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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Study of the relationship between selfstigma and subjective quality of life for individuals with chronic schizophrenia in the community显示文摘Background Studies conducted outside of China have found that stigma can predict low quality of life, and research in China has shown that stigma has an impact on the quality of life of convalescent patients with schizophrenia. Nevertheless, there is no indepth research on the impact of stigma on the quality of life of patients.Aims To research the correlation of stigma and the subjective quality of life of persons with chronic schizophrenia in the community.Methods We adopted a stratified sampling method.General questionnaire, quality of life scale and stigma scale were given to 602 persons with chronic schizophrenia in the community.Results The mean(SD) value of the Subjective Quality of Life Scale total scores was 32.99(13.85). The mean(SD)value of the total stigma scores was 43.50(5.02). After correlation analysis and multivariate stepwise regression analysis, it was shown that the total scores for self-stigma and each factor were positively correlated with subjective quality of life(r=0.462, p<0.001), psychosocial factors(r=0.517, p<0.001), and symptoms and adverse reaction factor scores(r=0.363, p<0.001),and the correlation coefficients were statistically significant.Conclusions The higher the stigma of persons with schizophrenia in the community, the lower the subjective quality of life is. This suggests that reduction of self-stigma should be considered in the improvement of the quality of life of persons with schizophrenia in the community. | Yi Guo Shumin Qu Hongyun Qin | 2018 | General Psychiatry2018，31，6： | 3 |
| 3 | The Sequence Architecture of Volcanic Basin Fillings-An Example From Xujiaweizi Faulted Depression In Songliao Basin显示文摘The basin filling geometric pattern of volcanic eruptive rocks depends on both of the eruptive locations in a basin and structural styles of fault terraces. It is divided into three types by eruptive locations and occurrences of eruptive rocks, including the pattern of eruption along fault and occurrence (PEAFO), the pattern of eruption on footwall of a fault and occurrence (PEOFO) and the pattern of eruption on hangingwall of fault and occurrence (PEOHO) in Xujiaweizi fault depression of Songliao basin, Northeast of China. Those basin filling patterns of volcanic eruptive rocks are of specific geometric characteristics controlling or affecting sedimentation, geometry of sedimentary body and sequence architecture during a sequence evolution. The study shows that the volcanic rocks developed at different stages of lowstand, transgressive and highstand can give different controls or affects on the sequence architecture. | CHENG Rihui, LIU Wanzhu, SHAN Xuanlong, WANG Pujun (Faculty of Earth Sciences at Jilin University, Changchun, 130061, P.R.China) CHEN Shumin and QU Yongbao (Daqing Petroleum Bureau Prospecting and Exploration Institute, Daqing, 163712, P.R.China) | 2001 | Global Geology2001，6，2： | 3 |
| 4 | Suppressing meta-holographic artifacts by laser coherence tuning显示文摘A metasurface hologram combines fine spatial resolution and large viewing angles with a planar form factor and compact size.However,it suffers coherent artifacts originating from electromagnetic cross-talk between closely packed meta-atoms and fabrication defects of nanoscale features.Here,we introduce an efficient method to suppress all artifacts by fine-tuning the spatial coherence of illumination.Our method is implemented with a degenerate cavity laser,which allows a precise and continuous tuning of the spatial coherence over a wide range,with little variation in the emission spectrum and total power.We find the optimal degree of spatial coherence to suppress the coherent artifacts of a meta-hologram while maintaining the image sharpness.This work paves the way to compact and dynamical holographic displays free of coherent defects. | Yaniv Eliezer Geyang Qu Wenhong Yang Yujie Wang Hasan Yılmaz Shumin Xiao Qinghai Song Hui Cao | 2021 | Light(Science & Applications)2021，10，7： | 0 |
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