate maintenance of blood glucose was an independent predictor of distant recurrence [adjusted relative risk 1.97(95%CI,1.33-2.91),(P = 0.0007)] after adjustment for other risk factors,such as number of HCC nodules [2.03(95%CI,1.51-2.73),P < 0.0001] and initial level of serum alpha fetoprotein(AFP) [1.43(95%CI,1.04-1.97),P = 0.028].Obesity was not an independent predictor of recurrence.The incidence of distant recurrence did not differ between diabetic patients with adequate maintenance of blood glucose and non-diabetic patients.Among 232 patients who had HCC recurrence,138 had a second recurrence.The 1-,2-,and 3-year rates of second recurrence were significantly higher in diabetic patients with inadequate maintenance of blood glucose than in the others:9.0% vs 5.9%,53.1% vs 24.3%,and 69.6% vs 42.3%,respectively(P = 0.0021).Inadequate maintenance of blood glucose in diabetic patients [1.99(95%CI,1.23-3.22),P = 0.0049] and presence of multiple HCC nodules [1.53(95%CI,1.06-2.22),P = 0.024] were again significantly associated with second HCC recurrence.Inadequate maintenance of blood glucose in diabetic patients was also a significant predictor of poor survival [2.77(95%CI,1.38-5.57),P = 0.0046] independent of excessive alcohol drinking [6.34(95%CI,1.35-29.7),P = 0.019],initial level of serum AFP [3.40(95%CI,1.88-6.18),P < 0.0001] and Child-Pugh classification grade B [2.24(95%CI,1.12-4.46),P = 0.022].Comparing diabetic patients with inadequate maintenance of blood glucose vs the others,the 1-,2-,and 3-year survival rates were significantly lower in diabetic patients with inadequate maintenance of blood glucose:92% vs 99%,85% vs 96%,and 70% vs 92%,respectively(P = 0.0003).CONCLUSION:Inadequate maintenance of blood glucose in diabetic patients is a significant risk factor for recurrence of HCC and for poor survival after curative RFA therapy. | Takanori Hosokawa Masayuki Kurosaki Kaoru Tsuchiya Shuya Matsuda Masaru Muraoka Yuichiro Suzuki Nobuharu Tamaki Yutaka Yasui Toru Nakata Takashi Nishimura Shoko Suzuki Ken Ueda Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Namiki Izumi | 2013 | World Journal of Gastroenterology2013，19，2： | 12 |
| 3 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 4 |
| 4 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 5 | Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors显示文摘 | Naoki Ishii Noriyuki Horiki Toshiyuki Itoh Masataka Maruyama Michitaka Matsuda Takeshi Setoyama Shoko Suzuki Shino Uchida Masayo Uemura Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2010 | Surgical Endoscopy2010，，6： | 3 |
| 6 | Endoscopic submucosal dissection with a combination of small-caliber-tip transparent hood and flex knife is a safe and effective treatment for superficial esophageal neoplasias显示文摘 | Naoki Ishii Noriyuki Horiki Toshiyuki Itoh Masayo Uemura Masataka Maruyama Shoko Suzuki Shino Uchida Yusuke Izuka Katsuyuki Fukuda Yoshiyuki Fujita | 2010 | Surgical Endoscopy2010，，2： | 2 |
| 7 | A semi- supervised learning approach using spatio-temporal informa tion for indoor location estimation显示文摘 | Hisashi Kashima Shoko Suzuki Shohei Hido | 2008 | IEEE Intelligent Sys- tems2008，，2： | 1 |
| 8 | Functional coupling of V-ATPase and CLC-5显示文摘Dent's disease is an X-linked renal tubulopathy characterized by low molecular weight proteinuria,hypercalciuria and progressive renal failure. Disease aetiology is associated with mutations in the CLCN5 gene coding for the electrogenic 2Cl^-/H^+ antiporter chloride channel 5(CLC-5),which is expressed in the apical endosomes of renal proximal tubules with the vacuolar type H^+-ATPase(V-ATPase). Initially identified as a member of the CLC family of Cl- channels,CLC-5 was presumed to provide Cl- shunt into the endosomal lumen to dissipate H^+ accumulation by V-ATPase,thereby facilitating efficient endosomal acidification. However,recent findings showing that CLC-5 is in fact not a Cl-channel but a 2Cl^-/H^+ antiporter challenged this classical shunt model,leading to a renewed and intense debate on its physiological roles. Cl- accumulation via CLC-5 is predicted to play a critical role in endocytosis,as illustrated in mice carrying an artificial Cl- channel mutation E211 A that developed defective endocytosis but normal endosomal acidification. Conversely,a recent functional analysis of a newly identified disease-causing Cl^- channel mutation E211 Q in a patient with typical Dent's disease confirmed the functional coupling between V-ATPase and CLC-5 in endosomal acidification,lending support to the classical shunt model. In this editorial,we will address the current recognition of the physiological role of CLC-5 with a specific focus on the functional coupling of V-ATPase and CLC-5. | Nobuhiko Satoh Masashi Suzuki Motonobu Nakamura Atsushi Suzuki Shoko Horita George Seki Kyoji Moriya | 2017 | World Journal of Nephrology2017，6，1： | 1 |
