|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of methotrexate on the developments of heart and vessel in zebrafish显示文摘Methotrexate (MTX ) , folic 酸的一个对手,能禁止在 tetrahydrofolic 酸和胚胎的开发的合成很重要的 dihydrofolate reductase (DHFR ) 。在这研究,我们在暴露于 1.5 以后发现了那 ? 在 610 个小时的公里 MTX 授精以后, zebrafish 胚胎没能形成正常心血管的系统。在对待 MTX 的胚胎,室和中庭的词法发展被破坏,心脏的扭曲是反常的,心率和室的弄短部分被减少,并且脉管的发展被破坏。我们也与钙盐五水合物(CF ) 能在对待 MTX 的胚胎在心和容器引起改进开发的 folinic 酸与 dhfrgfp mRNA 或处理发现那任何一个 microinjection,它证明那 MTX 由禁止 DHFR 导致了畸形性。象 hand2, mef2a, mef2c,和 flk-1 那样的基因的抄本层次在对待 MTX 的胚胎被减少。与对待 MTX 的组相比, hand2, mef2a, mef2c,和 flk-1 的抄本层次在 MTX + dhfrgfp 被增加注射 mRNA 的组并且在 MTX + CF 组。我们的结果显示在对待 MTX 的胚胎的心和容器的破坏发展与 hand2, mef2a, mef2c,和 flk-1 的减少的抄本层次有关。 | Shuna Sun Yonghao Gui Yuexiang Wang Linxi Qian Xuefei Liu Qiu Jiang Houyan Song | 2009 | Acta Biochimica et Biophysica Sinica2009，41，1： | 10 |
| 2 | Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish显示文摘Folic 酸为抑制能在脊椎动物引起先天的心缺点的胚胎的开发和 folic 酸是很重要的。Dihydrofolate reductase (DHFR ) 是在叶酸调停新陈代谢的关键酶。DHFR 的机能障碍破坏酸参予 folic 的关键生物过程。DHFR 基因在脊椎动物进化期间被保存。在心脏的开发调查 DHFR 的角色是重要的。在这研究,我们显示出那 DHFR 击倒在早阶段导致了 zebrafish 胚胎的反常开发。在心和流出道的明显的畸形性(经常) 也在 DHFR 击倒的胚胎被观察。DHFR overexpression 在 DHFR 击倒的组救了反常显型。DHFR NKX2.5 的表达式上的击倒的有的否定影响(NK2 抄写因素相关 5 ) , MEF2C (myocyte 特定的 enhancer 因素 2C ) , TBX20 (T 盒子 20 ) ,并且 TBX1 (T 盒子 1 ) 它在心脏的开发过程期间是重要 transcriptional 因素,当 DHFR overexpression 有积极效果时。DHFR 为刺猬小径被要求。DHFR 击倒的引起的减少的房间增长和增加的 apoptosis,当它的 overexpression 支持了房间增长并且禁止了 apoptosis 时。一起拿,我们的学习建议 DHFR 由调整基因抄写并且影响房间增长和 apoptosis 在 zebrafish 在心并且经常的发展起关键作用。 | Shuna Sun Yonghao Gui Qiu Jiang Houyan Song | 2011 | Acta Biochimica et Biophysica Sinica2011，43，12： | 5 |
| 3 | Quantitative analysis of the ribbon synapse number of cochlear inner hair cells in C57BL/6J mice using the three-dimensional modeling method显示文摘In mammals,the ribbon synapses of cochlear inner hair cells are a synaptic structure of the first sensory nerve in the pathway of acoustical signal transmission to the acoustic center,and it is directly involved in voice coding and neurotransmitter release. It is difficult to quantitatively analyze the ribbon synaptic number only using an electron microscope,because the ribbon synaptic number is relatively limited and their location is deep. In this study,the specific presynaptic structure-RIBEYE,and non-specific postsynaptic structure-GluR 2 & 3 in C57BL/6J mouse basilar membrane samples were treated by immunofluorescent labeling. Serial section was performed on the samples using a laser scanning confocal microscope,and then the serial sections were used to build three-dimensional models using 3DS MAX software. Each fluorescein color pair indicates one synapse,so the number of ribbon synapses of inner hair cells is obtained. The spatial distribution and the number of ribbon synapses of cochlear inner hair cells were clearly shown in this experiment,and the mean number of ribbon synapses per inner hair cell was 16.10±1.03. Our results have demonstrated the number of ribbon synapses is accurately calculated by double immunofluorescent labeling to presynaptic and postsynaptic structures,serial sections obtained using a laser scanning confocal microscope,and three-dimensional modeling obtained using 3DS MAX software. The method above is feasible and has important significance for further exploring the mechanism of sensorineural deafness. | LIU Ke,LI ShuNa & JIANG XueJun Department of Otolaryngology,the First Affiliated Hospital,China Medical University,Shenyang 110001,China | 2009 | Science China(Life Sciences)2009，52，9： | 5 |
