|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 2 | Signal-Based Intelligent Hydraulic Fault Diagnosis Methods: Review and Prospects显示文摘Hydraulic systems have the characteristics of strong fault concealment,powerful nonlinear time-varying signals,and a complex vibration transmission mechanism;hence,diagnosis of these systems is a challenge.To provide accurate diagnosis results automatically,numerous studies have been carried out.Among them,signal-based methods are commonly used,which employ signal processing techniques based on the state signal used for extracting features,and further input the features into the classifier for fault recognition.However,their main deficiencies include the following:(1)The features are manually designed and thus may have a lack of objectivity.(2)For signal processing,feature extraction and pattern recognition are conducted using independent models,which cannot be jointly optimized globally.(3)The machine learning algorithms adopted by these methods have a shallow architecture,which limits their capacity to deeply mine the essential features of a fault.As a breakthrough in artificial intelligence,deep learning holds the potential to overcome such deficiencies.Based on deep learning,deep neural networks(DNNs)can automatically learn the complex nonlinear relations implied in a signal,can be globally optimized,and can obtain the high-level features of multi-dimensional data.In this paper,the main technology used in an intelligent fault diagnosis and the current research status of hydraulic system fault diagnosis are summarized and analyzed.The significant prospect of applying deep learning in the field of intelligent fault diagnosis is presented,and the main ideas,methods,and principles of several typical DNNs are described and summarized.The commonality between a fault diagnosis and other issues regarding typical pattern recognition are analyzed,and research ideas for applying DNNs for hydraulic fault diagnosis are proposed.Meanwhile,the research advantages and development trend of DNNs(both domestically and overseas)as applied to an intelligent fault diagnosis are reviewed.Furthermore,the fault characteristics of a complex hydraulic system are summarized and discussed,and the key problems and possible research ideas of applying DNNs to an intelligent hydraulic fault diagnosis are presented and comprehensively analyzed. | Juying Dai Jian Tang Shuzhan Huang Yangyang Wang | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 11 |
| 3 | Rational design of nitrogen doped hierarchical porous carbon for optimized zinc-ion hybrid supercapacitors显示文摘Aqueous rechargeable zinc-ion hybrid supercapacitors are considered to be a promising candidate for large-scale energy storage devices owing to their high safety,long life,and low price.In this paper,a nitrogen doped hierarchical porous carbon is evaluated as the cathode for aqueous rechargeable zinc-ion hybrid supercapacitors.Benefiting from the synergistic merits of excellent structural features of N-HPC and tiny zinc dendrite of Zn anode in ZnSO4 electrolyte,the zinc-ion hybrid supercapacitor exhibits excellent energy storage performance including high capacity of 136.8 mAh·g^−1 at 0.1·Ag^−1,high energy density of 191 Wh·kg^−1,large power density of 3,633.4 W·kg^−1,and satisfactory cycling stability of up to 5,000 cycles with a capacity retention of 90.9%.This work presents a new prospect of developing high-performance aqueous rechargeable zinc ion energy storage devices. | Penggao Liu Yang Gao Yangyang Tan Weifang Liu Yanping Huang Jun Yan Kaiyu Liu | 2019 | Nano Research2019，12，11： | 10 |
| 4 | Continuous nitrogen-doped carbon nanotube matrix for boosting oxygen electrocatalysis in rechargeable Zn-air batteries显示文摘Developing robust oxygen electrocatalyst with high-performance is very significant for practical rechargeable Zn-air battery.We report herein the preparation of three-dimensional continuous nanocarbon network composed of interconnected nitrogen-doped carbon nanotubes and its application as oxygen electrocatalysis in rechargeable Zn-air battery.Except the excellent electrochemical bifunctionality,this carbon nanotube matrix also delivers an impressive battery performance.Specifically,an opencircuit voltage of 1.50 V as well as a high power density of 220 m W cm^(-2) with remarkable cycling stability for 1600 h is achieved in the rechargeable Zn-air battery.The study not only provides an efficient bifunctional oxygen electrocatalyst but more importantly may pave significant concepts in designing robust electrode for long-life rechargeable Zn-air battery and other energy technologies. | Guangda Chen Yangyang Xu Lei Huang Aboulkader Ibro Douka Bao Yu Xia | 2021 | Journal of Energy Chemistry2021，30，4： | 7 |
