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| 1 | PTEN and Ki67 expression is associated with clinicopathologic features of non-small cell lung cancer显示文摘Phosphatase and tensin homolog deleted on chromosome 10(PTEN) and the proliferating antigen Ki67 have been widely studied in several tumors.However,their role as indicator in non-small cell lung cancer(NSCLC)remains unknown.Here,we investigated the expression of PTEN and Ki67 in NSCLC tissues and paired normal lung tissues to identify whether these proteins are associated with lung cancer development and survival.Immunohistochemistry for PTEN and Ki67 was performed on 67 lung cancer tissues and 41 paired adjacent normal lung tissues to detect the expression of these two proteins.The expression of PTEN in NSCLC tissues(32.8%) was significantly lower than that in normal tissues(82.9%,P < 0.05).In contrast,the expression of Ki67 in NSCLC tissues(76.1%) was significantly higher than that in normal tissues(27.3%,P < 0.05).Expression of both PTEN and Ki67 were strongly associated with tumor histology,clinical stage,lymph node metastasis,differentiation and4-year postoperative survival rate(P < 0.05).However,PTEN expression was negatively correlated with Ki67 expression(r =-0.279,P < 0.05).In conclusion,low PTEN expression and Ki67 overexpression are associated with malignant invasion and lymph node metastasis of NSCLC.These proteins may serve as diagnostic and prognostic biomarkers of NSCLC. | Yong Ji Mingfeng Zheng Shugao Ye Jingyu Chen Yijiang Chen | 2014 | The Journal of Biomedical Research2014，28，6： | 16 |
| 2 | Fingerprinting hydrothermal fluids in porphyry Cu deposits using K and Mg isotopes显示文摘In this study, we performed an integrated investigation of K and Mg isotopes in hydrothermally altered rocks from the giant Dexing porphyry Cu deposit in China. Both the altered porphyry intrusion and the surrounding wall rocks exhibit large variations in K and Mg isotope compositions, with δ41K values ranging between-1.02‰ and 0.38‰, and δ26Mg values ranging between-0.49‰ and 0.32‰. The δ41K and δ26Mg values of the majority of altered samples are higher than the isotopic baseline values for upper continental crust. We attribute the general increase in δ41 K and δ26Mg in altered rocks to hydrothermal alteration,which caused preferential incorporation of heavy K and Mg isotopes in alteration products, particularly phyllosilicates. However,a few altered samples show anomalously low δ41K and δ26Mg values. The δ41K and δ26Mg values do not correlate with K and Mg concentrations, or mineralogy of altered samples. The variable K-Mg isotope data likely reflect fluids of different physicalchemical properties, or different isotopic compositions. Based on the combined K-Mg isotope data, at least three groups of hydrothermal fluids are distinguished from the Dexing porphyry deposit. Therefore, K-Mg isotopes are potentially a novel tracer for fingerprinting fluids in complex hydrothermal systems. | Weiqiang LI Shugao ZHAO Xiaomin WANG Shilei LI Guoguang WANG Tao YANG Zhangdong JIN | 2020 | Science China Earth Sciences2020，63，1： | 4 |
| 3 | Relationships between Artemisia ordosica communities and environmental factors following sand-dune stabilization in the Mu Us desert,northwest China显示文摘Artemisia ordosica is an excellent sand-fixing shrub for sand stabilization in northwestern China. Sand dune stabilization, a critically important process, leads changes in abiotic factors, such as soil structure and nutrient contents. However, the effects of factors on an A.ordosica community following sand stabilization remain unclear. In this study, we used canonical correspondence analysis(CCA) to examine the relationships between A.ordosica communities and environmental factors at three habitats: semi-fixed dune(SF), fixed dune with low-coverage biological soil crust(F), and fixed dune with highcoverage biological soil crust(FC) in Mu Us desert. The mean height and coverage of plants increased with sand stabilization, while species diversity and richness increased initially and then reduced significantly. Correlation analysis and CCA revealed that slope, soil organic carbon, and nutrient