| 4 | One-pot synthesis of Pt-Cu bimetallic nanocrystals with different structures and their enhanced electrocatalytic properties显示文摘 | Daowei Gao Shuna Li Guolong Song Pengfei Zha Cuncheng Li Qin Wei Yipin Lv Guozhu Chen | 2018 | Nano Research2018，11，5： | 5 |
| 5 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 6 | Association between 15 known or potential breast cancer susceptibility genes and breast cancer risks in Chinese women显示文摘Objective:There are many hereditary breast cancer patients in China,and multigene panel testing has been a new paradigm of genetic testing for these patients and their relatives.However,the magnitude of breast cancer risks related to multiple breast cancer susceptibility genes are largely unknown in Chinese women.Methods:We screened pathogenic variants in 15 established or potential breast cancer susceptibility genes from 8,067 consecutive Chinese female breast cancer patients and 13,129 Chinese cancer-free female controls.These breast cancer patients were unselected for age at diagnosis or family history.Results:We found that pathogenic variants in TP53[odds ratio(OR):16.9,95%confidence interval(CI):5.2–55.2];BRCA2(OR:10.4,95%CI:7.6–14.2);BRCA1(OR:9.7,95%CI:6.3–14.8);and PALB2(OR:5.2,95%CI:3.0–8.8)were associated with a high risk of breast cancer.ATM,BARD1,CHEK2,and RAD51D were associated with a moderate risk of breast cancer with ORs ranging from 2-fold to 4-fold.In contrast,pathogenic variants of NBN,RAD50,BRIP1,and RAD51C were not associated with increased risk of breast cancer in Chinese women.The pathogenic variants of PTEN,CDH1,and STK11 were very rare,so they had a limited contribution to Chinese breast cancer.Patients with pathogenic variants of TP53,BRCA1,BRCA2,and PALB2 more often had earlyonset breast cancer,bilateral breast cancer,and a family history of breast cancer and/or any cancer.Conclusions:This study provided breast cancer risk assessment data for multiple genes in Chinese women,which is useful for genetic testing and clinical management of Chinese hereditary breast cancer. | Fenfen Fu Dongjie Zhang Li Hu Senthil Sundaram Dingge Ying Ying Zhang Shuna Fu Juan Zhang Lu Yao Ye Xu Yuntao Xie | 2022 | Cancer Biology & Medicine2022，19，2： | 3 |
| 7 | Defect-density control of platinum-based nanoframes with high-index facets for enhanced electrochemical properties显示文摘Structure-engineered platinum-based nanoframes(NFs)at the atomic level can effectively improve the catalytic performance for fuel cells and other heterogeneous catalytic fields.We report herein,a microwave-assisted wet-chemical method for the preparation of platinum-copper-cobalt NFs with tunable defect density and architecture,which exhibit enhanced activity and durability towards the electro-oxidation reactions of methanol(MOR)and formic acid(FAOR).By altering the reduction/capping agents and thus the nucleation/growth kinetics,trimetallic platinum-copper-cobalt hexapod NFs with different density high-index facets are achieved.Especially,the rough hexapod nanoframes(rh-NFs)exhibit excellent specific activities towards MOR and FAOR,7.25 and 5.20 times higher than those of benchmark Pt/C,respectively,along with prolonged durability.The excellent activities of the rh-NFs are assigned to a synergistic effect,including high density of defects and high-index facets,suitable d-band center,and open-framework structure.This synergistic working mechanism opens up a new way for enhancing their electrocatalytic performances by increasing defect density and high-index facets in open-framework platinum-based NFs. | Shaohan Yang Shuna Li Lianghao Song Yipin Lv Zhongyao Duan Chunsheng Li Raphael Francesco Praeg Daowei Gao Guozhu Chen | 2019 | Nano Research2019，12，11： | 3 |