| 5 | Heteroatom-doped graphene for electrochemical energy storage显示文摘The increasing energy consumption and environmental concerns due to burning fossil fuel are key drivers for the development of effective energy storage systems based on innovative materials.Among these materials,graphene has emerged as one of the most promising due to its chemical,electrical,and mechanical properties.Heteroatom doping has been proven as an effective way to tailor the properties of graphene and render its potential use for energy storage devices.In this view,we review the recent developments in the synthesis and applications of heteroatom-doped graphene in supercapacitors and lithium ion batteries. | Yangyang Wen Congcong Huang Lianzhou Wang Denisa Hulicova-Jurcakova | 2014 | Chinese Science Bulletin2014，59，18： | 5 |
| 6 | Trade-offs and Synergies of Ecosystem Services in the Taihu Lake Ba- sin of China显示文摘Understanding the spatial interactions among multiple ecosystem services is crucial for ecosystem services management. Ecosystem services, including crop production, freshwater supply, aquatic production, net primary production, soil conservation, water conservation, flood regulation, forest recreation, were measured at 1-km grid scale covering the Taihu Lake Basin(TLB) of China. Our objective is to get a comprehensive understanding of the spatial distributions, trade-offs, synergies of multiple ecosystem services across the TLB. Our results found that: 1) majority of ecosystem services were clustered in space and had a similar spatial distribution pattern with the geographical resource endowment. Most of the landscape contributed a high supply of no services, one or two, and a low supply of three to seven services. 2) There were high correlation between forest recreation and freshwater supply and regulating services. Aquatic production had low correlation with other services. 3) The changes of provisioning services led to trade-offs between regulating services and cultural services in the TLB, while synergies mainly occurred among the provisioning service. 4) The spatial relationships of multiple services are consistent at 1-km spatial scale, counties and provinces. This research could help integrate multiple ecosystem services across scales and serve as a reference for decision making. | QIAO Xuning GU Yangyang ZOU Changxin WANG Lei LUO Juhua HUANG Xianfeng | 2018 | Chinese Geographical Science2018，28，1： | 5 |
| 7 | The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy显示文摘Cytokines exert powerful immunomodulatory effects that are critical to physiology and pathology in humans.The application of natural cytokines in clinical studies has not been clearly established,and there are often problems associated with toxicity or lack of efficacy.The key reasons can be attributed to the pleiotropy of cytokine receptors and undesired activation of off-target cells.With a deeper understanding of the structural principles and functional signals of cytokine-receptor interactions,artificial modification of cytokine signaling through protein engineering and synthetic immunology has become an increasingly feasible and powerful approach.Engineered cytokines are designed to selectively target cells.Herein,the theoretical and experimental evidence of cytokine engineering is reviewed,and the“supercytokines”resulting from structural enhancement and the“immunocytokines”generated by antibody fusion are described.Finally,the“engager cytokines”formed by the crosslinking of cytokines and bispecific immune engagers and other synthetic cytokines formed by nonnatural analogs are also discussed. | Xiaohu Zheng Yaqi Wu Jiacheng Bi Yingying Huang Ying Cheng Yangyang Li Yuwei Wu Guoshuai Cao Zhigang Tian | 2022 | Cellular & Molecular Immunology2022，19，2： | 4 |