contents, proportion of fine soil particles, soil moisture, and thickness of biological soil crust were allhighly correlated with vegetation characteristics. These environmental factors could explain 40.42 % of the vegetation–environment relationships at the three habitats. The distribution of plant species was positively related to soil moisture in the SF dune. Soil moisture, soil nutrient, and fine-particle contents mainly affected plants distribution in the F dune. In the FC dune, distribution of plant species was positively and negatively correlated with the thickness of biological soil crust and soil moisture at a depth0–20 cm, respectively. The dominance value of typical steppe species increased significantly following sand-dune stabilization and relations between species and samples in CCA ordination bi-plots showed that perennial grasses could invade the A. ordosica community on FC, indicating A. ordosica communities had a tendency to change into typical steppe vegetation with the further fixation. We conclude that the significant differentiation not only occurred in community characteristics, but also in the relationships between vegetation and environmental factors among the three stages of dune fixation. So, restoration of degraded dune ecosystems should be based on habitat conditions and ecological needs. | Dongqing Fan Yuqing Zhang Shugao Qin Bin Wu | 2017 | Journal of Forestry Research2017，28，1： | 3 |
| 4 | Design and implementation of remote/short-range smart home monitoring system based on ZigBee and STM32显示文摘 | LIN Y KONG R SHUGAO D R S | 2013 | 255-2632013，，： | 1 |
| 5 | Damping properties of blends based on EVM显示文摘 | Shi Xinyan Bi Weina Zhao Shugao | 2011 | Journal of Macromolecular Science (Part B) : Physics2011，50，10： | 1 |
| 6 | DMA analysis of the damping of ethylene-vinyl acetate/acrylonitrile butadiene rub- ber blends 显示文摘 | Shi Xinyan Bi Weina Zhao Shugao | 2012 | Journal of Applied Polymer Science2012，124，3： | 1 |
| 7 | Study on the Damping of EVM Based Blends显示文摘 | Shi X Y Bi Weina Zhao Shugao | 2011 | Journal of Applied Polymer Science2011，120，2： | 1 |
| 8 | A study of wettability and permeability change caused by absorption of nanometer structured polysilicon on the surface of porous media 显示文摘 | Ju Binshan Dai Shugao Luan Zhian | 2002 | SPE 779382002，，： | 1 |
| 9 | Properties and Structure of Dynamically Vulcanized TPU/EVA Blends显示文摘 | Xinyan S L Jiwen Z Shugao | 2009 | Jour- nal of Macromolecular Science Part B: Physics2009，48，6： | 1 |
| 10 | Damping properties of blends based on EVM显示文摘 | Shi Xingyan Bi Weina Zhao Shugao | 2011 | Journal of Macromolecular Science (part B)2011，50，10： | 1 |
| 11 | Experimental Verification and Finite Element Modeling of Radial Truck Tire under Static Loading显示文摘 | Wang Wei Yan Shan Zhao Shugao | 2013 | Journal of Re- inforced Plastics and Composites2013，32，7： | 1 |
| 12 | Off-gird compressive sensing through-the-wall radar imaging显示文摘 | XIA Shugao and LIU Fengshan | 2014 | Proceedings of SPIE2014，9077，： | 1 |
| 13 | Damping properties of blends based on EVM显示文摘 | Shi Xinyan Bi Weina Zhao Shugao | 2011 | Journal of Macromolecular Science (Part B) : Physics2011，50，10： | 1 |
| 14 | Study on dynamic fatigue properties of solution-polymerized styrene butadiene rubber T2000R显示文摘 | Sun Xuehong Zhao Fei Zhao Shugao | | 0，，05： | 1 |
| 15 | Synthesis of poly-cyclic isoindoline derivatives via tandem Pd-catalyzed coupling,propargyl-allenyl isomerization,[4+2] cycloaddi-tion and aromatization reaction显示文摘 | Zhu Shugao Cao Jian Wu Luling | | 0，，： | 1 |
| 16 | A study of wettability and permeability change caused by adsorption of nanometer structured polysilicon on the surface of porous media显示文摘 | Ju Binshan Dai Shugao Luan Zhian | | SPE779380，，： | 1 |