| 8 | Modification of physicochemical properties and degradation of barley flour upon enzymatic extrusion显示文摘In order to evaluate the application potential of enzyme-extruded barley flour(EEBF)in the brewing of whole-barley beer,the physicochemical properties,mashing and fermentation effects of EEBF were studied,and conventional extruded barley flour(CEBF)and steam-cooked barley flour(SCBF)were taken as controls.The water solubility index(WSI)of EEBF(46.88%-52.63%)was much higher than that of CEBF(6.70%)and SCBF(4.59%).The results of degree of gelatinization(DG)and enthalpy(ΔH)suggested that EEBF was almost completely gelatinized,and the rapid visco analyzer(RVA)exhibited that the peak viscosity of EEBF was drastically reduced.The weight-average molecular weight of EEBF(<10^(6) g/mol)was significantly lower than that of CEBF and SCBF.Scanning electron microscopy(SEM)showed that the heat-treatments caused starch granules to break and aggregate,and there were many hydrolyzed pores on the surface of EEBF.Both the long-and short-range order of EEBF were destroyed.Although EEBF caused serious filtration blocking,it greatly improved the alcohol content of finished beer(5.41%vol).Overall,the thermal modification of barley flour by enzyme-extrusion meets the needs of fermentation,and could improve the problem of limited leaching of unmalted barley,which was benefit for the production of whole-barley beer. | Shuna Zhao Aiquan Jiao Yueyue Yang Qing Liu Wenqi Wu Zhengyu Jin | 2022 | Food Bioscience2022，45，1： | 2 |
| 9 | Effect of aqueous extract of Sanweitanxiang powder on calcium homeostasis protein expression in ischemic-reperfusion injury rat heart显示文摘OBJECTIVE: To investigate the underlying mechanism of reduced myocardial ischemia-reperfusion (I/R) injury in rats using the traditionalTibetan medicine Sanweitanxiang powder (SWTX). METHODS: Rats were randomly divided into six groups (n=10) as follows: (a) propranolol dinitrate control group, given propranolol dinitrate 0.02 g/kg for 10 days before I/R, (b) SWTX with a high dose group, given SWTX 1.5 g/kg for 10 days before I/R, (c) SWTX with a medium dose group, given SWTX 1.25 g/kg for 10 days before I/R, (d) sham group (Sham), in which the rat heart was exposed by pericardiotomy but without I/R, (e) SWTX with a low dose group, given SWTX 1.0 g/kg for 10 days before I/R, and (f) I/R injury group. Rats were intragastrically pretreated with propranolol dinitrate orSWTX. After that, the operation to cause ischemia and reperfusion was conducted.The histopathologic changes of rat hearts were observed by hematoxylin and eosin staining and transmission electron microscopy. Ca2+ homeostasis protein expression was determined by western blot. RESULTS: After SWTX pretreatment, the development of ultrastructural pathological changes from IR injury was attenuated. A decrease in the expression of B-cell lymphoma 2 associated X protein, and an increase in the expression of B-cell lymphoma 2 were observed. An increased activation of extracellular signal regulated kinases were found. Compared with the sham group, the expression of sarcoplasmic reticulum calcium-ATPase, phospholamban, and calsequestrin were all up-regulated after pretreatment with SWTX. CONCLUSION: The protective mechanism of SWTX pretreatment on myocardial I/R injury might be related to its effect on maintaining the balance of calcium homeostasis in rat heart. | Mei Yang Shuna Zhang Shicun Ren Jinjun Wang Haixia Yun Sheng Yong Dejun Zhang Quanyu Yang Yiying Kou Dianxiang Lu Rili Ge | 2013 | Journal of Traditional Chinese Medicine2013，33，3： | 2 |
| 10 | Single-walled carbon nanotubes functionalized with poly(nile blue A) and their application to dehydrogenase-based biosensors显示文摘 | Pan Du Shuna Liu Ping Wu Chenxin Cai | 2007 | 53:1811-18232007，53，： | 1 |