| 8 | Extranodal involvement in young patients with diffuse large B-cell lymphoma: distribution, prognostic value and treatment options显示文摘Objective: Extranodal involvement represents a peculiar presentation of diffuse large B-cell lymphoma(DLBCL). Previous studies have suggested that older patients are more prone to extranodal involvement. This study retrospectively addressed the distribution, prognostic value and treatment options of extranodal involvement in young patients with DLBCL.Methods: A total of 329 patients were enrolled according to the inclusion requirements. The effects of gender,extranodal involvement, age-adjusted international prognostic index(aa IPI), rituximab infusion and radiotherapy on patient outcomes were evaluated.Results: Among these patients, 59% presented extranodal involvement in 16 anatomic sites. More than one instance was linked to many poorer clinical characteristics and poorer survival compared with either nodal disease or one instance. In patients with one extranodal lesion, multivariate analysis revealed that the site of extranodal involvement, but not the aa IPI or rituximab infusion, was independently related to the outcome, and radiotherapy had a negative influence on survival.Conclusions: Extranodal involvement is common in younger patients and exhibits a ubiquitous distribution.The site of extranodal involvement is of strong prognostic significance. Radiotherapy for extranodal lesions does not improve patient outcomes. | Shuna Yao Junbo Li Zhihua Yao Yuanlin Xu Junfeng Chu Jiuyang Zhang Shuiling Jin Yangyang Huang Jianbo Zhang Jie Ma Yan Zhao Shujun Yang Yanyan Liu | 2017 | Chinese Journal of Cancer Research2017，29，1： | 3 |
| 9 | Reactive oxygen species regulate auxin levels to mediate adventitious root induction in Arabidopsis hypocotyl cuttings显示文摘Adventitious root(AR)formation from leafy stem cuttings is critical for breeding of many forest and horticultural species.In addition to the plant hormone auxin,wound-induced signaling caused by the cutting excision is also essential for AR initiation.Here we found that reactive oxygen species(ROS)are rapidly generated at the excision site as a wound-induced signal and propagated throughout the hypocotyl cut-ting after excision of the Arabidopsis(Arabidopsis thaliana)primary root.ROS propagation was not ob-served in the presence of an NADPH oxidase inhibitor(diphenylene iodonium chloride)or in a knockout mu-tant of the NADPH oxidase gene respiratory burst oxi-dase homolog protein D(RBOHD).Respiratory burst oxidase homolog protein D was specifically upregulatedin hypocotyl cuttings at 0.5 h post excision(hpe).To-gether,these data suggest that RBOHD mediates ROS propagation in hypocotyl cuttings.We also found that auxin levels increased significantly in the shoot apex at 5 hpe and at the base of the cutting at 6 hpe;these effects were blocked by treatment with ROS scav-engers.Consistent with this,transcript levels of auxin biosynthesis and polar-transport genes generally in-creased between 1 to 6 hpe.Collectively,our results suggest that wound-induced ROS participate in AR in-duction through regulation of auxin biosynthesis and transport. | Aixia Huang Yongshun Wang Yangyang Liu Guodong Wang Xiaoping She | 2020 | Journal of Integrative Plant Biology2020，62，7： | 3 |
| 10 | Correlation between Climatic Factors and Genetic Diversity of Phrynocephalus forsythii显示文摘Global climate change is a threat to animals in nearly all biomes and ecosystems, especially for ectotherm whose life activities highly depend on environmental thermal regime. Population genetic diversity which is essential for adaptation to environmental change is a useful index for long-term species survival. In this paper, genetic diversity of eight Phrynocephalus forsythii population which distributed in Tarim Basin, China, were evaluated based on three mtDNA gene and its correlation with environment factors were investigated using RDA. Our result revealed that, the level of genetic diversity of P. forsythii populations was related to its location but there was no significant correlation between genetic distances and geographic distances in P. forsythii. However, we find that mtDNA of P. forsythii was subjected to selection pressure during evolution and population genetic diversity was significantly positively related to variation coefficient of rainfall(VCR) and altitude(AL), while significantly negatively related to longitude(N) and annual average temperature(AAT). Our result supported the previous prediction that excessive ambient heat is a threat to P. forsythii. | Yue QI Wei ZHAO Yongjie HUANG Xiaoning WANG Yangyang ZHAO | 2019 | Asian Herpetological Research2019，10，4： | 3 |