| 9 | Direct and rapid detection of porcine epidemic diarrhea virus by RT-PCR显示文摘 | Kiyoyasu Ishikawa Hideto Sekiguchi Tomoe Ogino Shoko Suzuki | 1997 | Journal of Virological Methods1997，，1： | 1 |
| 10 | A novel clinical entity, IgG4-related disease (IgG4RD): general concept and details显示文摘 | Hisanori Umehara Kazuichi Okazaki Yasufumi Masaki Mitsuhiro Kawano Motohisa Yamamoto Takako Saeki Shoko Matsui Takayuki Sumida Tsuneyo Mimori Yoshiya Tanaka Kazuo Tsubota Tadashi Yoshino Shigeyuki Kawa Ritsuro Suzuki Tsutomu Takegami Naohisa Tomosugi Nozo | 2012 | Modern Rheumatology2012，，1： | 1 |
| 11 | Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors显示文摘 | Naoki Ishii Noriyuki Horiki Toshiyuki Itoh Masataka Maruyama Michitaka Matsuda Takeshi Setoyama Shoko Suzuki Shino Uchida Masayo Uemura Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2010 | Surgical Endoscopy2010，，6： | 1 |
| 12 | Regulatory roles of nitric oxide and angiotensin Ⅱ on renal tubular transport显示文摘Renal tubules regulate blood pressure and humoral homeostasis.Mediators that play a significant role in regulating the transport of solutes and water include angiotensin Ⅱ(AngⅡ) and nitric oxide(NO).AngⅡ can significantly raise blood pressure via effects on the heart,vasculature,and renal tubules.AngⅡ generally stimulates sodium reabsorption by triggering sodium and fluid retention in almost all segments of renal tubules.Stimulation of renal proximal tubule(PT) transport is thought to be essential for AngⅡ-mediated hypertension.However,AngⅡ has a biphasic effect on in vitro PT transport in mice,rats,and rabbits:stimulation at low concentrations and inhibition at high concentrations.On the other hand,NO is generally thought to inhibit renal tubular transport.In PTs,NO seems to be involved in the inhibitory effect of AngⅡ.A recent study reports a surprising finding:AngⅡ has a monophasic stimulatory effect on human PT transport.Detailed analysis of signalling mechanisms indicates that in contrast to other species,the human NO/guanosine3',5'-cyclic monophosphate/extracellular signal-regulated kinase pathway seems to mediate this effect of AngⅡ on PT transport.In this review we will discuss recent progress in understanding the effects of AngⅡ and NO on renal tubular transport. | Shoko Horita Motonobu Nakamura Ayumi Shirai Osamu Yamazaki Nobuhiko Satoh Masashi Suzuki George Seki | 2014 | World Journal of Nephrology2014，3，4： | 1 |
| 13 | Erectile dysfunction in patients with chronic viral liver disease: its relevance to protein malnutrition显示文摘 | Katsuhisa Toda Yoshiyuki Miwa Shoko Kuriyama Hideki Fukushima Makoto Shiraki Nobuo Murakami Makoto Shimazaki Yoichiro Ito Toshiyuki Nakamura Jun’ichi Sugihara Eiichi Tomita Chisato Nagata Kazutomo Suzuki Hisataka Moriwaki | 2005 | Journal of Gastroenterology2005，，9： | 1 |
| 14 | Endoscopic submucosal dissection (ESD) for gastrointestinal carcinoid tumors显示文摘 | Shoko Suzuki Naoki Ishii Masayo Uemura Gautam A. Deshpande Michitaka Matsuda Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 15 | Endoscopic submucosal dissection (ESD) for gastrointestinal carcinoid tumors显示文摘 | Shoko Suzuki Naoki Ishii Masayo Uemura Gautam A. Deshpande Michitaka Matsuda Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 16 | Endoscopic band ligation for colonic diverticular hemorrhage显示文摘 | Naoki Ishii Takeshi Setoyama Gautam A. Deshpande Fumio Omata Michitaka Matsuda Shoko Suzuki Masayo Uemura Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 17 | Endoscopic band ligation for colonic diverticular hemorrhage显示文摘 | Naoki Ishii Takeshi Setoyama Gautam A. Deshpande Fumio Omata Michitaka Matsuda Shoko Suzuki Masayo Uemura Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2012 | Gastrointestinal Endoscopy2012，，2： | 1 |
| 18 | Endoscopic submucosal dissection with a combination of small-caliber-tip transparent hood and flex knife for large superficial colorectal neoplasias including ileocecal lesions显示文摘 | Naoki Ishii Toshiyuki Itoh Noriyuki Horiki Michitaka Matsuda Takeshi Setoyama Shoko Suzuki Masayo Uemura Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2010 | Surgical Endoscopy2010，，8： | 1 |
| 19 | Structural and physiological studies on the storage β-polyglucan of haptophyte Pleurochrysis haptonemofera显示文摘 | Yasutaka Hirokawa Shoko Fujiwara Motoya Suzuki Tomoka Akiyama Minako Sakamoto Saori Kobayashi Mikio Tsuzuki | 2008 | Planta2008，，3： | 1 |
| 20 | Prospective comparison of real‐time tissue elastography and serum fibrosis markers for the estimation of liver fibrosis in chronic hepatitis C patients显示文摘 | Nobuharu Tamaki Masayuki Kurosaki Shuya Matsuda Toru Nakata Masaru Muraoka Yuichiro Suzuki Yutaka Yasui Shoko Suzuki Takanori Hosokawa Takashi Nishimura Ken Ueda Kaoru Tsuchiya Hiroyuki Nakanishi Jun Itakura Yuka Takahashi Kotaro Matsunaga Kazuhiro Taki Y | 2014 | Hepatol Res2014，，7： | 1 |
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