| 17 | DEGRADATION DUE TO ENERGY PULSE IN HIGH-ENERGY ZnO VARISTORS显示文摘The degradation phenomena due to the energy pulse in the high-energy ZnO varistors used for deexitation and overvoltage protection of hydroelectric generator are investigated. The energy pulse, obtained by releasing the energy stored in an inductor, can be equivalent to the combination of the DC field components and the energy component. The variations of the characterized voltages, nonlinear coefficients and pre-breakdown V-A characteristics, increase with the number of the applied energy pulse. The asymmetrical variations of the electric properties of the high-energy ZnO varistors after the energy pulse arise from the deformation of the double Schottky barriers due to the ion migration occuring in the depletion layer and in the grain boundary. | Zhang Shugao Huang Baiyun Fang Xunhua (Powder Metallurgy Research Institute, Central South University of Technology, Changsha 410083, China)Ji Youzhang (Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, China) | 1997 | Journal of Central South University1997，9，2： | 0 |
| 18 | Association of cardiac disease with the risk of post-lung transplantation mortality in Chinese recipients aged over 65 years显示文摘The current organ allocation rules prioritize elderly and urgent patients on the lung transplantation(LT)waiting list.A steady increase in the threshold at which age is taken into consideration for LT has been observed.This retrospective cohort study recruited 166 lung transplant recipients aged≥65 years between January 2016 and October 2020 in the largest LT center in China.In the cohort,subgroups of patients aged 65–70 years(111 recipients,group 65–70)and≥70 years(55 recipients,group≥70)were included.Group D restrictive lung disease was the main indication of a lung transplant in recipients over 65 years.A significantly higher percentage of coronary artery stenosis was observed in the group≥70(30.9%vs.14.4%in group 65–70,P=0.014).ECMO bridging to LT was performed in 5.4%(group 65–70)and 7.3%(group≥70)of patients.Kaplan–Meier estimates showed that recipients with cardiac abnormalities had a significantly increased risk of mortality.After adjusting for potential confounders,cardiac abnormality was shown to be independently associated with the increased risk of post-LT mortality(HR 6.37,P=0.0060).Our result showed that LT can be performed in candidates with an advanced age and can provide life-extending benefits. | Guohui Jiao Shugao Ye Ji Zhang Bo Wu Dong Wei Dong Liu Feng Liu Chunxiao Hu Jingyu Chen | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 19 | Partial portacaval shunt with H-grafts to treat portal hypertension显示文摘Partial portosystemic shunts have been popularized because of a reported low rate of mortality and morbidity(especially encephalopathy,liver failure and occlusion).The results of partial portacaval shunts[small-diameter expanded polytetrafluoroethylene(ePTFE)H-graft portacaval shunt]were retrospectively reviewed to evaluate the clinical efficacy in the treatment of portal hypertension.Forty-three patients with portal hypertension were treated by small-diameter H-graft of ePTFE portacaval shunt from May 1995 to April 2006.Thirty-three had externally ringed grafts and ten had non-ringed ones.Ten had grafts of 10 mm in diameter and 33 had grafts of 8 mm.The left gastric artery and coronary vein were ligated in all the cases.Six had pericardial devascularization and splenectomy was performed in 42.An average decrease of free portal pressure(FPP)from(33.24 P4.78)cmH2O before shunting and(13.65P5.65)cmH2O after shunting was observed.The portal blood flow was reduced by one-third of that before shunt.Thirty-eight patients survived and no upper gastro-intestinal rebleeding occurred in the follow-up period(50.5 months in average).Two were out of contact.Color Doppler ultrasonography and/or portography revealed the shunts were patent in 38 cases and were occluded in three cases(3/41,7.3%).Encephalopathy developed in five cases(5/41,12.2%).Partial(small-diameter ePTFE H-graft)portacaval shunting can reduce the portal pressure effectively.Majority of the hepatic flow from the portal vein can be maintained adequately.The shunts with reinforced grafts can keep a higher rate of patency.The morbidity of encephalopathy was lower than those with total shunt.The partial portacaval shunt is effective in preventing recurrent variceal bleeding. | XU Geliang HU Hejie LI Jiansheng YANG Shugao CHAI Zhongpei XU Rongnan | 2007 | Frontiers of Medicine2007，1，3： | 0 |
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