| 11 | Dynamic tensile and failure behavior of bi-directional reinforced GFRP materials显示文摘In this paper,a series of static/dynamic tensile tests are performed for glass fiber reinforced plastic(GFRP)composites.Using the combination of high-speed photography and digital image correlation(DIC)technology,true stress-strain curves in different directions and strain rates are obtained.We also obtained the dynamic failure strain of the material in different directions,which are used to accurately describe the dynamic tensile and failure behavior of the material.The experimental results show that there is a stiffness change point N in three directions under different strain rate(10-3 s-1,10 s-1,100 s-1)tensile conditions.The stiffness before and after N point is recorded as Einitial and Echanged respectively.The values of Echanged in weft direction and warp direction are about 30%to 50%of Einitial,while Echanged in tilt direction is only about 10%of Einitial.The fiber has the highest strength in the weft direction and the tilt direction has the lowest strength.With the combination of high-speed photography and DIC technology,the dynamic failure parameters of different directions under the strain rate of 100 s-1 are obtained.The dynamic failure strains in three directions are 0.245,0.373 and 0.341,respectively.The parameters are verified by impact three-point bending test.These works can more accurately describe the dynamic mechanical behavior of glass fiber reinforced plastic(GFRP)composites and provide reference for the design of GFRP structures. | Zishang Liu Zhe Yang Yuchao Chen Yangyang Yu Yanpeng Wei Maohui Li Chenguang Huang | 2020 | Acta Mechanica Sinica2020，36，2： | 2 |
| 12 | Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration(IDD)is featured as enhanced catabolism of extracellular matrix(ECM)in the nucleus pulposus(NP),in which tumor necrosis factor-alpha(TNF-α)-related cell senescence is involved.Chromobox homolog protein 4(CBX4)exhibits anti-inflammatory effects and shows promising therapeutic potential.Thus,in the present study,we explore the role of CBX4 in IDD.Immunohistochemistry staining reveals that CBX4 expression is decreased in severe degenerative NP tissues compared to mild degenerative tissues,and real-time PCR and western blot analysis results show that CBX4 expression is downregulated under TNF-αstimulation in NP cells.siRNA and adenoviruses are used to knockdown or overexpress CBX4,respectively.The results demonstrate that CBX4 knockdown augments the catabolism of ECM in human NP cells,while CBX4 overexpression in rat NP cells restores the ECM degradation induced by TNF-α,as illustrated by immunofluorescence and western blot analysis.In addition,transcriptome sequencing results reveal the regulatory effect of CBX4 on the cell cycle,and further western blot analysis and senescence-associatedβ-galactosidase staining assay indicate that CBX4 overexpression alleviates cell senescence in the presence of TNF-α.Moreover,the phosphorylation of p65,which indicates the activation of NF-κB signaling,is measured by western blot analysis and immunofluorescence assay,and the results reveal that CBX4 overexpression reduces the TNF-α-induced increase in the p-p65/p65 ratio.In addition,the effect of CBX4 overexpression in NP cells is suppressed by NF-κB agonist.In summary,our results indicate that CBX4 overexpression can suppress TNF-α-induced matrix catabolism and cell senescence in the NP by inhibiting NF-κB activation.This study may provide new approaches for preventing and treating IDD. | Yangyang Zhang Shuangxing Li Junmin Hong Jiansen Yan Zhengqi Huang Jiajun Wu Zhihuai Deng Tianyu Qin Kang Xu Wei Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 2 |
| 13 | Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs显示文摘 | Wei Jiang Jilong Wang Jinbin Yang Zhiwei He Zhenhui Hou Yingli Luo Li Wang Jing Liu Houbing Zhang Yangyang Zhao Guoqing Zhang Fang Huang Xuechang Zhou Lifeng Yan Xianzhu Yang Yucai Wang Jun Wang | 2018 | Nano Research2018，11，10： | 2 |
| 14 | Simultaneous determination of four Sudan dyes in rat blood by UFLC–MS/MS and its application to a pharmacokinetic study in rats显示文摘A rapid and sensitive method based on ultrafast liquid chromatography–tandem mass spectrometry was developed and validated for simultaneous determination of Sudan I, Sudan II, Sudan III, and Sudan IV levels in rat whole blood. Cleanert C18 mixed-mode polymeric sorbent was used for effective solid-phase extraction cleanup. Separation was carried out on a reversed-phase C18column(100 mm 2.1 mm,1.8 μm) using 0.1%(v/v) formic acid in water/0.1%(v/v) formic acid in acetonitrile as the mobile phase in gradient elution. Quanti fi cation was performed by an electrospray ionization source in the positive multiple reaction monitoring mode using D5-Sudan I as the internal standard. Calibration curves showed good linearity between 0.2 and 20.0 μg/L, with correlation coef fi cients higher than 0.9990. The average recovery rates were between 93.05% and 114.98%. The intra- and inter-day relative standard deviations were within 6.2%. The lower limit of quanti fi cation was 0.2 μg/L. All the analytes were found to be stable in a series of stability studies. The proposed method was successfully applied to a pharmacokinetic study of four Sudan dyes after oral administration to rats. | Hao Zhu Yijun Chen Changshun Huang Yangyang Han Yiwei Zhang Shucan Xie Xiaohong Chen Micong Jin | 2015 | Journal of Pharmaceutical Analysis2015，5，4： | 1 |
