|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells显示文摘AIM: To determine the anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) which is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore the immunoregulatory mechanisms. METHODS: Peripheral blood mononuclear cells (PBMNC) from UC patients or HT-29 cells were co-cultured with heat-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate the amount of IL-10 or IL-8 secreted. RESULTS: Both strains of probiotic Bifidobacteria contained in the BFM induced IL-10 production in PBMNC from UC patients, though BbrY was more effective than BbiY. Conditioned medium (CM) and DNA of both strains inhibited IL-8 secretion in HT-29 cells stimulated with TNF-α, whereas no such effect was observed with heat- killed bacteria. The inhibitory effect of CM derived from BbiY was greater than that of CM derived from BbrY. DNAs of the two strains had a comparable inhibitory activity against the secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with a higher expression of IκB-ζ mRNA 4 h after culture of HT-29 cells compared to that in the absence of CM.CONCLUSION: Probiotic Bifidobacterium strains in BFM enhance IL-10 production in PBMNC and inhibit IL-8 secretion in intestinal epithelial cells, suggesting that BFM has anti-inflammatory effects against ulcerative colitis. | Akemi Imaoka Tatsuichiro Shima Kimitoshi Kato Shigeaki Mizuno Toshiki Uehara Satoshi Matsumoto Hiromi Setoyama Taeko Hara Yoshinori Umesaki | 2008 | World Journal of Gastroenterology2008，14，16： | 37 |
| 2 | Involvement of parasympathetic pelvic efferent pathway in psychological stress-induced defecation显示文摘AIM:To investigate the role of the pelvic nerve pathway in stress-induced acceleration of colorectal transit and defecation in rats.METHODS:Surgical transection of rectal nerves(rectal branches of the pelvic nerve),vagotomy(Vag) or adrenalectomy(Adx) were performed bilaterally in rats.Number of fecal pellet output of these rats was measured during 1-h water avoidance stress(WAS).To evaluate the colonic transit,rats were given phenol red through the catheter indwelled in the proximal colon and subjected to WAS.After WAS session,entire colon and rectum were isolated and distribution of phenol red was measured.Distal colonic and rectal transit was evaluated using glass bead.Rats were inserted the glass bead into the distal colon and evacuation rate of the bead was measured.Neural activation was assessed by immunohistochemical staining of c-Fos and PGP9.5 in colonic whole-mount preparations of longitudinal muscle myenteric plexus(LMMP).RESULTS:In the sham-operated rats(sham op),WAS significantly increased defecation and accelerated colorectal transit with marked elevation of plasma corticosterone level.Compared with sham-operated rats,increase in the excretion of fecal pellets during WAS was significantly reduced by rectal nerve transection(RNT)(sham op:6.9 ± 0.8 vs RNT:4.3 ± 0.6,P < 0.05) or Vag(sham op:6.4 ± 0.8 vs Vag:3.7 ± 1.1,P < 0.05),although corticosterone level remained elevated.Adx-rats significantly increased the defecation despite the lower corticosterone level.Distribution pattern of phenol red showed RNT inhibited distal colonic and rectal transit accelerated by WAS,while Vag inhibited proximal colonic transit.Suppression of distal colonic and rectal transit by RNT was further confirmed by the bead evacuation rate(sham op:80.0% vs RNT:53.8%).WAS significantly increased the number of c-Fos-immunoreactive neural cells in the LMMP of the proximal and distal colon,whereas c-Fos expression was decreased by RNT in the distal colon(sham op:9.0 ± 2.0 vs RNT:4.4 ± 1.0,P < 0.05) and decreased by Vag in the proximal colon.CONCLUSION:Pelvic nerve conveys WAS stimuli from the brain to the distal colon,and directly activate the myenteric neurons,followed by the increase of its motility. | Kazunori Suda Hiromi Setoyama Masanobu Nanno Satoshi Matsumoto Mitsuhisa Kawai | 2013 | World Journal of Gastroenterology2013，19，8： | 4 |