| 11 | Secure and Efficient Data Storage and Sharing Scheme Based on Double Blockchain显示文摘In the digital era,electronic medical record(EMR)has been a major way for hospitals to store patients’medical data.The traditional centralized medical system and semi-trusted cloud storage are difficult to achieve dynamic balance between privacy protection and data sharing.The storage capacity of blockchain is limited and single blockchain schemes have poor scalability and low throughput.To address these issues,we propose a secure and efficient medical data storage and sharing scheme based on double blockchain.In our scheme,we encrypt the original EMR and store it in the cloud.The storage blockchain stores the index of the complete EMR,and the shared blockchain stores the index of the shared part of the EMR.Users with different attributes can make requests to different blockchains to share different parts according to their own permissions.Through experiments,it was found that cloud storage combined with blockchain not only solved the problem of limited storage capacity of blockchain,but also greatly reduced the risk of leakage of the original EMR.Content Extraction Signature(CES)combined with the double blockchain technology realized the separation of the privacy part and the shared part of the original EMR.The symmetric encryption technology combined with Ciphertext-Policy Attribute-Based Encryption(CP–ABE)not only ensures the safe storage of data in the cloud,but also achieves the consistency and convenience of data update,avoiding redundant backup of data.Safety analysis and performance analysis verified the feasibility and effectiveness of our scheme. | Lejun Zhang Minghui Peng Weizheng Wang Yansen Su Shuna Cui Seokhoon Kim | 2021 | Computers, Materials & Continua2021，，1： | 1 |
| 12 | Investigation on ultrasound assisted extraction of saikosaponins from radix bupleuri 显示文摘 | ZHAO SHUNA KWOK KINCHOR LIANG HANHUA | 2007 | Separation and Purification Technology2007，55，3： | 1 |
| 13 | Structuralandfunctionaladaptationfollowingjejunalresectioninrabbits:effectofepidermalgrowthfactor显示文摘 | O'LoughlinE WinterM ShunA etal | 1994 | Gasteroenterology1994，107，1： | 1 |
| 14 | Enrichment of CO from syngas with Cu(I)Y adsorbent by five-bed VPSA显示文摘Cu (I) Y 吸附物被被离子交换在之间准备的 Cu (II ) Y 的减小准备否沸石和 Cu (II ) 的一个答案氯化物。为公司的 Cu (I) Y 的动态吸附能力被在 30o | Shuna LI Huawei YANG Donghui ZHANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，4： | 1 |
| 15 | Characterization of pigmentation and cellulose synthesis in colored cotton fibers显示文摘 | Shuijin Hua Xuede Wang Shuna Yuan | 2007 | Crop Science2007，47，： | 1 |
| 16 | Clifford Algebras Spinor and the Dirac wave Equations 显示文摘 | Yu Xuegang Zhang Shuna | 2001 | Advances in Applied Clifford Algebras2001，11，1： | 1 |
| 17 | Chemical properties and antioxidant activity of exopolysaceharides from mycelial cullane of Conensfungus Cs-HK1 显示文摘 | LEUNG P H ZHAO Shuna HO K P | 2009 | Food2009，114，4： | 1 |
| 18 | Investi- gation on ultrasound assisted extraeton of saikosaponins from Radix Bupleur 显示文摘 | ZHAO Shuna KWOK Kin-Chor LIANG Hanhua | 2007 | Separation and Purification Tech- nology2007，55，3： | 1 |
| 19 | A logic-based controller for the mitigation of ventilation air methane in a catalytic flow reversal reactor显示文摘 | Zhikai LI Zhangfeng QIN Yagang ZHANG Zhiwei WU Hui WANG Shuna LI Mei DONG Weibin FAN Jianguo WANG | 2013 | Frontiers of Chemical Science and Engineering2013，7，3： | 1 |
| 20 | Clifford Algebra and the Lorentz Transformation with(p,q)Form显示文摘 | Zhang Shuna | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员