| 15 | Hierarchical macro-microporous WPU-ECM scaffolds combined with Microfracture Promote in Situ Articular Cartilage Regeneration in Rabbits显示文摘Tissue engineering provides a promising avenue for treating cartilage defects.However,great challenges remain in the development of structurally and functionally optimized scaffolds for cartilage repair and regeneration.In this study,decellularized cartilage extracellular matrix(ECM)and waterborne polyurethane(WPU)were employed to construct WPU and WPU-ECM scaffolds by water-based 3D printing using low-temperature deposition manufacturing(LDM)system,which combines rapid deposition manufacturing with phase separation techniques.The scaffolds successfully achieved hierarchical macro-microporous structures.After adding ECM,WPU scaffolds were markedly optimized in terms of porosity,hydrophilia and bioactive components.Moreover,the optimized WPU-ECM scaffolds were found to be more suitable for cell distribution,adhesion,and proliferation than the WPU scaffolds.Most importantly,the WPU-ECM scaffold could facilitate the production of glycosaminoglycan(GAG)and collagen and the upregulation of cartilage-specific genes.These results indicated that the WPU-ECM scaffold with hierarchical macro-microporous structures could recreate a favorable microenvironment for cell adhesion,proliferation,differentiation,and ECM production.In vivo studies further revealed that the hierarchical macro-microporous WPU-ECM scaffold combined with the microfracture procedure successfully regenerated hyaline cartilage in a rabbit model.Six months after implantation,the repaired cartilage showed a similar histological structure and mechanical performance to that of normal cartilage.In conclusion,the hierarchical macro-microporous WPU-ECM scaffold may be a promising candidate for cartilage tissue engineering applications in the future. | Mingxue Chen YangYang Li Shuyun Liu Zhaoxuan Feng Hao Wang Dejin Yang Weimin Guo Zhiguo Yuan Shuang Gao Yu Zhang Kangkang Zha Bo Huang Fu Wei Xinyu Sang Qinyu Tian Xuan Yang Xiang sui Yixin Zhou Yufeng Zheng Quanyi Guo | 2021 | Bioactive Materials2021，6，7： | 1 |
| 16 | 3D-printed cell-free PCL-MECM scaffold with biomimetic micro-structure and micro-environment to enhance in situ meniscus regeneration显示文摘Despite intensive effort was made to regenerate injured meniscus by cell-free strategies through recruiting endogenous stem/progenitor cells,meniscus regeneration remains a great challenge in clinic.In this study,we found decellularized meniscal extracellular matrix(MECM)preserved native meniscal collagen and glycosaminoglycans which could be a good endogenous regeneration guider for stem cells.Moreover,MECM significantly promoted meniscal fibrochondrocytes viability and proliferation,increased the expression of type II collagen and proteoglycans in vitro.Meanwhile,we designed 3D-printed polycaprolactone(PCL)scaffolds which mimic the circumferential and radial collagen orientation in native meniscus.Taken these two advantages together,a micro-structure and micro-environment dually biomimetic cell-free scaffold was manipulated.This cell-free PCL-MECM scaffold displayed superior biocompatibility and yielded favorable biomechanical capacities closely to native meniscus.Strikingly,neo-menisci were regenerated within PCL-MECM scaffolds which were transplanted into knee joints underwent medial meniscectomy in rabbits and sheep models.Histological staining confirmed neo-menisci showed meniscus-like heterogeneous staining.Mankin scores showed PCL-MECM scaffold could protect articular cartilage well,and knee X-ray examination revealed same results.Knee magnetic resonance imaging(MRI)scanning also showed some neo-menisci in PCL-MECM scaffold group.In conclusion,PCL-MECM scaffold appears to optimize meniscus regeneration.This could represent a promising approach worthy of further investigation in preclinical applications. | Weimin Guo Mingxue Chen Zhenyong Wang Yue Tian Jinxuan Zheng Shuang Gao Yangyang Li Yufeng Zheng Xu Li Jingxiang Huang Wei Niu Shuangpeng Jiang Chunxiang Hao Zhiguo Yuan Yu Zhang Mingjie Wang Zehao Wang Jiang Peng Aiyuan Wang Yu Wang Xiang Sui Wenjing Xu Libo Hao Xifu Zheng Shuyun Liu Quanyi Guo | 2021 | Bioactive Materials2021，6，10： | 1 |