| 3 | Expression of vascular endothelial growth factor?C and vascular endothelialgrowth factor receptor?3 in esophageal squamous cell carcinoma显示文摘 | Itaru Omoto Masataka Matsumoto Hiroshi Okumura Yasuto Uchikado Tetsuro Setoyama Yoshiaki Kita Tetsuhiro Owaki Yuko Kijima Hiroyuki Shinchi Sumiya Ishigami Shinichi Ueno Shoji Natsugoe | 2014 | Oncology Letters2014，，4： | 3 |
| 4 | Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors显示文摘 | Naoki Ishii Noriyuki Horiki Toshiyuki Itoh Masataka Maruyama Michitaka Matsuda Takeshi Setoyama Shoko Suzuki Shino Uchida Masayo Uemura Yusuke Iizuka Katsuyuki Fukuda Koyu Suzuki Yoshiyuki Fujita | 2010 | Surgical Endoscopy2010，，6： | 3 |
| 5 | Inflammatory bowel disease-like enteritis and caecitis in a senescence accelerated mouse P1/Yit strain显示文摘 | Matsumoto S Okabe Y Setoyama H | 1998 | Gut1998，43，1： | 1 |
| 6 | Cytosolic free Ca2+ in human syncyt iotrophoblast cells increased by gonadotropin-releasing hormone显示文摘 | | | Endoc,199 3,133(5):2220-22260，，5： | 1 |
| 7 | Beneficial effects of perioperative low-dose inhaled carbon monoxide on pulmonary al- lograft survival in MHC-inbred CLAWN miniature swine 显示文摘 | Sahara H Shimizu A Setoyama K | 2010 | Transplantation2010，90，12： | 1 |
| 8 | Structure of the intestinal flora re- sponsible for development of the gut immune system in a rodent mod- el 显示文摘 | UMESAKI Y SETOYAMA H | 2000 | Microbes and Infection2000，2，11： | 1 |
| 9 | Snail plays a key role in E-cadherin-preserved esophageal squamous cellcarcinoma显示文摘 | Shoji Natsugoe Yasuto Uchikado Hiroshi Okumura Masataka Matsumoto Tetsuro Setoyama Kiyokazu Tamotsu Yoshiaki Kita Akihiko Sakamoto Testuhiro Owaki Sumiya Ishigami Takashi Aikou | 2007 | Oncology Reports2007，，3： | 1 |
| 10 | Improvement of human faecal flora-associated mouse model for evaluation of the functional foods显示文摘 | IMAOKA A SETOYAMA H TAKGI A | 2004 | Journal of Applied Microbiology2004，96，4： | 1 |
| 11 | A splice variant of the TCR zeta mRNA lacking exon 7 leads to the down-regulation of TCR zeta, TCR/CD3 complex and IL-2 production in the systemic lupus erythematosus T cells 显示文摘 | TSUZAKA K SETOYAMA Y YOSHIMOTO K | 2005 | J Immunol2005，174，6： | 1 |
| 12 | Peer support from online community on the internet among patients with breast cancer in Ja- pan 显示文摘 | Setoyama Y Nakayama K Yamazaki Y | 2009 | Stud Health Technol Inform2009，146，1： | 1 |
| 13 | FOXP3 is a direct target of miR15a/16 in umbilical cord blood regulatory T cells 显示文摘 | Liu X Robinson SN Setoyama T | 2014 | Bone Marrow Transplant2014，49，6： | 1 |
| 14 | Size-controlled synthesis and catalytic performance of Pt nanoparticles in micro and mesoporous silica prepared using supercritical solvents 显示文摘 | Wakayama H Setoyama N Fukushima Y | 2003 | Advanced Materials2003，15，9： | 1 |
| 15 | A pediatric case of sclerodermatous chronic graft-versus-host disease显示文摘 | Terasaki K4 Kanekura T Setoyama M | 2003 | Pediatr Dermatol2003，20，4： | 1 |
| 16 | A splice variant of the TCR zeta mRNA lacking exon 7 leads to the dowm regulation of TCR zeta, TCR/CD3 complex and IL-2 production in the systemic lupus erythematosus T cells显示文摘 | Tsuzaka K Setoyama Y Yoshimoto K | 2005 | J Immunol2005，174，6： | 1 |
| 17 | Signal transducer and acti- vator of transcription (STAT)-3 regulates microRNA gene expres- sion in chronic lymphocytic leukemia cells显示文摘 | Rozovski U Calin GA Setoyama T | 2013 | Mol Cancer2013，12，： | 1 |
| 18 | Formation of cubic-AlN in TiN/ AlN superlattice 显示文摘 | Setoyama M Nakayama A Tanaka M | 1996 | Surface and Coatings Technology1996，8687，1： | 1 |
| 19 | Formation of cubic-AlN in TiN/AlN super-lattice 显示文摘 | Setoyama M Nakayama A Tanaka M | 1996 | Surface and Coatings Technology1996，8687，13： | 1 |
| 20 | Overexpression of vascular endothelial growth factor-C correlates with lymph node micrometastasis in submucosal esophageal cancer显示文摘 | Masataka Matsumoto M.D. Ph.D. Shoji Natsugoe M.D. Ph.D. Hiroshi Okumura M.D. Ph.D. Hideo Arima M.D. Shigehiro Yanagita M.D. Yasuto Uchikado M.D. Ph.D. Naoya Yokomakura M.D. Tetsuro Setoyama M.D. Sumiya Ishigami M.D. Ph.D. Sonshin Takao M.D. Ph.D. Ta | 2006 | Journal of Gastrointestinal Surgery2006，，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员