| 17 | In situ delivery of apoptotic bodies derived from mesenchymal stem cells via a hyaluronic acid hydrogel:A therapy for intrauterine adhesions显示文摘Stem cell-based and stem cell-derived exosome-based therapies have shown promising potential for endometrial regeneration and the clinical treatment of intrauterine adhesions(IUAs).Evidence shows that apoptosis occurs in a majority of grafted stem cells,and apoptotic bodies(ABs)play a critical role in compensatory tissue regeneration.However,the therapeutic potential of AB-based therapy and its mechanism have not been explored in detail.Here,a cell-free therapeutic strategy was developed by incorporating mesenchymal stem cell-derived ABs into a hyaluronic acid(HA)hydrogel to achieve endometrial regeneration and fertility restoration.Specifically,we found that the ABs could induce macrophage immunomodulation,cell proliferation,and angiogenesis in vitro.The HA hydrogel promoted the retention of ABs and facilitated their continuous release.In a murine model of acute endometrial damage and a rat model of IUAs,in situ injection of the AB-laden HA hydrogel could efficiently reduce fibrosis and promote endometrial regeneration,resulting in the fertility restoration.Consequently,ABs show good potential as therapeutic vesicles,and the AB-laden HA hydrogel appears to be a clinically feasible and cell-free alternative for endometrial regeneration and IUA treatment. | Liaobing Xin Cheng Wei Xiaomei Tong Yangyang Dai Dong Huang Jianmin Chen Lie Ma Songying Zhang | 2022 | Bioactive Materials2022，7，6： | 1 |
| 18 | An acquisition system of digital nuclear signal processing for the algorithm development显示文摘A principle and method of constructing the digital acquisition system is presented in this work,which is convenient for the study on the theories and algorithms of digital nuclear signal processing.The hardware system of the digital acquisition system consists of front-end controller,waveform digitizer and PC workstation,on which the software system has been developed based on Visual C++under Windows environment.The alterable-frequency sampling(AFS)algorithm and the alterable-frequency trapezoidal filter(AFTF)algorithm have also been studied in the real-time environment,along with a digital nuclear spectrum acquisition system being set up based on the new algorithms and theγ-ray spectra of 241Am being shown.A useful experimental platform could be provided by this work for the successive work such as the development of global digitized nuclear measurement system and the study of digital nuclear signal processing. | WANG Peng ZHANG Ruanyu YAN Yangyang HAO Dejian HUANG Ning WU Qingxing AN Zhu | 2013 | Nuclear Science and Techniques2013，24，6： | 1 |
| 19 | A Modified Evisceration Technique with Scleral Quadrisection and Porous Polyethylene Implantation显示文摘 | Danping Huang Yangyang Yu Rong Lu Huasheng Yang Jianhao Cai | 2009 | American Journal of Ophthalmology2009，，5： | 1 |
| 20 | Surface etching induced ultrathin sandwich structure realizing enhanced photocatalytic activity显示文摘Photocatalytic conversion efficiency is limited by serious charge carrier recombination. Efficient carrier separation is usually achieved by elegantly-designed multi-component structures connected by directional electric field. Herein, we developed a twodimensional(2 D) sandwich structure, as a new photocatalytic system, to realize high-efficiency carrier separation. This strategy integrated multifunction into a single structure for the first time, which successfully introduces a stable built-in electric field,realizing high-effective carrier separation. Besides, the carrier concentration is dramatically increased due to dimensional confinement. Benefiting from above synergic advantages, 2 D sandwich photocatalyst achieves the highest nitrogen fixation rate(435 μmol g^(-1) h^(-1)) in inorganic solid photocatalysts under visible light irradiation. We anticipate that 2 D sandwich photocatalyst holds promises for the application and expansion of 2 D materials in photocatalysis research. | Bo Yang Wentuan Bi Yangyang Wan Xiaogang Li Mingcan Huang Ruilin Yuan Huanxin Ju Wangsheng Chu Xiaojun Wu Linghui He Changzheng Wu Yi Xie | 2018 | Science China Chemistry2018，61，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员